Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture

Journal of Cellular Biochemistry

Volumn 82, Issue 3, 2001, Pages 387-398

  Kavanagh, Kathryn T ^a,b   Hafer, Laurie J ^a   Kim, Dong W ^a   Mann, Koren K ^a   Sherr, David H ^b   Rogers, Adrianne E ^a   Sonenshein, Gail E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Breast cancer; DMBA; EGCG; Green tea; P27Kip1

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CAMELLIA SINENSIS EXTRACT; CYCLIN DEPENDENT KINASE INHIBITOR; EPIGALLOCATECHIN GALLATE; ESTROGEN RECEPTOR; PLANT EXTRACT; POLYPHENOL; PROTEIN P27; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE EXPRESSION; GENE INDUCTION; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; TEA; TUMOR GROWTH; TUMOR VOLUME;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOGENS; CATECHIN; CELL CYCLE PROTEINS; CELL DEATH; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; FEMALE; FLAVONOIDS; FLOW CYTOMETRY; MAMMARY NEOPLASMS, ANIMAL; PHENOLS; PLANT EXTRACTS; POLYMERS; PROBABILITY; RATS; TEA; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; CAMELLIA SINENSIS;

EID: 0034904091     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.1164     Document Type: Article

References (53)

1. Chemoprevention of mammary preneoplasia. In vitro effects of a green tea polyphenol
2. Transformation of human breast epithelial cells by chemical carcinogens
3. Prognostic implications of expression of the cell cycle inhibitor protein p27Kip1
4. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer
5. Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts
6. Inhibitory effect of green tea on tumorigenesis by chemicals and ultraviolet light
7. High level expression of p27(kip 1) and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27(kip 1) and degree of malignancy in human breast and colorectal cancers
8. Inhibitory effect of (-)epigallocatechin gallate on carcinogenesis with N-ethyl-N-nitro-N-nitrosoguanidine in mouse duodenum
9. Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma
10. Consumption of black tea and cancer risk: A prospective cohort study
11. Two syngeneic cell lines from human breast tissue: The aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines
12. Studies of Japanese migrants. I. Mortality from cancer and other disease among Japanese in the United States
13. Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation
14. Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene
15. Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats
16. Effects of green tea catechins on the progression or late promotion stage of mammary gland carcinogenesis in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene
17. Green tea consumption and the risk of pancreatic and colorectal cancers
18. Inhibition of 12-O-tetradecanoylphorphol-13-acetate-caused tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea
19. Green tea and skin
20. Epidemiology of breast cancer
21. Suppression of inducible cyclo-oxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
22. Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate
23. p27Kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
24. Cancer chemoprevention by green tea components
25. Clinical development plan: Tea extracts, green tea polyphenols, epigallocatechin gallate
26. Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1,2-dimethylhydrazine
27. p27Kip1: A cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
28. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
29. Dimethylbenzanthracene-induced mammary tumorigenesis in ethanol-fed rats
30. Black tea and mammary gland carcinogenesis by 7,12-dimethylbenz[a]anthracene in rats fed control or high fat diets
31. CDK inhibitors: Positive and negative regulators of G1-phase progression
32. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
33. Aberrant nuclear factor-kB/Rel expression and the pathogenesis of breast cancer
34. Polyphenols as cancer chemotherapeutic agents
35. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas
36. Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats
37. Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines
38. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
39. Prognostic impact of cyclin-dependent kinase inhibitor p27Kip1 in node-positive breast cancer
40. Protection against polycyclic aromatic hydrocarbon-induced skin tumor initiation in mice by green tea polyphenols
41. Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols
42. Inhibition of N-nitroso-diethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea
43. Inhibitory effect of green tea on the growth of established skin papillomas in mice
44. Inhibition of N-nitroso-diethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis by green tea and black tea in A/J mice
45. Inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by green and black tea
46. Tea, or tea and milk, inhibit mammary gland and colon carcinogenesis in rats
47. Inhibition of NF-κB/Rel induces apoptosis of murine B cells
48. Increased p27Kip1 cyclin-dependent kinase inhibitor gene expression following anti-IgM treatment promotes apoptosis of WEHI 231 B cells
49. Polyphenols as inhibitors of carcinogenesis
50. Tea consumption and cancer incidence in a prospective cohort study of postmenopausal women
51. Migration patterns and breast cancer risk in Asian-American women