In vitro oxidative metabolism of 6-mercaptopurine in human liver: Insights into the role of the molybdoflavoenzymes aldehyde oxidase, xanthine oxidase, and xanthine dehydrogenase

Drug Metabolism and Disposition

Volumn 42, Issue 8, 2014, Pages 1334-1340

  Choughule, Kanika V ^a   Barnaba, Carlo ^a   Joswig Jones, Carolyn A ^a   Jones, Jeffrey P ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 THIOURIC ACID; 6 THIOXANTHINE; ALDEHYDE OXIDASE; FEBUXOSTAT; MERCAPTOPURINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; RALOXIFENE; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE; 6-THIOURIC ACID; RECOMBINANT PROTEIN; URIC ACID;

ADULT; AEROBIC METABOLISM; AGED; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME KINETICS; FEMALE; HUMAN; IN VITRO STUDY; LIVER CYTOSOL; MALE; MIDDLE AGED; PRIORITY JOURNAL; YOUNG ADULT; ANALOGS AND DERIVATIVES; CYTOSOL; DRUG DETOXIFICATION; ENZYMOLOGY; ESCHERICHIA COLI; LIVER; METABOLISM; PHYSIOLOGY;

6-MERCAPTOPURINE; ADULT; AGED; ALDEHYDE OXIDASE; CYTOSOL; ESCHERICHIA COLI; FEMALE; HUMANS; LIVER; MALE; METABOLIC DETOXICATION, PHASE I; MIDDLE AGED; RECOMBINANT PROTEINS; URIC ACID; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE; YOUNG ADULT;

EID: 84927565744     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.058107     Document Type: Article

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