Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 8, 2011, Pages 3765-3773

  Shore, Anna C ^a   Deasy, Emily C ^a   Slickers, Peter ^b   Brennan, Grainne ^c   O'Connell, Brian ^c   Monecke, Stefan ^d   Ehricht, Ralf ^b   Coleman, David C ^a  

^a DUBLIN DENTAL UNIVERSITY HOSPITAL   (Ireland)

^b Alere Technologies GmbH   (Germany)

^c ST JAMES S HOSPITAL   (Ireland)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLAZ CHROMOSOME; CASSETTE CHROMOSOME RECOMBINASE; DNA MICROARRAY; DOWNSTREAM PROCESSING; GENE CASSETTE; HUMAN; IRELAND; MECA CHROMOSOME; MECI CHROMOSOME; MECR 1 CHROMOSOME; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR TYPING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AGED; AGED, 80 AND OVER; ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; CATTLE; DNA, BACTERIAL; FEMALE; GENES, BACTERIAL; HUMANS; INTERSPERSED REPETITIVE SEQUENCES; MALE; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR SEQUENCE DATA; MOLECULAR TYPING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PENICILLIN-BINDING PROTEINS; POLYMERASE CHAIN REACTION; RATS; SEQUENCE ANALYSIS, DNA; STAPHYLOCOCCAL INFECTIONS;

EID: 79960327957     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00187-11     Document Type: Article

References (76)

