메뉴 건너뛰기




Volumn 27, Issue 6, 2014, Pages 689-696

BRAF alterations in brain tumours: Molecular pathology and therapeutic opportunities

Author keywords

Brain metastasis; Brain tumours; Gene fusion; Gene mutation; Glioma; v RAF murine sarcoma viral oncogene homologue B1

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; BRAF PROTEIN, HUMAN;

EID: 84927788699     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0000000000000146     Document Type: Review
Times cited : (33)

References (73)
  • 1
    • 33846201272 scopus 로고    scopus 로고
    • New insight into BRAF mutations in cancer
    • Dhomen N, Marais R. New insight into BRAF mutations in cancer. Curr Opin Genet Dev 2007; 17:31-39.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 31-39
    • Dhomen, N.1    Marais, R.2
  • 2
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364:2507-2516.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 3
    • 84891648456 scopus 로고    scopus 로고
    • Phase II trial (BRAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma
    • Ascierto PA, Minor D, Ribas A, et al. Phase II trial (BRAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma. J Clin Oncol 2013; 31:3205-3211.
    • (2013) J Clin Oncol , vol.31 , pp. 3205-3211
    • Ascierto, P.A.1    Minor, D.2    Ribas, A.3
  • 4
    • 84880502601 scopus 로고    scopus 로고
    • Designing transformative clinical trials in the cancer genome era
    • Sleijfer S, Bogaerts J, Siu LL. Designing transformative clinical trials in the cancer genome era. J Clin Oncol 2013; 31:1834-1841.
    • (2013) J Clin Oncol , vol.31 , pp. 1834-1841
    • Sleijfer, S.1    Bogaerts, J.2    Siu, L.L.3
  • 5
    • 84868120907 scopus 로고    scopus 로고
    • Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, open-label, phase 2
    • Long GV, Trefzer U, Davies MA, et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2. Lancet Oncol 2012; 13:1087-1095.
    • (2012) Lancet Oncol , vol.13 , pp. 1087-1095
    • Long, G.V.1    Trefzer, U.2    Davies, M.A.3
  • 6
    • 84899473817 scopus 로고    scopus 로고
    • Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas
    • Bautista F, Paci A, Minard-Colin V, et al. Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas. Pediatr Blood Cancer 2014; 61:1101-1103.
    • (2014) Pediatr Blood Cancer , vol.61 , pp. 1101-1103
    • Bautista, F.1    Paci, A.2    Minard-Colin, V.3
  • 7
    • 84885059781 scopus 로고    scopus 로고
    • Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: A retrospective case series
    • Chamberlain MC. Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: a retrospective case series. J Neurooncol 2013; 114:237-240.
    • (2013) J Neurooncol , vol.114 , pp. 237-240
    • Chamberlain, M.C.1
  • 8
    • 84907291101 scopus 로고    scopus 로고
    • Pilomyxoid astrocytoma treated successfully with vemurafenib
    • Epub ahead of print
    • Skrypek M, Foreman N,Guillaume D, et al. Pilomyxoid astrocytoma treated successfully with vemurafenib. Pediatr Blood Cancer 2014. [Epub ahead of print]
    • (2014) Pediatr Blood Cancer
    • Skrypek, M.1    Foreman, N.2    Guillaume, D.3
  • 9
    • 34547122001 scopus 로고    scopus 로고
    • WHO classification of tumours of the central nervous system
    • Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007; 114:97-109.
    • (2007) Acta Neuropathol , vol.2007 , Issue.114 , pp. 97-109
    • Louis, D.N.1    Ohgaki, H.2    Wiestler, O.D.3    The, E.4
  • 10
    • 77953020697 scopus 로고    scopus 로고
    • Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas
    • Horbinski C, Hamilton RL, Nikiforov Y, et al. Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas. Acta Neuropathol 2010; 119:641-649.
    • (2010) Acta Neuropathol , vol.119 , pp. 641-649
    • Horbinski, C.1    Hamilton, R.L.2    Nikiforov, Y.3
  • 11
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • Jones DT, Kocialkowski S, Liu L, et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res 2008; 68:8673-8677.
    • (2008) Cancer Res , vol.68 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 12
    • 84655167688 scopus 로고    scopus 로고
    • BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants
    • Lin A, Rodriguez FJ, Karajannis MA, et al. BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. J Neuropathol Exp Neurol 2012; 71:66-72.
