Pharmacological characterization of [trans-5′-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2′,3′-dihydrospiro(cyclohexane-1,1′-inden)-4-yl]acetic acid monobenzenesulfonate (JTT-553), a novel acyl CoA:diacylglycerol transferase (DGAT) 1 inhibitor

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 2, 2015, Pages 263-269

  Tomimoto, Daisuke ^a   Okuma, Chihiro ^a   Ishii, Yukihito ^a   Akiyama, Yoshiyuki ^a   Ohta, Takeshi ^a   Kakutani, Makoto ^a   Ohkuma, Yoshiaki ^b   Ogawa, Nobuya ^a  

^a JAPAN TOBACCO INC   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Acyl CoA:diacylglycerol acyltransferase (DGAT) 1; Obesity; Triacylglycerol

Indexed keywords

ANTIOBESITY AGENT; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE 1; CHYLOMICRON; DIACYLGLYCEROL ACYLTRANSFERASE 2; DIACYLGLYCEROL KINASE INHIBITOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; [TRANS 5' (AMINO 7,7 DIMETHYL 2 TRIFLUOROMETHYL 7H PYRIMIDO [4,5 B] [1,4] OXAZIN 6 YL) 2'3' DIHYDROSPIRO(CYCLOHEXANE 1,1' INDEN) 4 YL]ACETIC ACID MONOBENZENESULFONATE; (5'-(4-AMINO-7,7-DIMETHYL-2-TRIFLUOROMETHYL-7H-PYRIMIDO(4,5-B)(1,4)OXAZIN-6-YL)-2',3'-DIHYDROSPIRO(CYCLOHEXANE-1,1'-INDEN)-4-YL)ACETIC ACID; DGAT1 PROTEIN, HUMAN; DGAT1 PROTEIN, MOUSE; DGAT1 PROTEIN, RAT; DIACYLGLYCEROL ACYLTRANSFERASE; ENZYME INHIBITOR; OXAZINE DERIVATIVE; SPIRO COMPOUND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOBESITY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; ENZYME ACTIVITY; ENZYME INHIBITION; FAT CONTENT; FAT MASS; FOOD INTAKE; IC50; IN VITRO STUDY; IN VIVO STUDY; LIPID ABSORPTION; LIPOGENESIS; MALE; MOUSE; NONHUMAN; OBESITY; RAT; REPEATED DRUG DOSE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; ADIPOSE TISSUE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; BODY WEIGHT; DRUG EFFECTS; EATING; HUMAN; LIVER; METABOLISM; SMALL INTESTINE; SPRAGUE DAWLEY RAT;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; DIACYLGLYCEROL O-ACYLTRANSFERASE; EATING; ENZYME INHIBITORS; HUMANS; INTESTINE, SMALL; LIVER; MALE; MICE; OBESITY; OXAZINES; RATS; RATS, SPRAGUE-DAWLEY; SPIRO COMPOUNDS; TRIGLYCERIDES;

EID: 84922346901     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b14-00655     Document Type: Article

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