RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis

International Journal of Molecular Medicine

Volumn 30, Issue 6, 2012, Pages 1281-1286

  Yagishita, Naoko ^a   Aratani, Satoko ^b   Leach, Craig ^c   Amano, Tetsuya ^a   Yamano, Yoshihisa ^a   Nakatani, Ko ^d   Nishioka, Kusuki ^b   Nakajima, Toshihiro ^a,b,d,e  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c Progenra Inc   (United States)

^d Bayside Misato Medical Center   (India)

^e NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

E3 ubiquitin ligase; Endoplasmic reticulum associated degradation; Inhibitor; Rheumatoid arthritis; Synoviolin

Indexed keywords

ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE; LS 101; LS 102; RING FINGER PROTEIN; SYNOVIOLIN PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; DRUG INDICATION; FEMALE; HELA CELL; HIGH THROUGHPUT SCREENING; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; UBIQUITINATION;

ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BENZODIAZEPINONES; BENZOXAZOLES; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FORELIMB; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HINDLIMB; HUMANS; JOINTS; MALE; MICE; MICE, INBRED DBA; TRIAZINES; UBIQUITIN-PROTEIN LIGASES;

EID: 84869464499     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.1129     Document Type: Article

References (43)

1. Gabriel SE: The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am 27: 269-281, 2001.
2. Aletaha D and Smolen JS: Effectiveness profiles and dose dependent retention of traditional disease modifying antirheumatic drugs for rheumatoid arthritis. An observational study. J Rheumatol 29: 1631-1638, 2002. (Pubitemid 34831234)
3. Smolen JS, Aletaha D, Koeller M, Weisman MH and Emery P: New therapies for treatment of rheumatoid arthritis. Lancet 370: 1861-1874, 2007. (Pubitemid 350180008)
4. Nurmohamed MT: Newer biological agents in the treatment of rheumatoid arthritis: do the benefits outweigh the risks? Drugs 69: 2035-2043, 2009.
5. Nakajima T, Aono H, Hasunuma T, Yamamoto K, Shirai T, Hirohata K and Nishioka K: Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 38: 485-491, 1995.
6. Amano T, Yamasaki S, Yagishita N, et al: Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev 17: 2436-2449, 2003. (Pubitemid 37214791)
7. Bordallo J, Plemper RK, Finger A and Wolf DH: Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9: 209-222, 1998. (Pubitemid 28065291)
8. Shearer AG and Hampton RY: Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem 279: 188-196, 2004. (Pubitemid 38044814)
9. Shearer AG and Hampton RY: Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. EMBO J 24: 149-159, 2005. (Pubitemid 40188472)
10. Toh ML, Marotte H, Blond JL, Jhumka U, Eljaafari A, Mougin B and Miossec P: Overexpression of synoviolin in peripheral blood and synoviocytes from rheumatoid arthritis patients and continued elevation in nonresponders to infliximab treatment. Arthritis Rheum 54: 2109-2118, 2006. (Pubitemid 44051066)
11. Gao B, Calhoun K and Fang D: The proinflammatory cytokines IL-1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway. Arthritis Res Ther 8: R172, 2006.
12. Gao B, Lee SM, Chen A, et al: Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep 9: 480-485, 2008. (Pubitemid 351627287)
13. Yagishita N, Yamasaki S, Nishioka K and Nakajima T: Synoviolin, protein folding and the maintenance of joint homeostasis. Nat Clin Pract Rheumatol 4: 91-97, 2008. (Pubitemid 351217658)
14. Yamasaki S, Yagishita N, Sasaki T, et al: Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J 26: 113-122, 2007. (Pubitemid 46094704)
15. Ohta T, Michel JJ, Schottelius AJ and Xiong Y: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell 3: 535-541, 1999. (Pubitemid 29292611)