    • (2012) J Neuropathol Exp Neurol , vol.71 , pp. 66-72
    • Lin, A.1    Rodriguez, F.J.2    Karajannis, M.A.3
  • 13
    • 84871704107 scopus 로고    scopus 로고
    • Analysis of the BRAF(V600E) mutation in central nervous system tumors
    • Myung JK, Cho H, Park CK, et al. Analysis of the BRAF(V600E) mutation in central nervous system tumors. Transl Oncol 2012; 5:430-436.
    • (2012) Transl Oncol , vol.5 , pp. 430-436
    • Myung, J.K.1    Cho, H.2    Park, C.K.3
  • 14
    • 79954441895 scopus 로고    scopus 로고
    • Analysis of BRAF V600E mutation in 1320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
    • Schindler G, Capper D, Meyer J, et al. Analysis of BRAF V600E mutation in 1320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 2011; 121:397-405.
    • (2011) Acta Neuropathol , vol.121 , pp. 397-405
    • Schindler, G.1    Capper, D.2    Meyer, J.3
  • 15
    • 84857030136 scopus 로고    scopus 로고
    • Immunohistochemical testing of BRAF V600E status in 1120 tumor tissue samples of patients with brain metastases
    • Capper D, Berghoff AS, Magerle M, et al. Immunohistochemical testing of BRAF V600E status in 1120 tumor tissue samples of patients with brain metastases. Acta Neuropathol 2012; 123:223-233.
    • (2012) Acta Neuropathol , vol.123 , pp. 223-233
    • Capper, D.1    Berghoff, A.S.2    Magerle, M.3
  • 16
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417:949-954.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 17
    • 43049124130 scopus 로고    scopus 로고
    • BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
    • Pfister S, Janzarik WG, Remke M, et al. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J Clin Invest 2008; 118:1739-1749.
    • (2008) J Clin Invest , vol.118 , pp. 1739-1749
    • Pfister, S.1    Janzarik, W.G.2    Remke, M.3
  • 18
    • 66849099801 scopus 로고    scopus 로고
    • Activation of the ERK/MAPK pathway: A signature genetic defect in posterior fossa pilocytic astrocytomas
    • Forshew T, Tatevossian RG, Lawson AR, et al. Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol 2009; 218:172-181.
    • (2009) J Pathol , vol.218 , pp. 172-181
    • Forshew, T.1    Tatevossian, R.G.2    Lawson, A.R.3
  • 19
    • 67349219657 scopus 로고    scopus 로고
    • Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
    • Jones DT, Kocialkowski S, Liu L, et al. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene 2009; 28:2119-2123.
    • (2009) Oncogene , vol.28 , pp. 2119-2123
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 20
    • 79953184268 scopus 로고    scopus 로고
    • BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: Diagnostic and therapeutic implications
    • Dias-Santagata D, Lam Q, Vernovsky K, et al. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One 2011; 6:e17948.
    • (2011) PLoS One , vol.6 , pp. e17948
    • Dias-Santagata, D.1    Lam, Q.2    Vernovsky, K.3
  • 21
    • 84893145278 scopus 로고    scopus 로고
    • BRAF-V600E mutation in pediatric and adult glioblastoma
    • Dahiya S, Emnett RJ, Haydon DH, et al. BRAF-V600E mutation in pediatric and adult glioblastoma. Neuro Oncol 2014; 16:318-319.
    • (2014) Neuro Oncol , vol.16 , pp. 318-319
    • Dahiya, S.1    Emnett, R.J.2    Haydon, D.H.3
  • 22
    • 84898545824 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of genomic imbalance in a case of epithelioid glioblastoma with BRAF V600E mutation
    • Nobusawa S, Hirato J, Kurihara H, et al. Intratumoral heterogeneity of genomic imbalance in a case of epithelioid glioblastoma with BRAF V600E mutation. Brain Pathol 2014; 24:239-246.
    • (2014) Brain Pathol , vol.24 , pp. 239-246
    • Nobusawa, S.1    Hirato, J.2    Kurihara, H.3
  • 23
    • 84896032762 scopus 로고    scopus 로고
    • Gliomatosis cerebri type 1 with extensive involvement of the spinal cord and BRAF V600E mutation
    • Fernandez-Vega I, Quirk J, Norwood FL, et al. Gliomatosis cerebri type 1 with extensive involvement of the spinal cord and BRAF V600E mutation. Pathol Oncol Res 2014; 20:215-220.
