Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer

JAMA - Journal of the American Medical Association

Volumn 313, Issue 13, 2015, Pages 1347-1361

  Rebbeck, Timothy R ^b   Mitra, Nandita ^b   Wan, Fei ^b   Sinilnikova, Olga M ^cn   Healey, Sue ^b   McGuffog, Lesley ^d   Chenevix Trench, Georgia ^b   Easton, Douglas F ^d   Antoniou, Antonis C ^d   Nathanson, Katherine L ^b   Laitman, Yael ^e   Kushnir, Anya ^f   Paluch Shimon, Shani ^e   Berger, Raanan ^e   Zidan, Jamal ^g   Friedman, Eitan ^e   Ehrencrona, Hans ^h,i   Stenmark Askmalm, Marie ^j   Einbeigi, Zakaria ^k   Loman, Niklas ^h   Harbst, Katja ^h   Rantala, Johanna ^l   Melin, Beatrice ^m   Huo, Dezheng ⁿ   Olopade, Olufunmilayo I ⁿ   Seldon, Joyce ^o   Ganz, Patricia A ^o   Nussbaum, Robert L ^p   Chan, Salina B ^p   Odunsi, Kunle ^q   Gayther, Simon A ^r   Domchek, Susan M ^a,b   Arun, Banu K ^s   Lu, Karen H ^s   Mitchell, Gillian ^t,u   Karlan, Beth Y ^v   Walsh, Christine ^v   Lester, Jenny ^v   Godwin, Andrew K ^w   Pathak, Harsh ^w   Ross, Eric ^x   Daly, Mary B ^y   Whittemore, Alice S ^p   John, Esther M ^z   Miron, Alexander ^aa   Terry, Mary Beth ^ab   Chung, Wendy K ^ab   Goldgar, David E ^ac   Buys, Saundra S ^ad   Janavičius, Ramunas ^ae   Tihomirova, Laima ^af   Tung, Nadine ^ag   Dorfling, Cecilia M ^ah   Van Rensburg, Elizabeth J ^ah   Steele, Linda ^ai   Neuhausen, Susan L ^ai   Ding, Yuan Chun ^ai   Ejlertsen, Bent ^aj   Gerdes, Anne Marie ^aj   Hansen, Thomas V O ^aj   Ramon Y Cajal, Teresa ^ak   Osorio, Ana ^al   Benitez, Javier ^al   Godino, Javier ^am   Tejada, Maria Isabel ^an   Duran, Mercedes ^ao   Weitzel, Jeffrey N ^ai   Bobolis, Kristie A ^ai   Sand, Sharon R ^ai   Fontaine, Annette ^ai   Savarese, Antonella ^ap   Pasini, Barbara ^aq   Peissel, Bernard ^ar   Bonanni, Bernardo ^as   Zaffaroni, Daniela ^ar   Vignolo Lutati, Francesca ^at   Scuvera, Giulietta ^ar   Giannini, Giuseppe ^au   Bernard, Loris ^as,av   Genuardi, Maurizio ^aw   Radice, Paolo ^ar,ax   Dolcetti, Riccardo ^ay   Manoukian, Siranoush ^ar   Pensotti, Valeria ^av,ax   Gismondi, Viviana ^az   Yannoukakos, Drakoulis ^ba   Fostira, Florentia ^ba   Garber, Judy ^aa   Torres, Diana ^bb,bc   Rashid, Muhammad Usman ^bc,bd   Hamann, Ute ^bc   Peock, Susan ^d   Frost, Debra ^d   Platte, Radka ^d   Evans, D Gareth ^be   Eeles, Rosalind ^bf   Davidson, Rosemarie ^bg   Eccles, Diana ^bh   Cole, Trevor ^bi   Cook, Jackie ^bj   Brewer, Carole ^bk   Hodgson, Shirley ^bl   Morrison, Patrick J ^bm   Walker, Lisa ^bn   Porteous, Mary E ^bo   Kennedy, M John ^bp   Izatt, Louise ^bq   Adlard, Julian ^br   Donaldson, Alan ^bs   Ellis, Steve ^d   Sharma, Priyanka ^bt   Schmutzler, Rita Katharina ^bu   Wappenschmidt, Barbara ^bu   Becker, Alexandra ^bu   Rhiem, Kerstin ^bu   Hahnen, Eric ^bu   Engel, Christoph ^bv   Meindl, Alfons ^bw   Engert, Stefanie ^bw   Ditsch, Nina ^bw   Arnold, Norbert ^bx   Plendl, Hans Jorg ^bx   Mundhenke, Christoph ^bx   Niederacher, Dieter ^by   Fleisch, Markus ^by   Sutter, Christian ^bz   Bartram, C R ^bz   Dikow, Nicola ^bz   Wang Gohrke, Shan ^ca   