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Volumn 4, Issue 7, 2008, Pages 965-972

Efavirenz - Still First-line King?

Author keywords

Efavirenz; Novel antiretroviral agents; Treatment native

Indexed keywords

ANTIRETROVIRUS AGENT; ATAZANAVIR; CHOLESTEROL; DARUNAVIR; DARUNAVIR PLUS RITONAVIR; DELAVIRDINE; EFAVIRENZ; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; EMTRICITABINE; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ETRAVIRINE; INDINAVIR; LAMIVUDINE; LAMIVUDINE PLUS TENOFOVIR DISOPROXIL; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MARAVIROC; NELFINAVIR; NEVIRAPINE; PLACEBO; PROTEINASE INHIBITOR; RALTEGRAVIR; RILPIVIRINE; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR; TENOFOVIR DISOPROXIL; UNINDEXED DRUG;

EID: 49649108542     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.4.7.965     Document Type: Review
Times cited : (40)

References (48)
  • 1
    • 49649092369 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adolescents and Adults. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of health and human services. January 29, 2008;1-128. Available from: http://www.aidsinfo.nih.gov/ContentFiles/ AdultandAdolescentGL.pdf. Accessed May 14, 2008
    • Panel on Antiretroviral Guidelines for Adolescents and Adults. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of health and human services. January 29, 2008;1-128. Available from: http://www.aidsinfo.nih.gov/ContentFiles/ AdultandAdolescentGL.pdf. Accessed May 14, 2008
  • 2
    • 49649096803 scopus 로고    scopus 로고
    • Sustiva® prescribing information. Princeton, NJ. March 2008 [cited 2008 May 14, Available from
    • Bristol-Myers Squib Company. Sustiva® prescribing information. Princeton, NJ. March 2008 [cited 2008 May 14]; Available from: www.sustiva.com
    • Company
    • Bristol-Myers Squib1
  • 3
    • 0028785708 scopus 로고
    • L-743, 726 (DMP-266): A novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase
    • Young SD, Britcher SF, Tran LO, et al. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 1995;39(12):2602-5
    • (1995) Antimicrob Agents Chemother , vol.39 , Issue.12 , pp. 2602-2605
    • Young, S.D.1    Britcher, S.F.2    Tran, L.O.3
  • 4
    • 1542319002 scopus 로고    scopus 로고
    • Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: Implications for treatment and postexposure prophylaxis
    • Witvrouw M, Pannecouque C, Switzer WM, et al. Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis. Antivir Ther 2004;9(1):57-65
    • (2004) Antivir Ther , vol.9 , Issue.1 , pp. 57-65
    • Witvrouw, M.1    Pannecouque, C.2    Switzer, W.M.3
  • 5
    • 0035399659 scopus 로고    scopus 로고
    • The steady-state pharmacokinetics of efavirenz and nevirapine when used in combination in human immunodeficiency virus type 1-infected persons
    • Veldkamp AI, Harris M, Montaner JS, et al. The steady-state pharmacokinetics of efavirenz and nevirapine when used in combination in human immunodeficiency virus type 1-infected persons. J Infect Dis 2001;184(1):37-42
    • (2001) J Infect Dis , vol.184 , Issue.1 , pp. 37-42
    • Veldkamp, A.I.1    Harris, M.2    Montaner, J.S.3
  • 6
    • 0032751029 scopus 로고    scopus 로고
    • Pharmacokinetics of efavirenz (EFV) alone and in combination therapy with nelfinavir (NFV) in HIV-1 infected patients
    • Villani P, Regazzi MB, Castelli F, et al. Pharmacokinetics of efavirenz (EFV) alone and in combination therapy with nelfinavir (NFV) in HIV-1 infected patients. Br J Clin Pharmacol 1999;48(5):712-5
    • (1999) Br J Clin Pharmacol , vol.48 , Issue.5 , pp. 712-715
    • Villani, P.1    Regazzi, M.B.2    Castelli, F.3
  • 7
    • 0037226529 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of efavirenz, nelfinavir, and indinavir: Adult AIDS Clinical Trial Group Study 398
    • Pfister M, Labbe L, Hammer SM, et al. Population pharmacokinetics and pharmacodynamics of efavirenz, nelfinavir, and indinavir: Adult AIDS Clinical Trial Group Study 398. Antimicrob Agents Chemother 2003;47(1):130-7
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.1 , pp. 130-137
    • Pfister, M.1    Labbe, L.2    Hammer, S.M.3
  • 8
