-
1
-
-
0036671894
-
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
-
Martinon F., Burns K., Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002, 10:417-426.
-
(2002)
Mol Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
2
-
-
79952250653
-
Interleukin-1beta activation during acute joint inflammation: a limited role for the NLRP3 inflammasome in vivo
-
Joosten L.A., Ea H.K., Netea M.G., et al. Interleukin-1beta activation during acute joint inflammation: a limited role for the NLRP3 inflammasome in vivo. Joint Bone Spine 2011, 78:107-110.
-
(2011)
Joint Bone Spine
, vol.78
, pp. 107-110
-
-
Joosten, L.A.1
Ea, H.K.2
Netea, M.G.3
-
3
-
-
34047174085
-
A pilot study of IL-1 inhibition by anakinra in acute gout
-
So A., De Smedt T., Revaz S., et al. A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther 2007, 9:R28.
-
(2007)
Arthritis Res Ther
, vol.9
, pp. R28
-
-
So, A.1
De Smedt, T.2
Revaz, S.3
-
4
-
-
84881334136
-
Treatment of acute gouty arthritis in complex hospitalized patients with anakinra
-
Ghosh P., Cho M., Rawat G., et al. Treatment of acute gouty arthritis in complex hospitalized patients with anakinra. Arthritis Care Res 2013, 65:1381-1384.
-
(2013)
Arthritis Care Res
, vol.65
, pp. 1381-1384
-
-
Ghosh, P.1
Cho, M.2
Rawat, G.3
-
5
-
-
84891378160
-
Efficacy of anakinra in gouty arthritis: a retrospective study of 40 cases
-
Ottaviani S., Molto A., Ea H.K., et al. Efficacy of anakinra in gouty arthritis: a retrospective study of 40 cases. Arthritis Res Ther 2013, 15:R123.
-
(2013)
Arthritis Res Ther
, vol.15
, pp. R123
-
-
Ottaviani, S.1
Molto, A.2
Ea, H.K.3
-
6
-
-
84864335117
-
Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: Results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study
-
Schumacher H.R., Evans R.R., Saag K.G., et al. Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: Results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study. Arthritis Care Res 2012, 64:1462-1470.
-
(2012)
Arthritis Care Res
, vol.64
, pp. 1462-1470
-
-
Schumacher, H.R.1
Evans, R.R.2
Saag, K.G.3
-
7
-
-
70349402166
-
The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study
-
Terkeltaub R., Sundy J.S., Schumacher H.R., et al. The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study. Ann Rheum Dis 2009, 68:1613-1617.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 1613-1617
-
-
Terkeltaub, R.1
Sundy, J.S.2
Schumacher, H.R.3
-
8
-
-
77957688721
-
Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study
-
So A., De Meulemeester M., Pikhlak A., et al. Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study. Arthritis Rheum 2010, 62:3064-3076.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 3064-3076
-
-
So, A.1
De Meulemeester, M.2
Pikhlak, A.3
-
9
-
-
79957646006
-
Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study
-
Schlesinger N., Mysler E., Lin H.Y., et al. Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study. Ann Rheum Dis 2011, 70:1264-1271.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1264-1271
-
-
Schlesinger, N.1
Mysler, E.2
Lin, H.Y.3
-
10
-
-
67649798632
-
Anakinra is a possible alternative in the treatment and prevention of acute attacks of pseudogout in end-stage renal failure
-
Announ N., Palmer G., Guerne P.A., et al. Anakinra is a possible alternative in the treatment and prevention of acute attacks of pseudogout in end-stage renal failure. Joint Bone Spine 2009, 76:424-426.
-
(2009)
Joint Bone Spine
, vol.76
, pp. 424-426
-
-
Announ, N.1
Palmer, G.2
Guerne, P.A.3
-
11
-
-
84875517323
-
Efficacy of anakinra in calcium pyrophosphate crystal-induced arthritis: a report of 16 cases and review of the literature
-
Ottaviani S., Brunier L., Sibilia J., et al. Efficacy of anakinra in calcium pyrophosphate crystal-induced arthritis: a report of 16 cases and review of the literature. Joint Bone Spine 2013, 80:178-182.
-
(2013)
Joint Bone Spine
, vol.80
, pp. 178-182
-
-
Ottaviani, S.1
Brunier, L.2
Sibilia, J.3
-
12
-
-
84870699350
-
Efficacy of anakinra for refractory acute calcium pyrophosphate crystal arthritis
-
Molto A., Ea H.K., Richette P., et al. Efficacy of anakinra for refractory acute calcium pyrophosphate crystal arthritis. Joint Bone Spine 2012, 79:621-623.
