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Volumn 7, Issue 1, 2014, Pages 157-168

Waldenström macroglobulinemia: From biology to treatment

Author keywords

biology; Brutons tyrosine; kinase; MYD88; treatment; Waldenstr m macroglobulinemia

Indexed keywords

BORTEZOMIB; BRUTON TYROSINE KINASE INHIBITOR; CARFILZOMIB; ENZASTAURIN; EVEROLIMUS; HISTONE DEACETYLASE INHIBITOR; IBRUTINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; IMMUNOMODULATING AGENT; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; JANUS KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOSIDE ANALOG; PANOBINOSTAT; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; POMALIDOMIDE; PROTEASOME INHIBITOR; PROTEIN KINASE B; RITUXIMAB; STAT PROTEIN;

EID: 84893245442     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/17474086.2014.871494     Document Type: Review
Times cited : (14)

References (116)
  • 1
    • 0033621661 scopus 로고    scopus 로고
    • Waldenstrom's macroglobulinemia: Clinical features, complications and management
    • Dimopoulos MA, Panayiotidis P, Moulopoulos LA, et al. Waldenstrom's macroglobulinemia: clinical features, complications and management. J Clin Oncol 2000;18(1):214-26
    • (2000) J Clin Oncol , vol.18 , Issue.1 , pp. 214-226
    • Dimopoulos, M.A.1    Panayiotidis, P.2    Moulopoulos, L.A.3
  • 3
    • 0030947418 scopus 로고    scopus 로고
    • A tribute to Jan Gosta Waldenstrom
    • Kyle RA, Anderson KC. A tribute to Jan Gosta Waldenstrom. Blood 1997;89(12): 4245-7
    • (1997) Blood , vol.89 , Issue.12 , pp. 4245-4247
    • Kyle, R.A.1    Anderson, K.C.2
  • 4
    • 0037396214 scopus 로고    scopus 로고
    • Clinicopathological definition of Waldenstrom's macroglobulinemia: Consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia
    • Owen RG, Treon SP, Al-Katib A, et al. Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. Semin Oncol 2003;30(2):110-15
    • (2003) Semin Oncol , vol.30 , Issue.2 , pp. 110-115
    • Owen, R.G.1    Treon, S.P.2    Al-Katib, A.3
  • 5
    • 14944377069 scopus 로고    scopus 로고
    • Diagnosis and management of Waldenstrom's macroglobulinemia
    • Dimopoulos MA, Kyle RA, Anagnostopoulos A, et al. Diagnosis and management of Waldenstrom's macroglobulinemia. J Clin Oncol 2005;23: 1564-77
    • (2005) J Clin Oncol , vol.23 , pp. 1564-1577
    • Dimopoulos, M.A.1    Kyle, R.A.2    Anagnostopoulos, A.3
  • 6
    • 0027339182 scopus 로고
    • Incidence of Waldenstrom's macroglobulinemia
    • Herrinton LJ, Weiss NS. Incidence of Waldenstrom's macroglobulinemia. Blood 1993;82(10):3148-50
    • (1993) Blood , vol.82 , Issue.10 , pp. 3148-3150
    • Herrinton, L.J.1    Weiss, N.S.2
  • 8
    • 0003964363 scopus 로고    scopus 로고
    • American Cancer Society American Cancer Society; Atlanta, GA, USA: 2012
    • American Cancer Society. Cancer Facts & Figures 2012. American Cancer Society; Atlanta, GA, USA: 2012
    • Cancer Facts & Figures 2012
  • 9
    • 0037103306 scopus 로고    scopus 로고
    • Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events
    • Sahota SS, Forconi F, Ottensmeier CH, et al. Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events. Blood 2002;100(4):1505-7
    • (2002) Blood , vol.100 , Issue.4 , pp. 1505-1507
    • Sahota, S.S.1    Forconi, F.2    Ottensmeier, C.H.3
  • 10
    • 0037108295 scopus 로고    scopus 로고
    • Waldenstrom macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions
    • Schop RF, Kuehl WM, Van Wier SA, et al. Waldenstrom macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions. Blood 2002;100(8):2996-3001
    • (2002) Blood , vol.100 , Issue.8 , pp. 2996-3001
    • Schop, R.F.1    Kuehl, W.M.2    Van Wier, S.A.3
  • 11
    • 67649510148 scopus 로고    scopus 로고
