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Volumn 97, Issue 3, 2015, Pages 298-306

Pharmacogenetics of pregnancy-induced changes in efavirenz pharmacokinetics

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; CYTOCHROME P450 2B6; EFAVIRENZ; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; LAMIVUDINE; TENOFOVIR DISOPROXIL; ZIDOVUDINE; ABCB1 PROTEIN, HUMAN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZOXAZINE DERIVATIVE; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP2A6 PROTEIN, HUMAN; CYP2B6 PROTEIN, HUMAN; CYTOCHROME P450 2A6; MULTIDRUG RESISTANCE PROTEIN;

EID: 84927686006     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/cpt.43     Document Type: Article
Times cited : (40)

References (48)
  • 1
    • 85070817148 scopus 로고    scopus 로고
    • PMTCT strategic vision 2010-2015. Preventing mother-to-child transmission of HIV to reach the UNGASS and Millennium Development Goals, Accessed 30 September 2014
    • World Health Organization. PMTCT strategic vision 2010-2015. Preventing mother-to-child transmission of HIV to reach the UNGASS and Millennium Development Goals . Accessed 30 September 2014.
  • 2
    • 85070825314 scopus 로고    scopus 로고
    • Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection, Accessed 30 September 2014
    • World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection . Accessed 30 September 2014.
  • 3
    • 84874747607 scopus 로고    scopus 로고
    • Impact of an innovative approach to prevent mother-to-child transmission of HIV – Malawi, July 2011–September 2012
    • Centers for Disease Control and Prevention. Impact of an innovative approach to prevent mother-to-child transmission of HIV – Malawi, July 2011–September 2012. MMWR Morb. Mortal. Wkly. Rep. 62, 148–151 (2013).
    • (2013) MMWR Morb. Mortal. Wkly. Rep , vol.62 , pp. 148-151
  • 4
    • 85070811948 scopus 로고    scopus 로고
    • Use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants programmatic update, Accessed 30 September 2014
    • World Health Organization. Use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: programmatic update . Accessed 30 September 2014.
  • 5
    • 85070806540 scopus 로고    scopus 로고
    • Global HIV/AIDS response. Epidemic update and health sector progress towards universal access progress report 2011, Accessed 25 July 2014
    • World Health Organization. Global HIV/AIDS response. Epidemic update and health sector progress towards universal access: progress report 2011 . Accessed 25 July 2014.
  • 6
    • 25144516296 scopus 로고    scopus 로고
    • Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach
    • Anderson, G.D. Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin. Pharmacokinet. 44, 989–1008 (2005).
    • (2005) Clin. Pharmacokinet , vol.44 , pp. 989-1008
    • Anderson, G.D.1
  • 8
    • 84859758788 scopus 로고    scopus 로고
    • Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum
    • Cressey, T.R. et al. Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum. J. Acquir. Immune Defic. Syndr. 59, 245–252 (2012).
    • (2012) J. Acquir. Immune Defic. Syndr , vol.59 , pp. 245-252
    • Cressey, T.R.1
  • 9
    • 84856075437 scopus 로고    scopus 로고
    • Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women
    • Benaboud, S. et al. Pregnancy-related effects on lamivudine pharmacokinetics in a population study with 228 women. Antimicrob. Agents Chemother. 56, 776–782 (2012).
    • (2012) Antimicrob. Agents Chemother , vol.56 , pp. 776-782
    • Benaboud, S.1
  • 10
    • 33645391801 scopus 로고    scopus 로고
    • Impact of pregnancy on abacavir pharmacokinetics
    • Best, B.M. et al. Impact of pregnancy on abacavir pharmacokinetics. AIDS 20, 553–560 (2006).
    • (2006) AIDS , vol.20 , pp. 553-560
    • Best, B.M.1
  • 11
    • 33748911183 scopus 로고    scopus 로고
    • Reduced lopinavir exposure during pregnancy
    • Stek, A.M. et al. Reduced lopinavir exposure during pregnancy. AIDS 20, 1931–1939 (2006).
    • (2006) AIDS , vol.20 , pp. 1931-1939
    • Stek, A.M.1
  • 12
    • 78049272719 scopus 로고    scopus 로고
    • Suboptimal nevirapine steady-state pharmacokinetics during intrapartum compared with postpartum in HIV-1-seropositive Ugandan women
    • Lamorde, M. et al. Suboptimal nevirapine steady-state pharmacokinetics during intrapartum compared with postpartum in HIV-1-seropositive Ugandan women. J. Acquir. Immune Defic. Syndr. 55, 345–350 (2010).
