Effects of selective β1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis

Critical Care

Volumn 18, Issue 6, 2014, Pages

  Calzavacca, Paolo ^a,b,d   Lankadeva, Yugeesh R ^a,e   Bailey, Simon R ^a   Bailey, Michael ^e   Bellomo, Rinaldo ^b,c   May, Clive N ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTIN HEALTH   (Australia)

^c Australian and New Zealand Intensive Care Research Centre   (Australia)

^d PO Uboldo ^*  (Italy)

^e MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CYTOKINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; HYPERDYNAMIC SEPSIS; KIDNEY FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PULMONARY ARTERY; RENAL ARTERY; SEPSIS; SHEEP; ANIMAL; BLOOD; DRUG EFFECTS; HEART OUTPUT; HEART RATE; KIDNEY; KIDNEY CIRCULATION; PATHOPHYSIOLOGY; PHYSIOLOGY; TREATMENT OUTCOME; VASCULARIZATION;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANIMALS; ATENOLOL; CARDIAC OUTPUT; CYTOKINES; HEART RATE; KIDNEY; RENAL CIRCULATION; SEPSIS; SHEEP; TREATMENT OUTCOME;

EID: 84927745468     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-014-0610-1     Document Type: Article

References (31)

1. Annane D, Trabold F, Sharshar T, Jarrin I, Blanc AS, Raphael JC, Gajdos P. Inappropriate sympathetic activation at onset of septic shock: a spectral analysis approach. Am J Respir Crit Care Med 1999, 160:458-465. 10.1164/ajrccm.160.2.9810073, 10430714.
2. Ramchandra R, Wan L, Hood SG, Frithiof R, Bellomo R, May CN. Septic shock induces distinct changes in sympathetic nerve activity to the heart and kidney in conscious sheep. Am J Physiol Regul Integr Comp Physiol 2009, 297:R1247-R1253. 10.1152/ajpregu.00437.2009, 19726712.
3. Vayssettes-Courchay C, Bouysset F, Verbeuren TJ. Sympathetic activation and tachycardia in lipopolysaccharide treated rats are temporally correlated and unrelated to the baroreflex. Auton Neurosci 2005, 120:35-45. 10.1016/j.autneu.2005.03.002, 15996623.
4. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013, 39:165-228. 10.1007/s00134-012-2769-8, 23361625.
5. Wilkman E, Kaukonen KM, Pettila V, Kuitunen A, Varpula M. Association between inotrope treatment and 90-day mortality in patients with septic shock. Acta Anaesthesiol Scand 2013, 57:431-442. 10.1111/aas.12056, 23298252.
6. Kumar A, Haery C, Parrillo JE. Myocardial dysfunction in septic shock: Part I. Clinical manifestation of cardiovascular dysfunction. J Cardiothorac Vasc Anesth 2001, 15:364-376. 10.1053/jcan.2001.22317, 11426372.
7. Rudiger A, Singer M. Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med 2007, 35:1599-1608. 10.1097/01.CCM.0000266683.64081.02, 17452940.
8. Berk JL, Hagen JF, Beyer WH, Gerber MJ, Dochat GR. The treatment of endotoxin shock by beta adrenergic blockade. Ann Surg 1969, 169:74-81. 10.1097/00000658-196901000-00007, 4883485.
9. Berk JL, Hagen JF, Maly G, Koo R. The treatment of shock with beta adrenergic blockade. Arch Surg 1972, 104:46-51. 10.1001/archsurg.1972.04180010040011, 4399892.
10. Schmitz D, Wilsenack K, Lendemanns S, Schedlowski M, Oberbeck R. beta-Adrenergic blockade during systemic inflammation: impact on cellular immune functions and survival in a murine model of sepsis. Resuscitation 2007, 72:286-294. 10.1016/j.resuscitation.2006.07.001, 17118511.
11. Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D'Egidio A, D'Ippoliti F, Raffone C, Venditti M, Guarracino F, Girardis M, Tritapepe L, Pietropaoli P, Mebazaa A, Singer M. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA 2013, 310:1683-1691. 10.1001/jama.2013.278477, 24108526.
12. Ackland GL, Yao ST, Rudiger A, Dyson A, Stidwill R, Poputnikov D, Singer M, Gourine AV. Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats. Crit Care Med 2009, 38:388-394. 10.1097/CCM.0b013e3181c03dfa.
