Gastric secretion

Current Opinion in Gastroenterology

Volumn 30, Issue 6, 2014, Pages 578-582

  Schubert, Mitchell L ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acid; Gastrin; H^{+< sup>K+< sup> ATPase; Helicobacter pylori; Histamine}

Indexed keywords

ACETYLCHOLINE; ADRENOMEDULLIN; AMPHIREGULIN; CALCITONIN GENE RELATED PEPTIDE; CALCIUM; CYANOCOBALAMIN; EZRIN; F ACTIN; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIN; GHRELIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HISTAMINE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; INTRINSIC FACTOR; IRON; MYOSIN IIB; PEPSIN A; RAB PROTEIN; SOMATOSTATIN; SONIC HEDGEHOG PROTEIN; TRIACYLGLYCEROL LIPASE; HISTAMINE H2 RECEPTOR ANTAGONIST;

ACID SECRETION; BACTERIAL OVERGROWTH; BACTERIAL PERITONITIS; COMMUNITY ACQUIRED PNEUMONIA; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; INTESTINE INFECTION; MYCOBACTERIUM TUBERCULOSIS; NEUROENDOCRINE SYSTEM; NONHUMAN; PARACRINE SIGNALING; PROTEIN DEGRADATION; REVIEW; STOMACH ABSORPTION; STOMACH ACID SECRETION; STOMACH PH; TUBERCULOSIS; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOPHYSIOLOGY; SECRETION (PROCESS); STOMACH; STOMACH ACID; STOMACH MUCOSA; STOMACH PARIETAL CELL; TRANSPORT AT THE CELLULAR LEVEL;

ACETYLCHOLINE; BIOLOGICAL TRANSPORT; GASTRIC ACID; GASTRIC MUCOSA; GASTRINS; GHRELIN; H(+)-K(+)-EXCHANGING ATPASE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HISTAMINE; HISTAMINE H2 ANTAGONISTS; HUMANS; PARIETAL CELLS, GASTRIC; STOMACH;

EID: 84927592146     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0000000000000125     Document Type: Review

References (48)

