Long-term controlled delivery of rhBMP-2 from collagen-hydroxyapatite scaffolds for superior bone tissue regeneration

Journal of Controlled Release

Volumn 207, Issue , 2015, Pages 112-119

  Quinlan, Elaine ^a,b   Thompson, Emmet M ^a,b   Matsiko, Amos ^a,b   O'Brien, Fergal J ^a,b   López Noriega, Adolfo ^a,b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Bone tissue regeneration; Collagen hydroxyapatite; Controlled release; Osteogenesis; Rat calvarial defect model; RhBMP 2

Indexed keywords

ALKALINITY; BIOACTIVITY; BIOCOMPATIBILITY; BONE; COLLAGEN; DEFECTS; HYDROXYAPATITE; PHOSPHATASES; PROTEINS; RATS; RECOMBINANT PROTEINS; SCAFFOLDS (BIOLOGY); TISSUE;

BONE TISSUE REGENERATION; CALVARIAL DEFECTS; CONTROLLED RELEASE; OSTEOGENESIS; RHBMP-2;

TISSUE REGENERATION;

ALKALINE PHOSPHATASE; CALCIUM; COLLAGEN SPONGE; HYDROXYAPATITE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; DELAYED RELEASE FORMULATION; DRUG CARRIER; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BONE REGENERATION; BONE REMODELING; BONE TISSUE; CALVARIA; CONTROLLED STUDY; FREEZE DRYING; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SKULL DEFECT; TISSUE SCAFFOLD; 3T3 CELL LINE; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; HUMAN; MEDICINAL CHEMISTRY; METABOLISM; MOUSE; PATHOPHYSIOLOGY; POROSITY; RADIOGRAPHY; SKULL; TIME FACTOR; WISTAR RAT;

3T3 CELLS; ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CALCIUM; CHEMISTRY, PHARMACEUTICAL; COLLAGEN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HUMANS; HYDROXYAPATITES; MALE; MICE; OSTEOBLASTS; POROSITY; RATS, WISTAR; RECOMBINANT PROTEINS; SKULL; TIME FACTORS; TISSUE SCAFFOLDS; X-RAY MICROTOMOGRAPHY;

EID: 84927734104     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.03.028     Document Type: Article

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