    • (2014) Pathol Oncol Res , vol.20 , pp. 215-220
    • Fernandez-Vega, I.1    Quirk, J.2    Norwood, F.L.3
  • 24
    • 84055212088 scopus 로고    scopus 로고
    • Targeted therapy for BRAFV600E malignant astrocytoma
    • Nicolaides TP, Li H, Solomon DA, et al. Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res 2011; 17:7595-7604.
    • (2011) Clin Cancer Res , vol.17 , pp. 7595-7604
    • Nicolaides, T.P.1    Li, H.2    Solomon, D.A.3
  • 25
    • 68349088073 scopus 로고    scopus 로고
    • Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma
    • Korshunov A, Meyer J, Capper D, et al. Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma. Acta Neuropathol 2009; 118:401-405.
    • (2009) Acta Neuropathol , vol.118 , pp. 401-405
    • Korshunov, A.1    Meyer, J.2    Capper, D.3
  • 26
    • 84877840626 scopus 로고    scopus 로고
    • Angiocentric glioma: Clinical, morphological, immunohistochemical and molecular features in three pediatric cases
    • Buccoliero AM, Castiglione F, Degl'innocenti DR, et al. Angiocentric glioma: clinical, morphological, immunohistochemical and molecular features in three pediatric cases. Clin Neuropathol 2013; 32:107-113.
    • (2013) Clin Neuropathol , vol.32 , pp. 107-113
    • Buccoliero, A.M.1    Castiglione, F.2    Degl'innocenti, D.R.3
  • 27
    • 84894226886 scopus 로고    scopus 로고
    • Pediatric brainstem gangliogliomas show BRAF(V600E) mutation in a high percentage of cases
    • Donson AM, Kleinschmidt-DeMasters BK, Aisner DL, et al. Pediatric brainstem gangliogliomas show BRAF(V600E) mutation in a high percentage of cases. Brain Pathol 2014; 24:173-183.
    • (2014) Brain Pathol , vol.24 , pp. 173-183
    • Donson, A.M.1    Kleinschmidt-Demasters, B.K.2    Aisner, D.L.3
  • 28
    • 84879417060 scopus 로고    scopus 로고
    • BRAF alterations in pediatric low grade gliomas and mixed neuronal-glial tumors
    • Dimitriadis E, Alexiou GA, Tsotsou P, et al. BRAF alterations in pediatric low grade gliomas and mixed neuronal-glial tumors. J Neurooncol 2013; 113:353-358.
    • (2013) J Neurooncol , vol.113 , pp. 353-358
    • Dimitriadis, E.1    Alexiou, G.A.2    Tsotsou, P.3
  • 29
    • 84882238982 scopus 로고    scopus 로고
    • Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression
    • Chappe C, Padovani L, Scavarda D, et al. Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. Brain Pathol 2013; 23:574-583.
    • (2013) Brain Pathol , vol.23 , pp. 574-583
    • Chappe, C.1    Padovani, L.2    Scavarda, D.3
  • 30
    • 84898540842 scopus 로고    scopus 로고
    • BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression
    • Koelsche C, Sahm F, Wohrer A, et al. BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. Brain Pathol 2014; 24:221-229.
    • (2014) Brain Pathol , vol.24 , pp. 221-229
    • Koelsche, C.1    Sahm, F.2    Wohrer, A.3
  • 31
    • 84871816998 scopus 로고    scopus 로고
    • Anaplastic PXA in adults: Case series with clinicopathologic and molecular features
    • Schmidt Y, Kleinschmidt-DeMasters BK, Aisner DL, et al. Anaplastic PXA in adults: case series with clinicopathologic and molecular features. J Neurooncol 2013; 111:59-69.
    • (2013) J Neurooncol , vol.111 , pp. 59-69
    • Schmidt, Y.1    Kleinschmidt-Demasters, B.K.2    Aisner, D.L.3
  • 32
    • 84878608078 scopus 로고    scopus 로고
    • Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells
    • Koelsche C, Wohrer A, Jeibmann A, et al. Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells. Acta Neuropathol 2013; 125:891-900.
