DUPA Conjugation of a Cytotoxic Indenoisoquinoline Topoisomerase i Inhibitor for Selective Prostate Cancer Cell Targeting

Journal of Medicinal Chemistry

Volumn 58, Issue 7, 2015, Pages 3094-3103

  Roy, Jyoti ^b   Nguyen, Trung Xuan ^a   Kanduluru, Ananda Kumar ^b   Venkatesh, Chelvam ^b   Lv, Wei ^a   Reddy, P V Narasimha ^a   Low, Philip S ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 (1,3 DICARBOXYPROPYL)UREIDO]PENTANEDIOIC ACID; 2 [3 (1,3 DICARBOXYPROPYL)UREIDO]PENTANEDIOIC ACID INDENOISOQUINOLINE TOPOISOMERASE I INHIBITOR CONJUGATE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; INDENOISOQUINOLINE TOPOISOMERASE I INHIBITOR; PROSTATE SPECIFIC MEMBRANE ANTIGEN; UNCLASSIFIED DRUG; 2-(3-(1,3-DICARBOXYPROPYL)UREIDO)PENTANEDIOIC ACID; GLUTARIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE; KALLIKREIN; KALLIKREIN-RELATED PEPTIDASE 3, HUMAN; PROSTATE SPECIFIC ANTIGEN; UREA;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG CONJUGATION; DRUG RECEPTOR BINDING; DRUG RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGENATION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; TUMOR XENOGRAFT; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; HUMAN; IC50; METABOLISM; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; PROSTATIC NEOPLASMS; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; GLUTARATES; HUMANS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; KALLIKREINS; MALE; MICE, NUDE; MOLECULAR TARGETED THERAPY; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; TOPOISOMERASE I INHIBITORS; UREA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84927648631     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5018384     Document Type: Article

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