메뉴 건너뛰기




Volumn 5, Issue 12, 2014, Pages

Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P100; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; BV6 PEPTIDE; DIABLO PROTEIN, HUMAN; IRF1 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; OLIGOPEPTIDE; SIGNAL PEPTIDE;

EID: 84927920476     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.498     Document Type: Article
Times cited : (30)

References (46)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84856495152 scopus 로고    scopus 로고
    • Targeting IAP proteins for therapeutic intervention in cancer
    • Fulda S, Vucic D. Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov 2012; 11: 109-124.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 109-124
    • Fulda, S.1    Vucic, D.2
  • 3
    • 44949240664 scopus 로고    scopus 로고
    • CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    • Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689-700.
    • (2008) Mol Cell , vol.30 , pp. 689-700
    • Bertrand, M.J.1    Milutinovic, S.2    Dickson, K.M.3    Ho, W.C.4    Boudreault, A.5    Durkin, J.6
  • 4
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008; 132: 344-362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 5
    • 56349164239 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
    • Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 2008; 9: 1371-1378.
    • (2008) Nat Immunol , vol.9 , pp. 1371-1378
    • Zarnegar, B.J.1    Wang, Y.2    Mahoney, D.J.3    Dempsey, P.W.4    Cheung, H.H.5    He, J.6
  • 6
    • 36048999753 scopus 로고    scopus 로고
    • IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
    • Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007; 131: 669-681.
    • (2007) Cell , vol.131 , pp. 669-681
    • Varfolomeev, E.1    Blankenship, J.W.2    Wayson, S.M.3    Fedorova, A.V.4    Kayagaki, N.5    Garg, P.6
  • 7
    • 36148954336 scopus 로고    scopus 로고
    • IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    • Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-693.
    • (2007) Cell , vol.131 , pp. 682-693
    • Vince, J.E.1    Wong, W.W.2    Khan, N.3    Feltham, R.4    Chau, D.5    Ahmed, A.U.6
  • 8
    • 77449101221 scopus 로고    scopus 로고
    • Regulation of immunity and oncogenesis by the IRF transcription factor family
    • Savitsky D, Tamura T, Yanai H, Taniguchi T. Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother 2010; 59: 489-510.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 489-510
    • Savitsky, D.1    Tamura, T.2    Yanai, H.3    Taniguchi, T.4
  • 9
    • 0023788435 scopus 로고
    • Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements
    • Miyamoto M, Fujita T, Kimura Y, Maruyama M, Harada H, Sudo Y et al. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell 1988; 54: 903-913.
    • (1988) Cell , vol.54 , pp. 903-913
    • Miyamoto, M.1    Fujita, T.2    Kimura, Y.3    Maruyama, M.4    Harada, H.5    Sudo, Y.6
  • 10
    • 0034019810 scopus 로고    scopus 로고
    • Degradation of transcription factor IRF-1 by the ubiquitin-proteasome pathway. the C-terminal region governs the protein stability
    • Nakagawa K, Yokosawa H. Degradation of transcription factor IRF-1 by the ubiquitin-proteasome pathway. The C-terminal region governs the protein stability. Eur J Biochem/FEBS 2000; 267: 1680-1686.
    • (2000) Eur J Biochem/FEBS , vol.267 , pp. 1680-1686
    • Nakagawa, K.1    Yokosawa, H.2
  • 11
    • 53549089344 scopus 로고    scopus 로고
    • CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1
    • Moschonas A, Kouraki M, Knox PG, Thymiakou E, Kardassis D, Eliopoulos AG. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol Cell Biol 2008; 28: 6208-6222.
    • (2008) Mol Cell Biol , vol.28 , pp. 6208-6222
    • Moschonas, A.1    Kouraki, M.2    Knox, P.G.3    Thymiakou, E.4    Kardassis, D.5    Eliopoulos, A.G.6
  • 12
    • 36849027823 scopus 로고    scopus 로고
    • EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells
    • Andersen P, Pedersen MW, Woetmann A, Villingshoj M, Stockhausen MT, Odum N et al. EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells. Int J Cancer 2008; 122: 342-349.
    • (2008) Int J Cancer , vol.122 , pp. 342-349
    • Andersen, P.1    Pedersen, M.W.2    Woetmann, A.3    Villingshoj, M.4    Stockhausen, M.T.5    Odum, N.6
  • 13
    • 0031570834 scopus 로고    scopus 로고
    • Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages
    • Lehtonen A, Matikainen S, Julkunen I. Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. J Immunol 1997; 159: 794-803.