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous system side effects: An Adult AIDS Clinical Trials Group study
    • Haas DW, Ribaudo HJ, Kim RB, et al. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS 2004;18(18):2391-400
    • (2004) AIDS , vol.18 , Issue.18 , pp. 2391-2400
    • Haas, D.W.1    Ribaudo, H.J.2    Kim, R.B.3
  • 9
    • 7444231093 scopus 로고    scopus 로고
    • Practical guidelines to interpret plasma concentrations of antiretroviral drugs
    • Kappelhoff BS, Crommentuyn KM, de Maat MM, et al. Practical guidelines to interpret plasma concentrations of antiretroviral drugs. Clin Pharmacokinet 2004;43(13):845-53
    • (2004) Clin Pharmacokinet , vol.43 , Issue.13 , pp. 845-853
    • Kappelhoff, B.S.1    Crommentuyn, K.M.2    de Maat, M.M.3
  • 10
    • 33645356967 scopus 로고    scopus 로고
    • Pharmacokinetic parameters of nevirapine and efavirenz in relation to antiretroviral efficacy
    • Leth FV, Kappelhoff BS, Johnson D, et al. Pharmacokinetic parameters of nevirapine and efavirenz in relation to antiretroviral efficacy. AIDS Res Hum Retroviruses 2006;22(3):232-9
    • (2006) AIDS Res Hum Retroviruses , vol.22 , Issue.3 , pp. 232-239
    • Leth, F.V.1    Kappelhoff, B.S.2    Johnson, D.3
  • 11
    • 0035875828 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • Marzolini C, Telenti A, Decosterd LA, et al. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS 2001;15(1):71-5
    • (2001) AIDS , vol.15 , Issue.1 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3
  • 12
    • 85043515692 scopus 로고    scopus 로고
    • Higher efavirenz plasma levels correlate with development of insomnia
    • Nunez M, Gonzalez de Requena D, Gallego L, et al. Higher efavirenz plasma levels correlate with development of insomnia. J Acquir Immune Defic Syndr 2001;28(4):399-400
    • (2001) J Acquir Immune Defic Syndr , vol.28 , Issue.4 , pp. 399-400
    • Nunez, M.1    Gonzalez de Requena, D.2    Gallego, L.3
  • 13
    • 0033840455 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy
    • Bacheler LT, Anton ED, Kudish P, et al. Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. Antimicrob Agents Chemother 2000;44(9):2475-84
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.9 , pp. 2475-2484
    • Bacheler, L.T.1    Anton, E.D.2    Kudish, P.3
  • 14
    • 0347992032 scopus 로고    scopus 로고
    • Evolution of human immunodeficiency virus type 1 (HIV-1) resistance mutations in nonnucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1-infected patients switched to antiretroviral therapy without NNRTIs
    • Joly V, Descamps D, Peytavin G, et al. Evolution of human immunodeficiency virus type 1 (HIV-1) resistance mutations in nonnucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1-infected patients switched to antiretroviral therapy without NNRTIs. Antimicrob Agents Chemother 2004;48(1):172-5
    • (2004) Antimicrob Agents Chemother , vol.48 , Issue.1 , pp. 172-175
    • Joly, V.1    Descamps, D.2    Peytavin, G.3
  • 15
    • 0037415062 scopus 로고    scopus 로고
    • A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors
    • Brenner B, Turner D, Oliveira M, et al. A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors. AIDS 2003;17(1):F1-5
    • (2003) AIDS , vol.17 , Issue.1
    • Brenner, B.1    Turner, D.2    Oliveira, M.3
  • 16
    • 0036843080 scopus 로고    scopus 로고
    • Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance
    • Loemba H, Brenner B, Parniak MA, et al. Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance. Antiviral Res 2002;56(2):129-42
    • (2002) Antiviral Res , vol.56 , Issue.2 , pp. 129-142
    • Loemba, H.1    Brenner, B.2    Parniak, M.A.3
  • 17
    • 0035984778 scopus 로고    scopus 로고
    • Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT
    • Loemba H, Brenner B, Parniak MA, et al. Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT. Antimicrob Agents Chemother 2002;46(7):2087-94
    • (2002) Antimicrob Agents Chemother , vol.46 , Issue.7 , pp. 2087-2094
    • Loemba, H.1    Brenner, B.2    Parniak, M.A.3
  • 18
    • 2442419529 scopus 로고    scopus 로고
    • Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: Effect on response to efavirenz-based therapy in an urban observational cohort
