Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro-in vivo evaluations

International Journal of Pharmaceutics

Volumn 487, Issue 1-2, 2015, Pages 167-176

  Pimparade, Manjeet B ^a   Morott, Joseph T ^a   Park, Jun Bom ^b   Kulkarni, Vijay I ^a   Majumdar, Soumyajit ^a   Murthy, S N ^a   Lian, Zhuoyang ^c   Pinto, Elanor ^c   Bi, Vivian ^c   Durig, Thomas ^c   Murthy, Reena ^d   Shivakumar, H N ^d   Vanaja, K ^e   Kumar, P C ^e   Repka, Michael A ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b Sahmyook University   (South Korea)

^c ASHLAND INC   (United States)

^d Institute for Drug Delivery and Biomedical Research (IDBR)   (India)

^e Visveswarapura Institute of Pharmaceutical Sciences   (India)

Author keywords

Ethylcellulose (EC); Hot melt extrusion; Modified screw design; Pediatric and geriatric; Taste masking

Indexed keywords

CAFFEINE CITRATE; CROSPOVIDONE; ETHYL CELLULOSE; MANNITOL; PLASTICIZER; CAFFEINE; CELLULOSE; CITRIC ACID; DRUG CARRIER; TABLET;

ADULT; ARTICLE; BITTER TASTE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; FOOD EXTRUSION; HOT MELT EXTRUSION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MASKING; ORALLY DISINTEGRATING TABLET; POLYMERIZATION; PRIORITY JOURNAL; TABLET; TABLET HARDNESS; TASTE MASKING; THERMOGRAVIMETRY; WEIGHT VARIATION; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; MEDICINAL CHEMISTRY; SOLUBILITY; TASTE;

CAFFEINE; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CITRATES; DRUG CARRIERS; DRUG COMPOUNDING; HUMANS; PLASTICIZERS; SOLUBILITY; TABLETS; TASTE; TASTE PERCEPTION;

EID: 84927719350     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.04.030     Document Type: Article

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