The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients

European Journal of Neurology

Volumn 21, Issue 3, 2014, Pages 463-469

  Song, T J ^a,b   Kim, J ^a,c   Kim, Y D ^a   Nam, H S ^a   Lee, H S ^a   Nam, C M ^a   Heo, J H ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c CHA University   (South Korea)

Author keywords

Arterial stiffness; Cerebral amyloid angiopathy; Cerebral microbleeds

Indexed keywords

ARTERIAL STIFFNESS; CEREBRAL AMYLOID ANGIOPATHY; CEREBRAL MICROBLEEDS;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BRAIN; CEREBRAL HEMORRHAGE; FEMALE; HUMANS; INTRACRANIAL ARTERIOSCLEROSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; STROKE; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL; VASCULAR STIFFNESS;

EID: 84893846046     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/ene.12332     Document Type: Article

References (27)

1. Greenberg SM, Vernooij MW, Cordonnier C, et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009; 8: 165-174.
2. Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: Cellular and molecular clues to heart and arterial aging. Circulation 2003; 107: 490-497.
3. Mattace-Raso FU, van der Cammen TJ, Hofman A, et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 2006; 113: 657-663.
4. O'Rourke MF, Safar ME. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005; 46: 200-204.
5. Saji N, Shimizu H, Kawarai T, Tadano M, Kita Y, Yokono K. Increased brachial-ankle pulse wave velocity is independently associated with white matter hyperintensities. Neuroepidemiology 2011; 36: 252-257.
6. Ochi N, Tabara Y, Igase M, et al. Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject. Hypertens Res 2009; 32: 255-260.
7. Seo WK, Lee JM, Park MH, Park KW, Lee DH. Cerebral microbleeds are independently associated with arterial stiffness in stroke patients. Cerebrovasc Dis 2008; 26: 618-623.
8. Tomiyama H, Yamashina A, Arai T, et al. Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement - a survey of 12517 subjects. Atherosclerosis 2003; 166: 303-309.
9. Lee BI, Nam HS, Heo JH, Kim DI. Yonsei Stroke Registry. Analysis of 1, 000 patients with acute cerebral infarctions. Cerebrovasc Dis 2001; 12: 145-151.
10. Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41.
11. Nam HS, Kim HC, Kim YD, et al. Long-term mortality in patients with stroke of undetermined etiology. Stroke 2012; 43: 2948-2956.
12. Tanaka H, Munakata M, Kawano Y, et al. Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness. J Hypertens 2009; 27: 2022-2027.
13. Ninomiya T, Kojima I, Doi Y, et al. Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study. J Hypertens 2013; 31: 477-483.
14. Kim J, Cha MJ, Lee DH, et al. The association between cerebral atherosclerosis and arterial stiffness in acute ischemic stroke. Atherosclerosis 2011; 219: 887-891.
15. Motobe K, Tomiyama H, Koji Y, et al. Cut-off value of the ankle-brachial pressure index at which the accuracy of brachial-ankle pulse wave velocity measurement is diminished. Circ J 2005; 69: 55-60.
16. Vernooij MW, van der Lugt A, Ikram MA, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 2008; 70: 1208-1214.
17. Greenberg SM. Cerebral amyloid angiopathy: prospects for clinical diagnosis and treatment. Neurology 1998; 51: 690-694.
18. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987; 149: 351-356.
19. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis.N Engl J Med 1991; 325: 445-453.
20. Warfarin Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators. Warfarin-Aspirin Symptomatic Intracranial Disease Trial I. Design, progress and challenges of a double-blind trial of warfarin versus aspirin for symptomatic intracranial arterial stenosis. Neuroepidemiology 2003; 22: 106-117.
21. Poels MM, Zaccai K, Verwoert GC, et al. Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study. Stroke 2012; 43: 2637-2642.
22. Webb AJ, Simoni M, Mazzucco S, Kuker W, Schulz U, Rothwell PM. Increased cerebral arterial pulsatility in patients with leukoaraiosis: arterial stiffness enhances transmission of aortic pulsatility. Stroke 2012; 43: 2631-2636.
23. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007; 130: 1988-2003.
24. Saji N, Kimura K, Shimizu H, Kita Y. Silent brain infarct is independently associated with arterial stiffness indicated by cardio-ankle vascular index (CAVI). Hypertens Res 2012; 35: 756-760.
25. Lockhart CJ, Hamilton PK, Quinn CE, McVeigh GE. End-organ dysfunction and cardiovascular outcomes: the role of the microcirculation. Clin Sci (Lond) 2009; 116: 175-190.
26. Mahmud A, Feely J. Arterial stiffness is related to systemic inflammation in essential hypertension. Hypertension 2005; 46: 1118-1122.
27. Miwa K, Tanaka M, Okazaki S, Furukado S, Sakaguchi M, Kitagawa K. Relations of blood inflammatory marker levels with cerebral microbleeds. Stroke 2011; 42: 3202-3206.