    • Tozzi V, Zaccarelli M, Narciso P, et al. Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort. J Infect Dis 2004;189(9):1688-95
    • (2004) J Infect Dis , vol.189 , Issue.9 , pp. 1688-1695
    • Tozzi, V.1    Zaccarelli, M.2    Narciso, P.3
  • 19
    • 4444371619 scopus 로고    scopus 로고
    • Genetic correlates of efavirenz hypersusceptibility
    • Shulman NS, Bosch RJ, Mellors JW, et al. Genetic correlates of efavirenz hypersusceptibility. AIDS 2004;18(13):1781-5
    • (2004) AIDS , vol.18 , Issue.13 , pp. 1781-1785
    • Shulman, N.S.1    Bosch, R.J.2    Mellors, J.W.3
  • 20
    • 33646376232 scopus 로고    scopus 로고
    • Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors
    • Clark SA, Shulman NS, Bosch RJ, Mellors JW. Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors. AIDS 2006;20(7):981-4
    • (2006) AIDS , vol.20 , Issue.7 , pp. 981-984
    • Clark, S.A.1    Shulman, N.S.2    Bosch, R.J.3    Mellors, J.W.4
  • 21
    • 34548655652 scopus 로고    scopus 로고
    • Emergence of HIV-1 drug resistance in previously untreated patients initiating combination antiretroviral treatment: A comparison of different regimen types
    • von Wyl V, Yerly S, Boni J, et al. Emergence of HIV-1 drug resistance in previously untreated patients initiating combination antiretroviral treatment: a comparison of different regimen types. Arch Intern Med 2007;167(16):1782-90
    • (2007) Arch Intern Med , vol.167 , Issue.16 , pp. 1782-1790
    • von Wyl, V.1    Yerly, S.2    Boni, J.3
  • 22
    • 3843140513 scopus 로고    scopus 로고
    • HIV drug resistance surveillance: Summary of an April 2003 WHO consultation
    • Lazzari S, de Felici A, Sobel H, Bertagnolio S. HIV drug resistance surveillance: summary of an April 2003 WHO consultation. AIDS 2004;18(Suppl 3):S49-53
    • (2004) AIDS , vol.18 , Issue.SUPPL. 3
    • Lazzari, S.1    de Felici, A.2    Sobel, H.3    Bertagnolio, S.4
  • 23
    • 7244234570 scopus 로고    scopus 로고
    • Current patterns in the epidemiology of primary HIV drug resistance in North America and Europe
    • Pillay D. Current patterns in the epidemiology of primary HIV drug resistance in North America and Europe. Antivir Ther 2004;9(5):695-702
    • (2004) Antivir Ther , vol.9 , Issue.5 , pp. 695-702
    • Pillay, D.1
  • 24
    • 33750267263 scopus 로고    scopus 로고
    • Long-term results of initial therapy with abacavir and Lamivudine combined with Efavirenz, Amprenavir/ Ritonavir, or Stavudine
    • Bartlett JA, Johnson J, Herrera G, et al. Long-term results of initial therapy with abacavir and Lamivudine combined with Efavirenz, Amprenavir/ Ritonavir, or Stavudine. J Acquir Immune Defic Syndr 2006;43(3):284-92
    • (2006) J Acquir Immune Defic Syndr , vol.43 , Issue.3 , pp. 284-292
    • Bartlett, J.A.1    Johnson, J.2    Herrera, G.3
  • 25
    • 3342924014 scopus 로고    scopus 로고
    • Comparison of once-daily atazanavir with efavirenz each in combination with fixed-dose zidovudine and lamivudine, as initial therapy for patients infected with HIV
    • Squires K, Lazzarin A, Gatell JM, et al. Comparison of once-daily atazanavir with efavirenz each in combination with fixed-dose zidovudine and lamivudine, as initial therapy for patients infected with HIV. J Acquir Immune Defic Syndr 2004;36(5):1011-9
    • (2004) J Acquir Immune Defic Syndr , vol.36 , Issue.5 , pp. 1011-1019
    • Squires, K.1    Lazzarin, A.2    Gatell, J.M.3
  • 26
    • 11144357656 scopus 로고    scopus 로고
    • Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: A randomised open-label trial, the 2NN Study
    • van Leth F, Phanuphak P, Ruxrungtham K, et al. Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study. Lancet 2004;363(9417):1253-63
    • (2004) Lancet , vol.363 , Issue.9417 , pp. 1253-1263
    • van Leth, F.1    Phanuphak, P.2    Ruxrungtham, K.3
  • 27
    • 28144452516 scopus 로고    scopus 로고
    • Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals
    • Clifford DB, Evans S, Yang Y, et al. Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals. Ann Intern Med 2005;143(10):714-21
    • (2005) Ann Intern Med , vol.143 , Issue.10 , pp. 714-721
    • Clifford, D.B.1    Evans, S.2    Yang, Y.3
  • 28
    • 20244378824 scopus 로고    scopus 로고