    • High-resolution genomic analysis in Waldenstrom's macroglobulinemia identifies disease-specific and common abnormalities with marginal zone lymphomas
    • Braggio E, Keats JJ, Leleu X, et al. High-resolution genomic analysis in Waldenstrom's macroglobulinemia identifies disease-specific and common abnormalities with marginal zone lymphomas. Clin Lymphoma Myeloma 2009;9(1):39-42
    • (2009) Clin Lymphoma Myeloma , vol.9 , Issue.1 , pp. 39-42
    • Braggio, E.1    Keats, J.J.2    Leleu, X.3
  • 12
    • 34547761265 scopus 로고    scopus 로고
    • Analysis of 6q deletion in Waldenstrom macroglobulinemia
    • Chang H, Qi X, Xu W, et al. Analysis of 6q deletion in Waldenstrom macroglobulinemia. Eur J Haematol 2007; 79(3):244-7
    • (2007) Eur J Haematol , vol.79 , Issue.3 , pp. 244-247
    • Chang, H.1    Qi, X.2    Xu, W.3
  • 13
    • 65949104846 scopus 로고    scopus 로고
    • Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia
    • Braggio E, Keats JJ, Leleu X, et al. Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia. Cancer Res 2009;69(8): 3579-88
    • (2009) Cancer Res , vol.69 , Issue.8 , pp. 3579-3588
    • Braggio, E.1    Keats, J.J.2    Leleu, X.3
  • 14
    • 33847185954 scopus 로고    scopus 로고
    • Gene expression profiling of B lymphocytes and plasma cells from Waldenstrom's macroglobulinemia: Comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individuals
    • Gutierrez NC, Ocio EM, De Las Rivas J, et al. Gene expression profiling of B lymphocytes and plasma cells from Waldenstrom's macroglobulinemia: comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individuals. Leukemia 2007; 21(3):541-9
    • (2007) Leukemia , vol.21 , Issue.3 , pp. 541-549
    • Gutierrez, N.C.1    Ocio, E.M.2    De Las Rivas, J.3
  • 15
    • 79953716822 scopus 로고    scopus 로고
    • High-throughput genomic analysis in waldenstrom's macroglobulinemia
    • Poulain S, Braggio E, Roumier C, et al. High-throughput genomic analysis in Waldenstrom's macroglobulinemia. Clin Lymphoma Myeloma Leuk 2011;11(1): 106-8
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , Issue.1 , pp. 106-108
    • Poulain, S.1    Braggio, E.2    Roumier, C.3
  • 16
    • 23444459544 scopus 로고
    • BLIMP-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
    • Turner CA Jr, Mack DH, Davis MM. BLIMP-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin- secreting cells. Cell 1994;77(2):297-306
    • (1994) Cell , vol.77 , Issue.2 , pp. 297-306
    • Turner Jr., C.A.1    Mack, D.H.2    Davis, M.M.3
  • 17
    • 84875653870 scopus 로고    scopus 로고
    • Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with waldenstrom's macroglobulinemia
    • Nguyen-Khac F, Lambert J, Chapiro E, et al. Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenstrom's macroglobulinemia. Haematologica 2013; 98(4):649-54
    • (2013) Haematologica , vol.98 , Issue.4 , pp. 649-654
    • Nguyen-Khac, F.1    Lambert, J.2    Chapiro, E.3
  • 18
    • 84865475885 scopus 로고    scopus 로고
    • MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia
    • Treon SP, Xu L, Yang G, et al. MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia. N Engl J Med 2012;367(9):826-33
    • (2012) N Engl J Med , vol.367 , Issue.9 , pp. 826-833
    • Treon, S.P.1    Xu, L.2    Yang, G.3
  • 19
    • 84877343691 scopus 로고    scopus 로고
    • MYD88 L265P in waldenstrom macroglobulinemia immunoglobulin m monoclonal gammopathy and other b-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction
    • Xu L, Hunter ZR, Yang G, et al. MYD88 L265P in Waldenstrom macroglobulinemia, immunoglobulin M monoclonal gammopathy and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. Blood 2013; 121(11):2051-8
    • (2013) Blood , vol.121 , Issue.11 , pp. 2051-2058
    • Xu, L.1    Hunter, Z.R.2    Yang, G.3
  • 20
    • 84878423649 scopus 로고    scopus 로고
