N-Benzoyl-1,5-benzothiazepine and Its S-Oxide as Vasopressin Receptor Ligands: Insight into the Active Stereochemistry around the Seven-Membered Ring

Journal of Medicinal Chemistry

Volumn 58, Issue 7, 2015, Pages 3268-3273

  Yoneda, Tetsuya ^a   Tabata, Hidetsugu ^a   Tasaka, Tomohiko ^b   Oshitari, Tetsuta ^a   Takahashi, Hideyo ^a   Natsugari, Hideaki ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b Affinity Science Corporation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTHIAZEPINE DERIVATIVE; METHYL GROUP; VASOPRESSIN RECEPTOR; VASOPRESSIN RECEPTOR ANTAGONIST; LIGAND; OXIDE; THIAZEPINE DERIVATIVE;

ARTICLE; CHIRALITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIASTEREOISOMER; DRUG CONFORMATION; DRUG SYNTHESIS; DRUG TARGETING; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; MOLECULAR RECOGNITION; OXIDATION; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIC MIXTURE; RACEMIZATION; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ANALYSIS; X RAY ANALYSIS; CHEMISTRY; CONFORMATION; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CHEMISTRY TECHNIQUES, SYNTHETIC; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MOLECULAR CONFORMATION; OXIDES; RECEPTORS, VASOPRESSIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZEPINES;

EID: 84927608409     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00289     Document Type: Article

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