Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets

Thrombosis Research

Volumn 134, Issue 5, 2014, Pages 1066-1073

  Liu, Xueqing ^a   Yan, Yan ^a   Bao, Li ^a   Chen, Beidong ^a   Zhao, Yanyang ^a   Qi, Ruomei ^a  

^a BEIJING HOSPITAL   (China)

Author keywords

CD40L; Ginkgolide B; P38MAPK; PF4; Platelets; Syk

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE TRIPHOSPHATE; CALCIUM; CD40 LIGAND; FOSTAMATINIB; GINKGOLIDE B; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE SYK; THROMBIN; THROMBOCYTE FACTOR 4; GINKGOLIDE; LACTONE; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; THROMBOCYTE ACTIVATING FACTOR;

ARTICLE; CALCIUM TRANSPORT; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE FUNCTION; THROMBOCYTE RELEASE REACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; THROMBOCYTE;

ADENOSINE TRIPHOSPHATE; BLOOD PLATELETS; CD40 LIGAND; GINKGOLIDES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTONES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION; PROTEIN-TYROSINE KINASES;

EID: 84927626336     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.08.025     Document Type: Article

References (35)

1. Koenen RR, von Hundelshausen P, Nesmelova IV, Zernecke A, Liehn E.A., Sarabi A., et al. Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Nat Med 2009; 15:97-103.
2. King SM, McNamee RA, Houng A.K., Patel R., Brands M, Reed GL Platelet dense-granule secretion plays a critical role in thrombosis and subsequent vascular remodeling in atherosclerotic mice. Circulation 2009; 120:785-91.
3. Zerr M, Hechler B, Freund M., Magnenat S, Lanois I, Cazenave J.P., et al. Major contribution of the P2Y1 receptor in purinergic regulation of TNFct-induced vascular inflammation. Circulation 2011; 123:2404-13.
4. Lam FW, Burns AR, Smith C.W., Rumbaut RE. Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1. Am J Physiol Heart Circ Physiol 2011; 300:H468-75.
5. Fateh-Moghadam S, Li Z, Ersel S., Reuter T, Htun P, Plöckinger U, et al. Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2. Arterioscler Thromb Vasc Biol 2005; 25:1299-303.
6. Nadar SK, Blann AD, Kamath S, Beevers D.G., Lip GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Am Coll Cardiol 2004; 44:415-22.
7. Shi G, Morrell CN. Platelets as initiators and mediators of inflammation at the vessel wall. Thromb Res 2011; 127:387-90.
8. Gleissner CA, von Hundelshausen P, Ley K. Platelet chemokines in vascular disease. Arterioscler Thromb Vasc Biol 2008; 28:1920-7.
9. Seizer P, Gawaz M, May AE. Platelet-monocyte interactions: a dangerous liaison linking thrombosis, inflammation and atherosclerosis. Curr Med Chem 2008; 15: 1976-80.
10. Jedlitschky G, Tirschmann K, Lubenow L.E., Nieuwenhuis HK, Akkerman JW, Greinacher A, et al. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood 2004; 104:3603-10.
11. Hawrylowics CM, Santoro SA, Platt F.M., Unanue ER. Activated platelet expression IL-1 activity. J Immunol 1989; 143:4015-8.
12. Thornton P, McColl BW, Greenhalgh A, Denes A., Allan SM, Rothwell NJ. Platelet interleukin-1 alpha drives cerebrovascular inflammation. Blood 2010; 115:3632-9.
13. Mehta SK, Tucci MA, Benghuzzi HA Effect of platelet dense granule contents upon osteoblast viability. Biomed Sci Instrum 2012; 48:288-95.
14. Aidoudi S, Bikfalvi A. Interaction of PF4 (CXCL4) with the vasculature: a role in atherosclerosis and angiogenesis. Thromb Haemost 2010; 104:941-8.
15. Scheuerer B, Ernst M, Dürrbaum-Landmann I, Fleischer J, Grage-Griebenow E, Brandt E, et al. The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. Blood 2000; 95:1158-66.
16. Chakrabarti S, Varghese S, Vitseva O., Tanriverdi K, Freedman JE. CD40 ligand influences platelet release of reactive oxygen intermediates. Arterioscler Thromb Vasc Biol 2005; 25:2428-34.
17. Lamant V, Mauco G, Braquet P., Chap H, Douste-Blazy L Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. Biochem Pharmacol 1987; 36:2749-52.
18. Heinroth-Hoffmann I, Hauser A, Mest HJ. Effects of platelet activating factor antagonists on arachidonic acid-induced platelet aggregation and TXA2 formation. Prostaglandins Leukot Essent Fatty Acids 1990; 41:181-2.
19. -/- mice. PLoS One 2012; 7:e36237.
20. Mazharian A, Thomas SG, Dhanjal T.S., Buckley CD, Watson SP. Critical role of Src-Syk-PLCγ2 signaling in megakaryocyte migration and thrombopoiesis. Blood 2010; 116: 793-800.
21. Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Niwa M., Tokuda H, Akamatsu S, et al. alphaB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets. FEBS Lett 2009; 583:2464-8.
22. Borst O, Walker B, Münzer P, Russo A., Schmid E, Faggio C, et al. Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation. Cell Physiol Biochem 2013; 31:914-24
23. Briquet-Laugier V, Lavenu-Bombled C, Schmitt A., Leboeuf M, Uzan G, Dubart-Kupperschmitt A, et al. Probing platelet factor 4 ct-granule targeting. J Thromb Haemost 2004; 2:2231-40.
24. Santilli F, Basili S, Ferroni P., Davì G. CD40/CD40L system and vascular disease. Intern Emerg Med 2007; 2:256-68.
25. 3 integrin-dependent mechanism. Nat Med 2002; 8: 247-52.
26. Kulathu Y, Hobeika E, Turchinovich G., Reth M. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO J 2008; 27:1333-44.
27. 2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. J Cell Biol 2007; 177:317-28.
28. Lösing M, Goldbeck I, Manno B., Oellerich T, Schnyder T, Bohnenberger H., et al. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters. J Biol Chem 2013; 288:2303-13.
29. 2+ mobilization in platelets. Thromb Res 2005; 115:409-15.
30. Takaya N, Katoh Y, Iwabuchi K., Hayashi I, Konishi H, Itoh S., et al. Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor γ-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury. J Mol Cell Cardiol 2005; 39:856-64.
31. Suzuki-Inoue K, Wilde JI, Andrews R.K., Auger JM, Siraganian RP, Sekiya F, et al. Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cγ2 at distinct sites. Biochem J 2004; 378:1023-9.
32. Mazharian A, Roger S, Maurice P., Berrou E, Popoff MR, Hoylaerts M.F., et al. Differential involvement of ERK2 and p38 in platelet adhesion to collagen. J Biol Chem 2005; 280:26002-10.
33. Sakurai K, Matsuo Y, Sudo T., Takuwa Y, Kimura S, Kasuya Y. Role of p38 mitogen-activated protein kinase in thrombus formation. J Recept Signal Transduct Res 2004; 24:283-96.
34. Zhang S, Chen B, Wu W., Bao L, Qi R. Ginkgolide B reduces inflammatory protein expression in oxidized low-density lipoprotein-stimulated human vascular endothelial cells. J Cardiovasc Pharmacol 2011; 57:721-7.
35. Ma L, Liu X, Zhao Y., Chen B, Bao L, Qi R. Ginkgolide B reduces LOX-1 expression by inhibiting Akt phosphorylation and increasing Sirt1 expression in oxidized LDL-stimulated human umbilical vein endothelial cells. PLoS One 2013; 8:e74769.