-
(2012)
Joint Bone Spine
, vol.79
, pp. 621-623
-
-
Molto, A.1
Ea, H.K.2
Richette, P.3
-
13
-
-
84873742291
-
A pilot study of IL-1 inhibition in acute calcific periarthritis of the shoulder
-
Zufferey P., So A. A pilot study of IL-1 inhibition in acute calcific periarthritis of the shoulder. Ann Rheum Dis 2013, 72:465-467.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 465-467
-
-
Zufferey, P.1
So, A.2
-
14
-
-
78249286865
-
Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
-
Joosten L.A., Netea M.G., Mylona E., et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum 2010, 62:3237-3248.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 3237-3248
-
-
Joosten, L.A.1
Netea, M.G.2
Mylona, E.3
-
15
-
-
84864886219
-
Purine-rich foods intake and recurrent gout attacks
-
Zhang Y., Chen C., Choi H., et al. Purine-rich foods intake and recurrent gout attacks. Ann Rheum Dis 2012, 71:1448-1453.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1448-1453
-
-
Zhang, Y.1
Chen, C.2
Choi, H.3
-
16
-
-
1942471074
-
Alcohol intake and risk of incident gout in men: a prospective study
-
Choi H.K., Atkinson K., Karlson E.W., et al. Alcohol intake and risk of incident gout in men: a prospective study. Lancet 2004, 363:1277-1281.
-
(2004)
Lancet
, vol.363
, pp. 1277-1281
-
-
Choi, H.K.1
Atkinson, K.2
Karlson, E.W.3
-
17
-
-
67650736238
-
Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease
-
Masters S.L., Simon A., Aksentijevich I., et al. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Ann Rev Immunol 2009, 27:621-668.
-
(2009)
Ann Rev Immunol
, vol.27
, pp. 621-668
-
-
Masters, S.L.1
Simon, A.2
Aksentijevich, I.3
-
18
-
-
66049094734
-
In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes
-
Lachmann H.J., Lowe P., Felix S.D., et al. In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes. J Exp Med 2009, 206:1029-1036.
-
(2009)
J Exp Med
, vol.206
, pp. 1029-1036
-
-
Lachmann, H.J.1
Lowe, P.2
Felix, S.D.3
-
19
-
-
77953105116
-
Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
-
Tassi S., Carta S., Delfino L., et al. Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion. Proc Natl Acad Sci USA 2010, 107:9789-9794.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 9789-9794
-
-
Tassi, S.1
Carta, S.2
Delfino, L.3
-
20
-
-
0037792866
-
Interleukin-1-receptor antagonist in the Muckle-Wells syndrome
-
Hawkins P.N., Lachmann H.J., McDermott M.F. Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med 2003, 348:2583-2584.
-
(2003)
N Engl J Med
, vol.348
, pp. 2583-2584
-
-
Hawkins, P.N.1
Lachmann, H.J.2
McDermott, M.F.3
-
21
-
-
23444455462
-
Successful treatment of acute visual loss in Muckle-Wells syndrome with interleukin 1 receptor antagonist
-
Alexander T., Klotz O., Feist E., et al. Successful treatment of acute visual loss in Muckle-Wells syndrome with interleukin 1 receptor antagonist. Ann Rheum Dis 2005, 64:1245-1246.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 1245-1246
-
-
Alexander, T.1
Klotz, O.2
Feist, E.3
-
22
-
-
66649102432
-
Use of canakinumab in the cryopyrin-associated periodic syndrome
-
Lachmann H.J., Kone-Paut I., Kuemmerle-Deschner J.B., et al. Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med 2009, 360:2416-2425.
-
(2009)
N Engl J Med
, vol.360
, pp. 2416-2425
-
-
Lachmann, H.J.1
Kone-Paut, I.2
Kuemmerle-Deschner, J.B.3
-
23
-
-
49449094179
-
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies
-
Hoffman H.M., Throne M.L., Amar N.J., et al. Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum 2008, 58:2443-2452.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2443-2452
-
-
Hoffman, H.M.1
Throne, M.L.2
Amar, N.J.3
-
24
-
-
8444225132
-
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
-
Hoffman H.M., Rosengren S., Boyle D.L., et al. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 2004, 364:1779-1785.