13. Abdalmula A, Washington EA, House JV, Dooley LM, Blacklaws BA, Ghosh P, Bailey SR, Kimpton WG. Clinical and histopathological characterization of a large animal (ovine) model of collagen-induced arthritis. Vet Immunol Immunopathol 2014, 159:83-90. 10.1016/j.vetimm.2014.03.007, 24703062.
14. Gore DC, Wolfe RR. Hemodynamic and metabolic effects of selective beta1 adrenergic blockade during sepsis. Surgery 2006, 139:686-694. 10.1016/j.surg.2005.10.010, 16701103.
15. Macchia A, Romero M, Comignani PD, Mariani J, D'Ettorre A, Prini N, Santopinto M, Tognoni G. Previous prescription of beta-blockers is associated with reduced mortality among patients hospitalized in intensive care units for sepsis. Crit Care Med 2012, 40:2768-2772. 10.1097/CCM.0b013e31825b9509, 22824934.
16. Suzuki T, Morisaki H, Serita R, Yamamoto M, Kotake Y, Ishizaka A, Takeda J. Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med 2005, 33:2294-2301. 10.1097/01.CCM.0000182796.11329.3B, 16215384.
17. Hofer S, Steppan J, Wagner T, Funke B, Lichtenstern C, Martin E, Graf BM, Bierhaus A, Weigand MA. Central sympatholytics prolong survival in experimental sepsis. Crit Care 2009, 13:R11. 10.1186/cc7709, 19196475.
18. Leentjens J, Kox M, van der Hoeven JG, Netea MG, Pickkers P. Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?. Am J Respir Crit Care Med 2013, 187:1287-1293. 10.1164/rccm.201301-0036CP, 23590272.
19. Veld AJ MI', Schalekamp MA. How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta-adrenoceptor antagonists. A clue to the nature of their antihypertensive mechanism. Br J Clin Pharmacol 1982, 13:245S-257S. 10.1111/j.1365-2125.1982.tb01922.x.
20. Morelli A, Donati A, Ertmer C, Rehberg S, Kampmeier T, Orecchioni A, D'Egidio A, Cecchini V, Landoni G, Pietropaoli P, Westphal M, Venditti M, Mebazaa A, Singer M. Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study. Crit Care Med 2013, 41:2162-2168. 10.1097/CCM.0b013e31828a678d, 23873274.
21. Calzavacca P, Bailey M, Velkoska E, Burrell LM, Ramchandra R, Bellomo R, May CN. Effects of renal denervation on regional hemodynamics and kidney function in experimental hyperdynamic sepsis. Crit Care Med 2014, 42:401-409. 10.1097/CCM.0000000000000302.
22. Di Giantomasso D, May CN, Bellomo R. Vital organ blood flow during hyperdynamic sepsis. Chest 2003, 124:1053-1059. 10.1378/chest.124.3.1053, 12970037.
23. Langenberg C, Bellomo R, May C, Wan L, Egi M, Morgera S. Renal blood flow in sepsis. Crit Care 2005, 9:R363-R374. 10.1186/cc3540, 16137349.
24. van Dissel JT, van Langevelde P, Westendorp RG, Kwappenberg K, Frolich M. Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet 1998, 351:950-953. 10.1016/S0140-6736(05)60606-X, 9734942.
25. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 1997, 25:1813-1819. 10.1097/00003246-199711000-00018, 9366763.
26. Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007, 167:1655-1663. 10.1001/archinte.167.15.1655, 17698689.
27. Izeboud CA, Mocking JA, Monshouwer M, van Miert AS, Witkamp RF. Participation of beta-adrenergic receptors on macrophages in modulation of LPS-induced cytokine release. J Recept Signal Transduct Res 1999, 19:191-202. 10.3109/10799899909036645, 10071758.
28. Szelenyi J, Kiss JP, Puskas E, Szelenyi M, Vizi ES. Contribution of differently localized alpha 2- and beta-adrenoceptors in the modulation of TNF-alpha and IL-10 production in endotoxemic mice. Ann N Y Acad Sci 2000, 917:145-153. 10.1111/j.1749-6632.2000.tb05378.x, 11268338.
29. Hagiwara S, Iwasaka H, Maeda H, Noguchi T. Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model. Shock 2009, 31:515-520. 10.1097/SHK.0b013e3181863689, 18791493.
30. Warren HS, Fitting C, Hoff E, Adib-Conquy M, Beasley-Topliffe L, Tesini B, Liang X, Valentine C, Hellman J, Hayden D, Cavaillon JM. Resilience to bacterial infection: difference between species could be due to proteins in serum. J Infect Dis 2010, 201:223-232. 10.1086/649557, 20001600.
31. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A 2013, 110:3507-3512. 10.1073/pnas.1222878110, 23401516.