    • Prevalence and clinical significance of the myd88 (l265p) somatic mutation in waldenstrom's macroglobulinemia and related lymphoid neoplasms
    • Varettoni M, Arcaini L, Zibellini S, et al. Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms. Blood 2013; 121(13):2522-8
    • (2013) Blood , vol.121 , Issue.13 , pp. 2522-2528
    • Varettoni, M.1    Arcaini, L.2    Zibellini, S.3
  • 21
    • 84873568405 scopus 로고    scopus 로고
    • IGHV gene features and myd88 l265p mutation separate the three marginal zone lymphoma entities and waldenstrom macroglobulinemialymphoplasmacytic lymphomas
    • Gachard N, Parrens M, Soubeyran I, et al. IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenstrom macroglobulinemia/lymphoplasmacytic lymphomas. Leukemia 2013;27(1):183-9
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 183-189
    • Gachard, N.1    Parrens, M.2    Soubeyran, I.3
  • 22
    • 84881482021 scopus 로고    scopus 로고
    • MYD88 L265P is a marker highly characteristic of but not restricted to waldenstrom's macroglobulinemia
    • Jimenez C, Sebastian E, Chillon MC, et al. MYD88 L265P is a marker highly characteristic of, but not restricted to, Waldenstrom's macroglobulinemia. Leukemia 2013;27(8):1722-8
    • (2013) Leukemia , vol.27 , Issue.8 , pp. 1722-1728
    • Jimenez, C.1    Sebastian, E.2    Chillon, M.C.3
  • 23
    • 84879404052 scopus 로고    scopus 로고
    • MYD88 L265P mutation in waldenstrom macroglobulinemia
    • Poulain S, Roumier C, Decambron A, et al. MYD88 L265P mutation in Waldenstrom macroglobulinemia. Blood 2013;121(22): 4504-11
    • (2013) Blood , vol.121 , Issue.22 , pp. 4504-4511
    • Poulain, S.1    Roumier, C.2    Decambron, A.3
  • 24
    • 84892429710 scopus 로고    scopus 로고
    • L265P mutation of the myd88 gene is frequent in waldenstrom's macroglobulinemia and its absence in myeloma
    • Mori N, Ohwashi M, Yoshinaga K, et al. L265P Mutation of the MYD88 Gene Is Frequent in Waldenstrom's Macroglobulinemia and Its Absence in Myeloma. PLoS ONE 2013;8(11):e80088
    • (2013) PLoS ONE , vol.8 , Issue.11
    • Mori, N.1    Ohwashi, M.2    Yoshinaga, K.3
  • 25
    • 84882786151 scopus 로고    scopus 로고
    • MYD88 L265P somatic mutation: Its usefulness in the differential diagnosis of bone marrow involvement by B-cell lymphoproliferative disorders
    • Ondrejka SL, Lin JJ, Warden DW, et al. MYD88 L265P somatic mutation: its usefulness in the differential diagnosis of bone marrow involvement by B-cell lymphoproliferative disorders. Am J Clin Pathol 2013;140(3):387-94
    • (2013) Am J Clin Pathol , vol.140 , Issue.3 , pp. 387-394
    • Ondrejka, S.L.1    Lin, J.J.2    Warden, D.W.3
  • 26
    • 84870496453 scopus 로고    scopus 로고
    • MYD88 L265P somatic mutation in IgM MGUS
    • Landgren O, Staudt L. MYD88 L265P somatic mutation in IgM MGUS. N Engl J Med 2012;367(23):2255-6
    • N Engl J Med 2012 , vol.367 , Issue.23 , pp. 2255-2256
    • Landgren, O.1    Staudt, L.2
  • 27
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997;278(5343): 1612-15
    • (1997) Science , vol.278 , Issue.5343 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 28
    • 0031423761 scopus 로고    scopus 로고
    • MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
    • Wesche H, Henzel WJ, Shillinglaw W, et al. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 1997;7(6):837-47
    • (1997) Immunity , vol.7 , Issue.6 , pp. 837-847
    • Wesche, H.1    Henzel, W.J.2    Shillinglaw, W.3
  • 29
    • 84880420868 scopus 로고    scopus 로고
    • Candidate genes of Waldenstrom's macroglobulinemia: Current evidence and research
    • Bianchi G, Sacco A, Kumar S, et al. Candidate genes of Waldenstrom's macroglobulinemia: current evidence and research. Appl Clin Genet 2013;6:33-42
    • (2013) Appl Clin Genet , vol.6 , pp. 33-42
