Design and optimization of mefloquine hydrochloride microparticles for bitter taste masking

AAPS PharmSciTech

Volumn 9, Issue 2, 2008, Pages 377-389

  Shah, Punit P ^a   Mashru, Rajashree C ^a   Rane, Yogesh M ^a   Thakkar, Arti ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Bitterness; Eudragit; Full factorial design; Mefloquine HCl; Microparticles

Indexed keywords

EUDRAGIT; MEFLOQUINE; NANOCAPSULE; SODIUM HYDROXIDE; ANTIMALARIAL AGENT; EUDRAGIT-E; METHACRYLIC ACID DERIVATIVE;

ACIDITY; ARTICLE; BITTER TASTE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG SOLUBILITY; FACTORIAL DESIGN; GUSTATORY SYSTEM; HUMAN; HUMAN EXPERIMENT; HYDROPHILICITY; INFRARED SPECTROSCOPY; NANOENCAPSULATION; PARTICLE SIZE; PH; POROSITY; PROCESS OPTIMIZATION; WETTABILITY; X RAY POWDER DIFFRACTION; CHEMISTRY; DRUG FORMULATION; KINETICS; METHODOLOGY; ORAL DRUG ADMINISTRATION; PERCEPTION; PHARMACEUTICS; POWDER DIFFRACTION; REPRODUCIBILITY; SCANNING ELECTRON MICROSCOPY; SOLUBILITY; SYNTHESIS; TASTE; THEORETICAL MODEL; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANTIMALARIALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG COMPOUNDING; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MEFLOQUINE; METHACRYLATES; MICROSCOPY, ELECTRON, SCANNING; MODELS, THEORETICAL; PARTICLE SIZE; PERCEPTUAL MASKING; POROSITY; POWDER DIFFRACTION; REPRODUCIBILITY OF RESULTS; SODIUM HYDROXIDE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TASTE; TECHNOLOGY, PHARMACEUTICAL; WETTABILITY;

EID: 51449092362     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9052-x     Document Type: Article

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