Structural basis for penetration of the glycan shield of hepatitis C virus E2 glycoprotein by a broadly neutralizing human antibody

Journal of Biological Chemistry

Volumn 290, Issue 16, 2015, Pages 10117-10125

  Li, Yili ^a,b   Pierce, Brian G ^a   Wang, Qian ^a,b   Keck, Zhen Yong ^c   Fuerst, Thomas R ^a,b   Foung, Steven K H ^c   Mariuzza, Roy A ^a,b  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b Bldg 142   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPES; GLYCOPROTEINS; GLYCOSYLATION; POLYSACCHARIDES; VIRUSES;

ADAPTIVE MUTATION; ANTIBODY BINDING; COMPLEMENTARITY-DETERMINING REGION 3; ENVELOPE GLYCOPROTEINS; HEPATITIS C VIRUS; HEPATOCELLULAR CARCINOMA; STRUCTURAL FLEXIBILITIES; VACCINE DEVELOPMENT;

ANTIBODIES;

ASPARAGINE; GLYCAN; GLYCOPROTEIN E2; MONOCLONAL ANTIBODY AP33; MONOCLONAL ANTIBODY HC33.1; MONOCLONAL ANTIBODY HCV1; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; ANTIGEN ANTIBODY COMPLEX; COMPLEMENTARITY DETERMINING REGION; EPITOPE; GLYCOPROTEIN E2, HEPATITIS C VIRUS; HEPATITIS C ANTIGEN; POLYSACCHARIDE; RECOMBINANT PROTEIN; VIRUS ENVELOPE PROTEIN;

ANTIBODY STRUCTURE; ANTIGEN ANTIBODY REACTION; ANTIGENICITY; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; VIRUS NEUTRALIZATION; ANTIGEN ANTIBODY COMPLEX; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; GLYCOSYLATION; HEPACIVIRUS; HUMAN; IMMUNE EVASION; IMMUNOLOGY; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

HEPATITIS C VIRUS;

ANTIBODIES, NEUTRALIZING; ANTIGEN-ANTIBODY COMPLEX; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLOGRAPHY, X-RAY; EPITOPES; GENE EXPRESSION REGULATION, VIRAL; GLYCOSYLATION; HEPACIVIRUS; HEPATITIS C ANTIGENS; HUMANS; IMMUNE EVASION; MODELS, MOLECULAR; POLYSACCHARIDES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; VIRAL ENVELOPE PROTEINS;

EID: 84927920900     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.643528     Document Type: Article

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