    • Long-term neuropsychiatric disorders on efavirenz-based approaches: Quality of life, psychologic issues, and adherence
    • Fumaz CR, Munoz-Moreno JA, Molto J, et al. Long-term neuropsychiatric disorders on efavirenz-based approaches: quality of life, psychologic issues, and adherence. J Acquir Immune Defic Syndr 2005;38(5):560-5
    • (2005) J Acquir Immune Defic Syndr , vol.38 , Issue.5 , pp. 560-565
    • Fumaz, C.R.1    Munoz-Moreno, J.A.2    Molto, J.3
  • 29
    • 0037271311 scopus 로고    scopus 로고
    • Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz
    • Lochet P, Peyriere H, Lotthe A, et al. Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz. HIV Med 2003;4(1):62-6
    • (2003) HIV Med , vol.4 , Issue.1 , pp. 62-66
    • Lochet, P.1    Peyriere, H.2    Lotthe, A.3
  • 30
    • 0037169263 scopus 로고    scopus 로고
    • Myelomeningocele in a child with intrauterine exposure to efavirenz
    • Fundaro C, Genovese O, Rendeli C, et al. Myelomeningocele in a child with intrauterine exposure to efavirenz. AIDS 2002;16(2):299-300
    • (2002) AIDS , vol.16 , Issue.2 , pp. 299-300
    • Fundaro, C.1    Genovese, O.2    Rendeli, C.3
  • 31
    • 33748353997 scopus 로고    scopus 로고
    • Efavirenz use during pregnancy and for women of child-bearing potential
    • Chersich MF, Urban MF, Venter FW, et al. Efavirenz use during pregnancy and for women of child-bearing potential. AIDS Res Ther 2006;3:11
    • (2006) AIDS Res Ther , vol.3 , pp. 11
    • Chersich, M.F.1    Urban, M.F.2    Venter, F.W.3
  • 32
    • 2342537759 scopus 로고    scopus 로고
    • Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection
    • Gulick RM, Ribaudo HJ, Shikuma CM, et al. Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection. N Engl J Med 2004;350(18):1850-61
    • (2004) N Engl J Med , vol.350 , Issue.18 , pp. 1850-1861
    • Gulick, R.M.1    Ribaudo, H.J.2    Shikuma, C.M.3
  • 33
    • 33847058002 scopus 로고    scopus 로고
    • Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: First-line therapy for all?
    • Goicoechea M, Best B. Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line therapy for all? Expert Opin Pharmacother 2007;8(3):371-82
    • (2007) Expert Opin Pharmacother , vol.8 , Issue.3 , pp. 371-382
    • Goicoechea, M.1    Best, B.2
  • 36
    • 0035833452 scopus 로고    scopus 로고
    • Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection
    • Albrecht MA, Bosch RJ, Hammer SM, et al. Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection. N Engl J Med 2001;345(6):398-407
    • (2001) N Engl J Med , vol.345 , Issue.6 , pp. 398-407
    • Albrecht, M.A.1    Bosch, R.J.2    Hammer, S.M.3
  • 37
    • 0033576816 scopus 로고    scopus 로고
    • Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team
    • Staszewski S, Morales-Ramirez J, Tashima KT, et al. Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team. N Engl J Med 1999;341(25):1865-73
    • (1999) N Engl J Med , vol.341 , Issue.25 , pp. 1865-1873
    • Staszewski, S.1    Morales-Ramirez, J.2    Tashima, K.T.3
  • 38
    • 10244230857 scopus 로고    scopus 로고
    • First-line efavirenz versus lopinavir-ritonavir-based highly active antiretroviral therapy for naive patients
    • Manfredi R, Calza L, Chiodo F. First-line efavirenz versus lopinavir-ritonavir-based highly active antiretroviral therapy for naive patients. AIDS 2004;18(17):2331-3
    • (2004) AIDS , vol.18 , Issue.17 , pp. 2331-2333
    • Manfredi, R.1    Calza, L.2    Chiodo, F.3
  • 39
    • 4444340700 scopus 로고    scopus 로고
    • A comparison of the CD4 response to antiretroviral regimens in patients commencing therapy with low CD4 counts
    • Waters L, Stebbing J, Jones R, et al. A comparison of the CD4 response to antiretroviral regimens in patients commencing therapy with low CD4 counts. J Antimicrob Chemother 2004;54(2):503-7
    • (2004) J Antimicrob Chemother , vol.54 , Issue.2 , pp. 503-507
    • Waters, L.1    Stebbing, J.2    Jones, R.3
  • 40
    • 33749869583 scopus 로고    scopus 로고
    • A prospective, randomized, Phase III trial of NRTI-, PI-, and NNRTI-sparing regimens for initial treatment of HIV-1 infection - ACTG 5142
    • Toronto, Canada
