Conversion of aminodeoxychorismate synthase into anthranilate synthase with janus mutations: Mechanism of pyruvate elimination catalyzed by chorismate enzymes

Biochemistry

Volumn 54, Issue 14, 2015, Pages 2372-2384

  Culbertson, Justin E ^a   Chung, Dong Hee ^a   Ziebart, Kristin T ^b   Espiritu, Eduardo ^c   Toney, Michael D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINO ACIDS; BIOINFORMATICS; CATALYSIS; ESCHERICHIA COLI; FUNCTIONAL GROUPS; ISOTOPES; MOLECULAR DYNAMICS;

ANTHRANILATE SYNTHASE; BIOINFORMATICS METHODS; CATALYZED CONVERSION; COMPLEMENTATION; GENETIC SELECTION; MUTANT ENZYMES; SALICYLATE SYNTHASE; SOLVENT KINETIC ISOTOPE EFFECTS;

ENZYMES;

ACID; AMINODEOXYCHORISMATE SYNTHASE; ANTHRANILATE SYNTHASE; BASE; CHORISMIC ACID; LYSINE; METHYL GROUP; MUTANT PROTEIN; PYRUVIC ACID; SYNTHETASE; UNCLASSIFIED DRUG; AMINOTRANSFERASE; LYASE; PYRUVIC ACID DERIVATIVE; SALICYLATE SYNTHETASE;

AMINATION; AROMATIZATION; ARTICLE; BACTERIAL STRAIN; BIOINFORMATICS; BIOTRANSFORMATION; CONFORMATIONAL TRANSITION; ELIMINATION REACTION; ENZYME ACTIVE SITE; ENZYME MECHANISM; ESCHERICHIA COLI; GENETIC SELECTION; MOLECULAR DYNAMICS; MOLECULAR LIBRARY; MUTATION; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY; BIOLOGY; CHEMISTRY; GENETICS; KINETICS; METABOLISM; PROTEIN CONFORMATION; THERMODYNAMICS;

ESCHERICHIA COLI; FUNGI; MAMMALIA;

ANTHRANILATE SYNTHASE; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; KINETICS; LYASES; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN CONFORMATION; PYRUVATES; THERMODYNAMICS; TRANSAMINASES;

EID: 84927732564     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00013     Document Type: Article

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