-
2
-
-
45149100665
-
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
-
Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12):5446-5456.
-
(2008)
Blood
, vol.111
, Issue.12
, pp. 5446-5456
-
-
Hallek, M.1
Cheson, B.D.2
Catovsky, D.3
-
3
-
-
34249733155
-
Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia
-
Wierda WG, O'Brien S, Wang X, et al. Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia. Blood. 2007;109(11):4679-4685.
-
(2007)
Blood
, vol.109
, Issue.11
, pp. 4679-4685
-
-
Wierda, W.G.1
O'Brien, S.2
Wang, X.3
-
4
-
-
0034727833
-
Genomic aberrations and survival in chronic lymphocytic leukemia
-
Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343(26): 1910-1916.
-
(2000)
N Engl J Med
, vol.343
, Issue.26
, pp. 1910-1916
-
-
Dohner, H.1
Stilgenbauer, S.2
Benner, A.3
-
5
-
-
0347318114
-
ZAP-70 expression and prognosis in chronic lymphocytic leukaemia
-
Orchard JA, Ibbotson RE, Davis Z, et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet. 2004;363(9403): 105-111.
-
(2004)
Lancet
, vol.363
, Issue.9403
, pp. 105-111
-
-
Orchard, J.A.1
Ibbotson, R.E.2
Davis, Z.3
-
6
-
-
84894552888
-
Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
-
Goede V, Fischer K, Busch R, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med. 2014;370(12):1101-1110.
-
(2014)
N Engl J Med
, vol.370
, Issue.12
, pp. 1101-1110
-
-
Goede, V.1
Fischer, K.2
Busch, R.3
-
7
-
-
77957664665
-
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
-
Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376(9747):1164-1174.
-
(2010)
Lancet
, vol.376
, Issue.9747
, pp. 1164-1174
-
-
Hallek, M.1
Fischer, K.2
Fingerle-Rowson, G.3
-
8
-
-
77956266018
-
Chemoimmunotherapy of chronic lymphocytic leukemia
-
Tam CS, Keating MJ. Chemoimmunotherapy of chronic lymphocytic leukemia. Nat Rev Clin Oncol. 2010;7(9):521-532.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, Issue.9
, pp. 521-532
-
-
Tam, C.S.1
Keating, M.J.2
-
9
-
-
84901408966
-
Gene mutations and treatment outcome in chronic lymphocytic leukemia: Results from the CLL8 trial
-
Stilgenbauer S, Schnaiter A, Paschka P, et al. Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial. Blood. 2014;123(21):3247-3254.
-
(2014)
Blood
, vol.123
, Issue.21
, pp. 3247-3254
-
-
Stilgenbauer, S.1
Schnaiter, A.2
Paschka, P.3
-
10
-
-
84893245442
-
Waldenström macroglobulinemia: From biology to treatment
-
Sahin I, Leblebjian H, Treon SP, Ghobrial IM. Waldenström macroglobulinemia: from biology to treatment. Expert Rev Hematol. 2014; 7(1):157-168.
-
(2014)
Expert Rev Hematol
, vol.7
, Issue.1
, pp. 157-168
-
-
Sahin, I.1
Leblebjian, H.2
Treon, S.P.3
Ghobrial, I.M.4
-
11
-
-
84887613770
-
B-cell receptor signaling as a driver of lymphoma development and evolution
-
Niemann CU, Wiestner A. B-cell receptor signaling as a driver of lymphoma development and evolution. Semin Cancer Biol. 2013;23(6): 410-421.
-
(2013)
Semin Cancer Biol
, vol.23
, Issue.6
, pp. 410-421
-
-
Niemann, C.U.1
Wiestner, A.2
-
12
-
-
84875185728
-
Targeting pathological B cell receptor signalling in lymphoid malignancies
-
Young RM, Staudt LM. Targeting pathological B cell receptor signalling in lymphoid malignancies. Nat Rev Drug Discov. 2013;12(3): 229-243.
-
(2013)
Nat Rev Drug Discov
, vol.12
, Issue.3
, pp. 229-243
-
-
Young, R.M.1
Staudt, L.M.2
-
13
-
-
0032532668
-
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
-
Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest. 1998;102(8):1515-1525.
-
(1998)
J Clin Invest
, vol.102
, Issue.8
, pp. 1515-1525
-
-
Fais, F.1
Ghiotto, F.2
Hashimoto, S.3
-
14
-
-
7244232709
-
Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia
-
Tobin G, Thunberg U, Karlsson K, et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood. 2004;104(9):2879-2885.
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2879-2885
-
-
Tobin, G.1
Thunberg, U.2
Karlsson, K.3
-
15
-
-
47249152803
-
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: A molecular signature of anergy
-
Muzio M, Apollonio B, Scielzo C, et al. Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood. 2008;112(1):188-195.
-
(2008)
Blood
, vol.112
, Issue.1
, pp. 188-195
-
-
Muzio, M.1
Apollonio, B.2
Scielzo, C.3
-
16
-
-
84861033763
-
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: A molecular classification with implications for targeted therapies
-
Agathangelidis A, Darzentas N, Hadzidimitriou A, et al. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood. 2012;119(19):4467-4475.
-
(2012)
Blood
, vol.119
, Issue.19
, pp. 4467-4475
-
-
Agathangelidis, A.1
Darzentas, N.2
Hadzidimitriou, A.3
-
17
-
-
4344704897
-
Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
-
Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med. 2004;200(4):519-525.
