Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: Mitochondrial inhibition as driver of cardiac failure?

Respiratory Research

Volumn 16, Issue 1, 2015, Pages

  Balestra, Gianmarco M ^a   Mik, Egbert G ^a   Eerbeek, Otto ^b   Specht, Patricia A C ^a   van der Laarse, Willem J ^c   Zuurbier, Coert J ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Heart failure; Heart hypertrophy; Mitochondria; Oxygen; Pulmonary arterial hypertension

Indexed keywords

HEXOKINASE; LACTATE DEHYDROGENASE; OXYGEN; CARDIOTONIC AGENT; DOBUTAMINE; MONOCROTALINE; PROTOPORPHYRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD OXYGENATION; CONTROLLED STUDY; DOWN REGULATION; HEART RATE; HEART RIGHT VENTRICLE FAILURE; IN VIVO STUDY; LUNG WEIGHT; MALE; MEAN ARTERIAL PRESSURE; MITOCHONDRION; MORTALITY; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN SATURATION; OXYGEN SUPPLY; OXYGEN TENSION; OXYGENATION; PRESSURE; PULMONARY HYPERTENSION; RAT; WEIGHT REDUCTION; ANIMAL; ARTERIAL PRESSURE; BLOOD; CHEMICALLY INDUCED; COMPLICATION; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; ENERGY METABOLISM; HEART FAILURE; HEART MITOCHONDRION; HEART RIGHT VENTRICLE FUNCTION; HYPERTROPHY, RIGHT VENTRICULAR; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; PATHOPHYSIOLOGY; PULMONARY ARTERY; WISTAR RAT;

ADMINISTRATION, INHALATION; ANIMALS; ARTERIAL PRESSURE; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOBUTAMINE; ENERGY METABOLISM; HEART FAILURE; HEXOKINASE; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; L-LACTATE DEHYDROGENASE; MALE; MITOCHONDRIA, HEART; MONOCROTALINE; OXYGEN; OXYGEN CONSUMPTION; PROTOPORPHYRINS; PULMONARY ARTERY; RATS, WISTAR; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, RIGHT;

EID: 84927743427     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-015-0178-6     Document Type: Article

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