1. Abbott, Y., B. Leggett, A. S. Rossney, F. C. Leonard, and B. K. Markey. 2010. Isolation rates of meticillin-resistant Staphylococcus aureus in dogs, cats and horses in Ireland. Vet. Rec. 166:451-455.
2. Abbott, Y., F. C. Leonard, and B. K. Markey. 2010. Detection of three distinct genetic lineages in methicillin-resistant Staphylococcus aureus (MRSA) isolates from animals and veterinary personnel. Epidemiol. Infect. 138:764-771.
3. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
4. Baba, T., et al. 2009. Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci. J. Bacteriol. 191:1180-1190.
5. Banerjee, R., M. Gretes, C. Harlem, L. Basuino, and H. F. Chambers. 2010. A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level beta-lactam resistance contains mutations in three genes. Antimicrob. Agents Chemother. 54:4900-4902.
6. Barbier, F., et al. 2010. Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus. J. Infect. Dis. 202:270-281.
7. Berglund, C., et al. 2008. Novel type of staphylococcal cassette chromosome mec in a methicillin-resistant Staphylococcus aureus strain isolated in Sweden. Antimicrob. Agents Chemother. 52:3512-3516.
8. Berglund, C., and B. Soderquist. 2008. The origin of a methicillin-resistant Staphylococcus aureus isolate at a neonatal ward in Sweden-possible horizontal transfer of a staphylococcal cassette chromosome mec between methicillin-resistant Staphylococcus haemolyticus and Staphylococcus aureus. Clin. Microbiol. Infect. 14:1048-1056. (Pubitemid 352748846)
9. Black, C. C., et al. 2009. Identification of a predominant multilocus sequence type, pulsed-field gel electrophoresis cluster, and novel staphylococcal chromosomal cassette in clinical isolates of mecA-containing, methicillin-resistant Staphylococcus pseudintermedius. Vet. Microbiol. 139:333-338.
10. Bloemendaal, A. L., E. C. Brouwer, and A. C. Fluit. 2010. Methicillin resistance transfer from Staphylococcus epidermidis to methicillin-susceptible Staphylococcus aureus in a patient during antibiotic therapy. PLoS One 5:e11841.
11. Boyle-Vavra, S., B. Ereshefsky, C. C. Wang, and R. S. Daum. 2005. Successful multiresistant community-associated methicillin-resistant Staphylococcus aureus lineage from Taipei, Taiwan, that carries either the novel staphylococcal chromosome cassette mec (SCCmec) type VT or SCCmec type IV. J. Clin. Microbiol. 43:4719-4730.
12. Carroll, D., M. A. Kehoe, D. Cavanagh, and D. C. Coleman. 1995. Novel organization of the site-specific integration and excision recombination functions of the Staphylococcus aureus serotype F virulence-converting phages phi 13 and phi 42. Mol. Microbiol. 16:877-893.
13. CLSI. 2006. Performance standards for antimicrobial susceptibility testing; 16th informational supplement. CLSI document M100-S16. CLSI, Wayne, PA.
14. Enright, M. C., N. P. Day, C. E. Davies, S. J. Peacock, and B. G. Spratt. 2000. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J. Clin. Microbiol. 38:1008-1015.
15. Garza-Gonzalez, E., et al. 2010. Diversity of staphylococcal cassette chromosome mec structures in coagulase-negative staphylococci and relationship to drug resistance. J. Med. Microbiol. 59:323-329.
16. Garza-Gonzalez, E., R. Morfin-Otero, J. M. Llaca-Diaz, and E. Rodriguez-Noriega. 2010. Staphylococcal cassette chromosome mec (SCCmec) in methicillin-resistant coagulase-negative staphylococci. A review and the experience in a tertiary-care setting. Epidemiol. Infect. 138:645-654.
17. Hanssen, A. M., and J. U. Ericson Sollid. 2006. SCCmec in staphylococci: genes on the move. FEMS Immunol. Med. Microbiol. 46:8-20.
18. Hanssen, A. M., G. Kjeldsen, and J. U. Sollid. 2004. Local variants of staphylococcal cassette chromosome mec in sporadic methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci: evidence of horizontal gene transfer? Antimicrob. Agents Chemother. 48:285-296.
19. Holden, M. T., et al. 2004. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc. Natl. Acad. Sci. U. S. A. 101:9786-9791.
20. Hyatt, D., et al. 2010. Prodigal: prokaryotic gene recognition and translation initiation site identification. BMC Bioinform. 11:119-130.
21. International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC). 2009. Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements. Antimicrob. Agents Chemother. 53:4961-4967.
22. Ito, T., Y. et al. 2001. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 45:1323-1336.
23. Ito, T., et al. 2004. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob. Agents Chemother. 48:2637-2651. (Pubitemid 38823437)
24. Jevons, M. P. 1961. Celbenin-resistant staphylococci. Br. Med. J. i:124-125.
25. Jorgensen, H. J., T. Mork, D. A. Caugant, A. Kearns, and L. M. Rorvik. 2005. Genetic variation among Staphylococcus aureus strains from Norwegian bulk milk. Appl. Environ. Microbiol. 71:8352-8361.