-
(2004)
J Exp Med
, vol.200
, Issue.4
, pp. 519-525
-
-
Messmer, B.T.1
Albesiano, E.2
Efremov, D.G.3
-
18
-
-
84888440844
-
B cell receptor signaling in chronic lymphocytic leukemia
-
Burger JA, Chiorazzi N. B cell receptor signaling in chronic lymphocytic leukemia. Trends Immunol. 2013;34(12):592-601.
-
(2013)
Trends Immunol
, vol.34
, Issue.12
, pp. 592-601
-
-
Burger, J.A.1
Chiorazzi, N.2
-
19
-
-
84866152172
-
Chronic lymphocytic leukaemia is driven by antigen-independent cellautonomous signalling
-
Duhren-von Minden M, Ubelhart R, Schneider D, et al. Chronic lymphocytic leukaemia is driven by antigen-independent cellautonomous signalling. Nature. 2012;489(7415):309-312.
-
(2012)
Nature
, vol.489
, Issue.7415
, pp. 309-312
-
-
Duhren-von Minden, M.1
Ubelhart, R.2
Schneider, D.3
-
20
-
-
78751549662
-
The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
-
Herishanu Y, Perez-Galan P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117(2):563-574.
-
(2011)
Blood
, vol.117
, Issue.2
, pp. 563-574
-
-
Herishanu, Y.1
Perez-Galan, P.2
Liu, D.3
-
21
-
-
34248354409
-
Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
-
Mockridge CI, Potter KN, Wheatley I, Neville LA, Packham G, Stevenson FK. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood. 2007;109(10):4424-4431.
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4424-4431
-
-
Mockridge, C.I.1
Potter, K.N.2
Wheatley, I.3
Neville, L.A.4
Packham, G.5
Stevenson, F.K.6
-
22
-
-
38349107623
-
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
-
Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood. 2008;111(2):846-855.
-
(2008)
Blood
, vol.111
, Issue.2
, pp. 846-855
-
-
Longo, P.G.1
Laurenti, L.2
Gobessi, S.3
Sica, S.4
Leone, G.5
Efremov, D.G.6
-
23
-
-
64849113027
-
Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells
-
Gobessi S, Laurenti L, Longo PG, et al. Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells. Leukemia. 2009;23(4):686-697.
-
(2009)
Leukemia
, vol.23
, Issue.4
, pp. 686-697
-
-
Gobessi, S.1
Laurenti, L.2
Longo, P.G.3
-
24
-
-
70349237504
-
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
-
Quiroga MP, Balakrishnan K, Kurtova AV, et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood. 2009;114(5):1029-1037.
-
(2009)
Blood
, vol.114
, Issue.5
, pp. 1029-1037
-
-
Quiroga, M.P.1
Balakrishnan, K.2
Kurtova, A.V.3
-
25
-
-
0035892106
-
Survival of leukemic B cells promoted by engagement of the antigen receptor
-
Bernal A, Pastore RD, Asgary Z, et al. Survival of leukemic B cells promoted by engagement of the antigen receptor. Blood. 2001;98(10): 3050-3057.
-
(2001)
Blood
, vol.98
, Issue.10
, pp. 3050-3057
-
-
Bernal, A.1
Pastore, R.D.2
Asgary, Z.3
-
26
-
-
84857497433
-
Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia
-
Paterson A, Mockridge CI, Adams JE, et al. Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia. Blood. 2012;119(7):1726-1736.
-
(2012)
Blood
, vol.119
, Issue.7
, pp. 1726-1736
-
-
Paterson, A.1
Mockridge, C.I.2
Adams, J.E.3
-
27
-
-
84864075343
-
The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia
-
Le Roy C, Deglesne PA, Chevallier N, et al. The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia. Blood. 2012;120(2):356-365.
-
(2012)
Blood
, vol.120
, Issue.2
, pp. 356-365
-
-
Le Roy, C.1
Deglesne, P.A.2
Chevallier, N.3
-
28
-
-
33847412872
-
ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
-
Gobessi S, Laurenti L, Longo PG, Sica S, Leone G, Efremov DG. ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells. Blood. 2007;109(5):2032-2039.
-
(2007)
Blood
, vol.109
, Issue.5
, pp. 2032-2039
-
-
Gobessi, S.1
Laurenti, L.2
Longo, P.G.3
Sica, S.4
Leone, G.5
Efremov, D.G.6
-
29
-
-
80054853285
-
B-cell receptor signaling in chronic lymphocytic leukemia
-
Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G. B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011; 118(16):4313-4320.
-
(2011)
Blood
, vol.118
, Issue.16
, pp. 4313-4320
-
-
Stevenson, F.K.1
Krysov, S.2
Davies, A.J.3
Steele, A.J.4
Packham, G.5
-
30
-
-
84859398461
-
Nurture versus nature: The microenvironment in chronic lymphocytic leukemia
-
Burger JA. Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2011;2011:96-103.
-
(2011)
Hematology Am Soc Hematol Educ Program
, vol.2011
, pp. 96-103
-
-
Burger, J.A.1
-
31
-
-
0034667624
-
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
-
Burger JA, Tsukada N, Burger M, Zvaifler NJ, Dell'Aquila M, Kipps TJ. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood. 2000;96(8):2655-2663.
