Substrate orientation and catalytic specificity in the action of xanthine oxidase: The sequential hydroxylation of hypoxanthine to uric acid

Journal of Biological Chemistry

Volumn 285, Issue 36, 2010, Pages 28044-28053

  Cao, Hongnan ^a   Pauff, James M ^a,b   Hille, Russ ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; CRYSTAL ORIENTATION; ENZYMES; MOLECULAR VIBRATIONS; MOLYBDENUM; ORGANIC ACIDS; SUBSTRATES;

6-MERCAPTOPURINE; ACTIVE SITE; ASYMMETRIC UNIT; BOVINE ENZYME; CHEMOTHERAPEUTIC AGENTS; HETEROCYCLES; INTRINSIC REACTIVITY; KINETIC EXPERIMENT; PHYSIOLOGICAL SUBSTRATE; SUBSTRATE ORIENTATION; THEORETICAL CALCULATIONS; URIC ACIDS; XANTHINE OXIDASE;

HYDROXYLATION;

6,8 DIHYDROXYPURINE; ARGININE; GLUTAMINE; HYPOXANTHINE; UNCLASSIFIED DRUG; URIC ACID; XANTHINE OXIDASE; MERCAPTOPURINE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTALLOGRAPHY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HYDROXYLATION; KINETICS; PRIORITY JOURNAL; ANIMAL; BIOCATALYSIS; BOVINAE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; METABOLISM; OXIDATION REDUCTION REACTION; X RAY CRYSTALLOGRAPHY;

BOVINAE;

6-MERCAPTOPURINE; ANIMALS; BIOCATALYSIS; CATALYTIC DOMAIN; CATTLE; CRYSTALLOGRAPHY, X-RAY; HYDROXYLATION; HYPOXANTHINE; KINETICS; MODELS, MOLECULAR; OXIDATION-REDUCTION; SUBSTRATE SPECIFICITY; URIC ACID; XANTHINE OXIDASE;

EID: 77956233305     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.128561     Document Type: Article

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