Critical role of Src-Syk-PLCγ2 signaling in megakaryocyte migration and thrombopoiesis

Blood

Volumn 116, Issue 5, 2010, Pages 793-800

  Mazharian, Alexandra ^a   Thomas, Steve G ^a   Dhanjal, Tarvinder S ^a   Buckley, Christopher D ^a   Watson, Steve P ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2BBETA3 INTEGRIN; GLYCOPROTEIN VI; INTEGRIN; LOTRAFIBAN; PHOSPHOLIPASE C GAMMA2; PROTEIN CD148; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG; 4 AMINO 5 (4 METHYLPHENYL) 7 (TERT BUTYL)PYRAZOLO(3,4 D)PYRIMIDINE; 4-AMINO-5-(4-METHYLPHENYL)-7-(TERT-BUTYL)PYRAZOLO(3,4-D)PYRIMIDINE; BENZODIAZEPINE DERIVATIVE; FIBRINOGEN RECEPTOR; N4 (2,2 DIMETHYL 3 OXO 4H PYRID(1,4)OXAZIN 6 YL) 5 FLUORO N2 (3,4,5 TRIMETHOXYPHENYL) 2,4 PYRIMIDINEDIAMINE; N4-(2,2-DIMETHYL-3-OXO-4H-PYRID(1,4)OXAZIN-6-YL)-5-FLUORO-N2-(3,4,5-TRIMETHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE; OXAZINE DERIVATIVE; PHOSPHOLIPASE C GAMMA; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE P60; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL SPREADING; CONTROLLED STUDY; ENZYME INHIBITION; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MOTION; CELL SHAPE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MOUSE MUTANT; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; THROMBOCYTE;

ANIMALS; BENZODIAZEPINES; BLOOD PLATELETS; CELL MOVEMENT; CELL SHAPE; CELLS, CULTURED; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXAZINES; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PIPERIDINES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS PP60(C-SRC); PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; PYRAZOLES; PYRIDINES; PYRIMIDINES; SIGNAL TRANSDUCTION; THROMBOPOIESIS;

EID: 77956296321     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-03-275990     Document Type: Article

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