-
(2000)
Blood
, vol.96
, Issue.8
, pp. 2655-2663
-
-
Burger, J.A.1
Tsukada, N.2
Burger, M.3
Zvaifler, N.J.4
Dell'Aquila, M.5
Kipps, T.J.6
-
32
-
-
66749133418
-
Chronic lymphocytic leukemia microenvironment: Shifting the balance from apoptosis to proliferation
-
Deaglio S, Malavasi F. Chronic lymphocytic leukemia microenvironment: shifting the balance from apoptosis to proliferation. Haematologica. 2009;94(6):752-756.
-
(2009)
Haematologica
, vol.94
, Issue.6
, pp. 752-756
-
-
Deaglio, S.1
Malavasi, F.2
-
33
-
-
79956275845
-
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
-
Bagnara D, Kaufman MS, Calissano C, et al. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood. 2011;117(20):5463-5472.
-
(2011)
Blood
, vol.117
, Issue.20
, pp. 5463-5472
-
-
Bagnara, D.1
Kaufman, M.S.2
Calissano, C.3
-
34
-
-
58549120954
-
Expression and function of toll like receptors in chronic lymphocytic leukaemia cells
-
Muzio M, Scielzo C, Bertilaccio MT, Frenquelli M, Ghia P, Caligaris-Cappio F. Expression and function of toll like receptors in chronic lymphocytic leukaemia cells. Br J Haematol. 2009;144(4):507-516.
-
(2009)
Br J Haematol
, vol.144
, Issue.4
, pp. 507-516
-
-
Muzio, M.1
Scielzo, C.2
Bertilaccio, M.T.3
Frenquelli, M.4
Ghia, P.5
Caligaris-Cappio, F.6
-
35
-
-
50949133383
-
The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells
-
Luqman M, Klabunde S, Lin K, et al. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood. 2008;112(3):711-720.
-
(2008)
Blood
, vol.112
, Issue.3
, pp. 711-720
-
-
Luqman, M.1
Klabunde, S.2
Lin, K.3
-
36
-
-
33846258010
-
BAFF and April support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway
-
Endo T, Nishio M, Enzler T, et al. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007;109(2):703-710.
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 703-710
-
-
Endo, T.1
Nishio, M.2
Enzler, T.3
-
37
-
-
80052074643
-
Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1
-
Herishanu Y, Gibellini F, Njuguna N, et al. Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1. Leuk Lymphoma. 2011;52(9):1758-1769.
-
(2011)
Leuk Lymphoma
, vol.52
, Issue.9
, pp. 1758-1769
-
-
Herishanu, Y.1
Gibellini, F.2
Njuguna, N.3
-
38
-
-
77952886100
-
Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia
-
Buchner M, Baer C, Prinz G, et al. Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia. Blood. 2010;115(22):4497-4506.
-
(2010)
Blood
, vol.115
, Issue.22
, pp. 4497-4506
-
-
Buchner, M.1
Baer, C.2
Prinz, G.3
-
39
-
-
84870734255
-
Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia
-
Wiestner A. Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia. Blood. 2012;120(24):4684-4691.
-
(2012)
Blood
, vol.120
, Issue.24
, pp. 4684-4691
-
-
Wiestner, A.1
-
40
-
-
84899742457
-
CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia
-
Bulian P, Shanafelt TD, Fegan C, et al. CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia. J Clin Oncol. 2014;32(9):897-904.
-
(2014)
J Clin Oncol
, vol.32
, Issue.9
, pp. 897-904
-
-
Bulian, P.1
Shanafelt, T.D.2
Fegan, C.3
-
41
-
-
79551629508
-
CCL3 (MIP-1alpha) plasma levels and the risk for disease progression in chronic lymphocytic leukemia
-
Sivina M, Hartmann E, Kipps TJ, et al. CCL3 (MIP-1alpha) plasma levels and the risk for disease progression in chronic lymphocytic leukemia. Blood. 2011;117(5):1662-1669.
-
(2011)
Blood
, vol.117
, Issue.5
, pp. 1662-1669
-
-
Sivina, M.1
Hartmann, E.2
Kipps, T.J.3
-
42
-
-
84870496453
-
MYD88 L265P somatic mutation in IgM MGUS
-
author reply 2256-2257
-
Landgren O, Staudt L. MYD88 L265P somatic mutation in IgM MGUS. N Engl J Med. 2012;367(23):2255-2256; author reply 2256-2257.
-
(2012)
N Engl J Med
, vol.367
, Issue.23
, pp. 2255-2256
-
-
Landgren, O.1
Staudt, L.2
-
43
-
-
84865475885
-
MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia
-
Treon SP, Xu L, Yang G, et al. MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia. N Engl J Med. 2012;367(9):826-833.
-
(2012)
N Engl J Med
, vol.367
, Issue.9
, pp. 826-833
-
-
Treon, S.P.1
Xu, L.2
Yang, G.3
-
44
-
-
84883876958
-
A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenstrom macroglobulinemia
-
Yang G, Zhou Y, Liu X, et al. A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenstrom macroglobulinemia. Blood. 2013; 122(7):1222-1232.
-
(2013)
Blood
, vol.122
, Issue.7
, pp. 1222-1232
-
-
Yang, G.1
Zhou, Y.2
Liu, X.3
-
45
-
-
84895785316
-
BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activity
-
Cheng S, Ma J, Guo A, et al. BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activity. Leukemia. 2014;28(3):649-657.