-
(2004)
Lancet
, vol.364
, pp. 1779-1785
-
-
Hoffman, H.M.1
Rosengren, S.2
Boyle, D.L.3
-
25
-
-
84875952203
-
Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review
-
Ter Haar N., Lachmann H., Ozen S., et al. Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann Rheum Dis 2012.
-
(2012)
Ann Rheum Dis
-
-
Ter Haar, N.1
Lachmann, H.2
Ozen, S.3
-
26
-
-
18644385243
-
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
-
Pascual V., Allantaz F., Arce E., et al. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med 2005, 201:1479-1486.
-
(2005)
J Exp Med
, vol.201
, pp. 1479-1486
-
-
Pascual, V.1
Allantaz, F.2
Arce, E.3
-
27
-
-
75749100258
-
IL1-receptor antagonist anakinra provides long-lasting efficacy in the treatment of refractory adult-onset Still's disease
-
Naumann L., Feist E., Natusch A., et al. IL1-receptor antagonist anakinra provides long-lasting efficacy in the treatment of refractory adult-onset Still's disease. Ann Rheum Dis 2010, 69:466-467.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 466-467
-
-
Naumann, L.1
Feist, E.2
Natusch, A.3
-
28
-
-
84860919264
-
Anakinra treatment of SAPHO syndrome: short-term results of an open study
-
Wendling D., Prati C., Aubin F. Anakinra treatment of SAPHO syndrome: short-term results of an open study. Ann Rheum Dis 2012, 71:1098-1100.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1098-1100
-
-
Wendling, D.1
Prati, C.2
Aubin, F.3
-
29
-
-
84862010053
-
Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: an open-label study
-
Krause K., Weller K., Stefaniak R., et al. Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: an open-label study. Allergy 2012, 67:943-950.
-
(2012)
Allergy
, vol.67
, pp. 943-950
-
-
Krause, K.1
Weller, K.2
Stefaniak, R.3
-
30
-
-
47249152715
-
How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets
-
Pascual V., Allantaz F., Patel P., et al. How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets. Immunol Rev 2008, 223:39-59.
-
(2008)
Immunol Rev
, vol.223
, pp. 39-59
-
-
Pascual, V.1
Allantaz, F.2
Patel, P.3
-
31
-
-
84871321221
-
Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis
-
Ruperto N., Brunner H.I., Quartier P., et al. Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis. N Engl J Med 2012, 367:2396-2406.
-
(2012)
N Engl J Med
, vol.367
, pp. 2396-2406
-
-
Ruperto, N.1
Brunner, H.I.2
Quartier, P.3
-
32
-
-
84876744340
-
Anakinra in adult-onset still's disease: long-term treatment in patients resistant to conventional therapy
-
Giampietro C., Ridene M., Lequerre T., et al. Anakinra in adult-onset still's disease: long-term treatment in patients resistant to conventional therapy. Arthritis Care Res 2013, 65:822-826.
-
(2013)
Arthritis Care Res
, vol.65
, pp. 822-826
-
-
Giampietro, C.1
Ridene, M.2
Lequerre, T.3
-
34
-
-
70849110199
-
Free circulating interleukin-18 is increased in Schnitzler syndrome: a new autoinflammatory disease?
-
Migliorini P., Corso I.D., Tommasi C., et al. Free circulating interleukin-18 is increased in Schnitzler syndrome: a new autoinflammatory disease?. Eur Cytokine Netw 2009, 20:108-111.
-
(2009)
Eur Cytokine Netw
, vol.20
, pp. 108-111
-
-
Migliorini, P.1
Corso, I.D.2
Tommasi, C.3
-
35
-
-
0033764203
-
Arguments for interleukin 1 as a target in chronic arthritis
-
van den Berg W.B. Arguments for interleukin 1 as a target in chronic arthritis. Ann Rheum Dis 2000, 59:i81-i84.
-
(2000)
Ann Rheum Dis
, vol.59
, pp. i81-i84
-
-
van den Berg, W.B.1
-
36
-
-
43049177426
-
Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity
-
Fontalba A., Martinez-Taboada V., Gutierrez O., et al. Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. J Immunol 2007, 179:4867-4873.