16. Hughes C, Wolos JA, Giannini EH and Hirsch R: Induction of T helper cell hyporesponsiveness in an experimental model of autoimmunity by using nonmitogenic anti-CD3 monoclonal antibody. J Immunol 153: 3319-3325, 1994. (Pubitemid 24292558)
17. Tomita T, Takeuchi E, Tomita N, et al: Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum 42: 2532-2542, 1999. (Pubitemid 30327169)
18. Dunn DA and Feygin I: Challenges and solutions to ultra-high-throughput screening assay miniaturization: submicroliter fluid handling. Drug Discov Today 5: 84-91, 2000.
19. Moynihan TP, Ardley HC, Nuber U, et al: The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING-finger/IBR motif-containing domains of HHARI and H7-AP1. J Biol Chem 274: 30963-30968, 1999.
20. Hashizume R, Fukuda M, Maeda I, et al: The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem 276: 14537-14540, 2001.
21. Urano T, Saito T, Tsukui T, et al: Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Nature 417: 871-875, 2002.
22. Hershko A and Ciechanover A: The ubiquitin system. Annu Rev Biochem 67: 425-479, 1998. (Pubitemid 28411135)
23. Pickart CM: Mechanisms underlying ubiquitination. Annu Rev Biochem 70: 503-533, 2001.
24. Deshaies RJ and Joazeiro CA: RING domain E3 ubiquitin ligases. Annu Rev Biochem 78: 399-434, 2009.
25. Kaufman RJ: Orchestrating the unfolded protein response in health and disease. J Clin Invest 110: 1389-1398, 2002.
26. Araki E, Oyadomari S and Mori M: Endoplasmic reticulum stress and diabetes mellitus. Intern Med 42: 7-14, 2003. (Pubitemid 36267657)
27. Cvek B and Dvorak Z: The ubiquitin-proteasome system (UPS) and the mechanism of action of bortezomib. Curr Pharm Des 17: 1483-1499, 2011.
28. Adams J: Development of the proteasome inhibitor PS-341. Oncologist 7: 9-16, 2002.
29. Mitchell BS: The proteasome - an emerging therapeutic target in cancer. N Engl J Med 348: 2597-2598, 2003.
30. Burger AM and Seth AK: The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications. Eur J Cancer 40: 2217-2229, 2004. (Pubitemid 39348871)
31. Chen D, Frezza M, Schmitt S, Kanwar J and Q PD: Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives. Curr Cancer Drug Targets 11: 239-253, 2011.
32. Hopkins AL and Groom CR: The druggable genome. Nat Rev Drug Discov 1: 727-730, 2002. (Pubitemid 37361545)
33. Arend WP: Physiology of cytokine pathways in rheumatoid arthritis. Arthritis Rheum 45: 101-106, 2001.
34. McInnes IB and Schett G: Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7: 429-442, 2007. (Pubitemid 46834849)
35. Stanczyk J, Ospelt C, Gay RE and Gay S: Synovial cell activation. Curr Opin Rheumatol 18: 262-267, 2006. (Pubitemid 43740378)
36. Huber LC, Distler O, Tarner I, Gay RE, Gay S and Pap T: Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology (Oxford) 45: 669-675, 2006. (Pubitemid 43985334)
37. Knedla A, Neumann E and Muller-Ladner U: Developments in the synovial biology field 2006. Arthritis Res Ther 9: 209, 2007.
38. Hasegawa D, Fujii R, Yagishita N, et al: E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis. PLoS One 5: e13590, 2010.
39. Toh ML, Gonzales G, Koenders MI, et al: Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression. PLoS One 5: e13416, 2010.
40. Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM and Lehner PJ: HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc Natl Acad Sci USA 108: 2034-2039, 2011.
41. Gomez-Puerta JA and Bosch X: Therapy: Spleen tyrosine kinase inhibitors - novel therapies for RA? Nat Rev Rheumatol 7: 134-136, 2011.
42. Weinblatt ME, Kavanaugh A, Genovese MC, Musser TK, Grossbard EB and Magilavy DB: An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N Engl J Med 363: 1303-1312, 2010.
43. Koenders MI, Marijnissen RJ, Devesa I, et al: Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1beta, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis. Arthritis Rheum 63: 2329-2339, 2011.