    • Bianchi, G.1    Sacco, A.2    Kumar, S.3
  • 30
    • 84893331060 scopus 로고    scopus 로고
    • The genomic landscape of Waldenstom's Macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis
    • Hunter Z, Xu L, Yang G, et al. The genomic landscape of Waldenstom's Macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis. Blood 2013
    • (2013) Blood
    • Hunter, Z.1    Xu, L.2    Yang, G.3
  • 31
    • 84893222241 scopus 로고    scopus 로고
    • A novel activating mutation of CXCR4 plays a crucial role in waldenstrom macroglobulinemia biology
    • Roccaro AM, Sacco A, Jimenez C, et al. A novel activating mutation of CXCR4 plays a crucial role in waldenstrom macroglobulinemia biology. Blood (ASH annual meeting abstracts) 2013;122(21):272
    • (2013) Blood (ASH Annual Meeting Abstracts) , vol.122 , Issue.21 , pp. 272
    • Roccaro, A.M.1    Sacco, A.2    Jimenez, C.3
  • 32
    • 84889076722 scopus 로고    scopus 로고
    • Whole genome sequencing identifies recurring somatic mutations in the C-Terminal domain of CXCR4, including a gain of function mutation in waldenstrom's macroglobinemia
    • Cao Y, Xu L, Liu X, et al. Whole genome sequencing identifies recurring somatic mutations in the C-Terminal domain of CXCR4, including a gain of function mutation in waldenstrom's macroglobinemia. Blood (ASH annual meeting abstracts) 2013;120(21):2715
    • (2013) Blood (ASH Annual Meeting Abstracts) , vol.120 , Issue.21 , pp. 2715
    • Cao, Y.1    Xu, L.2    Liu, X.3
  • 33
    • 31444437920 scopus 로고    scopus 로고
    • Epigenetics provides a new generation of oncogenes and tumoursuppressor genes
    • Esteller M. Epigenetics provides a new generation of oncogenes and tumoursuppressor genes. Br J Cancer 2006;94(2): 179-183
    • (2006) Br J Cancer , vol.94 , Issue.2 , pp. 179-183
    • Esteller, M.1
  • 34
    • 35348849607 scopus 로고    scopus 로고
    • Epigenetics provides a new generation of oncogenes and tumour-suppressor genes
    • Esteller M. Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. Br J Cancer 2007; 96(Suppl):R26-30
    • (2007) Br J Cancer , vol.96 , Issue.SUPPL..
    • Esteller, M.1
  • 35
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med 2008;358(11):1148-59
    • (2008) N Engl J Med , vol.358 , Issue.11 , pp. 1148-1159
    • Esteller, M.1
  • 36
    • 66149084384 scopus 로고    scopus 로고
    • MicroRNA expression in the biology, prognosis and therapy of Waldenstrom macroglobulinemia
    • Roccaro AM, Sacco A, Chen C, et al. MicroRNA expression in the biology, prognosis and therapy of Waldenstrom macroglobulinemia. Blood 2009;113(18): 4391-402
    • (2009) Blood , vol.113 , Issue.18 , pp. 4391-4402
    • Roccaro, A.M.1    Sacco, A.2    Chen, C.3
  • 37
    • 78149459414 scopus 로고    scopus 로고
    • Epigenetics in waldenstrom's macroglobulinemia
    • Sacco A, Ghobrial IM, Roccaro AM. Epigenetics in Waldenstrom's macroglobulinemia. Epigenomics 2010;2(5): 691-6
    • (2010) Epigenomics , vol.2 , Issue.5 , pp. 691-696
    • Sacco, A.1    Ghobrial, I.M.2    Roccaro, A.M.3
  • 38
    • 42449152333 scopus 로고    scopus 로고
    • MiR-15a and miR-16-1 cluster functions in human leukemia
    • Calin GA, Cimmino A, Fabbri M, et al. MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A 2008;105(13):5166-71
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.13 , pp. 5166-5171
    • Calin, G.A.1    Cimmino, A.2    Fabbri, M.3
  • 39
    • 33750619898 scopus 로고    scopus 로고
    • Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma
    • Chng WJ, Schop RF, Price-Troska T, et al. Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma. Blood 2006;108(8):2755-63
    • (2006) Blood , vol.108 , Issue.8 , pp. 2755-2763
    • Chng, W.J.1    Schop, R.F.2    Price-Troska, T.3
  • 40
    • 84877600690 scopus 로고    scopus 로고
