Progression of brain microbleeds in essential hypertensive patients: A 2-year follow-up study

American Journal of Hypertension

Volumn 27, Issue 8, 2014, Pages 1045-1051

  Van Dooren, Miesje ^a   Staals, Julie ^a,b   De Leeuw, Peter W ^a,b   Kroon, Abraham A ^a,b   Henskens, Léon H ^a   Van Oostenbrugge, Robert J ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Ambulatory blood pressure monitoring; Blood pressure; Brain microbleeds; Essential hypertension; Hypertension; Magnetic resonance imaging

Indexed keywords

AGE; AGED; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; DISEASE COURSE; FEMALE; FOLLOW UP; HUMAN; HYPERTENSION; INTRACRANIAL HEMORRHAGES; MALE; MIDDLE AGED; PATHOLOGY; PREVALENCE; ADULT; ARTICLE; COHORT ANALYSIS; ELEVATED BLOOD PRESSURE; ESSENTIAL HYPERTENSION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PULSE PRESSURE; SLEEP; WAKEFULNESS;

AGE FACTORS; AGED; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; INTRACRANIAL HEMORRHAGES; MALE; MIDDLE AGED; PREVALENCE;

BIOLOGICAL MARKER; BRAIN MICROBLEED; UNCLASSIFIED DRUG;

EID: 84905868690     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpu032     Document Type: Article

References (20)

1. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007; 130: 1988-2003.
2. Werring DJ, Frazer DW, Coward LJ, Losseff NA, Watt H, Cipolotti L, Brown MM, Jager HR. Cognitive dysfunction in patients with cerebral microbleeds on T2-weighted gradient-echo MRI. Brain 2004; 127: 2265-2275.
3. Yakushiji Y, Nishiyama M, Yakushiji S, Hirotsu T, Uchino A, Nakajima J, Eriguchi M, Nanri Y, Hara M, Horikawa E, Kuroda Y. Brain microbleeds and global cognitive function in adults without neurological disorder. Stroke 2008; 39: 3323-3328.
4. de Laat KF, van den Berg HA, van Norden AG, Gons RA, Olde Rikkert MG, de Leeuw FE. Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease. Stroke 2011; 42: 494-497.
5. Thijs V, Lemmens R, Schoofs C, Gorner A, Van Damme P, Schrooten M, Demaerel P. Microbleeds and the risk of recurrent stroke. Stroke 2010; 41: 2005-2009.
6. Bokura H, Saika R, Yamaguchi T, Nagai A, Oguro H, Kobayashi S, Yamaguchi S. Microbleeds are associated with subsequent hemorrhagic and ischemic stroke in healthy elderly individuals. Stroke 2011; 42: 1867-1871.
7. Altmann-Schneider I, Trompet S, de Craen AJ, van Es AC, Jukema JW, Stott DJ, Sattar N, Westendorp RG, van Buchem MA, van der Grond J. Cerebral microbleeds are predictive of mortality in the elderly. Stroke 2011; 42: 638-644.
8. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, Krestin GP, Breteler MM. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 2008; 70: 1208-1214.
9. Jeerakathil T, Wolf PA, Beiser A, Hald JK, Au R, Kase CS, Massaro JM, DeCarli C. Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study. Stroke 2004; 35: 1831-1835.
10. Henskens LH, van Oostenbrugge RJ, Kroon AA, de Leeuw PW, Lodder J. Brain microbleeds are associated with ambulatory blood pressure levels in a hypertensive population. Hypertension 2008; 51: 62-68.
11. Staals J, van Oostenbrugge RJ, Knottnerus IL, Rouhl RP, Henskens LH, Lodder J. Brain microbleeds relate to higher ambulatory blood pressure levels in first-ever lacunar stroke patients. Stroke 2009; 40: 3264-3268.
12. Gregoire SM, Brown MM, Kallis C, Jager HR, Yousry TA, Werring DJ. MRI detection of new microbleeds in patients with ischemic stroke: five-year cohort follow-up study. Stroke 2010; 41: 184-186.
13. Poels MM, Ikram MA, van der Lugt A, Hofman A, Krestin GP, Breteler MM, Vernooij MW. Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study. Stroke 2011; 42: 656-661.
14. Goos JD, Henneman WJ, Sluimer JD, Vrenken H, Sluimer IC, Barkhof F, Blankenstein MA, Scheltens PH, van der Flier WM. Incidence of cerebral microbleeds: a longitudinal study in a memory clinic population. Neurology 2010; 74: 1954-1960.
15. Klarenbeek P, van Oostenbrugge RJ, Rouhl RP, Knottnerus IL, Staals J. Higher ambulatory blood pressure relates to new cerebral microbleeds: 2-year follow-up study in lacunar stroke patients. Stroke 2013;44: 978-983.
16. Baumgart P, Kamp J. Accuracy of the Spacelabs medical 90217 ambulatory blood pressure monitor. Blood Press Monit 1998; 3: 303-307.
17. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Boudier HA, Zanchetti A. 2007 ESH-ESC practice guidelines for the management of arterial hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 2007; 25: 1751-1762.
18. Lammie GA. Hypertensive cerebral small vessel disease and stroke. Brain Pathol 2002; 12: 358-370.
19. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010; 9: 689-701.
20. Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 2003; 34: 806-812.