-
(2014)
Leukemia
, vol.28
, Issue.3
, pp. 649-657
-
-
Cheng, S.1
Ma, J.2
Guo, A.3
-
46
-
-
84901439281
-
Ibrutinib inhibits B-cell receptor and NF-kappaB signaling and reduces tumor proliferation in tissue-resident cells of patients with chronic lymphocytic leukemia
-
Herman SE, Mustafa RZ, Gyamfi JA, et al. Ibrutinib inhibits B-cell receptor and NF-kappaB signaling and reduces tumor proliferation in tissue-resident cells of patients with chronic lymphocytic leukemia. Blood. 2014;123(21):3286-3295.
-
(2014)
Blood
, vol.123
, Issue.21
, pp. 3286-3295
-
-
Herman, S.E.1
Mustafa, R.Z.2
Gyamfi, J.A.3
-
47
-
-
84897069190
-
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
-
Woyach JA, Smucker K, Smith LL, et al. Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy. Blood. 2014;123(12):1810-1817.
-
(2014)
Blood
, vol.123
, Issue.12
, pp. 1810-1817
-
-
Woyach, J.A.1
Smucker, K.2
Smith, L.L.3
-
48
-
-
80053345977
-
The phosphoinositide 3-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
-
Hoellenriegel J, Meadows SA, Sivina M, et al. The phosphoinositide 3-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood. 2011;118(13):3603-3612.
-
(2011)
Blood
, vol.118
, Issue.13
, pp. 3603-3612
-
-
Hoellenriegel, J.1
Meadows, S.A.2
Sivina, M.3
-
49
-
-
78751553221
-
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
-
Lannutti BJ, Meadows SA, Herman SE, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2011;117(2):591-594.
-
(2011)
Blood
, vol.117
, Issue.2
, pp. 591-594
-
-
Lannutti, B.J.1
Meadows, S.A.2
Herman, S.E.3
-
50
-
-
77957201023
-
Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116(12):2078-2088.
-
(2010)
Blood
, vol.116
, Issue.12
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
51
-
-
84888216911
-
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
-
Dubovsky JA, Beckwith KA, Natarajan G, et al. Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood. 2013;122(15):2539-2549.
-
(2013)
Blood
, vol.122
, Issue.15
, pp. 2539-2549
-
-
Dubovsky, J.A.1
Beckwith, K.A.2
Natarajan, G.3
-
52
-
-
84901712964
-
Idelalisib, an inhibitor of phosphatidylinositol 3 kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia
-
Brown JR, Byrd JC, Coutre SE, et al. Idelalisib, an inhibitor of phosphatidylinositol 3 kinase p110delta, for relapsed/refractory chronic lymphocytic leukemia. Blood. 2014;123(22):3390-3397.
-
(2014)
Blood
, vol.123
, Issue.22
, pp. 3390-3397
-
-
Brown, J.R.1
Byrd, J.C.2
Coutre, S.E.3
-
53
-
-
84879748062
-
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
-
Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013;369(1):32-42.
-
(2013)
N Engl J Med
, vol.369
, Issue.1
, pp. 32-42
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
-
54
-
-
84931595414
-
Ibrutinib-induced lymphocytosis in patients with chronic lymphocytic leukemia: Correlative analyses from a phase II study
-
In press
-
Herman SEM, Carsten NU, Farooqui M, et al. Ibrutinib-induced lymphocytosis in patients with chronic lymphocytic leukemia: correlative analyses from a phase II study. Leukemia. In press.
-
Leukemia
-
-
Herman, S.E.M.1
Carsten, N.U.2
Farooqui, M.3
-
55
-
-
84865082196
-
Novel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemia
-
Cheson BD, Byrd JC, Rai KR, et al. Novel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemia. J Clin Oncol. 2012;30(23):2820-2822.
-
(2012)
J Clin Oncol
, vol.30
, Issue.23
, pp. 2820-2822
-
-
Cheson, B.D.1
Byrd, J.C.2
Rai, K.R.3
-
56
-
-
84901703641
-
Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-delta, as therapy for previously treated indolent non-Hodgkin lymphoma
-
Flinn IW, Kahl BS, Leonard JP, et al. Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-delta, as therapy for previously treated indolent non-Hodgkin lymphoma. Blood. 2014;123(22):3406-3413.
-
(2014)
Blood
, vol.123
, Issue.22
, pp. 3406-3413
-
-
Flinn, I.W.1
Kahl, B.S.2
Leonard, J.P.3
-
57
-
-
84881225049
-
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma
-
Wang ML, Rule S, Martin P, et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med. 2013; 369(6):507-516.
-
(2013)
N Engl J Med
, vol.369
, Issue.6
, pp. 507-516
-
-
Wang, M.L.1
Rule, S.2
Martin, P.3
-
58
-
-
84858636448
-
The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
-
de Rooij MF, Kuil A, Geest CR, et al. The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood. 2012;119(11):2590-2594.
-
(2012)
Blood
, vol.119
, Issue.11
, pp. 2590-2594
-
-
De Rooij, M.F.1
Kuil, A.2
Geest, C.R.3
-
59
-
-
84863011553
-
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
-
Ponader S, Chen SS, Buggy JJ, et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood. 2012;119(5):1182-1189.
