Critical assessment of rhBMP-2 mediated bone induction: An in vitro and in vivo evaluation

Journal of Controlled Release

Volumn 162, Issue 3, 2012, Pages 646-653

  Kisiel, Marta ^a   Ventura, Manuela ^b   Oommen, Oommen P ^a   George, Anu ^a   Walboomers, X Frank ^b   Hilborn, Jöns ^a   Varghese, Oommen P ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bone morphogenetic protein 2; Hyaluronic acid; Hydrogel; Protein stability; Tissue engineering

Indexed keywords

AGGREGATION BEHAVIOR; BONE INDUCTION; BONE MORPHOGENETIC PROTEIN-2; BONE VOLUME; CLINICAL APPLICATION; CRITICAL ASSESSMENT; D-SYSTEM; HYALURONIC ACIDS; IN-VITRO; IN-VIVO; IN-VIVO EXPERIMENTS; LINEAR AGGREGATION; PHYSIOLOGICAL PH; PLASTIC SURFACES; POST-IMPLANTATION; PROTEIN STABILITY; RESEARCH GROUPS; RHBMP-2; STORAGE CONDITION;

BIOACTIVITY; BONE; COLLAGEN; HYDROGELS; ORGANIC ACIDS; PH EFFECTS; PHYSIOLOGY; POLYPROPYLENES; TISSUE ENGINEERING;

EXPERIMENTS;

COLLAGEN; HYALURONIC ACID; PLASTIC; POLYPROPYLENE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; HISTOLOGY; HYDROGEL; LIGHT SCATTERING; MALE; NONHUMAN; OSSIFICATION; PH; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ALDEHYDES; ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; COLLAGEN; DRUG CARRIERS; DRUG STABILITY; HYALURONIC ACID; HYDRAZINES; HYDROGELS; HYDROGEN-ION CONCENTRATION; MALE; MICE; NIH 3T3 CELLS; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RHEOLOGY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84865808757     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.08.004     Document Type: Article

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