    • (2013) Acta Neuropathol , vol.125 , pp. 891-900
    • Koelsche, C.1    Wohrer, A.2    Jeibmann, A.3
  • 33
    • 84903890597 scopus 로고    scopus 로고
    • Pediatric posterior fossa ganglioglioma: Unique MRI Features and Correlation with BRAF V600E mutation status
    • Lindsay AJ, Rush SZ, Fenton LZ. Pediatric posterior fossa ganglioglioma: unique MRI Features and Correlation with BRAF V600E mutation status. J Neurooncol 2014; 118:395-404.
    • (2014) J Neurooncol , vol.118 , pp. 395-404
    • Lindsay, A.J.1    Rush, S.Z.2    Fenton, L.Z.3
  • 34
    • 84890802998 scopus 로고    scopus 로고
    • BRAF V600E expression and distribution in desmoplastic infantile astrocytoma/ganglioglioma
    • Koelsche C, Sahm F, Paulus W, et al. BRAF V600E expression and distribution in desmoplastic infantile astrocytoma/ganglioglioma. Neuropathol Appl Neurobiol 2014; 40:337-344.
    • (2014) Neuropathol Appl Neurobiol , vol.40 , pp. 337-344
    • Koelsche, C.1    Sahm, F.2    Paulus, W.3
  • 35
    • 84866624067 scopus 로고    scopus 로고
    • BRAFV600E mutant protein is expressed in cells of variable maturation in langerhans cell histiocytosis
    • Sahm F, Capper D, Preusser M, et al. BRAFV600E mutant protein is expressed in cells of variable maturation in langerhans cell histiocytosis. Blood 2012; 120:e28-e34.
    • (2012) Blood , vol.120 , pp. e28-e34
    • Sahm, F.1    Capper, D.2    Preusser, M.3
  • 36
    • 84895831760 scopus 로고    scopus 로고
    • Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas
    • Brastianos PK, Taylor-Weiner A, Manley PE, et al. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet 2014; 46:161-165.
    • (2014) Nat Genet , vol.46 , pp. 161-165
    • Brastianos, P.K.1    Taylor-Weiner, A.2    Manley, P.E.3
  • 37
    • 84880924090 scopus 로고    scopus 로고
    • Lack of BRAF V600E protein expression in primary central nervous system lymphoma
    • Berghoff AS, Capper D, Preusser M. Lack of BRAF V600E protein expression in primary central nervous system lymphoma. Appl Immunohistochem Mol Morphol 2013; 21:351-353.
    • (2013) Appl Immunohistochem Mol Morphol , vol.21 , pp. 351-353
    • Berghoff, A.S.1    Capper, D.2    Preusser, M.3
  • 38
    • 84867574186 scopus 로고    scopus 로고
    • KIAA1549-BRAF fusions and IDH mutations can coexist in diffuse gliomas of adults
    • Badiali M, Gleize V, Paris S, et al. KIAA1549-BRAF fusions and IDH mutations can coexist in diffuse gliomas of adults. Brain Pathol 2012; 22: 841-847.
    • (2012) Brain Pathol , vol.22 , pp. 841-847
    • Badiali, M.1    Gleize, V.2    Paris, S.3
  • 39
    • 84866409009 scopus 로고    scopus 로고
    • Absence of KIAA1549-BRAF fusion in rosette-forming glioneuronal tumors of the fourth ventricle (RGNT)
    • Gessi M, Lambert SR, Lauriola L, et al. Absence of KIAA1549-BRAF fusion in rosette-forming glioneuronal tumors of the fourth ventricle (RGNT). J Neurooncol 2012; 110:21-25.
    • (2012) J Neurooncol , vol.110 , pp. 21-25
    • Gessi, M.1    Lambert, S.R.2    Lauriola, L.3
  • 40
    • 81955161241 scopus 로고    scopus 로고
    • Analysis of KIAA1549-BRAF fusion status in a case of rosette-forming glioneuronal tumor of the fourth ventricle (RGNT)
    • Gessi M, Waha A, Setty P, et al. Analysis of KIAA1549-BRAF fusion status in a case of rosette-forming glioneuronal tumor of the fourth ventricle (RGNT). Neuropathology 2011; 31:654-657.