    • (2010) J. Acquir. Immune Defic. Syndr , vol.55 , pp. 345-350
    • Lamorde, M.1
  • 13
    • 84857993084 scopus 로고    scopus 로고
    • Effect of pregnancy on emtricitabine pharmacokinetics
    • Stek, A.M. et al. Effect of pregnancy on emtricitabine pharmacokinetics. HIV Med. 13, 226–235 (2012).
    • (2012) HIV Med , vol.13 , pp. 226-235
    • Stek, A.M.1
  • 14
    • 84856069811 scopus 로고    scopus 로고
    • Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women
    • Benaboud, S. et al. Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women. Antimicrob. Agents Chemother. 56, 857–862 (2012).
    • (2012) Antimicrob. Agents Chemother , vol.56 , pp. 857-862
    • Benaboud, S.1
  • 15
    • 79953052608 scopus 로고    scopus 로고
    • Atazanavir pharmacokinetics with and without tenofovir during pregnancy
    • Mirochnick, M. et al. Atazanavir pharmacokinetics with and without tenofovir during pregnancy. J. Acquir. Immune Defic. Syndr. 56, 412–419 (2011).
    • (2011) J. Acquir. Immune Defic. Syndr , vol.56 , pp. 412-419
    • Mirochnick, M.1
  • 16
    • 84882644760 scopus 로고    scopus 로고
    • Reduced indinavir exposure during pregnancy
    • Cressey, T.R. et al. Reduced indinavir exposure during pregnancy. Br. J. Clin. Pharmacol. 76, 475–483 (2013).
    • (2013) Br. J. Clin. Pharmacol , vol.76 , pp. 475-483
    • Cressey, T.R.1
  • 17
    • 84873466060 scopus 로고    scopus 로고
    • Pharmacokinetic optimization of antiretroviral therapy in pregnancy
    • &
    • Buckoreelall, K., Cressey, T.R. & King, J.R. Pharmacokinetic optimization of antiretroviral therapy in pregnancy. Clin. Pharmacokinet. 51, 639–659 (2012).
    • (2012) Clin. Pharmacokinet , vol.51 , pp. 639-659
    • Buckoreelall, K.1    Cressey, T.R.2    King, J.R.3
  • 18
    • 10944246142 scopus 로고    scopus 로고
    • Pharmacokinetics of antiretrovirals in pregnant women
    • &
    • Mirochnick, M. & Capparelli, E. Pharmacokinetics of antiretrovirals in pregnant women. Clin. Pharmacokinet. 43, 1071–1087 (2004).
    • (2004) Clin. Pharmacokinet , vol.43 , pp. 1071-1087
    • Mirochnick, M.1    Capparelli, E.2
  • 19
    • 84867567023 scopus 로고    scopus 로고
    • Potential effect of pharmacogenetics on maternal, fetal and infant antiretroviral drug exposure during pregnancy and breastfeeding
    • &
    • Olagunju, A., Owen, A. & Creesey, T.R. Potential effect of pharmacogenetics on maternal, fetal and infant antiretroviral drug exposure during pregnancy and breastfeeding. Pharmacogenomics 13, 1501–1522 (2012).
    • (2012) Pharmacogenomics , vol.13 , pp. 1501-1522
    • Olagunju, A.1    Owen, A.2    Creesey, T.R.3
  • 21
    • 0038002981 scopus 로고    scopus 로고
    • The cytochrome P4502B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
    • &
    • Ward, B.A., Gorski, J.C., Jones, D.R., Hall, S.D., Flockhart, D.A. & Desta, Z. The cytochrome P4502B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J. Pharmacol. Exp. Ther. 306, 287–300 (2003).
    • (2003) J. Pharmacol. Exp. Ther , vol.306 , pp. 287-300
    • Ward, B.A.1    Gorski, J.C.2    Jones, D.R.3    Hall, S.D.4    Flockhart, D.A.5    Desta, Z.6
  • 22
    • 84892471332 scopus 로고    scopus 로고
    • Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients
    • Sarfo, F.S. et al. Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients. J. Antimicrob. Chemother. 69, 491–499 (2014).
    • (2014) J. Antimicrob. Chemother , vol.69 , pp. 491-499
    • Sarfo, F.S.1
  • 23
    • 41149092923 scopus 로고    scopus 로고
    • Impact of CYP2B6 983T > C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients
    • Wyen, C. et al. Impact of CYP2B6 983T > C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients. J. Antimicrob. Chemother. 61, 914–918 (2008).
