Changes in Ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction

Circulation: Heart Failure

Volumn 4, Issue 4, 2011, Pages 496-508

  Yanni, Joseph ^a   Tellez, James O ^a   Ma̧cZewski, Michal ^d   MacKiewicz, Urszula ^b   Beresewicz, Andrzej ^b   Billeter, Rudi ^c   Dobrzynski, Halina ^a   Boyett, M R ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d NONE

Author keywords

Heart failure; Ion channels; Sinoatrial node

Indexed keywords

ADENOSINE A1 RECEPTOR; CALCIUM CHANNEL; CALSEQUESTRIN; SODIUM CHANNEL; BMYO PROTEIN, RAT; GAP JUNCTION PROTEIN; ION CHANNEL; MYOSIN HEAVY CHAIN; POTASSIUM CHANNEL; SLC9A1 PROTEIN, RAT; SODIUM PROTON EXCHANGE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; GAP JUNCTION; GENE EXPRESSION; HEART ATRIUM MUSCLE; HEART FAILURE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART RHYTHM; HUMAN; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; QUANTITATIVE ANALYSIS; RAT; SHAM PROCEDURE; SINUS NODE DISEASE; SYSTOLIC BLOOD PRESSURE; ANIMAL; DISEASE MODEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HEART ATRIUM; HEART INFARCTION; HEART RATE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SINUS NODE; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIUM CHANNELS; CONNEXINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEART ATRIA; HEART FAILURE; HEART RATE; ION CHANNELS; MALE; MYOCARDIAL INFARCTION; MYOSIN HEAVY CHAINS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SINOATRIAL NODE; SODIUM CHANNELS; SODIUM-HYDROGEN ANTIPORTER;

EID: 80052795091     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.110.957647     Document Type: Article

References (42)

