Cerebral microbleeds are independently associated with arterial stiffness in stroke patients

Cerebrovascular Diseases

Volumn 26, Issue 6, 2008, Pages 618-623

  Seo, Woo Keun ^a   Lee, Jong Moon ^a   Park, Moon Ho ^a   Park, Kun Woo ^a   Lee, Dae Hie ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Arterial stiffness; Cerebral microbleeds; Hypertension; Ischemic stroke

Indexed keywords

ADULT; AGED; ARTERIAL STIFFNESS; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN HEMORRHAGE; BRAIN INFARCTION; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORONARY HEMODYNAMICS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; STROKE; TRANSIENT ISCHEMIC ATTACK; WHITE MATTER;

AGED; AGED, 80 AND OVER; ANKLE BRACHIAL INDEX; BASAL GANGLIA; BRAIN ISCHEMIA; CEREBRAL ARTERIES; CEREBRAL CORTEX; CEREBRAL HEMORRHAGE; ELASTICITY; FEMALE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; ISCHEMIC ATTACK, TRANSIENT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PULSATILE FLOW; REGISTRIES; RETROSPECTIVE STUDIES; RISK FACTORS; SMOKING; VASCULAR RESISTANCE;

EID: 55149097199     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000166837     Document Type: Article

References (25)

1. Lakatta EG: Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. III. Cellular and molecular clues to heart and arterial aging. Circulation 2003;107:490-497.
2. Laurent S, Boutouyrie P: Recent advances in arterial stiffness and wave reflection in human hypertension. Hypertension 2007;49:1202-1206.
3. Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, Asmar R, Reneman RS, Hoeks AP, Breteler MM, Witteman JC: Arterial stiffness and risk of coronary heart disease and stroke: The Rotterdam Study. Circulation 2006;113:657-663.
4. Hirata K, Kawakami M, O'Rourke MF: Pulse wave analysis and pulse wave velocity: a review of blood pressure interpretation 100 years after Korotkov. Circ J 2006;70:1231-1239.
5. O'Rourke MF, Safar ME: Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005;46:200-204.
6. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, Hartung HP: Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999;20:637-642.
7. Cordonnier C, Al-Shahi Salman R, Wardlaw J: Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007;130:1988-2003.
8. Lee SH, Bae HJ, Kwon SJ, Kim H, Kim YH, Yoon BW, Roh JK: Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology 2004;62:72-76.
9. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd: Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in acute stroke treatment. Stroke 1993;24:35-41.
10. Kim M, Bae HJ, Lee J, Kang L, Lee S, Kim S, Lee JE, Lee KM, Yoon BW, Kwon O, Koo JS, Kim BK: APOE ε2/ε4 polymorphism and cerebral microbleeds on gradient-echo MRI. Neurology 2005;65:1474-1475.
11. Kim S, Jeong J: Vaskor MRI Protocol. Seoul, Vaskor, 2006.
12. Munakata M, Ito N, Nunokawa T, Yoshinaga K: Utility of automated brachial ankle pulse wave velocity measurements in hypertensive patients. Am J Hypertens 2003;16:653-657.
13. Sugawara J, Hayashi K, Yokoi T, Cortez-Cooper MY, DeVan AE, Anton MA, Tanaka H: Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens 2005;19:401-406.
14. Kato H, Izumiyama M, Izumiyama K, Takahashi A, Itoyama Y: Silent cerebral microbleeds on T2*-weighted MRI: correlation with stroke subtype, stroke recurrence, and leukoaraiosis. Stroke 2002;33:1536-1540.
15. Kinoshita T, Okudera T, Tamura H, Ogawa T, Hatazawa J: Assessment of lacunar hemorrhage associated with hypertensive stroke by echo-planar gradient-echo T2*-weighted MRI. Stroke 2000;31:1646-1650.
16. Kwa VI, Franke CL, Verbeeten B Jr, Stam J: Silent intracerebral microhemorrhages in patients with ischemic stroke. Amsterdam Vascular Medicine Group. Ann Neurol 1998;44:372-377.
17. Tsushima Y, Tanizaki Y, Aoki J, Endo K: MR detection of microhemorrhages in neurologically healthy adults. Neuroradiology 2002;44:31-36.
18. Zieman SJ, Melenovsky V, Kass DA: Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005;25:932-943.
19. Wardlaw JM, Lewis SC, Keir SL, Dennis MS, Shenkin S: Cerebral microbleeds are associated with lacunar stroke defined clinically and radiologically, independently of white matter lesions. Stroke 2006;37:2633-2636.
20. Fisher CM: Lacunes: small, deep cerebral infarcts. Neurology 1965;15:774-784.
21. van Swieten JC, van den Hout JH, van Ketel BA, Hijdra A, Wokke JH, van Gijn J: Periventricular lesions in the white matter on magnetic resonance imaging in the elderly: a morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain 1991;114:761-774.
22. Inzitari D: Leukoaraiosis: an independent risk factor for stroke? Stroke 2003;34:2067-2071.
23. Naka H, Nomura E, Wakabayashi S, Kajikawa H, Kohriyama T, Mimori Y, Nakamura S, Matsumoto M: Frequency of asymptomatic microbleeds on T2*-weighted MR images of patients with recurrent stroke: association with combination of stroke subtypes and leukoaraiosis. AJNR Am J Neuroradiol 2004;25:714-719.
24. Lee SH, Park JM, Kwon SJ, Kim H, Kim YH, Roh JK, Yoon BW: Left ventricular hypertrophy is associated with cerebral microbleeds in hypertensive patients. Neurology 2004;63:16-21.
25. Gosse P, Jullien V, Jarnier P, Lemetayer P, Clementy J: Reduction in arterial distensibility in hypertensive patients as evaluated by ambulatory measurement of the QKD interval is correlated with concentric remodeling of the left ventricle. Am J Hypertens 1999;12:1252-1255.