Restricted diversity of antigen binding residues of antibodies revealed by computational alanine scanning of 227 antibody-antigen complexes

Journal of Molecular Biology

Volumn 426, Issue 22, 2014, Pages 3729-3743

  Robin, Gautier ^a,b,c   Sato, Yoshiteru ^d   Desplancq, Dominique ^d   Rochel, Natacha ^d   Weiss, Etienne ^d   Martineau, Pierre ^a,b,c  

^a INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^b UNIV MONTPELLIER   (France)

^c CENTRE VAL D AURELLE   (France)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

antibody library; binding free energy; protein protein interaction; X ray crystal structure analysis

Indexed keywords

ALANINE; ANTIBODY; ANTIGEN; GLYCINE; SERINE; ANTIGEN ANTIBODY COMPLEX; COMPLEMENTARITY DETERMINING REGION; EPITOPE; PEPTIDE LIBRARY; PROTEIN BINDING;

ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; COMPLEMENTARITY DETERMINING REGION; DATA BASE; ENERGY; PHAGE DISPLAY; SITE DIRECTED MUTAGENESIS; STATISTICAL ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; HYDROGEN BOND; METABOLISM; MUTAGENESIS; MUTATION; PEPTIDE LIBRARY; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALANINE; ANTIBODIES; ANTIGEN-ANTIBODY COMPLEX; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84908061371     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.08.013     Document Type: Article

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