Gadzicki, Dorothea ^cb   Steinemann, Doris ^cb   Kast, Karin ^cc   Beer, Marit ^cd   Varon Mateeva, Raymonda ^ce   Gehrig, Andrea ^cf   Weber, Bernhard H ^cg   Stoppa Lyonnet, Dominique ^ch,ci,cj   Belotti, Muriel ^ch   Gauthier Villars, Marion ^ch   Damiola, Francesca ^cl   Boutry Kryza, Nadia ^ck   Lasset, Christine ^cm,cn   Sobol, Hagay ^co   Peyrat, Jean Philippe ^cp   Muller, Daniele ^cq   Fricker, Jean Pierre ^cq   Collonge Rame, Marie Agnes ^cr   Mortemousque, Isabelle ^cs   Nogues, Catherine ^ch   Rouleau, Etienne ^ch   Isaacs, Claudine ^ct   De Paepe, Anne ^cu   Poppe, Bruce ^cu   Claes, Kathleen ^cu   De Leeneer, Kim ^cu   Piedmonte, Marion ^cv   Rodriguez, Gustavo ^cw   Wakely, Katie ^cx   Boggess, John ^cy   Blank, Stephanie V ^cz   Basil, Jack ^da   Azodi, Masoud ^db   Phillips, Kelly Anne ^t,u   Caldes, Trinidad ^dc   De La Hoya, Miguel ^dc   Romero, Atocha ^dc   Nevanlinna, Heli ^dd   Aittomaki, Kristiina ^de   Van Der Hout, Annemarie H ^df   Hogervorst, Frans B L ^dg   Verhoef, Senno ^dg   Collee, J Margriet ^dh   Seynaeve, Caroline ^dh   Oosterwijk, Jan C ^df   Gille, Johannes J P ^di   Wijnen, Juul T ^dj   Gomez Garcia, Encarna B ^dk   Kets, Carolien M ^dl   Ausems, Margreet G E M ^dm   Aalfs, Cora M ^dn   Devilee, Peter ^dj   Mensenkamp, Arjen R ^dl   Kwong, Ava ^do,dp,dq   Olah, Edith ^dr   Papp, Janos ^dr   Diez, Orland ^ds,dt   Lazaro, Conxi ^du   Darder, Esther ^du   Blanco, Ignacio ^du   Salinas, Monica ^du   Jakubowska, Anna ^dv   Lubinski, Jan ^dv   Gronwald, Jacek ^dv   Jaworska Bieniek, Katarzyna ^dv,dw   Durda, Katarzyna ^dv   Sukiennicki, Grzegorz ^dv   Huzarski, Tomasz ^dv   Byrski, Tomasz ^dv   Cybulski, Cezary ^dv   Toloczko Grabarek, Aleksandra ^dv   Złowocka Perłowska, Elzbieta ^dv   Menkiszak, Janusz ^dv   Arason, Adalgeir ^dx,dy   Barkardottir, Rosa B ^dx,dy   Simard, Jacques ^dz,ea   Laframboise, Rachel ^eb,ec   Montagna, Marco ^ec   Agata, Simona ^ec   Alducci, Elisa ^ec   Peixoto, Ana ^ed   Teixeira, Manuel R ^ed,ee   Spurdle, Amanda B ^c   Lee, Min Hyuk ^ef   Park, Sue K ^eg   Kim, Sung Won ^eh   Friebel, Tara M ^b   Couch, Fergus J ^ei   Lindor, Noralane M ^ei   Pankratz, Vernon S ^ei   Guidugli, Lucia ^ei   Wang, Xianshu ^ei   Tischkowitz, Marc ^d,ej   Foretova, Lenka ^ek   Vijai, Joseph ^el   Offit, Kenneth ^el   Robson, Mark ^el   Rau Murthy, Rohini ^el   Kauff, Noah ^el   Fink Retter, Anneliese ^em   Singer, Christian F ^em   Rappaport, Christine ^em   Gschwantler Kaulich, Daphne ^em   Pfeiler, Georg ^em   Tea, Muy Kheng ^em   Berger, Andreas ^em   Greene, Mark H ^en   Mai, Phuong L ^en   Imyanitov, Evgeny N ^eo   Toland, Amanda Ewart ^ep   Senter, Leigha ^ep   Bojesen, Anders ^eq   Pedersen, Inge Sokilde ^er   Skytte, Anne Bine ^eq   Sunde, Lone ^es   Thomassen, Mads ^et   Moeller, Sanne Traasdahl ^et   Kruse, Torben A ^et   Jensen, Uffe Birk ^es   Caligo, Maria Adelaide ^eu   Aretini, Paolo ^eu   Teo, Soo Hwang ^ev,ew   Selkirk, Christina G ^ex   Hulick, Peter J ^ex   Andrulis, Irene ^ey   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e SHEBA MEDICAL CENTER   (Israel)