1. Cleland JG, Khand A, Clark A. The heart failure epidemic: exactly how big is it? Eur Heart J. 2001;22:623-626. (Pubitemid 32622421)
2. Uretsky BF, Sheahan RG. Primary prevention of sudden cardiac death in heart failure: will the solution be shocking? J Am Coll Cardiol. 1997;30: 1589-1597. (Pubitemid 27521237)
3. Stevenson WG, Stevenson LW, Middlekauff HR, Saxon LA. Sudden death prevention in patients with advanced ventricular dysfunction. Circulation. 1993;88:2953-2961. (Pubitemid 23360223)
4. Dobrzynski H, Boyett MR, Anderson RH. New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation. 2007;115:1921-1932. (Pubitemid 46598906)
5. Muir-Nisbet A. The Electrophysiology of the Atrioventricular Node in Normal and Failing Rabbit Hearts [dissertation]. Glasgow, UK: University of Glasgow; 2008.
6. Sanders P, Kistler PM, Morton JB, Spence SJ, Kalman JM. Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve. Circulation. 2004;110:897-903. (Pubitemid 39128614)
7. Zicha S, Fernandez-Velasco M, Lonardo G, L'Heureux N, Nattel S. Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model. Cardiovasc Res. 2005;66: 472-481. (Pubitemid 40725759)
8. Opthof T, Coronel R, Rademaker HM, Vermeulen JT, Wilms-Schopman FJ, Janse MJ. Changes in sinus node function in a rabbit model of heart failure with ventricular arrhythmias and sudden death. Circulation. 2000; 101:2975-2980. (Pubitemid 30415890)
9. White CW. Abnormalities in baroreflex control of heart rate in canine heart failure. Am J Physiol. 1981;240:H793-H799. (Pubitemid 11112691)
10. Nattel S, Maguy A, Le Bouter S, Yeh YH. Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev. 2007;87:425-456. (Pubitemid 47084677)
11. Mangoni ME, Nargeot J. Genesis and regulation of the heart automaticity. Physiol Rev. 2008;88:919-982.
12. Irisawa H, Brown HF, Giles W. Cardiac pacemaking in the sino-atrial node. Physiol Rev. 1993;73:197-227.
13. Miake J, Marban E, Nuss HB. Biological pacemaker created by gene transfer. Nature. 2002;419:132-133. (Pubitemid 35025436)
14. Ryu KH, Tanaka N, Ross J Jr. Effects of a sinus node inhibitor on the normal and failing rabbit heart. Basic Res Cardiol. 1996;91:131-139.
15. Verkerk AO, Wilders R, Coronel R, Ravesloot JH, Verheijck EE. Ionic remodeling of sinoatrial node cells by heart failure. Circulation. 2003; 108:760-766. (Pubitemid 36999264)
16. Cingolani HE, Ennis IL. Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. Circulation. 2007;115:1090-1100. (Pubitemid 46673171)
17. Maczewski M, Mackiewicz U. Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart. Cardiovasc Res. 2008;79:42-51.
18. Tellez JO, Dobrzynski H, Yanni J, Billeter R, Boyett MR. Effects of aging on gene expression in the rat sinoatrial node. J Mol Cell Cardiol. 2006;40:982-982.
19. Maier SKG, Westenbroek RE, Yamanushi TT, Dobrzynski H, Boyett MR, Catterall WA, Scheuer T. An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc Natl Acad Sci U S A. 2003;100:3507-3512. (Pubitemid 36356614)
20. + currents in rat atrial myocytes. J Physiol. 1999;517:407-420. (Pubitemid 29294886)
21. + channel Kv2.1 in adult cardiomyocytes. Am J Physiol. 2008;294:H229-H237.
22. + influx and expression of TRPC genes in mouse sinoatrial node. Circ Res. 2007;100:1605-1614. (Pubitemid 46897264)
23. Gupta MP. Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure. J Mol Cell Cardiol. 2007;43:388-403. (Pubitemid 47469981)
24. Hoogaars WM, Engel A, Brons JF, Verkerk AO, de Lange FJ, Wong LY, Bakker ML, Clout DE, Wakker V, Barnett P, Ravesloot JH, Moorman AF, Verheijck EE, Christoffels VM. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007;21:1098-1112. (Pubitemid 46686478)
25. Hoogaars WMH. The Role of Tbx3 in the Formation of the Cardiac Conduction System [dissertation]. Amsterdam, The Netherlands: University of Amsterdam; 2007.
26. Du Y, Huang X, Wang T, Han K, Zhang J, Xi Y, Wu G, Ma A. Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat. Pflugers Arch. 2007;454:451-459. (Pubitemid 46742433)
27. Maier S, Westenbroek RE, Chen C, Marble DR, Feigl EO, Isom LL, Catterall WA, Scheuer T. The +2-subunit of voltage-gated sodium channels is required for maintenance of regular sinus rhythm in the heart. Biophys J. 2002;82:609a.
28. Walker D, De Waard M. Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function. Trends Neurosci. 1998;21:148-154. (Pubitemid 28157183)
29. Lancaster MK, Jones SA, Harrison SM, Boyett MR. Intracellular Ca2+ and pacemaking within the rabbit sinoatrial node: heterogeneity of role and control. J Physiol. 2004;556:481-494. (Pubitemid 38579001)
30. Go LO, Moschella MC, Watras J, Handa KK, Fyfe BS, Marks AR. Differential regulation of two types of intracellular calcium release channels during end-stage heart failure. J Clin Invest. 1995;95:888-894.
31. Masumiya H, Yamamoto H, Hemberger M, Tanaka H, Shigenobu K, Chen SR, Furukawa T. The mouse sino-atrial node expresses both the type 2 and type 3 Ca2+ release channels/ryanodine receptors. FEBS Lett. 2003;553:141-144. (Pubitemid 37206340)
32. Tellez JO, Dobrzynski H, Greener ID, Graham GM, Laing E, Honjo H, Hubbard SJ, Boyett MR, Billeter R. Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ Res. 2006; 99:1384-1393. (Pubitemid 44949674)
33. Sato Y, Ferguson DG, Sako H, Dorn GW, II, Kadambi VJ, Yatani A, Hoit BD, Walsh RA, Kranias EG. Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. J Biol Chem. 1998;273:28470-28477. (Pubitemid 28496153)
34. DiMarco JP, Sellers TD, Berne RM, West GA, Belardinelli L. Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia. Circulation. 1983;68:1254-1263. (Pubitemid 14207037)
35. Matherne GP, Linden J, Byford AM, Gauthier NS, Headrick JP. Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia. Proc Natl Acad Sci U S A. 1997;94:6541-6546. (Pubitemid 27270721)
36. Li D, Melnyk P, Feng J, Wang Z, Petrecca K, Shrier A, Nattel S. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation. 2000;101:2631-2638. (Pubitemid 30350643)
37. Janse MJ. Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. Cardiovasc Res. 2004;61:208-217. (Pubitemid 38091761)
38. Xu Y, Tuteja D, Zhang Z, Xu D, Zhang Y, Rodriguez J, Nie L, Tuxson HR, Young JN, Glatter KA, Vazquez AE, Yamoah EN, Chiamvimonvat N. Molecular identification and functional roles of a Ca2+-activated K+ channel in human and mouse hearts. J Biol Chem. 2003;278:49085-49094.
39. Tuteja D, Xu D, Timofeyev V, Lu L, Sharma D, Zhang Z, Xu Y, Nie L, Vazquez AE, Young JN, Glatter KA, Chiamvimonvat N. Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol. 2005;289:H2714-H2723. (Pubitemid 41698589)
40. Kreuzberg MM, Sohl G, Kim JS, Verselis VK, Willecke K, Bukauskas FF. Functional properties of mouse connexin30.2 expressed in the conduction system of the heart. Circ Res. 2005;96:1169-1177. (Pubitemid 40827692)
41. Boyett MR, Inada S, Yoo S, Li J, Liu J, Tellez JO, Greener ID, Honjo H, Billeter R, Lei M, Zhang H, Efimov IR, Dobrzynski H. Connexins in the sinoatrial and atrioventricular nodes. Adv Cardiol. 2006;42:175-197. (Pubitemid 43805864)
42. Aberra A, Komukai K, Howarth FC, Orchard CH. The effect of acidosis on the ECG of the rat heart. Exp Physiol. 2001;86:27-31. (Pubitemid 32162296)