-
(2012)
Blood
, vol.119
, Issue.5
, pp. 1182-1189
-
-
Ponader, S.1
Chen, S.S.2
Buggy, J.J.3
-
60
-
-
84937550122
-
Ibrutinib inhibits B-cell adhesion and causes an efflux of chronic lymphocytic leukemia cells from the tissue microenvironment into the blood leading to a transient treatment-induced lymphocytosis [abstract]
-
Mustafa R, Herman SEM, Jones J, Gyamfi J, Farooqui M, Wiestner A. Ibrutinib inhibits B-cell adhesion and causes an efflux of chronic lymphocytic leukemia cells from the tissue microenvironment into the blood leading to a transient treatment-induced lymphocytosis [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):674.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 674
-
-
Mustafa, R.1
Herman, S.E.M.2
Jones, J.3
Gyamfi, J.4
Farooqui, M.5
Wiestner, A.6
-
61
-
-
84903650423
-
Kinetics of chronic lymphocytic leukemia (CLL) cells in tissues and blood during therapy with the BTK inhibitor ibrutinib
-
Wodarz D, Garg N, Komarova NL, et al. Kinetics of chronic lymphocytic leukemia (CLL) cells in tissues and blood during therapy with the BTK inhibitor ibrutinib. Blood. 2014;123(26):4132-4135.
-
(2014)
Blood
, vol.123
, Issue.26
, pp. 4132-4135
-
-
Wodarz, D.1
Garg, N.2
Komarova, N.L.3
-
62
-
-
84904252369
-
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
-
Byrd JC, Brown JR, O'Brien S, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med. 2014; 371(3):213-223.
-
(2014)
N Engl J Med
, vol.371
, Issue.3
, pp. 213-223
-
-
Byrd, J.C.1
Brown, J.R.2
O'Brien, S.3
-
63
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
Furman RR, Sharman JP, Coutre SE, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med. 2014;370(11): 997-1007.
-
(2014)
N Engl J Med
, vol.370
, Issue.11
, pp. 997-1007
-
-
Furman, R.R.1
Sharman, J.P.2
Coutre, S.E.3
-
64
-
-
84891373281
-
Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: An open-label, multicentre, phase 1b/2 trial
-
O'Brien S, Furman RR, Coutre SE, et al. Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial. Lancet Oncol. 2014;15(1):48-58.
-
(2014)
Lancet Oncol
, vol.15
, Issue.1
, pp. 48-58
-
-
O'Brien, S.1
Furman, R.R.2
Coutre, S.E.3
-
66
-
-
77955625479
-
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
-
Honigberg LA, Smith AM, Sirisawad M, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010;107(29):13075-13080.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.29
, pp. 13075-13080
-
-
Honigberg, L.A.1
Smith, A.M.2
Sirisawad, M.3
-
67
-
-
38049084406
-
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
-
Pan Z, Scheerens H, Li SJ, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. Chem Med Chem. 2007;2(1):58-61.
-
(2007)
Chem Med Chem
, vol.2
, Issue.1
, pp. 58-61
-
-
Pan, Z.1
Scheerens, H.2
Li, S.J.3
-
68
-
-
84860433198
-
Bruton tyrosine kinase (BTK) and its role in B-cell malignancy
-
Buggy JJ, Elias L. Bruton tyrosine kinase (BTK) and its role in B-cell malignancy. Int Rev Immunol. 2012;31(2):119-132.
-
(2012)
Int Rev Immunol
, vol.31
, Issue.2
, pp. 119-132
-
-
Buggy, J.J.1
Elias, L.2
-
69
-
-
79960257240
-
Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man
-
Hendriks RW, Bredius RG, Pike-Overzet K, Staal FJ. Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man. Expert Opin Ther Targets. 2011;15(8):1003-1021.
-
(2011)
Expert Opin Ther Targets
, vol.15
, Issue.8
, pp. 1003-1021
-
-
Hendriks, R.W.1
Bredius, R.G.2
Pike-Overzet, K.3
Staal, F.J.4
-
70
-
-
84885655403
-
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765)
-
Burger JA, Buggy JJ. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765). Leuk Lymphoma. 2013;54(11):2385-2391.
-
(2013)
Leuk Lymphoma
, vol.54
, Issue.11
, pp. 2385-2391
-
-
Burger, J.A.1
Buggy, J.J.2
-
71
-
-
84871806385
-
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
-
Advani RH, Buggy JJ, Sharman JP, et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol. 2013; 31(1):88-94.
-
(2013)
J Clin Oncol
, vol.31
, Issue.1
, pp. 88-94
-
-
Advani, R.H.1
Buggy, J.J.2
Sharman, J.P.3
-
72
-
-
84896733911
-
Ibrutinib (PCI 32765) rapidly improves platelet counts in chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL) patients and has minimal effects on platelet aggregation [abstract]
-
Farooqui M, Lozier JN, Valdez J, et al. Ibrutinib (PCI 32765) rapidly improves platelet counts in chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL) patients and has minimal effects on platelet aggregation [abstract]. Blood (ASH Annual Meeting Abstracts). 2012;120(21):1789.