    • (1997) J Immunol , vol.159 , pp. 794-803
    • Lehtonen, A.1    Matikainen, S.2    Julkunen, I.3
  • 14
    • 0035061538 scopus 로고    scopus 로고
    • IRF family of transcription factors as regulators of host defense
    • Taniguchi T, Ogasawara K, Takaoka A, Tanaka N. IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 2001; 19: 623-655.
    • (2001) Annu Rev Immunol , vol.19 , pp. 623-655
    • Taniguchi, T.1    Ogasawara, K.2    Takaoka, A.3    Tanaka, N.4
  • 15
    • 0037038696 scopus 로고    scopus 로고
    • Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway
    • Pamment J, Ramsay E, Kelleher M, Dornan D, Ball KL. Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway. Oncogene 2002; 21: 7776-7785.
    • (2002) Oncogene , vol.21 , pp. 7776-7785
    • Pamment, J.1    Ramsay, E.2    Kelleher, M.3    Dornan, D.4    Ball, K.L.5
  • 16
    • 24344507725 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis
    • Bouker KB, Skaar TC, Riggins RB, Harburger DS, Fernandez DR, Zwart A et al. Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. Carcinogenesis 2005; 26: 1527-1535.
    • (2005) Carcinogenesis , vol.26 , pp. 1527-1535
    • Bouker, K.B.1    Skaar, T.C.2    Riggins, R.B.3    Harburger, D.S.4    Fernandez, D.R.5    Zwart, A.6
  • 17
    • 4143116932 scopus 로고    scopus 로고
    • Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL
    • Clarke N, Jimenez-Lara AM, Voltz E, Gronemeyer H. Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL. EMBO J 2004; 23: 3051-3060.
    • (2004) EMBO J , vol.23 , pp. 3051-3060
    • Clarke, N.1    Jimenez-Lara, A.M.2    Voltz, E.3    Gronemeyer, H.4
  • 18
    • 77949539947 scopus 로고    scopus 로고
    • IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells
    • Gao J, Senthil M, Ren B, Yan J, Xing Q, Yu J et al. IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells. Cell Death Differ 2010; 17: 699-709.
    • (2010) Cell Death Differ , vol.17 , pp. 699-709
    • Gao, J.1    Senthil, M.2    Ren, B.3    Yan, J.4    Xing, Q.5    Yu, J.6
  • 19
    • 49149119083 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 (IRF-1) regulates VEGF-induced angiogenesis in HUVECs
    • Lee JH, Chun T, Park SY, Rho SB. Interferon regulatory factor-1 (IRF-1) regulates VEGF-induced angiogenesis in HUVECs. Biochim Biophys Acta 2008; 1783: 1654-1662.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 1654-1662
    • Lee, J.H.1    Chun, T.2    Park, S.Y.3    Rho, S.B.4
  • 20
    • 28944440894 scopus 로고    scopus 로고
    • IRF-1 and NF-kappaB p50/cRel bind to distinct regions of the proximal murine IL-12 p35 promoter during costimulation with IFN-gamma and LPS
    • Kollet JI, Petro TM. IRF-1 and NF-kappaB p50/cRel bind to distinct regions of the proximal murine IL-12 p35 promoter during costimulation with IFN-gamma and LPS. Mol Immunol 2006; 43: 623-633.
    • (2006) Mol Immunol , vol.43 , pp. 623-633
    • Kollet, J.I.1    Petro, T.M.2
  • 21
    • 41149122048 scopus 로고    scopus 로고
    • IRF-1 is required for full NF-kappaB transcriptional activity at the human immunodeficiency virus type 1 long terminal repeat enhancer
    • Sgarbanti M, Remoli AL, Marsili G, Ridolfi B, Borsetti A, Perrotti E et al. IRF-1 is required for full NF-kappaB transcriptional activity at the human immunodeficiency virus type 1 long terminal repeat enhancer. J Virol 2008; 82: 3632-3641.
    • (2008) J Virol , vol.82 , pp. 3632-3641
    • Sgarbanti, M.1    Remoli, A.L.2    Marsili, G.3    Ridolfi, B.4    Borsetti, A.5    Perrotti, E.6
  • 22
    • 84874763808 scopus 로고    scopus 로고
    • Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1-and NF-kappaB-dependent manner
    • Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K et al. Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1-and NF-kappaB-dependent manner. Oncogene 2013; 32: 988-997.