    • (2011) Neuropathology , vol.31 , pp. 654-657
    • Gessi, M.1    Waha, A.2    Setty, P.3
  • 42
    • 8844252330 scopus 로고    scopus 로고
    • Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas
    • Knobbe CB, Reifenberger J, Reifenberger G. Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas. Acta Neuropathol 2004; 108:467-470.
    • (2004) Acta Neuropathol , vol.108 , pp. 467-470
    • Knobbe, C.B.1    Reifenberger, J.2    Reifenberger, G.3
  • 43
    • 84896029276 scopus 로고    scopus 로고
    • Clinical, radiological, histological and molecular characteristics of paediatric epithelioid glioblastoma
    • Broniscer A, Tatevossian RG, Sabin ND, et al. Clinical, radiological, histological and molecular characteristics of paediatric epithelioid glioblastoma. Neuropathol Appl Neurobiol 2014; 40:327-336.
    • (2014) Neuropathol Appl Neurobiol , vol.40 , pp. 327-336
    • Broniscer, A.1    Tatevossian, R.G.2    Sabin, N.D.3
  • 44
    • 84905085877 scopus 로고    scopus 로고
    • Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation
    • Tanaka S, Nakada M, Nobusawa S, et al. Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation. Brain Tumor Pathol 2014; 31:172-176.
    • (2014) Brain Tumor Pathol , vol.31 , pp. 172-176
    • Tanaka, S.1    Nakada, M.2    Nobusawa, S.3
  • 45
    • 79960801311 scopus 로고    scopus 로고
    • Current concepts and management of glioblastoma
    • Preusser M, de Ribaupierre S, Wohrer A, et al. Current concepts and management of glioblastoma. Ann Neurol 2011; 70:9-21.
    • (2011) Ann Neurol , vol.70 , pp. 9-21
    • Preusser, M.1    De Ribaupierre, S.2    Wohrer, A.3
  • 46
    • 84899485468 scopus 로고    scopus 로고
    • Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy
    • Robinson GW, Orr BA, Gajjar A. Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy. BMC Cancer 2014; 14:258.
    • (2014) BMC Cancer , vol.14 , pp. 258
    • Robinson, G.W.1    Orr, B.A.2    Gajjar, A.3
  • 48
    • 84869994008 scopus 로고    scopus 로고
    • Molecular predictors of outcome in low-grade glioma
    • Weiler M, Wick W. Molecular predictors of outcome in low-grade glioma. Curr Opin Neurol 2012; 25:767-773.
    • (2012) Curr Opin Neurol , vol.25 , pp. 767-773
    • Weiler, M.1    Wick, W.2
  • 49
    • 84878545588 scopus 로고    scopus 로고
    • BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma
    • Dahiya S, Haydon DH, Alvarado D, et al. BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma. Acta Neuropathol 2013; 125:901-910.
    • (2013) Acta Neuropathol , vol.125 , pp. 901-910
    • Dahiya, S.1    Haydon, D.H.2    Alvarado, D.3
  • 50
    • 78349232314 scopus 로고    scopus 로고
    • MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; A novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential
    • Jeuken JW, Wesseling P. MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential. J Pathol 2010; 222:324-328.
    • (2010) J Pathol , vol.222 , pp. 324-328
    • Jeuken, J.W.1    Wesseling, P.2
  • 51
    • 84862900240 scopus 로고    scopus 로고
    • Mapk pathway activation in pilocytic astrocytoma
    • Jones DT, Gronych J, Lichter P, et al. Mapk pathway activation in pilocytic astrocytoma. Cell Mol Life Sci 2012; 69:1799-1811.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 1799-1811
    • Jones, D.T.1    Gronych, J.2    Lichter, P.3
  • 52
    • 84878723078 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    • Zhang J, Wu G, Miller CP, et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet 2013; 45:602-612.
    • (2013) Nat Genet , vol.45 , pp. 602-612
    • Zhang, J.1    Wu, G.2    Miller, C.P.3
  • 53
    • 80055084211 scopus 로고    scopus 로고
    • BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults
    • Hasselblatt M, Riesmeier B, Lechtape B, et al. BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults. Neuropathol Appl Neurobiol 2011; 37:803-806.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 803-806
    • Hasselblatt, M.1    Riesmeier, B.2    Lechtape, B.3
  • 54
    • 84862193195 scopus 로고    scopus 로고
    • Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas
    • Horbinski C, Nikiforova MN, Hagenkord JM, et al. Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas. Neuro Oncol 2012; 14:777-789.