-
(2012)
Blood (ASH Annual Meeting Abstracts)
, vol.120
, Issue.21
, pp. 1789
-
-
Farooqui, M.1
Lozier, J.N.2
Valdez, J.3
-
73
-
-
84902304587
-
In patients with chronic lymphocytic leukemia (CLL) ibrutinib effectively reduces clonal IgM paraproteins and serum free light chains while increasing normal IgM, IgA serum levels, suggesting a nascent recovery of humoral immunity [abstract]
-
Aue G, Farooqui M, Jones J, et al. In patients with chronic lymphocytic leukemia (CLL) ibrutinib effectively reduces clonal IgM paraproteins and serum free light chains while increasing normal IgM, IgA serum levels, suggesting a nascent recovery of humoral immunity [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):4182.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 4182
-
-
Aue, G.1
Farooqui, M.2
Jones, J.3
-
74
-
-
84896464977
-
Single agent ibrutinib (PCI-32765) achieves equally good and durable responses in chronic lymphocytic leukemia (CLL) patients with and without deletion 17p [abstract]
-
Farooqui M, Aue G, Valdez J, et al. Single agent ibrutinib (PCI-32765) achieves equally good and durable responses in chronic lymphocytic leukemia (CLL) patients with and without deletion 17p [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):673.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 673
-
-
Farooqui, M.1
Aue, G.2
Valdez, J.3
-
75
-
-
84896484537
-
Ibrutinib in combination with rituximab (iR) is well tolerated and induces a high rate of durable remissions in patients with high-risk chronic lymphocytic leukemia (CLL): New, updated results of a phase II trial in 40 patients [abstract]
-
Burger JA, Keating MJ, Wierda WG, et al. Ibrutinib in combination with rituximab (iR) is well tolerated and induces a high rate of durable remissions in patients with high-risk chronic lymphocytic leukemia (CLL): new, updated results of a phase II trial in 40 patients [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):675.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 675
-
-
Burger, J.A.1
Keating, M.J.2
Wierda, W.G.3
-
76
-
-
84876001198
-
The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib combined with bendamustine and rituximab is active and tolerable in patients with relapsed/refractory CLL, interim results of a phase IB/II study [abstract]
-
Brown JR, Barrientos J, Flinn I, Barr P, Burger J, Navarro T. The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib combined with bendamustine and rituximab is active and tolerable in patients with relapsed/refractory CLL, interim results of a phase IB/II study [abstract]. Haematologica. 2012;97(S1):218.
-
(2012)
Haematologica
, vol.97
, Issue.S1
, pp. 218
-
-
Brown, J.R.1
Barrientos, J.2
Flinn, I.3
Barr, P.4
Burger, J.5
Navarro, T.6
-
77
-
-
79953112441
-
Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation
-
Baracho GV, Miletic AV, Omori SA, Cato MH, Rickert RC. Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation. Curr Opin Immunol. 2011;23(2):178-183.
-
(2011)
Curr Opin Immunol
, vol.23
, Issue.2
, pp. 178-183
-
-
Baracho, G.V.1
Miletic, A.V.2
Omori, S.A.3
Cato, M.H.4
Rickert, R.C.5
-
78
-
-
84857875585
-
PI3K signalling in B- and T-lymphocytes: New developments and therapeutic advances
-
So L, Fruman DA. PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. Biochem J. 2012;442(3):465-481.
-
(2012)
Biochem J
, vol.442
, Issue.3
, pp. 465-481
-
-
So, L.1
Fruman, D.A.2
-
79
-
-
84877930029
-
P110alpha-mediated constitutive PI3K signaling limits the efficacy of p110delta-selective inhibition in mantle cell lymphoma, particularly with multiple relapse
-
Iyengar S, Clear A, Bodor C, et al. P110alpha-mediated constitutive PI3K signaling limits the efficacy of p110delta-selective inhibition in mantle cell lymphoma, particularly with multiple relapse. Blood. 2013;121(12):2274-2284.
-
(2013)
Blood
, vol.121
, Issue.12
, pp. 2274-2284
-
-
Iyengar, S.1
Clear, A.2
Bodor, C.3
-
80
-
-
84901724050
-
Results of a phase i study of idelalisib, a PI3Kdelta inhibitor, in patients with relapsed or refractory mantle cell lymphoma (MCL)
-
Kahl BS, Spurgeon SE, Furman RR, et al. Results of a phase I study of idelalisib, a PI3Kdelta inhibitor, in patients with relapsed or refractory mantle cell lymphoma (MCL). Blood. 2014;123(22):3398-3405.
-
(2014)
Blood
, vol.123
, Issue.22
, pp. 3398-3405
-
-
Kahl, B.S.1
Spurgeon, S.E.2
Furman, R.R.3
-
81
-
-
0036534380
-
Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: Implications for clinical trials in this patient population
-
Perkins JG, Flynn JM, Howard RS, Byrd JC. Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: implications for clinical trials in this patient population. Cancer. 2002;94(7):2033-2039.
-
(2002)
Cancer
, vol.94
, Issue.7
, pp. 2033-2039
-
-
Perkins, J.G.1
Flynn, J.M.2
Howard, R.S.3
Byrd, J.C.4
-
82
-
-
84896693794
-
PI3Kdelta inhibition by idelalisib in patients with relapsed indolent lymphoma
-
Gopal AK, Kahl BS, de Vos S, et al. PI3Kdelta inhibition by idelalisib in patients with relapsed indolent lymphoma. N Engl J Med. 2014; 370(11):1008-1018.
-
(2014)
N Engl J Med
, vol.370
, Issue.11
, pp. 1008-1018
-
-
Gopal, A.K.1
Kahl, B.S.2
De Vos, S.3
-
83
-
-
77951002653
-
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
-
Friedberg JW, Sharman J, Sweetenham J, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood. 2010;115(13): 2578-2585.