^f GERTNER INSTITUTE FOR EPIDEMIOLOGY AND HEALTH POLICY RESEARCH   (Israel)

^g Rebecca Sieff Government Hospital   (Israel)

^h LUND UNIVERSITY   (Sweden)

ⁱ UPPSALA UNIVERSITY   (Sweden)

^j LINKÖPING UNIVERSITY   (Sweden)

^k SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^l KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^m UMEÅ UNIVERSITY   (Sweden)

ⁿ UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^o UNIVERSITY OF CALIFORNIA   (United States)

^p UNIVERSITY OF CALIFORNIA   (United States)

^q ROSWELL PARK CANCER INSTITUTE   (United States)

^r UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^s UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^t PETER MACCALLUM CANCER CENTRE   (Australia)

^u UNIVERSITY OF MELBOURNE   (Australia)

^v CEDARS SINAI MEDICAL CENTER   (United States)

^w UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^x FOX CHASE CANCER CENTER   (United States)

^y STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^z CANCER PREVENTION INSTITUTE OF CALIFORNIA   (United States)

^aa DANA FARBER CANCER INSTITUTE   (United States)

^ab Och Spine at New York Presbyterian Hospitals   (United States)

^ac UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^ad UNIVERSITY OF UTAH   (United States)

^ae VILNIUS UNIVERSITY   (Lithuania)

^af LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^ag BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^ah UNIVERSITY OF PRETORIA   (South Africa)

^ai CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^aj Rigshospitalet   (Denmark)

^ak HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^al Structural Biology and Biocomputing Programme   (Spain)

^am HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^an HOSPITAL DE CRUCES   (Spain)

^ao University of Valladolid   (Spain)

^ap REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^aq UNIVERSITY OF TURIN   (Italy)

^ar NATIONAL CANCER INSTITUTE   (Italy)

^as EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^at CITTÀ DELLA SALUTE E DELLA SCIENZA HOSPITAL   (Italy)

^au SAPIENZA UNIVERSITY OF ROME   (Italy)

^av A Gemelli Hospital ^*  (Italy)

^aw CATHOLIC UNIVERSITY   (Italy)

^ax FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^ay CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^az UNIVERSITY OF GENOA   (Italy)

^ba INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^bb PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^bc GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^bd SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL AND RESEARCH CENTRE   (Pakistan)

^be UNIVERSITY OF MANCHESTER   (United Kingdom)

^bf INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^bg ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^bh PRINCESS ANNE HOSPITAL   (United Kingdom)

^bi BIRMINGHAM CHILDREN S HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^bj SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^bk ROYAL DEVON AND EXETER HOSPITAL   (United Kingdom)

^bl ST GEORGE S HOSPITAL   (United Kingdom)

^bm BELFAST CITY HOSPITAL   (United Kingdom)

^bn CHURCHILL HOSPITAL   (United Kingdom)

^bo WESTERN GENERAL HOSPITAL   (United Kingdom)

^bp ST JAMES S HOSPITAL   (Ireland)

^bq GUY S HOSPITAL   (United Kingdom)

^br Yorkshire Regional Genetics Service   (United Kingdom)

^bs South West Regional Genetics Service   (United Kingdom)

^bt UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^bu UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^bv UNIVERSITY OF LEIPZIG   (Germany)

^bw TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^bx UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^by UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^bz UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^ca UNIVERSITY HOSPITAL ULM   (Germany)

^cb HANNOVER MEDICAL SCHOOL   (Germany)

^cc UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^cd DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^ce CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^cf UNIVERSITY OF WÜRZBURG   (Germany)

^cg UNIVERSITY OF REGENSBURG   (Germany)

^ch INSTITUT CURIE   (France)

^ci INSTITUT CURIE   (France)

^cj UNIVERSITÉ PARIS DESCARTES   (France)