    • Microarray demonstrates different gene expression profiling signatures between waldenstrom macroglobulinemia and igm monoclonal gammopathy of undetermined significance
    • Trojani A, Greco A, Tedeschi A, et al. Microarray demonstrates different gene expression profiling signatures between Waldenstrom macroglobulinemia and IgM monoclonal gammopathy of undetermined significance. Clin Lymphoma Myeloma Leuk 2013;13(2):208-10
    • (2013) Clin Lymphoma Myeloma Leuk , vol.13 , Issue.2 , pp. 208-210
    • Trojani, A.1    Greco, A.2    Tedeschi, A.3
  • 41
    • 34248571776 scopus 로고    scopus 로고
    • Proteomic analysis of waldenstrom macroglobulinemia
    • Hatjiharissi E, Ngo H, Leontovich AA, et al. Proteomic analysis of waldenstrom macroglobulinemia. Cancer Res 2007;67(8): 3777-84
    • (2007) Cancer Res , vol.67 , Issue.8 , pp. 3777-3784
    • Hatjiharissi, E.1    Ngo, H.2    Leontovich, A.A.3
  • 42
    • 37549002500 scopus 로고    scopus 로고
    • IRAK1: A critical signaling mediator of innate immunity
    • Gottipati S, Rao NL, Fung-Leung WP. IRAK1: a critical signaling mediator of innate immunity. Cell Signal 2008;20(2): 269-76
    • (2008) Cell Signal , vol.20 , Issue.2 , pp. 269-276
    • Gottipati, S.1    Rao, N.L.2    Fung-Leung, W.P.3
  • 43
    • 84883876958 scopus 로고    scopus 로고
    • A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of bruton tyrosine kinase in waldenstrom macroglobulinemia
    • Yang G, Zhou Y, Liu X, et al. A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenstrom macroglobulinemia. Blood 2013;122(7): 1222-32
    • (2013) Blood , vol.122 , Issue.7 , pp. 1222-1232
    • Yang, G.1    Zhou, Y.2    Liu, X.3
  • 44
    • 84880835216 scopus 로고    scopus 로고
    • A new era for waldenstrom macroglobulinemia: MYD88 L265P
    • Treon SP, Hunter ZR. A new era for Waldenstrom macroglobulinemia: MYD88 L265P. Blood 2013;121(22): 4434-6
    • (2013) Blood , vol.121 , Issue.22 , pp. 4434-4436
    • Treon, S.P.1    Hunter, Z.R.2
  • 45
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2(7):489-501
    • (2002) Nat Rev Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 46
    • 39149141606 scopus 로고    scopus 로고
    • The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia
    • Leleu X, Jia X, Runnels J, et al. The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. Blood 2007;110(13):4417-26
    • (2007) Blood , vol.110 , Issue.13 , pp. 4417-4426
    • Leleu, X.1    Jia, X.2    Runnels, J.3
  • 47
    • 79958011128 scopus 로고    scopus 로고
    • Role of dual PI3Akt and MTOR inhibition in waldenstrom's macroglobulinemia
    • Sacco A, Roccaro A, Ghobrial IM. Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia. Oncotarget 2010;1(7):578-82
    • (2010) Oncotarget , vol.1 , Issue.7 , pp. 578-582
    • Sacco, A.1    Roccaro, A.2    Ghobrial, I.M.3
  • 48
    • 84893306575 scopus 로고    scopus 로고
    • PI3K/AKT Pathway Is Activated by MYD88 L265P and Use of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing in Waldenstrom's Macroglobulinemia
    • Yang G, Liu X, Zhou Y, et al. PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom's Macroglobulinemia. Blood (ASH annual meeting abstracts) 2013; 122(21):4255
    • (2013) Blood (ASH Annual Meeting Abstracts) , vol.122 , Issue.21 , pp. 4255
    • Yang, G.1    Liu, X.2    Zhou, Y.3
  • 49
    • 77449114201 scopus 로고    scopus 로고
    • Dual targeting of the PI3KAktmTOR pathway as an antitumor strategy in waldenstrom macroglobulinemia
    • Roccaro AM, Sacco A, Husu EN, et al. Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. Blood 2010;115(3):559-69
    • (2010) Blood , vol.115 , Issue.3 , pp. 559-569
    • Roccaro, A.M.1    Sacco, A.2    Husu, E.N.3
  • 50
    • 79953722251 scopus 로고    scopus 로고
    • JakStat pathway in waldenstrom's macroglobulinemia