-
(2010)
Blood
, vol.115
, Issue.13
, pp. 2578-2585
-
-
Friedberg, J.W.1
Sharman, J.2
Sweetenham, J.3
-
84
-
-
84897055483
-
Targeting Bruton's tyrosine kinase in B cell malignancies
-
Hendriks RW, Yuvaraj S, Kil LP. Targeting Bruton's tyrosine kinase in B cell malignancies. Nat Rev Cancer. 2014;14(4):219-232.
-
(2014)
Nat Rev Cancer
, vol.14
, Issue.4
, pp. 219-232
-
-
Hendriks, R.W.1
Yuvaraj, S.2
Kil, L.P.3
-
85
-
-
77951621262
-
The emerging mechanisms of isoform-specific PI3K signalling
-
Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B. The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol. 2010;11(5):329-341.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, Issue.5
, pp. 329-341
-
-
Vanhaesebroeck, B.1
Guillermet-Guibert, J.2
Graupera, M.3
Bilanges, B.4
-
86
-
-
14944352799
-
ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
-
Chen L, Apgar J, Huynh L, et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood. 2005;105(5):2036-2041.
-
(2005)
Blood
, vol.105
, Issue.5
, pp. 2036-2041
-
-
Chen, L.1
Apgar, J.2
Huynh, L.3
-
87
-
-
77952887713
-
The SYK tyrosine kinase: A crucial player in diverse biological functions
-
Mocsai A, Ruland J, Tybulewicz VL. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol. 2010;10(6):387-402.
-
(2010)
Nat Rev Immunol
, vol.10
, Issue.6
, pp. 387-402
-
-
Mocsai, A.1
Ruland, J.2
Tybulewicz, V.L.3
-
88
-
-
84880907601
-
Fostamatinib inhibits BCR signaling, and reduces tumor cell activation and proliferation in patients with relapsed refractory chronic lymphocytic leukemia [abstract]
-
Herman SEM, Barr PM, McAuley EM, Liu D, Friedberg JW, Wiestner A. Fostamatinib inhibits BCR signaling, and reduces tumor cell activation and proliferation in patients with relapsed refractory chronic lymphocytic leukemia [abstract]. Blood (ASH Annual Meeting Abstracts). 2012;120(21):2882-.
-
(2012)
Blood (ASH Annual Meeting Abstracts)
, vol.120
, Issue.21
, pp. 2882
-
-
Herman, S.E.M.1
Barr, P.M.2
McAuley, E.M.3
Liu, D.4
Friedberg, J.W.5
Wiestner, A.6
-
89
-
-
84897112247
-
Spleen tyrosine kinase inhibitors for rheumatoid arthritis: Where are we now?
-
Scott IC, Scott DL. Spleen tyrosine kinase inhibitors for rheumatoid arthritis: where are we now? Drugs. 2014;74(4):415-422.
-
(2014)
Drugs
, vol.74
, Issue.4
, pp. 415-422
-
-
Scott, I.C.1
Scott, D.L.2
-
90
-
-
84897451152
-
A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor
-
Burke RT, Meadows S, Loriaux MM, et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget. 2014;5(4):908-915.
-
(2014)
Oncotarget
, vol.5
, Issue.4
, pp. 908-915
-
-
Burke, R.T.1
Meadows, S.2
Loriaux, M.M.3
-
91
-
-
84896467545
-
Phase 2 trial of GS-9973, a selective Syk inhibitor, in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) [abstract]
-
Sharman JP, Klein L, Boxer M, et al. Phase 2 trial of GS-9973, a selective Syk inhibitor, in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):1634.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 1634
-
-
Sharman, J.P.1
Klein, L.2
Boxer, M.3
-
92
-
-
84865176364
-
The B-cell receptor signaling pathway as a therapeutic target in CLL
-
Woyach JA, Johnson AJ, Byrd JC. The B-cell receptor signaling pathway as a therapeutic target in CLL. Blood. 2012;120(6):1175-1184.
-
(2012)
Blood
, vol.120
, Issue.6
, pp. 1175-1184
-
-
Woyach, J.A.1
Johnson, A.J.2
Byrd, J.C.3
-
93
-
-
84892840003
-
How the microenvironment wires the natural history of chronic lymphocytic leukemia
-
Caligaris-Cappio F, Bertilaccio MT, Scielzo C. How the microenvironment wires the natural history of chronic lymphocytic leukemia. Semin Cancer Biol. 2014;24:43-48.
-
(2014)
Semin Cancer Biol
, vol.24
, pp. 43-48
-
-
Caligaris-Cappio, F.1
Bertilaccio, M.T.2
Scielzo, C.3
-
94
-
-
84890438137
-
Modeling tumor-host interactions of chronic lymphocytic leukemia in xenografted mice to study tumor biology and evaluate targeted therapy
-
Herman SE, Sun X, McAuley EM, et al. Modeling tumor-host interactions of chronic lymphocytic leukemia in xenografted mice to study tumor biology and evaluate targeted therapy. Leukemia. 2013; 27(8):1769-1773.
-
(2013)
Leukemia
, vol.27
, Issue.8
, pp. 1769-1773
-
-
Herman, S.E.1
Sun, X.2
McAuley, E.M.3
-
95
-
-
84900443158
-
Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia
-
Treon SP, Cao Y, Xu L, Yang G, Liu X, Hunter ZR. Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia. Blood. 2014; 123(18):2791-2796.