^ck HOSPICES CIVILS DE LYON   (France)

^cl CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^cm UNIVERSITÉ LYON 1   (France)

^cn CENTRE LÉON BÉRARD   (France)

^co AIX MARSEILLE UNIVERSITY   (France)

^cp CENTRE OSCAR LAMBRET   (France)

^cq Unité d'Oncogénétique   (France)

^cr UNIVERSITY HOSPITAL OF BESANÇON   (France)

^cs CHU BRETONNEAU   (France)

^ct GEORGETOWN UNIVERSITY   (United States)

^cu GHENT UNIVERSITY HOSPITAL   (Belgium)

^cv Buffalo Niagara Enterprise   (United States)

^cw EVANSTON HOSPITAL   (United States)

^cx TUFTS UNIVERSITY   (United States)

^cy UNIVERSITY OF NORTH CAROLINA   (United States)

^cz NEW YORK UNIVERSITY   (United States)

^da Good Samaritan Hospital   (United States)

^db YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^dc HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^dd UNIVERSITY OF HELSINKI   (Finland)

^de HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^df UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^dg NETHERLANDS CANCER INSTITUTE   (Netherlands)

^dh ERASMUS MEDICAL CENTER   (Netherlands)

^di VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^dj LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^dk MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^dl RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^dm UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^dn ACADEMIC MEDICAL CENTER   (Netherlands)

^do Hong Kong Hereditary Breast Cancer Family Registry   (Hong Kong)

^dp HONG KONG SANATORIUM AND HOSPITAL   (Hong Kong)

^dq UNIVERSITY OF HONG KONG   (Hong Kong)

^dr NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^ds UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^dt HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^du CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^dv POMERANIAN MEDICAL UNIVERSITY   (Poland)

^dw MEDICAL UNIVERSITY OF WARSAW   (Poland)

^dx LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^dy UNIVERSITY OF ICELAND   (Iceland)

^dz University Laval   (Canada)

^ea UNIVERSITÉ LAVAL   (Canada)

^eb LAVAL UNIVERSITY   (Canada)

^ec VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^ed PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^ee UNIVERSITY OF PORTO   (Portugal)

^ef Soonchunhyang University   (South Korea)

^eg Seoul National University College of Medicine   (South Korea)

^eh The Catholic University of Korea   (South Korea)

^ei MAYO CLINIC   (United States)

^ej MCGILL UNIVERSITY   (Canada)

^ek MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

^el MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^em MEDICAL UNIVERSITY OF VIENNA   (Austria)

^en NATIONAL CANCER INSTITUTE   (United States)

^eo N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

^ep OHIO STATE UNIVERSITY   (United States)

^eq LILLEBAELT HOSPITAL   (Denmark)

^er AALBORG UNIVERSITY HOSPITAL   (Denmark)

^es AARHUS UNIVERSITY HOSPITAL   (Denmark)

^et ODENSE UNIVERSITY HOSPITAL   (Denmark)

^eu UNIVERSITY OF PISA   (Italy)

^ev CANCER RESEARCH INITIATIVES FOUNDATION   (Malaysia)

^ew UNIVERSITY OF MALAYA   (Malaysia)

^ex NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^ey MOUNT SINAI HOSPITAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; BREAST CANCER; BREAST CANCER CLUSTER REGION; CANCER RISK; CAUCASIAN; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FLANKING REGION; EXON; FEMALE; FRAMESHIFT MUTATION; GENE DELETION; GENE FUNCTION; GENE LOCATION; GENE MUTATION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC PARAMETERS; HETEROZYGOTE; HUMAN; IN FRAME DELETION; JEW; MAJOR CLINICAL STUDY; MEDICAL DECISION MAKING; MIDDLE AGED; MISSENSE MUTATION; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NONSENSE MUTATION; NUCLEOTIDE POSITION; OBSERVATIONAL STUDY; ONSET AGE; OVARIAN CANCER CLUSTER REGION; OVARY CANCER; PRIORITY JOURNAL; RISK ASSESSMENT; TUMOR SUPPRESSOR GENE; BREAST TUMOR; GENETIC PREDISPOSITION; GENETICS; MUTATION; OVARY TUMOR; RISK FACTOR;

NUCLEOTIDE;

ADULT; AGE OF ONSET; BREAST NEOPLASMS; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; MIDDLE AGED; MUTATION; NUCLEOTIDES; OVARIAN NEOPLASMS; RISK FACTORS;

EID: 84927556016     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2014.5985     Document Type: Article

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