    • (2013) Oncogene , vol.32 , pp. 988-997
    • Wagner, L.1    Marschall, V.2    Karl, S.3    Cristofanon, S.4    Zobel, K.5    Deshayes, K.6
  • 23
    • 84855440150 scopus 로고    scopus 로고
    • Requirement of nuclear factor kappaB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis
    • Stadel D, Cristofanon S, Abhari BA, Deshayes K, Zobel K, Vucic D et al. Requirement of nuclear factor kappaB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis. Neoplasia 2011; 13: 1162-1170.
    • (2011) Neoplasia , vol.13 , pp. 1162-1170
    • Stadel, D.1    Cristofanon, S.2    Abhari, B.A.3    Deshayes, K.4    Zobel, K.5    Vucic, D.6
  • 24
    • 80053933840 scopus 로고    scopus 로고
    • NF-{kappa}B is required for smac mimetic-mediated sensitization of glioblastoma cells for {gamma}-irradiation-induced apoptosis
    • Berger R, Jennewein C, Marschall V, Karl S, Cristofanon S, Wagner L et al. NF-{kappa}B is required for smac mimetic-mediated sensitization of glioblastoma cells for {gamma}-irradiation-induced apoptosis. Mol Cancer Ther 2011; 10: 1867-1875.
    • (2011) Mol Cancer Ther , pp. 10
    • Berger, R.1    Jennewein, C.2    Marschall, V.3    Karl, S.4    Cristofanon, S.5    Wagner, L.6
  • 25
    • 1442278664 scopus 로고    scopus 로고
    • IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo
    • Kim PK, Armstrong M, Liu Y, Yan P, Bucher B, Zuckerbraun BS et al. IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo. Oncogene 2004; 23: 1125-1135.
    • (2004) Oncogene , vol.23 , pp. 1125-1135
    • Kim, P.K.1    Armstrong, M.2    Liu, Y.3    Yan, P.4    Bucher, B.5    Zuckerbraun, B.S.6
  • 26
    • 84889560425 scopus 로고    scopus 로고
    • Identification of DR5 as a critical, NF-kappaB-regulated mediator of Smac-induced apoptosis
    • Eckhardt I, Roesler S, Fulda S. Identification of DR5 as a critical, NF-kappaB-regulated mediator of Smac-induced apoptosis. Cell Death Dis 2013; 4: e936.
    • (2013) Cell Death Dis , vol.4 , pp. e936
    • Eckhardt, I.1    Roesler, S.2    Fulda, S.3
  • 27
    • 84875877848 scopus 로고    scopus 로고
    • Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells
    • Tchoghandjian A, Jennewein C, Eckhardt I, Rajalingam K, Fulda S. Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells. Cell Death Dis 2013; 4: e564.
    • (2013) Cell Death Dis , vol.4 , pp. e564
    • Tchoghandjian, A.1    Jennewein, C.2    Eckhardt, I.3    Rajalingam, K.4    Fulda, S.5
  • 30
    • 0030022331 scopus 로고    scopus 로고
    • Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach
    • Tamura G, Ogasawara S, Nishizuka S, Sakata K, Maesawa C, Suzuki Y et al. Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach. Cancer Res 1996; 56: 612-615.
    • (1996) Cancer Res , vol.56 , pp. 612-615
    • Tamura, G.1    Ogasawara, S.2    Nishizuka, S.3    Sakata, K.4    Maesawa, C.5    Suzuki, Y.6
  • 31
    • 0027519370 scopus 로고
    • Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: Retention of IRF1 on the 5q-chromosome in some patients with the 5q-syndrome
    • Boultwood J, Fidler C, Lewis S, MacCarthy A, Sheridan H, Kelly S et al. Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q-chromosome in some patients with the 5q-syndrome. Blood 1993; 82: 2611-2616.
    • (1993) Blood , vol.82 , pp. 2611-2616
    • Boultwood, J.1    Fidler, C.2    Lewis, S.3    MacCarthy, A.4    Sheridan, H.5    Kelly, S.6
  • 32
    • 77951297779 scopus 로고    scopus 로고
    • Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer
    • Cavalli LR, Riggins RB, Wang A, Clarke R, Haddad BR. Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer. Breast Cancer Res Treat 2010; 121: 227-231.
    • (2010) Breast Cancer Res Treat , vol.121 , pp. 227-231
    • Cavalli, L.R.1    Riggins, R.B.2    Wang, A.3    Clarke, R.4    Haddad, B.R.5
  • 34
    • 58149300251 scopus 로고    scopus 로고
    • IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages
    • Vila-del Sol V, Punzon C, Fresno M. IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages. J Immunol 2008; 181: 4461-4470.
