OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans

European Journal of Immunology

Volumn 45, Issue 4, 2015, Pages 1116-1128

  Burrows, Katie E ^a   Dumont, Celine ^a   Thompson, Clare L ^a   Catley, Matthew C ^a   Dixon, Kate L ^a   Marshall, Diane ^a  

^a UCB PHARMA   (Belgium)

Author keywords

Allergic asthma; House dust mite; Lung inflammation; Memory T cells; OX40

Indexed keywords

HOUSE DUST ALLERGEN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 5; METHACHOLINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OX40; OX40 LIGAND; UNCLASSIFIED DRUG; BLOCKING ANTIBODY; CD134 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; TNFRSF4 PROTEIN, MOUSE;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BODY PLETHYSMOGRAPHY; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DERMATOPHAGOIDES; EOSINOPHIL; HOUSE DUST ALLERGY; HUMAN; HUMAN CELL; IMMUNOPROPHYLAXIS; IN VITRO STUDY; INFLAMMATORY CELL; LONG TERM EXPOSURE; LUNG LAVAGE; LUNG PARENCHYMA; MEMORY T LYMPHOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SECONDARY IMMUNE RESPONSE; TH17 CELL; TH2 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTHMA; BAGG ALBINO MOUSE; BLOOD; BRONCHUS HYPERREACTIVITY; CYTOLOGY; DISEASE MODEL; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LUNG; LYMPHOCYTE COUNT; METABOLISM; PNEUMONIA; PYROGLYPHIDAE; SECRETION (PROCESS);

ANIMALS; ANTIBODIES, BLOCKING; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; EOSINOPHILS; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOLOGIC MEMORY; INTERLEUKIN-13; INTERLEUKIN-5; LUNG; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; NEUTROPHILS; PNEUMONIA; PYROGLYPHIDAE; RECEPTORS, OX40; TH17 CELLS; TH2 CELLS;

EID: 84926977970     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445163     Document Type: Article

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