    • Riddler SA, Haubrich R, DiRienzo G, et al. A prospective, randomized, Phase III trial of NRTI-, PI-, and NNRTI-sparing regimens for initial treatment of HIV-1 infection - ACTG 5142. XVI International AIDS Conference; 2006; Toronto, Canada
    • (2006) XVI International AIDS Conference
    • Riddler, S.A.1    Haubrich, R.2    DiRienzo, G.3
  • 41
    • 49649119663 scopus 로고    scopus 로고
    • Haubrich R RS, DiRienzo G, Komartow L, et al., and the ACTG 5142 Team. Metabolic outcomes of AVTG 5142: a prospective, randomized, phase III trial of NRTI-, PI-, and NNRTI-sparing regimens for initial treatment of HIV-1 infection. 14th conference on retroviruses and opportunistic infections; 2007 February 25-28: Los Angeles, USA
    • Haubrich R RS, DiRienzo G, Komartow L, et al., and the ACTG 5142 Team. Metabolic outcomes of AVTG 5142: a prospective, randomized, phase III trial of NRTI-, PI-, and NNRTI-sparing regimens for initial treatment of HIV-1 infection. 14th conference on retroviruses and opportunistic infections; 2007 February 25-28: Los Angeles, USA
  • 42
    • 49649102051 scopus 로고    scopus 로고
    • Clumeck N vLJ, Chiliade P, et al. ARTEMIS: efficacy and safety of lopinavir (BID vs QD) and darunavir (QD) in antiretroviral-naive patients. European AIDS conference; 2007 October 24-27; Madrid, Spain
    • Clumeck N vLJ, Chiliade P, et al. ARTEMIS: efficacy and safety of lopinavir (BID vs QD) and darunavir (QD) in antiretroviral-naive patients. European AIDS conference; 2007 October 24-27; Madrid, Spain
  • 43
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
    • Markowitz M, Nguyen BY, Gotuzzo E, et al. Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr 2007;46(2):125-33
    • (2007) J Acquir Immune Defic Syndr , vol.46 , Issue.2 , pp. 125-133
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3
  • 44
    • 35548983281 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, comparative trial of a novel CCR5 antagonist, maraviroc versus efavirenz, both in combination with Combivir (zidovudine/lamivudine), for the treatment of antiretroviral naive subjects infected with R5 HIV-1: Week 48 results of the MERIT study
    • July 22, 25; Sydney, Australia
    • Saag MS IP, Heera J, et al. A multicenter, randomized, double-blind, comparative trial of a novel CCR5 antagonist, maraviroc versus efavirenz, both in combination with Combivir (zidovudine/lamivudine), for the treatment of antiretroviral naive subjects infected with R5 HIV-1: week 48 results of the MERIT study. 4th IAS conference on HIV pathogenesis, treatment, and prevention; 2007 July 22 - 25; Sydney, Australia
    • (2007) 4th IAS conference on HIV pathogenesis, treatment, and prevention
    • Saag1    MS, I.P.2    Heera, J.3
  • 45
    • 34347354196 scopus 로고    scopus 로고
    • Efficacy and safety of TMC 125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
    • Lazzarin A, Campbell T, Clotet B, et al. Efficacy and safety of TMC 125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007;370(9581):39-48
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 39-48
    • Lazzarin, A.1    Campbell, T.2    Clotet, B.3
  • 46
    • 34347327010 scopus 로고    scopus 로고
    • Efficacy and safety of TMC 125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
    • Madruga JV, Cahn P, Grinsztejn B, et al. Efficacy and safety of TMC 125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007;370(9581):29-38
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 29-38
    • Madruga, J.V.1    Cahn, P.2    Grinsztejn, B.3
  • 48
    • 40549109383 scopus 로고    scopus 로고
    • Impact of NNRTI and NRTI resistance on the response to the regimen of TMC125 plus two NRTIs in study TMC125-C227 [abstract no. 483]
    • November 12, 16; Glasgow, Scotland
    • Woodfall B, Vingerhoets J, Peeters M, et al. Impact of NNRTI and NRTI resistance on the response to the regimen of TMC125 plus two NRTIs in study TMC125-C227 [abstract no. 483]. 8th International congress on drug therapy in HIV infection; 2006 November 12 - 16; Glasgow, Scotland
    • (2006) 8th International congress on drug therapy in HIV infection
    • Woodfall, B.1    Vingerhoets, J.2    Peeters, M.3


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