    • Hodge LS, Ansell SM. Jak/Stat pathway in Waldenstrom's macroglobulinemia. Clin Lymphoma Myeloma Leuk 2011;11(1): 112-14
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , Issue.1 , pp. 112-114
    • Hodge, L.S.1    Ansell, S.M.2
  • 51
    • 81555205140 scopus 로고    scopus 로고
    • Comprehensive analysis of tumor microenvironment cytokines in waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of il-6 activity
    • Elsawa SF, Novak AJ, Ziesmer SC, et al. Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity. Blood 2011;118(20):5540-9
    • (2011) Blood , vol.118 , Issue.20 , pp. 5540-5549
    • Elsawa, S.F.1    Novak, A.J.2    Ziesmer, S.C.3
  • 52
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004;18(18): 2195-224
    • (2004) Genes Dev , vol.18 , Issue.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 53
    • 44649148060 scopus 로고    scopus 로고
    • Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia
    • Roccaro AM, Leleu X, Sacco A, et al. Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia. Blood 2008;111(9): 4752-63
    • (2008) Blood , vol.111 , Issue.9 , pp. 4752-4763
    • Roccaro, A.M.1    Leleu, X.2    Sacco, A.3
  • 54
    • 77953264178 scopus 로고    scopus 로고
    • Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in waldenstrom macroglobulinemia
    • Roccaro AM, Sacco A, Aujay M, et al. Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia. Blood 2010;115(20): 4051-60
    • (2010) Blood , vol.115 , Issue.20 , pp. 4051-4060
    • Roccaro, A.M.1    Sacco, A.2    Aujay, M.3
  • 55
    • 68949135695 scopus 로고    scopus 로고
    • Primary therapy of Waldenstrom macroglobulinemia with bortezomib, dexamethasone and rituximab: WMCTG clinical trial 05-180
    • Treon SP, Ioakimidis L, Soumerai JD, et al. Primary therapy of Waldenstrom macroglobulinemia with bortezomib, dexamethasone and rituximab: WMCTG clinical trial 05-180. J Clin Oncol 2009; 27(23):3830-5
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3830-3835
    • Treon, S.P.1    Ioakimidis, L.2    Soumerai, J.D.3
  • 56
    • 77956485113 scopus 로고    scopus 로고
    • Phase II trial of weekly bortezomib in combination with rituximab in untreated patients with Waldenstrom Macroglobulinemia
    • Ghobrial IM, Xie W, Padmanabhan S, et al. Phase II trial of weekly bortezomib in combination with rituximab in untreated patients with Waldenstrom Macroglobulinemia. Am J Hematol 2010; 85(9):670-4
    • (2010) Am J Hematol , vol.85 , Issue.9 , pp. 670-674
    • Ghobrial, I.M.1    Xie, W.2    Padmanabhan, S.3
  • 57
    • 77950487663 scopus 로고    scopus 로고
    • Phase II trial of weekly bortezomib in combination with rituximab in relapsed or relapsed and refractory Waldenstrom macroglobulinemia
    • Ghobrial IM, Hong F, Padmanabhan S, et al. Phase II trial of weekly bortezomib in combination with rituximab in relapsed or relapsed and refractory Waldenstrom macroglobulinemia. J Clin Oncol 2010; 28(8):1422-8
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1422-1428
    • Ghobrial, I.M.1    Hong, F.2    Padmanabhan, S.3
  • 58
    • 0242411463 scopus 로고    scopus 로고
    • Long-term follow-up of IgM monoclonal gammopathy of undetermined significance
    • Kyle RA, Therneau TM, Rajkumar SV, et al. Long-term follow-up of IgM monoclonal gammopathy of undetermined significance. Blood 2003;102(10):3759-64
    • (2003) Blood , vol.102 , Issue.10 , pp. 3759-3764
    • Kyle, R.A.1    Therneau, T.M.2    Rajkumar, S.V.3
  • 59
    • 23044481861 scopus 로고    scopus 로고
    • Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance
    • Rajkumar SV, Kyle RA, Therneau TM, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood 2005;106(3):812-17
    • (2005) Blood , vol.106 , Issue.3 , pp. 812-817