1. Waldum HL, Hauso O, Fossmark R. The regulation of gastric acid secretion: clinical perspectives. Acta Physiol 2014;210:239-256. An excellent review of the regulation of gastric acid secretion with emphasis on the adverse effects of hypergastrinemia, including ECL hyperplasia and acid rebound.
2. Freedberg DE, Abrams JA. Clostridium difficile infection in the community: are proton pump inhibitors to blame? World J Gastroenterol 2013;19:6710-6713.
3. Johnson DA, Oldfield EC. Reported side effects and complications of longterm proton pump inhibitor use: dissecting the evidence. Clin Gastroenterol Hepatol 2013;11:458-464. An excellent review assessing the evidence for and against adverse effects associated with the use of PPIs.
4. De Vos M, De Vroey B, Garcoa BG, et al. The role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites. Liver Int 2013;33:1-8.
5. Brophy S, Jones KH, Rahman MS, et al. Incidence of Campylobacter and Salmonella infections following first prescription for PPI: a cohort study using routine data. Am J Gastroenterol 2013;108:1094-10100.
6. Lo W-K, Chan WW. Proton pump inhibitor use and the risk of small intestinal bacterial overgorwth: a meta-analysis. Clin Gastroenterol Hepatol 2013;11:483-490.
7. Jacobs C, Adame EC, Attaluri A, et al. Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth. Aliment Pharmacol Ther 2013;37:1103-1111.
8. Hsu WH, Kuo CH, Wang SS, et al. Acid suppressive agents and risk of Mycobacterium tuberculosis: case-control study. BMC Gastroenterol 2014;14:91.
9. Wedemeyer R-S, Blume H. Pharmacokinetic drug interaction profiles of proton pump inhibitors: an update. Drug Saf 2014;37:201-211.
10. Rosas-Blum E, Tatevian N, Hashmi SS, et al. Nonspecific gastric inflammation in children is associated with proton pump inhibitor treatment for more than 6 weeks. Fron Pediatr 2014;2:1-5.
11. Keszthelyi D, Masclee AA. Effects of proton pump inhibitor therapy in the distal gut: putting the pieces together. Dig Dis Sci 2012;57:2487-2489.
12. Yu Y, Han DS, Choi EY, et al. Is use of PPIs related to increased intraepithelial lymphocytes in the colon? Dig Dis Sci 2012;57:2669-2674.
13. Weinstein DH, deRijke S, Chow CC, et al. A new method for determining gastric acid output using a wireless pH-sensing capsule. Aliment Pharmacol Ther 2013;37:1198-1209.
14. Mostafalu P, Sonkusale S. Flexible and transparent gastric battery: energy harvesting from gastric acid for endoscopy application. Biosens Bioelectron 2014;54:292-296.
15. Engevik A, Feng R, Yang L, Zavros Y. The aicd-secreting parietal cell as an endocrine source of sonic hedgehog during gastric repair. Endocrinology 2013;154:4627-4639.
16. Charpignon C, Lesgourgues B, Pariente A, et al. Peptic ulcer disease: one in five is related to neither Helicobacter pylorior nor aspirin/NSAID intake. Aliment Pharmacol Ther 2013;38:946-954.
17. Solcia E, Vanoli A. Histogenesis and natural history of gut neuroendocrine tumors: present status. Endocr Pathol 2014;25:165-170.
18. Beales IL. Glycine-extended gastrin enhances somatostatin release from cultured rabbit fundic D-cells. F1000Res 2013;2:56.
19. Bitziou E, Patel BA. Simultaneous detection of gastric acid and histamine release to unravel the regulation of acid secretion from the guinea pig stomach. Am J Physiol Gastrointest Liver Physiol 2012;303:G396-G403.
20. Wakim SA, Ahmed MA, Ali RH. Gastric acid secretion in experimental acute uremia. Can J Physiol Pharmacol 2013;91:693-699. Acute renal failure in rats is associated with increased serum gastrin and acid secretion, pressumably because the kidney is the major site for gastrin degradation.
21. Dupre D, Tostivint H. Evolution of the gastrin-cholecystokinin gene family revealed by synteny analysis. Gen Comp Endocrinol 2014;195:164-173.
22. Boyce M, Warrington S. Effect of repeated doses of netazepide, a gastrin receptor anagonist, omeprazole and placebo on 24-h gastric acidity and gastrin in healthy subjects. Br J Pharmacol 2013;76:680-688.
23. Boyce M, Warrington S, Black J. Netazepide, a gastrin/CCK2 receptor antagonist, causes dose-dependent, persistent inhibition of the responses to pentagastrin in healthy subjects. Br J Clin Pharmacol 2013;76:689-698.
24. Xiao L, Kovac S, Chang M, et al. Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter. J Mol Endocrinol 2014;52:29-42.
25. Helgadottir H, Metz DC, Yang Y-X, et al. The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. Dig Liver Dis 2014;46:125-130.
26. Bundett AW, Zaiken K. Impact of clinical pharmacists' recommendations on a proton pump inhibitor taper protocol in an ambulatory care practice. J Manag Care Pharm 2013;19:325-333.