    • (2008) J. Antimicrob. Chemother , vol.61 , pp. 914-918
    • Wyen, C.1
  • 24
    • 84880922434 scopus 로고    scopus 로고
    • High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients
    • &
    • Swart, M., Skelton, M., Ren, Y., Smith, P., Takuva, S. & Dandara, C. High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients. Pharmacogenet. Genomics 23, 415–427 (2013).
    • (2013) Pharmacogenet. Genomics , vol.23 , pp. 415-427
    • Swart, M.1    Skelton, M.2    Ren, Y.3    Smith, P.4    Takuva, S.5    Dandara, C.6
  • 25
    • 84870335137 scopus 로고    scopus 로고
    • Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants
    • Holzinger, E.R. et al. Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants. Pharmacogenet. Genomics 22, 858–867 (2012).
    • (2012) Pharmacogenet. Genomics , vol.22 , pp. 858-867
    • Holzinger, E.R.1
  • 26
    • 77952322356 scopus 로고    scopus 로고
    • CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients
    • &
    • Kwara, A., Lartey, M., Sagoe, K.W.C., Kenu, E. & Court, M.H. CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients. AIDS 23, 2101–2106 (2009).
    • (2009) AIDS , vol.23 , pp. 2101-2106
    • Kwara, A.1    Lartey, M.2    Sagoe, K.W.C.3    Kenu, E.4    Court, M.H.5
  • 27
    • 84869862527 scopus 로고    scopus 로고
    • PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients
    • &
    • Swart, M., Whitehorn, H., Ren, Y., Smith, P., Ramesar, R.S. & Dandara, C. PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients. BMC Med. Genet. 13, 112 (2012).
    • (2012) BMC Med. Genet , vol.13 , pp. 112
    • Swart, M.1    Whitehorn, H.2    Ren, Y.3    Smith, P.4    Ramesar, R.S.5    Dandara, C.6
  • 28
    • 0037022006 scopus 로고    scopus 로고
    • Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
    • Fellay, J. et al. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 359, 30–36 (2002).
    • (2002) Lancet , vol.359 , pp. 30-36
    • Fellay, J.1
  • 30
    • 0035808574 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • &
    • Marzolini, C., Telenti, A., Decosterd, L.A., Greub, G., Biollaz, J. & Buclin, T. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS 15, 71–75 (2001).
    • (2001) AIDS , vol.15 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3    Greub, G.4    Biollaz, J.5    Buclin, T.6
  • 32
    • 0037167163 scopus 로고    scopus 로고
    • Efavirenz plasma levels for the prediction of treatment failure in heavily pretreated HIV-1 infected patients
    • Langmann, P. et al. Efavirenz plasma levels for the prediction of treatment failure in heavily pretreated HIV-1 infected patients. Eur. J. Med. Res. 7, 309–314 (2002).
    • (2002) Eur. J. Med. Res , vol.7 , pp. 309-314
    • Langmann, P.1
  • 33
    • 85070840572 scopus 로고    scopus 로고
    • Efavirenz (EFV) 400 versus 600 mg daily: Results of the ENCORE1 intensive PK substudy
    • &
    • Dickinson, L. & Puls, R. Efavirenz (EFV) 400 versus 600 mg daily: Results of the ENCORE1 intensive PK substudy [abstract 510]. Top. Antivir. Med. 22, 244–245 (2014).
    • (2014) Top. Antivir. Med , vol.22 , pp. 244-245
    • Dickinson, L.1    Puls, R.2
  • 34
    • 84899620845 scopus 로고    scopus 로고
    • Efficacy of 400 mg efavirenz vs. standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial
    • Puls, R.L. et al. Efficacy of 400 mg efavirenz vs. standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial. Lancet 383, 1474–1482 (2014).
    • (2014) Lancet , vol.383 , pp. 1474-1482
    • Puls, R.L.1
  • 35
    • 41149132905 scopus 로고    scopus 로고
    • Aberrant splicing caused by single nucleotide polymorphism c.516G > T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver
    • Hofmann, M.H. et al. Aberrant splicing caused by single nucleotide polymorphism c.516G > T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver. J. Pharmacol. Exp. Ther. 325, 284–292 (2008).
    • (2008) J. Pharmacol. Exp. Ther , vol.325 , pp. 284-292
    • Hofmann, M.H.1
  • 36
    • 80052905460 scopus 로고    scopus 로고
    • Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients
    • Habtewold, A. et al. Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients. Antimicrob. Agents Chemother. 66, 2350–2361 (2011).