    • Rajkumar, S.V.1    Kyle, R.A.2    Therneau, T.M.3
  • 60
    • 84887396799 scopus 로고    scopus 로고
    • MYD88 (L265P) mutation is an independent risk factor for progression in patients with igm monoclonal gammopathy of undetermined significance
    • Varettoni M, Zibellini S, Arcaini L, et al. MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance. Blood 2013; 122(13):2284-5
    • (2013) Blood , vol.122 , Issue.13 , pp. 2284-2285
    • Varettoni, M.1    Zibellini, S.2    Arcaini, L.3
  • 61
    • 0023240678 scopus 로고
    • The spectrum of IgM monoclonal gammopathy in 430 cases
    • Kyle RA, Garton JP. The spectrum of IgM monoclonal gammopathy in 430 cases. Mayo Clin Proc 1987;62(8):719-31
    • (1987) Mayo Clin Proc , vol.62 , Issue.8 , pp. 719-731
    • Kyle, R.A.1    Garton, J.P.2
  • 62
    • 46749092617 scopus 로고    scopus 로고
    • Serum immunoglobulin free light chain correlates with tumor burden markers in Waldenstrom macroglobulinemia
    • Leleu X, Moreau AS, Weller E, et al. Serum immunoglobulin free light chain correlates with tumor burden markers in Waldenstrom macroglobulinemia. Leuk Lymphoma 2008;49(6):1104-7
    • (2008) Leuk Lymphoma , vol.49 , Issue.6 , pp. 1104-1107
    • Leleu, X.1    Moreau, A.S.2    Weller, E.3
  • 63
    • 33748649283 scopus 로고    scopus 로고
    • 6q deletion discriminates Waldenstrom macroglobulinemia from IgM monoclonal gammopathy of undetermined significance
    • Schop RF, Van Wier SA, Xu R, et al. 6q deletion discriminates Waldenstrom macroglobulinemia from IgM monoclonal gammopathy of undetermined significance. Cancer Genet Cytogenet 2006;169(2):150-3
    • (2006) Cancer Genet Cytogenet , vol.169 , Issue.2 , pp. 150-153
    • Schop, R.F.1    Van Wier, S.A.2    Xu, R.3
  • 64
    • 33644681507 scopus 로고    scopus 로고
    • Characterization of familial Waldenstrom's macroglobulinemia
    • Treon SP, Hunter ZR, Aggarwal A, et al. Characterization of familial Waldenstrom's macroglobulinemia. Ann Oncol 2006;17(3): 488-94
    • (2006) Ann Oncol , vol.17 , Issue.3 , pp. 488-494
    • Treon, S.P.1    Hunter, Z.R.2    Aggarwal, A.3
  • 65
    • 54049129700 scopus 로고    scopus 로고
    • Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients: A population-based study in Sweden
    • Kristinsson SY, Bjorkholm M, Goldin LR, et al. Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients: a population-based study in Sweden. Blood 2008;112(8):3052-6
    • (2008) Blood , vol.112 , Issue.8 , pp. 3052-3056
    • Kristinsson, S.Y.1    Bjorkholm, M.2    Goldin, L.R.3
  • 66
    • 84875026846 scopus 로고    scopus 로고
    • Guideline for diagnosis and treatment of Waldenstrom's macroglobulinaemia
    • Vos JM, Minnema MC, Wijermans PW, et al. Guideline for diagnosis and treatment of Waldenstrom's macroglobulinaemia. Neth J Med 2013;71(2):54-62
    • (2013) Neth J Med , vol.71 , Issue.2 , pp. 54-62
    • Vos, J.M.1    Minnema, M.C.2    Wijermans, P.W.3
  • 68
    • 18144425186 scopus 로고    scopus 로고
    • CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemia
    • Hunter ZR, Branagan AR, Manning R, et al. CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemia. Clin Lymphoma 2005;5(4):246-249
    • (2005) Clin Lymphoma , vol.5 , Issue.4 , pp. 246-249
    • Hunter, Z.R.1    Branagan, A.R.2    Manning, R.3
  • 70
    • 84859883028 scopus 로고    scopus 로고
    • Waldenstrom macroglobulinemia: 2012 update on diagnosis, risk stratification and management
    • Gertz M.A. Waldenstrom macroglobulinemia: 2012 update on diagnosis, risk stratification and management. Am J Hematol 2012;87(5): 503-10
    • (2012) Am J Hematol , vol.87 , Issue.5 , pp. 503-510
    • Gertz, M.A.1
  • 71
    • 84860902202 scopus 로고    scopus 로고
    • Progression in smoldering waldenstrom macroglobulinemia: Long-term results