26. Katayama, Y., T. Ito, and K. Hiramatsu. 2001. Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains: role of IS431-mediated mecI deletion in expression of resistance in mecA-carrying, low-level methicillin-resistant Staphylococcus haemolyticus. Antimicrob. Agents Chemother. 45:1955-1963. (Pubitemid 32591683)
27. Katayama, Y., T. Ito, and K. Hiramatsu. 2000. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 44:1549-1555. (Pubitemid 30340793)
28. Kreiswirth, B. N., et al. 1983. The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature 305:709-712. (Pubitemid 13021519)
29. Kuroda, M., et al. 2001. Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet 357:1225-1240.
30. Luedicke, C., P. Slickers, R. Ehricht, and S. Monecke. 2010. Molecular fingerprinting of Staphylococcus aureus from bone and joint infections. Eur. J. Clin. Microbiol. Infect. Dis. 29:457-463.
31. Ma, X. X., et al. 2002. Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains. Antimicrob. Agents Chemother. 46:1147-1152.
32. Maeda, Y., et al. 2007. Community-associated MRSA SCCmec type IVd in Irish equids. Vet. Rec. 161:35-36.
33. Malachowa, N., and F. R. Deleo. 2010. Mobile genetic elements of Staphylococcus aureus. Cell. Mol. Life Sci. 67:3057-3071.
34. McCarthy, A. J., and J. A. Lindsay. 2010. Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions. BMC Microbiol. 10:173-188.
35. Monecke, S., L. Jatzwauk, S. Weber, P. Slickers, and R. Ehricht. 2008. DNA microarray-based genotyping of methicillin-resistant Staphylococcus aureus strains from Eastern Saxony. Clin. Microbiol. Infect. 14:534-545.
36. Monecke, S., P. Kuhnert, H. Hotzel, P. Slickers, and R. Ehricht. 2007. Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle. Vet. Microbiol. 125: 128-140.
37. Monecke, S., L. Leube, and R. Ehricht. 2003. Simple and robust array-based methods for the parallel detection of resistance genes of Staphylococcus aureus. Genome Lett. 2:106-118.
38. Monecke, S., C. Luedicke, P. Slickers, and R. Ehricht. 2009. Molecular epidemiology of Staphylococcus aureus in asymptomatic carriers. Eur. J. Clin. Microbiol. Infect. Dis. 28:1159-1165.
39. Monecke, S., et al. 2006. Microarray-based characterisation of a Panton-Valentine leukocidin-positive community-acquired strain of methicillin-resistant Staphylococcus aureus. Clin. Microbiol. Infect. 12:718-728. (Pubitemid 43983796)
40. Mongkolrattanothai, K., S. Boyle, T. V. Murphy, and R. S. Daum. 2004. Novel non-mecA-containing staphylococcal chromosomal cassette composite island containing pbp4 and tagF genes in a commensal staphylococcal species: a possible reservoir for antibiotic resistance islands in Staphylococcus aureus. Antimicrob. Agents Chemother. 48:1823-1836.
41. Moodley, A., et al. 2006. spa typing of methicillin-resistant Staphylococcus aureus isolated from domestic animals and veterinary staff in the UK and Ireland. J. Antimicrob. Chemother. 58:1118-1123.
42. Novick, R. 1967. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology 33:155-166.
43. O'Brien, F. G., et al. 2004. Diversity among community isolates of methicillin-resistant Staphylococcus aureus in Australia. J. Clin. Microbiol. 42:3185-3190.
44. Oliveira, D. C., and H. de Lencastre. 2002. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 46: 2155-2161. (Pubitemid 34665910)
45. Oliveira, D. C., C. Milheirico, and H. de Lencastre. 2006. Redefining a structural variant of staphylococcal cassette chromosome mec, SCCmec type VI. Antimicrob. Agents Chemother. 50:3457-3459. (Pubitemid 44527525)
46. Otto, M. 2010. Staphylococcus aureus toxin gene hitchhikes on a transferable antibiotic resistance element. Virulence 1:49-51.
47. Paez-Espino, D., J. Tamames, V. de Lorenzo, and D. Canovas. 2009. Microbial responses to environmental arsenic. Biometals 22:117-130.
48. Reynolds, P. E., and D. F. Brown. 1985. Penicillin-binding proteins of betalactam-resistant strains of Staphylococcus aureus. Effect of growth conditions. FEBS Lett. 192:28-32.
49. Rice, P., I. Longden, and A. Bleasby. 2000. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet. 16:276-277.
50. Rossney, A. S., L. F. English, and C. T. Keane. 1990. Coagulase testing compared with commercial kits for routinely identifying Staphylococcus aureus. J. Clin. Pathol. 43:246-252.
51. Rossney, A. S., et al. 2006. Epidemiological typing of MRSA isolates from blood cultures taken in Irish hospitals participating in the European Antimicrobial Resistance Surveillance System (1999-2003). Eur. J. Clin. Microbiol. Infect. Dis. 25:79-89.
52. Rossney, A. S., et al. 2007. The emergence and importation of diverse genotypes of methicillin-resistant Staphylococcus aureus (MRSA) harboring the Panton-Valentine leukocidin gene (pvl) reveal that pvl is a poor marker for community-acquired MRSA strains in Ireland. J. Clin. Microbiol. 45: 2554-2563. (Pubitemid 47295487)