    • (2011) Antimicrob. Agents Chemother , vol.66 , pp. 2350-2361
    • Habtewold, A.1
  • 37
    • 84860676728 scopus 로고    scopus 로고
    • Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy
    • Koh, K.H. et al. Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy. Biochem. Pharmacol. 84, 93–103 (2012).
    • (2012) Biochem. Pharmacol , vol.84 , pp. 93-103
    • Koh, K.H.1
  • 38
    • 84925862510 scopus 로고    scopus 로고
    • A validated method for quantification of efavirenz in dried blood spots (DBS) using HPLC-MS/MS
    • ; published online 26 August
    • Amara, A.B. et al. A validated method for quantification of efavirenz in dried blood spots (DBS) using HPLC-MS/MS. Ther. Drug Monit. (2014); published online 26 August (doi: 10.1097/FTD.0000000000000127).
    • (2014) Ther. Drug Monit.
    • Amara, A.B.1
  • 39
    • 84859571569 scopus 로고    scopus 로고
    • Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz
    • &
    • Kromdijk, W., Mulder, J.W., Rosing, H., Smit, P.M., Beijnen, J.H. & Huitema, A.D. Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz. J. Antimicrob. Chemother. 67, 1211–1216 (2012).
    • (2012) J. Antimicrob. Chemother , vol.67 , pp. 1211-1216
    • Kromdijk, W.1    Mulder, J.W.2    Rosing, H.3    Smit, P.M.4    Beijnen, J.H.5    Huitema, A.D.6
  • 40
    • 84895758293 scopus 로고    scopus 로고
    • Pharmacokinetics of lopinavir/ritonavir and efavirenz in food insecure HIV-infected pregnant and breastfeeding women in Tororo, Uganda
    • Bartelink, I.H. et al. Pharmacokinetics of lopinavir/ritonavir and efavirenz in food insecure HIV-infected pregnant and breastfeeding women in Tororo, Uganda. J. Clin. Pharmacol. 54, 121–132 (2014).
    • (2014) J. Clin. Pharmacol , vol.54 , pp. 121-132
    • Bartelink, I.H.1
  • 41
    • 84922576048 scopus 로고    scopus 로고
    • Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis co-infection
    • ; published online 31 July
    • Dooley, K.E. et al. Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis co-infection. J. Infect. Dis. (2014); published online 31 July (doi: 10.1093/infdis/jiu429).
    • (2014) J. Infect. Dis.
    • Dooley, K.E.1
  • 42
    • 84875391572 scopus 로고    scopus 로고
    • Ensembl 2013
    • Flicek, P. et al. Ensembl 2013. Nucleic Acids Res. 41, D48–55 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. D48-55
    • Flicek, P.1
  • 44
    • 78449283356 scopus 로고    scopus 로고
    • Enrichment of clinical study populations
    • Temple, R. Enrichment of clinical study populations. Clin. Pharmacol. Ther. 88, 774–778 (2010).
    • (2010) Clin. Pharmacol. Ther , vol.88 , pp. 774-778
    • Temple, R.1
  • 46
    • 84903151392 scopus 로고    scopus 로고
    • Dose reduction of efavirenz: an observational study describing cost-effectiveness, pharmacokinetics and pharmacogenetics
    • Martin, A.S. et al. Dose reduction of efavirenz: an observational study describing cost-effectiveness, pharmacokinetics and pharmacogenetics. Pharmacogenomics 15, 997–1006 (2014).
    • (2014) Pharmacogenomics , vol.15 , pp. 997-1006
    • Martin, A.S.1
  • 47
    • 84899629480 scopus 로고    scopus 로고
    • Antiretroviral dose reduction: good for patients and rollout
    • &
    • Lundgren, J.D. & Phillips, A. Antiretroviral dose reduction: good for patients and rollout. Lancet 383, 1442–1443 (2014).
    • (2014) Lancet , vol.383 , pp. 1442-1443
    • Lundgren, J.D.1    Phillips, A.2
  • 48
    • 60149090387 scopus 로고    scopus 로고
    • Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies
    • &
    • Rodriguez, S., Gaunt, T.R. & Day, I.N. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am. J. Epidemiol. 169, 505–514 (2009).
    • (2009) Am. J. Epidemiol , vol.169 , pp. 505-514
    • Rodriguez, S.1    Gaunt, T.R.2    Day, I.N.3


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