    • (2012) Neuro Oncol , vol.14 , pp. 777-789
    • Horbinski, C.1    Nikiforova, M.N.2    Hagenkord, J.M.3
  • 55
    • 84876040346 scopus 로고    scopus 로고
    • Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas
    • Sievert AJ, Lang SS, Boucher KL, et al. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proc Natl Acad Sci U S A 2013; 110:5957-5962.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 5957-5962
    • Sievert, A.J.1    Lang, S.S.2    Boucher, K.L.3
  • 56
    • 77956904045 scopus 로고    scopus 로고
    • Recurrent BRAF mutations in Langerhans cell histiocytosis
    • Badalian-Very G, Vergilio JA, Degar BA, et al. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood 2010; 116:1919-1923.
    • (2010) Blood , vol.116 , pp. 1919-1923
    • Badalian-Very, G.1    Vergilio, J.A.2    Degar, B.A.3
  • 57
    • 84905124784 scopus 로고    scopus 로고
    • Potential clinical implications of BRAF mutations in histiocytic proliferations
    • Bubolz AM, Weissinger SE, Stenzinger A, et al. Potential clinical implications of BRAF mutations in histiocytic proliferations. Oncotarget 2014; 5:4060-4070.
    • (2014) Oncotarget , vol.5 , pp. 4060-4070
    • Bubolz, A.M.1    Weissinger, S.E.2    Stenzinger, A.3
  • 58
    • 84876498502 scopus 로고    scopus 로고
    • Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation
    • Haroche J, Cohen-Aubart F, Emile JF, et al. Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation. Blood 2013; 121:1495-1500.
    • (2013) Blood , vol.121 , pp. 1495-1500
    • Haroche, J.1    Cohen-Aubart, F.2    Emile, J.F.3
  • 59
    • 84876473827 scopus 로고    scopus 로고
    • Saving orphans: BRAF targeting of histiocytosis
    • Heaney ML. Saving orphans: BRAF targeting of histiocytosis. Blood 2013; 121:1487-1488.
    • (2013) Blood , vol.121 , pp. 1487-1488
    • Heaney, M.L.1
  • 60
    • 84901651929 scopus 로고    scopus 로고
    • BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma
    • Larkin SJ, Preda V, Karavitaki N, et al.BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma. Acta Neuropathol 2014; 127:927-929.
    • (2014) Acta Neuropathol , vol.127 , pp. 927-929
    • Larkin, S.J.1    Preda, V.2    Karavitaki, N.3
  • 61
    • 84864002333 scopus 로고    scopus 로고
    • Clinical neuropathology practice news 2-2012: BRAF V600E testing
    • Capper D, Berghoff AS, von Deimling A, et al. Clinical neuropathology practice news 2-2012: BRAF V600E testing. Clin Neuropathol 2012; 31:64-66.
    • (2012) Clin Neuropathol , vol.31 , pp. 64-66
    • Capper, D.1    Berghoff, A.S.2    Von Deimling, A.3
  • 62
    • 84893661769 scopus 로고    scopus 로고
    • Vemurafenib in patients with BRAF(V600) mutation-positive melanoma with symptomatic brain metastases: Final results of an open-label pilot study
    • Dummer R, Goldinger SM, Turtschi CP, et al. Vemurafenib in patients with BRAF(V600) mutation-positive melanoma with symptomatic brain metastases: final results of an open-label pilot study. Eur J Cancer 2014; 50: 611-621.
    • (2014) Eur J Cancer , vol.50 , pp. 611-621
    • Dummer, R.1    Goldinger, S.M.2    Turtschi, C.P.3
  • 63
    • 84904098850 scopus 로고    scopus 로고
    • BRAF V600Emutated lung adenocarcinoma with metastases to the brain responding to treatment with vemurafenib
    • Robinson SD, O'Shaughnessy JA, Lance Cowey C, et al. BRAF V600Emutated lung adenocarcinoma with metastases to the brain responding to treatment with vemurafenib. Lung Cancer 2014; 85:326-330.
