Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling

Human Immunology

Volumn 75, Issue 12, 2014, Pages 1192-1196

  Verschoor, Chris P ^a   Johnstone, Jennie ^a   Loeb, Mark ^a   Bramson, Jonathan L ^a   Bowdish, Dawn M E ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Aging; AKT; Cytokine; Macrophage; Streptococcus pneumoniae

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANDROSTANE DERIVATIVE; CHROMONE DERIVATIVE; IL1B PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; MORPHOLINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ADULT; ADVANCED AGE; AGE; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; DENDRITIC CELL; DISEASE PREDISPOSITION; FRAIL ELDERLY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MONOCYTE DERIVED MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; RNA STABILITY; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; YOUNG ADULT; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; IMMUNOLOGY; MICROBIOLOGY; MIDDLE AGED; MORTALITY; STREPTOCOCCUS PNEUMONIA; VERY ELDERLY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANDROSTADIENES; CHROMONES; DISEASE SUSCEPTIBILITY; FRAIL ELDERLY; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; MACROPHAGES; MIDDLE AGED; MORPHOLINES; PHAGOCYTOSIS; PHOSPHATIDYLINOSITOL 3-KINASES; PNEUMONIA, PNEUMOCOCCAL; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84927570907     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2014.10.004     Document Type: Article

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