The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

Cell Death and Disease

Volumn 6, Issue 1, 2015, Pages

  Xu, J ^a,e   Eriksson, S E ^a   Cebula, M ^a   Sandalova, T ^a   Hedstrom E ^a   Pader, I ^a   Cheng, Q ^a   Myers, C R ^b   Antholine, W E ^b   Nagy, P ^c   Hellman, U ^d   Selivanova, G ^a   Lindqvist, Y ^a   Arner E S J ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^e DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; THIOREDOXIN REDUCTASE; TRYPTOPHAN; CROSS LINKING REAGENT; FLAVINE ADENINE NUCLEOTIDE; FURAN DERIVATIVE; MUTANT PROTEIN; NORDIHYDROGUAIARETIC ACID; NSC 652287; THIOREDOXIN REDUCTASE 1;

AMINO ACID ANALYSIS; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CROSS LINKING; CRYSTAL STRUCTURE; HCT116 CELL LINE; OLIGOMERIZATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; ANIMAL; CHEMICAL STRUCTURE; DRUG EFFECTS; HUMAN; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PROTEIN MULTIMERIZATION; RAT; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANIMALS; CELL DEATH; CELL LINE, TUMOR; CONSERVED SEQUENCE; CROSS-LINKING REAGENTS; FLAVIN-ADENINE DINUCLEOTIDE; FURANS; HCT116 CELLS; HUMANS; KINETICS; MASOPROCOL; MODELS, MOLECULAR; MUTANT PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN MULTIMERIZATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXIN REDUCTASE 1; TRYPTOPHAN;

EID: 84927620824     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.574     Document Type: Article

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