    • (2008) J Immunol , vol.181 , pp. 4461-4470
    • Vila-Del Sol, V.1    Punzon, C.2    Fresno, M.3
  • 35
    • 51549118941 scopus 로고    scopus 로고
    • TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol
    • Zhao XJ, Dong Q, Bindas J, Piganelli JD, Magill A, Reiser J et al. TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol. J Immunol 2008; 181: 3049-3056.
    • (2008) J Immunol , vol.181 , pp. 3049-3056
    • Zhao, X.J.1    Dong, Q.2    Bindas, J.3    Piganelli, J.D.4    Magill, A.5    Reiser, J.6
  • 36
    • 84874087182 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production
    • Kearney CJ, Sheridan C, Cullen SP, Tynan GA, Logue SE, Afonina IS et al. Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production. J Biol Chem 2013; 288: 4878-4890.
    • (2013) J Biol Chem , vol.288 , pp. 4878-4890
    • Kearney, C.J.1    Sheridan, C.2    Cullen, S.P.3    Tynan, G.A.4    Logue, S.E.5    Afonina, I.S.6
  • 38
    • 84858163320 scopus 로고    scopus 로고
    • Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy
    • Emeagi PU, Van Lint S, Goyvaerts C, Maenhout S, Cauwels A, McNeish IA et al. Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy. Cancer Res 2012; 72: 1342-1352.
    • (2012) Cancer Res , vol.72 , pp. 1342-1352
    • Emeagi, P.U.1    Van Lint, S.2    Goyvaerts, C.3    Maenhout, S.4    Cauwels, A.5    McNeish, I.A.6
  • 39
    • 55549115035 scopus 로고    scopus 로고
    • Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2
    • Hu Y, Park-Min KH, Yarilina A, Ivashkiv LB. Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2. J Leukoc Biol 2008; 84: 1353-1360.
    • (2008) J Leukoc Biol , vol.84 , pp. 1353-1360
    • Hu, Y.1    Park-Min, K.H.2    Yarilina, A.3    Ivashkiv, L.B.4
  • 40
  • 41
    • 65549151902 scopus 로고    scopus 로고
    • IRF-1 and p65 mediate upregulation of constitutive HLA-A antigen expression by hepatocellular carcinoma cells
    • Shen Y, Xia M, Zhang J, Xu L, Yang J, Chen A et al. IRF-1 and p65 mediate upregulation of constitutive HLA-A antigen expression by hepatocellular carcinoma cells. Mol Immunol 2009; 46: 2045-2053.
    • (2009) Mol Immunol , vol.46 , pp. 2045-2053
    • Shen, Y.1    Xia, M.2    Zhang, J.3    Xu, L.4    Yang, J.5    Chen, A.6
  • 43
    • 77449136821 scopus 로고    scopus 로고
    • Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response
    • Karl S, Pritschow Y, Volcic M, Hacker S, Baumann B, Wiesmuller L et al. Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response. J Cell Mol Med 2009; 13: 4239-4256.
    • (2009) J Cell Mol Med , vol.13 , pp. 4239-4256
    • Karl, S.1    Pritschow, Y.2    Volcic, M.3    Hacker, S.4    Baumann, B.5    Wiesmuller, L.6
  • 44
    • 0030815250 scopus 로고    scopus 로고
    • Betulinic acid triggers CD95 (APO-1/Fas)-and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
    • Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M et al. Betulinic acid triggers CD95 (APO-1/Fas)-and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 1997; 57: 4956-4964.
    • (1997) Cancer Res , vol.57 , pp. 4956-4964
    • Fulda, S.1    Friesen, C.2    Los, M.3    Scaffidi, C.4    Mier, W.5    Benedict, M.6
  • 45
    • 33846222280 scopus 로고    scopus 로고
    • Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells
    • Vogler M, Durr K, Jovanovic M, Debatin KM, Fulda S. Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells. Oncogene 2007; 26: 248-257.
    • (2007) Oncogene , vol.26 , pp. 248-257
    • Vogler, M.1    Durr, K.2    Jovanovic, M.3    Debatin, K.M.4    Fulda, S.5
  • 46
    • 27144547145 scopus 로고    scopus 로고
    • Betulinic acid as new activator of NF-kappaB: Molecular mechanisms and implications for cancer therapy
    • Kasperczyk H, La Ferla-Brühl K, Westhoff MA, Behrend L, Zwacka RM, Debatin KM et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene 2005; 24: 6945-6956.
    • (2005) Oncogene , vol.24 , pp. 6945-6956
    • Kasperczyk, H.1    La Ferla-Brühl, K.2    Westhoff, M.A.3    Behrend, L.4    Zwacka, R.M.5    Debatin, K.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.