53. Ruppe, E., et al. 2009. Diversity of staphylococcal cassette chromosome mec structures in methicillin-resistant Staphylococcus epidermidis and Staphylococcus haemolyticus strains among outpatients from four countries. Antimicrob. Agents Chemother. 53:442-449.
54. Rutherford, K., et al. 2000. Artemis: sequence visualization and annotation. Bioinformatics 16:944-945.
55. Schnellmann, C., et al. 2006. Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission. J. Clin. Microbiol. 44:4444-4454.
56. Shore, A., A. S. Rossney, C. T. Keane, M. C. Enright, and D. C. Coleman. 2005. Seven novel variants of the staphylococcal chromosomal cassette mec in methicillin-resistant Staphylococcus aureus isolates from Ireland. Antimicrob. Agents Chemother. 49:2070-2083.
57. Shore, A. C., et al. 2010. Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate. Antimicrob. Agents Chemother. 54:4978-4984.
58. Shore, A. C., et al. 2011. Characterization of a novel arginine catabolic mobile element (ACME) and staphylococcal chromosomal cassette mec composite island with significant homology to Staphylococcus epidermidis ACME type II in methicillin-resistant Staphylococcus aureus genotype ST22-MRSA-IV. Antimicrob. Agents Chemother. 55:1896-1905.
59. Shore, A. C., et al. 2010. Enhanced discrimination of highly clonal ST22-methicillin-resistant Staphylococcus aureus IV isolates achieved by combining spa, dru, and pulsed-field gel electrophoresis typing data. J. Clin. Microbiol. 48:1839-1852.
60. Shore, A. C., et al. 2008. Detection of staphylococcal cassette chromosome mec-associated DNA segments in multiresistant methicillin-susceptible Staphylococcus aureus (MSSA) and identification of Staphylococcus epidermidis ccrAB4 in both methicillin-resistant S. aureus and MSSA. Antimicrob. Agents Chemother. 52:4407-4419.
61. Smyth, D. S., A. Wong, and D. A. Robinson. 2011. Cross-species spread of SCCmec IV subtypes in staphylococci. Infect. Genet. Evol. 11:446-453.
62. Soderquist, B., and C. Berglund. 2009. Methicillin-resistant Staphylococcus saprophyticus in Sweden carries various types of staphylococcal cassette chromosome mec (SCCmec). Clin. Microbiol. Infect. 15:1176-1178.
63. Song, M. D., M. Wachi, M. Doi, F. Ishino, and M. Matsuhashi. 1987. Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion. FEBS Lett. 221:167-171. (Pubitemid 17124049)
64. Sung, J. M., D. H. Lloyd, and J. A. Lindsay. 2008. Staphylococcus aureus host specificity: comparative genomics of human versus animal isolates by multistrain microarray. Microbiology 154:1949-1959.
65. Tsubakishita, S., K. Kuwahara-Arai, T. Baba, and K. Hiramatsu. 2010. Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus. Antimicrob. Agents Chemother. 54:1469-1475.
66. Tsubakishita, S., K. Kuwahara-Arai, T. Sasaki, and K. Hiramatsu. 2010. Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. Antimicrob. Agents Chemother. 54:4352-4359.
67. van de Giessen, A. W., et al. 2009. Occurrence of methicillin-resistant Staphylococcus aureus in rats living on pig farms. Prev. Vet. Med. 91:270-273.
68. Van Den Broek, I., et al. 2009. Methicillin-resistant Staphylococcus aureus in people living and working in pig farms. Epidemiol. Infect. 137:700-708.
69. Weese, J. S. 2010. Methicillin-resistant Staphylococcus aureus in animals. ILAR J. 51:233-244.
70. Wisplinghoff, H., et al. 2003. Related clones containing SCCmec type IV predominate among clinically significant Staphylococcus epidermidis isolates. Antimicrob. Agents Chemother. 47:3574-3579. (Pubitemid 37345722)
71. Wolk, D. M., et al. 2009. Rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in wound specimens and blood cultures: multicenter preclinical evaluation of the Cepheid Xpert MRSA/SA skin and soft tissue and blood culture assays. J. Clin. Microbiol. 47:823-826.
72. Wu, S., H. de Lencastre, and A. Tomasz. 1998. Genetic organization of the mecA region in methicillin-susceptible and methicillin-resistant strains of Staphylococcus sciuri. J. Bacteriol. 180:236-242. (Pubitemid 28100287)
73. Wu, S., C. Piscitelli, H. de Lencastre, and A. Tomasz. 1996. Tracking the evolutionary origin of the methicillin resistance gene: cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri. Microb. Drug Resist. 2:435-441. (Pubitemid 27030512)
74. Yokoi, K. J., et al. 2011. Characterization of the histidine decarboxylase gene of Staphylococcus epidermidis TYH1 coded on the staphylococcal cassette chromosome. Gene 477:32-41.
75. Zhang, K., J. A. McClure, S. Elsayed, and J. M. Conly. 2009. Novel staphylococcal cassette chromosome mec type, tentatively designated type VIII, harboring class A mec and type 4 ccr gene complexes in a Canadian epidemic strain of methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 53:531-540.
76. Zong, Z., and X. Lu. 2010. Characterization of a new SCCmec element in Staphylococcus cohnii. PLoS One 5:e14016.