    • (2014) Lung Cancer , vol.85 , pp. 326-330
    • Robinson, S.D.1    O'shaughnessy, J.A.2    Lance Cowey, C.3
  • 64
    • 84869504594 scopus 로고    scopus 로고
    • Trial design on prophylaxis and treatment of brain metastases: Lessons learned from the Eortc Brain Metastases Strategic Meeting
    • Preusser M, Winkler F, Collette L, et al. Trial design on prophylaxis and treatment of brain metastases: lessons learned from the Eortc Brain Metastases Strategic Meeting 2012. Eur J Cancer 2012; 48:3439-3447.
    • (2012) Eur J Cancer , vol.2012 , Issue.48 , pp. 3439-3447
    • Preusser, M.1    Winkler, F.2    Collette, L.3
  • 65
  • 66
    • 79959580390 scopus 로고    scopus 로고
    • Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
    • Capper D, Preusser M, Habel A, et al. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 2011; 122:11-19.
    • (2011) Acta Neuropathol , vol.122 , pp. 11-19
    • Capper, D.1    Preusser, M.2    Habel, A.3
  • 67
    • 84862109270 scopus 로고    scopus 로고
    • Immunohistochemical detection of the BRAF V600E mutated protein in papillary thyroid carcinoma
    • Koperek O, Kornauth C, Capper D, et al. Immunohistochemical detection of the BRAF V600E mutated protein in papillary thyroid carcinoma. Am J Surg Pathol 2012; 36:844-850.
    • (2012) Am J Surg Pathol , vol.36 , pp. 844-850
    • Koperek, O.1    Kornauth, C.2    Capper, D.3
  • 68
    • 84874930598 scopus 로고    scopus 로고
    • Expression of BRAF V600E mutant protein in epithelial ovarian tumors
    • Preusser M, Capper D, Berghoff AS, et al. Expression of BRAF V600E mutant protein in epithelial ovarian tumors. Appl Immunohistochem Mol Morphol 2013; 21:159-164.
    • (2013) Appl Immunohistochem Mol Morphol , vol.21 , pp. 159-164
    • Preusser, M.1    Capper, D.2    Berghoff, A.S.3
  • 69
    • 84871619722 scopus 로고    scopus 로고
    • Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma
    • Long GV, Wilmott JS, Capper D, et al. Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma. Am J Surg Pathol 2013; 37:61-65.
    • (2013) Am J Surg Pathol , vol.37 , pp. 61-65
    • Long, G.V.1    Wilmott, J.S.2    Capper, D.3
  • 70
    • 84885086057 scopus 로고    scopus 로고
    • No Evidence for BRAF-V600E mutations in gastroeosophageal tumors: Results from a high-throughput analysis of 534 cases using a mutation-specific antibody
    • Preusser M, Berghoff AS, Capper D, et al. No Evidence for BRAF-V600E mutations in gastroeosophageal tumors: results from a high-throughput analysis of 534 cases using a mutation-specific antibody. Appl Immunohistochem Mol Morphol 2013; 21:426-430.
    • (2013) Appl Immunohistochem Mol Morphol , vol.21 , pp. 426-430
    • Preusser, M.1    Berghoff, A.S.2    Capper, D.3
  • 71
    • 84866402680 scopus 로고    scopus 로고
    • Prospective, high-throughput molecular profiling of human gliomas
    • Chi AS, Batchelor TT, Dias-Santagata D, et al. Prospective, high-throughput molecular profiling of human gliomas. J Neurooncol 2012; 110:89-98.
    • (2012) J Neurooncol , vol.110 , pp. 89-98
    • Chi, A.S.1    Batchelor, T.T.2    Dias-Santagata, D.3
  • 72
    • 84901623187 scopus 로고    scopus 로고
    • Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors
    • Roth JJ, Santi M, Rorke-Adams LB, et al. Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors. Cancer Genet 2014; 207:111-123.
    • (2014) Cancer Genet , vol.207 , pp. 111-123
    • Roth, J.J.1    Santi, M.2    Rorke-Adams, L.B.3
  • 73
    • 84903512238 scopus 로고    scopus 로고
    • BRAF V600E mutations in urine and plasma cell-free DNA from patients with erdheim-chester disease
    • Janku F, Vibat CR, Kosco K, et al. BRAF V600E mutations in urine and plasma cell-free DNA from patients with erdheim-chester disease. Oncotarget 2014; 5:3607-3610.
    • (2014) Oncotarget , vol.5 , pp. 3607-3610
    • Janku, F.1    Vibat, C.R.2    Kosco, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.