-
(2007)
J Immunol
, vol.179
, pp. 4867-4873
-
-
Fontalba, A.1
Martinez-Taboada, V.2
Gutierrez, O.3
-
37
-
-
43049159804
-
Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project)
-
Kastbom A., Verma D., Eriksson P., et al. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). Rheumatology (Oxford) 2008, 47:415-417.
-
(2008)
Rheumatology (Oxford)
, vol.47
, pp. 415-417
-
-
Kastbom, A.1
Verma, D.2
Eriksson, P.3
-
38
-
-
77950304735
-
CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis
-
Kastbom A., Johansson M., Verma D., et al. CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis. Ann Rheum Dis 2010, 69:723-726.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 723-726
-
-
Kastbom, A.1
Johansson, M.2
Verma, D.3
-
39
-
-
84858074606
-
Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations
-
Ben Hamad M., Cornelis F., Marzouk S., et al. Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations. Int J Immunogenet 2012, 39:131-136.
-
(2012)
Int J Immunogenet
, vol.39
, pp. 131-136
-
-
Ben Hamad, M.1
Cornelis, F.2
Marzouk, S.3
-
40
-
-
70349331255
-
Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1. NALP-3, and IPAF
-
Kolly L., Karababa M., Joosten L.A., et al. Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1. NALP-3, and IPAF. J Immunol 2009, 183:4003-4012.
-
(2009)
J Immunol
, vol.183
, pp. 4003-4012
-
-
Kolly, L.1
Karababa, M.2
Joosten, L.A.3
-
41
-
-
84863874210
-
ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis
-
Yamazaki H., Takeoka M., Kitazawa M., et al. ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis. Rheumatol Int 2012, 32:1625-1632.
-
(2012)
Rheumatol Int
, vol.32
, pp. 1625-1632
-
-
Yamazaki, H.1
Takeoka, M.2
Kitazawa, M.3
-
42
-
-
17644417155
-
ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP
-
Hasegawa M., Imamura R., Kinoshita T., et al. ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP. J Biol Chem 2005, 280:15122-15130.
-
(2005)
J Biol Chem
, vol.280
, pp. 15122-15130
-
-
Hasegawa, M.1
Imamura, R.2
Kinoshita, T.3
-
43
-
-
67649201757
-
Mechanism and repertoire of ASC-mediated gene expression
-
Hasegawa M., Imamura R., Motani K., et al. Mechanism and repertoire of ASC-mediated gene expression. J Immunol 2009, 182:7655-7662.
-
(2009)
J Immunol
, vol.182
, pp. 7655-7662
-
-
Hasegawa, M.1
Imamura, R.2
Motani, K.3
-
44
-
-
73949092133
-
Expression and function of the NALP3 inflammasome in rheumatoid synovium
-
Kolly L., Busso N., Palmer G., et al. Expression and function of the NALP3 inflammasome in rheumatoid synovium. Immunology 2010, 129:178-185.
-
(2010)
Immunology
, vol.129
, pp. 178-185
-
-
Kolly, L.1
Busso, N.2
Palmer, G.3
-
45
-
-
62549104691
-
Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study
-
Chevalier X., Goupille P., Beaulieu A.D., et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 2009, 61:344-352.
-
(2009)
Arthritis Rheum
, vol.61
, pp. 344-352
-
-
Chevalier, X.1
Goupille, P.2
Beaulieu, A.D.3
-
46
-
-
80052581043
-
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
-
Jin C., Frayssinet P., Pelker R., et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc Natl Acad Sci USA 2011, 108:14867-14872.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14867-14872
-
-
Jin, C.1
Frayssinet, P.2
Pelker, R.3
-
47
-
-
84870360269
-
Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models
-
Bougault C., Gosset M., Houard X., et al. Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models. Arthritis Rheum 2012, 64:3972-3981.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 3972-3981
-
-
Bougault, C.1
Gosset, M.2
Houard, X.3
-
48
-
-
84859861944
-
Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus
-
Pontillo A., Girardelli M., Kamada A.J., et al. Polimorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus. Autoimmunity 2012, 45:271-278.
-
(2012)
Autoimmunity
, vol.45
, pp. 271-278
-
-
Pontillo, A.1
Girardelli, M.2
Kamada, A.J.3
-
49
-
-
82455175944
-
Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE
-
Panchanathan R., Duan X., Arumugam M., et al. Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE. Mol Immunol 2011, 49:273-280.
-
(2011)
Mol Immunol
, vol.49
, pp. 273-280
-
-
Panchanathan, R.1
Duan, X.2
Arumugam, M.3
|