-
(2014)
Blood
, vol.123
, Issue.18
, pp. 2791-2796
-
-
Treon, S.P.1
Cao, Y.2
Xu, L.3
Yang, G.4
Liu, X.5
Hunter, Z.R.6
-
96
-
-
84897563710
-
Ibrutinib antagonizes rituximabdependent NK cell-mediated cytotoxicity
-
Kohrt HE, Sagiv-Barfi I, Rafiq S, et al. Ibrutinib antagonizes rituximabdependent NK cell-mediated cytotoxicity. Blood. 2014;123(12):1957-1960.
-
(2014)
Blood
, vol.123
, Issue.12
, pp. 1957-1960
-
-
Kohrt, H.E.1
Sagiv-Barfi, I.2
Rafiq, S.3
-
97
-
-
84883184095
-
Bruton's tyrosine kinase mediated signaling enhances leukemogenesis in a mouse model for chronic lymphocytic leukemia
-
Kil LP, de Bruijn MJ, van Hulst JA, Langerak AW, Yuvaraj S, Hendriks RW. Bruton's tyrosine kinase mediated signaling enhances leukemogenesis in a mouse model for chronic lymphocytic leukemia. Am J Blood Res. 2013;3(1):71-83.
-
(2013)
Am J Blood Res
, vol.3
, Issue.1
, pp. 71-83
-
-
Kil, L.P.1
De Bruijn, M.J.2
Van Hulst, J.A.3
Langerak, A.W.4
Yuvaraj, S.5
Hendriks, R.W.6
-
98
-
-
84897901864
-
Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)
-
Woyach JA, Bojnik E, Ruppert AS, et al. Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL). Blood. 2014;123(8):1207-1213.
-
(2014)
Blood
, vol.123
, Issue.8
, pp. 1207-1213
-
-
Woyach, J.A.1
Bojnik, E.2
Ruppert, A.S.3
-
99
-
-
84902183019
-
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
-
Woyach JA, Furman RR, Liu TM, et al. Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. N Engl J Med. 2014; 370(24):2286-2294.
-
(2014)
N Engl J Med
, vol.370
, Issue.24
, pp. 2286-2294
-
-
Woyach, J.A.1
Furman, R.R.2
Liu, T.M.3
-
100
-
-
84902137363
-
Ibrutinib resistance in chronic lymphocytic leukemia
-
Furman RR, Cheng S, Lu P, et al. Ibrutinib resistance in chronic lymphocytic leukemia. N Engl J Med. 2014;370(24):2352-2354.
-
(2014)
N Engl J Med
, vol.370
, Issue.24
, pp. 2352-2354
-
-
Furman, R.R.1
Cheng, S.2
Lu, P.3
-
101
-
-
84902343396
-
Breaking good: The inexorable rise of BTK inhibitors in the treatment of chronic lymphocytic leukaemia
-
Hutchinson CV, Dyer MJ. Breaking good: the inexorable rise of BTK inhibitors in the treatment of chronic lymphocytic leukaemia. Br J Haematol. 2014;166(1):12-22
-
(2014)
Br J Haematol
, vol.166
, Issue.1
, pp. 12-22
-
-
Hutchinson, C.V.1
Dyer, M.J.2
-
103
-
-
84896487631
-
Phase 1 study of single agent CC-292, a highly selective Bruton's tyrosine kinase (BTK) inhibitor, in relapsed/refractory chronic lymphocytic leukemia (CLL) [abstract]
-
Brown JR, Harb WA, Hill BT, et al. Phase 1 study of single agent CC-292, a highly selective Bruton's tyrosine kinase (BTK) inhibitor, in relapsed/refractory chronic lymphocytic leukemia (CLL) [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):1630.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 1630
-
-
Brown, J.R.1
Harb, W.A.2
Hill, B.T.3
-
104
-
-
84907044156
-
A phase i study of the oral Btk inhibitor ONO-4059 in patients with relapsed/refractory and high risk chronic lymphocytic leukaemia (CLL) [abstract]
-
Salles GA, Karlin L, Rule S, et al. A phase I study of the oral Btk inhibitor ONO-4059 in patients with relapsed/refractory and high risk chronic lymphocytic leukaemia (CLL) [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):676.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 676
-
-
Salles, G.A.1
Karlin, L.2
Rule, S.3
-
105
-
-
84899490552
-
Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-δ,γ, in patients with chronic lymphocytic leukemia [abstract]
-
Flinn I, Patel M, Kahl BS, et al. Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-δ,γ, in patients with chronic lymphocytic leukemia [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):677.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 677
-
-
Flinn, I.1
Patel, M.2
Kahl, B.S.3
-
106
-
-
84909943632
-
First-in-human study of AMG 319, a highly selective, small molecule inhibitor of PI3Kδ, in adult patients with relapsed or refractory lymphoid malignancies [abstract]
-
Lanasa MC, Glenn M, Mato AR, et al. First-in-human study of AMG 319, a highly selective, small molecule inhibitor of PI3Kδ, in adult patients with relapsed or refractory lymphoid malignancies [abstract]. Blood (ASH Annual Meeting Abstracts). 2013;122(21):678.
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, Issue.21
, pp. 678
-
-
Lanasa, M.C.1
Glenn, M.2
Mato, A.R.3
|