27. Epelboym I, Mazeh H. Zollinger-Ellison syndrome: classical considerations and current controversies. Oncologist 2014;19:44-50. Succinct review of the management of ZES.
28. Krampitz GW, Norton JA. Current management of the Zollinger-Ellison syndrome. Advances in Surgery 2013;47:59-79. Excellent review of the diagnostic and surgical approach to ZES.
29. Poitras P, Gingras M-H, Rehfeld JF. Secretin stimulation test for gastrin release in Zollinger-Ellison syndrome. Pancreas 2013;46:903-904.
30. Shah P, Singh MH, Yang Y-X, Metz DC. Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome. Pancreas 2013;42:932-936. In 27 patients with hypochlorhydria, 15% exhibited a false-positive secretin stimulation test.
31. Steigedal TS, Prestvik WS, Selvik LM, et al. Gastrin-induced proliferation involves MEK partner 1 (MP1). In Vitro Cell Dev Biol Anim 2013;49:162-169.
32. Goetze JP, Eiland S, Svendsen LB, et al. Characterization of gastrins and their receptor in solid human gastric adenocarcinomas. Scand J Gastroenterol 2013;48:688-695. Gastrin is not only a secretagogue but also a trophic hormone capable of inducing proliferation in tissues and tumors containing the CCK2R. In this study, both gastrin and its receptor were detected in 80% of gastric adenocarcinomas.
33. Jin G, Westphalen CB, Hayakawa Y, et al. Progastrin stimulates colonic cell proliferation via CCK2R- and B-Arrestin-dependent suppression of BMP2. Gastroenterology 2013;145:820-830. In mice and human tissue, progastrin stimulates proliferation via CCK2 receptors linked tob-arrestin 1 and arrestin 2-dependent suppression of Bmp2 signaling. Bone morphogenetic proteins normally suppress proliferation and induce apoptosis.
34. Li HJ, Johnston B, Aiello D, et al. Distinct cellular origins for serotoninexpresing and enterochhromaffin-like cells in the gastric corpus. Gastroenterology 2014;146:754-764.
35. Zhao C-M, Chen D. The ECL cell: relay station for gastric integrity. Curr Med Chem 2012;19:98-108.
36. Stengel A, Hofmann T, Goebel-Stengel M, et al. Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects. Histochem Cell Biol 2013;139:909-918.
37. Gahete MD, Rincon-Fernandez D, Villa-Osaba A, et al. Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight. J Endocrinol 2014;220:R1-R24.
38. Paoluzi OA, Del Vechio Blanco G, Caruso R, et al. Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation. World J Gastroenterol 2014;20:639-646.
39. Rau TT, Sonst A, Rogler A, et al. Gastrin mediated down regulation of ghrelin and its pathophysiological role in atrophic gastritis. J Physiol Pharmacol 2013;64:719-725.
40. Woolley MJ, Conner AC. Comparing the molecular pharmacology of CGRP and adrenomedullin. Curr Protein Pept Sci 2013;14:358-374.
41. Shindo T, Sakurai T, Kamiyoshi A, et al. Regulation of adrenomedullin and its family peptide by RAMP system: lessons from genetically engineered mice. Curr Protein Pept Sci 2013;14:347-357.
42. Dickerson IM. Role of CGRP-receptor component protein (RCP) in CLR/RAMP function. Curr Protein Pept Sci 2013;14:407-415.
43. Zhang Y-M, Noto JM, Hammond CE, et al. Helicobater pylori-induced posttranscriptional regulation of H-K-ATPase a-subunit gene expression by miRNA. Am J Physiol Gastrointest Liver Physiol 2014;306:G606-G613. H. pylori type 4 secretion system protein, CagL, is instrumental in injecting the oncogenic bacterial protein, CagA, into cells that mobilizes nuclear factor-kB p50 homodimers that bind to H-K-ATPase a-subunit promoter to repress HKa gene expression.
44. Zaki M, Coudron PE, McCuen RW, et al. H. pylori acutely inhibits gastric secretion by activating CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine secretion. Am J Physiol Gastrointest Liver Physiol 2013;304:G715-G722. Acute infection with H. pylori activates CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine and acid secretion. Inhibition of acid secretion promotes colonization of the superficial gastric mucosa by the bacterium. Activation of neural pathways may explain how a small number of organisms can profoundly inhibit acid secretion.
45. Uehara T, Ma D, Yao Y, et al. H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer. Dig Dis Sci 2013;58:140-149.
46. Peek RM Jr. Chronic Helicobacter pylori infection and DNA-damaged stem cells: a recipe for disaster. Dig Dis Sci 2013;58:13-16.
47. Natarajan P, Crothers JM Jr, Rosen JE, et al. Myosin IIB and F-actin control apical vacuolar morphology and histamine-induced trafficking of H-K-ATPasecontaining tubulovesicles in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol 2014;306:G699-G710.
48. Mukhopadhyay A, Quiroz JA, Wolkoff AW. Rab1a regulates sorting of early endocytic vesicles. Am J Physiol Lung Cell Mol Physiol 2014;306:G412-G424.