CrossTalk opposing view: Bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node

Journal of Physiology

Volumn 593, Issue 8, 2015, Pages 1749-1751

  D'Souza, Alicia ^a   Sharma, Sanjay ^b   Boyett, Mark R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERPOLARIZATION ACTIVATED CHANNEL SUBUNIT 4; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; ION CHANNEL; UNCLASSIFIED DRUG;

ATHLETE; BRADYCARDIA; DOWN REGULATION; ENDURANCE SPORT; FITNESS; HEART BLOCK; HEART RATE VARIABILITY; HUMAN; NONHUMAN; NOTE; PRIORITY JOURNAL; RESTING HEART RATE; SINUS NODE; TREADMILL EXERCISE; VAGUS TONE; CARDIAC MUSCLE; GENETICS; HEART RATE; METABOLISM; PHYSIOLOGY;

ATHLETES; DOWN-REGULATION; HEART RATE; HUMANS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; MYOCARDIUM; SINOATRIAL NODE;

EID: 84927654022     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.284356     Document Type: Note

References (20)

1. Albarado-Ibañez A, Avelino-Cruz JE, Velasco M, Torres-Jacome J & Hiriart M (2013). Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats. PLoS One 8, e76534.
2. Aubert AE, Seps B & Beckers F (2003). Heart rate variability in athletes. Sports Med 33, 889-919.
3. Baldesberger S, Bauersfeld U, Candinas R, Seifert B, Zuber M, Ritter M, Jenni R, Oechslin E, Luthi P, Scharf C, Marti B & Attenhofer Jost CH (2008). Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists. Eur Heart J 29, 71-78.
4. Boyett MR, D'Souza A, Zhang H, Morris GM, Dobrzynski H & Monfredi O (2013). Viewpoint: Is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone? J Appl Physiol (1985) 114, 1351-1355.
5. D'Souza A, Bucchi A, Johnsen AB, Logantha SJ, Monfredi O, Yanni J, Prehar S, Hart G, Cartwright E, Wisloff U, Dobryznski H, DiFrancesco D, Morris GM & Boyett MR (2014). Exercise training reduces resting heart rate via downregulation of the funny channel HCN4. Nat Commun 5, 3775.
6. El Khoury N, Mathieu S, Marger L, Ross J, El Gebeily G, Ethier N & Fiset C (2013). Upregulation of the hyperpolarization-activated current increases pacemaker activity of the sinoatrial node and heart rate during pregnancy in mice. Circulation 127, 2009-2020.
7. 1-mediated fibrosis and ion channel remodeling are key mechanisms in producing sinus node dysfunction associated with SCN5A deficiency and aging. Circ Arrhythm Electrophysiol 4, 397-406.
8. Jensen-Urstad K, Saltin B, Ericson M, Storck N & Jensen-Urstad M (1997). Pronounced resting bradycardia in male elite runners is associated with high heart rate variability. Scand J Med Sci Sports 7, 274-278.
9. Katona PG, Mclean M, Dighton DH & Guz A (1982). Sympathetic and parasympathetic cardiac control in athletes and nonathletes at rest. J Appl Physiol Respir Environ Exerc Physiol 52, 1652-1657.
10. Maron BJ & Pelliccia A (2006). The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death. Circulation 114, 1633-1644.
11. Milanesi R, Baruscotti M, Gnecchi-Ruscone T & DiFrancesco D (2006). Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N Engl J Med 354, 151-157.
12. Monfredi O, Lyashkov AE, Johnsen AB, Inada S, Schneider H, Wang R, Nirmalan M, Wisloff U, Maltsev VA, Lakatta EG, Zhang H & Boyett MR (2014). Biophysical characterisation of the under-appreciated and important relationship between heart rate variability and heart rate. Hypertension 64, 1334-1343.
13. Northcote RJ, Canning GP & Ballantyne D (1989). Electrocardiographic findings in male veteran endurance athletes. Br Heart J 61, 155-160.
14. Ostchega Y, Porter KS, Hughes J, Dillon CF & Nwankwo T (2011). Resting pulse rate reference data for children, adolescents, and adults: United States, 1999-2008. Natl Health Stat Report 41, 1-16.
15. Stein R, Medeiros CM, Rosito GA, Zimerman LI & Ribeiro JP (2002). Intrinsic sinus and atrioventricular node electrophysiologic adaptations in endurance athletes. J Am Coll Cardiol 39, 1033-1038.
16. Yamanushi TT, Yanni J, Dobrzynski H, Kabuto H & Boyett MR (2010). Changes in ion channel expression in right-sided congestive heart failure. J Mol Cell Cardiol 48, (Suppl.) S73.
17. Yanni J, Tellez JO, Maczewski M, Mackiewicz U, Beresewicz A, Billeter R, Dobrzynski H & Boyett MR (2011a). Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfun-ction. Circ Heart Fail 4, 496-508.
18. 2+ clock genes underlying sinoatrial node pacemaking. Exp Physiol 96, 1163-1178.
19. Yeh YH, Burstein B, Qi XY, Sakabe M, Chartier D, Comtois P, Wang Z, Kuo CT & Nattel S (2009). Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome. Circulation 119, 1576-1585.
20. Zicha S, Fernández-Velasco M, Lonardo G, L'Heureux N & Nattel S (2005). Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model. Cardiovasc Res 66, 472-481.