    • Kyle RA, Benson JT, Larson DR, et al. Progression in smoldering Waldenstrom macroglobulinemia: long-term results. Blood 2012;119(19):4462-6
    • (2012) Blood , vol.119 , Issue.19 , pp. 4462-4466
    • Kyle, R.A.1    Benson, J.T.2    Larson, D.R.3
  • 72
    • 33645082474 scopus 로고    scopus 로고
    • Prognostic model for disease-specific and overall mortality in newly diagnosed symptomatic patients with Waldenstrom macroglobulinaemia
    • Ghobrial IM, Fonseca R, Gertz MA, et al. Prognostic model for disease-specific and overall mortality in newly diagnosed symptomatic patients with Waldenstrom macroglobulinaemia. Br J Haematol 2006; 133(2):158-64
    • (2006) Br J Haematol , vol.133 , Issue.2 , pp. 158-164
    • Ghobrial, I.M.1    Fonseca, R.2    Gertz, M.A.3
  • 73
    • 18144449054 scopus 로고    scopus 로고
    • Prognostic factors and response to fludarabine therapy in patients with Waldenstrom macroglobulinemia: Results of United States intergroup trial (Southwest Oncology Group S9003)
    • Dhodapkar MV, Jacobson JL, Gertz MA, et al. Prognostic factors and response to fludarabine therapy in patients with Waldenstrom macroglobulinemia: results of United States intergroup trial (Southwest Oncology Group S9003). Blood 2001; 98(1):41-8
    • (2001) Blood , vol.98 , Issue.1 , pp. 41-48
    • Dhodapkar, M.V.1    Jacobson, J.L.2    Gertz, M.A.3
  • 74
    • 17644433685 scopus 로고    scopus 로고
    • Survival and prognostic factors after initiation of treatment in Waldenstrom's macroglobulinemia
    • Dimopoulos MA, Hamilos G, Zervas K, et al. Survival and prognostic factors after initiation of treatment in Waldenstrom's macroglobulinemia. Ann Oncol 2003;14(8): 1299-305
    • (2003) Ann Oncol , vol.14 , Issue.8 , pp. 1299-1305
    • Dimopoulos, M.A.1    Hamilos, G.2    Zervas, K.3
  • 75
    • 0037397347 scopus 로고    scopus 로고
    • Prognostic markers and criteria to initiate therapy in Waldenstrom's macroglobulinemia: Consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia
    • Kyle RA, Treon SP, Alexanian R, et al. Prognostic markers and criteria to initiate therapy in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. Semin Oncol 2003; 30(2):116-20
    • (2003) Semin Oncol , vol.30 , Issue.2 , pp. 116-120
    • Kyle, R.A.1    Treon, S.P.2    Alexanian, R.3
  • 76
    • 3242877830 scopus 로고    scopus 로고
    • The international staging system for multiple myeloma is applicable in symptomatic Waldenstrom's macroglobulinemia
    • Dimopoulos M, Gika D, Zervas K, et al. The international staging system for multiple myeloma is applicable in symptomatic Waldenstrom's macroglobulinemia. Leuk Lymphoma 2004; 45(9):1809-13
    • (2004) Leuk Lymphoma , vol.45 , Issue.9 , pp. 1809-1813
    • Dimopoulos, M.1    Gika, D.2    Zervas, K.3
  • 77
    • 66149155411 scopus 로고    scopus 로고
    • International prognostic scoring system for Waldenstrom macroglobulinemia
    • Morel P, Duhamel A, Gobbi P, et al. International prognostic scoring system for Waldenstrom macroglobulinemia. Blood 2009;113(18):4163-70
    • (2009) Blood , vol.113 , Issue.18 , pp. 4163-4170
    • Morel, P.1    Duhamel, A.2    Gobbi, P.3
  • 78
    • 84879579412 scopus 로고    scopus 로고
    • Recognizing nodal marginal zone lymphoma: Recent advances and pitfalls. A systematic review
    • Van Den Brand M, Van Krieken JH. Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review. Haematologica 2013; 98(7):1003-13
    • (2013) Haematologica , vol.98 , Issue.7 , pp. 1003-1013
    • Van Den Brand, M.1    Van Krieken, J.H.2
  • 79
    • 0037397404 scopus 로고    scopus 로고
    • 14q32 Translocations discriminate IgM multiple myeloma from Waldenstrom's macroglobulinemia
    • Avet-Loiseau H, Garand R, Lode L, et al. 14q32 Translocations discriminate IgM multiple myeloma from Waldenstrom's macroglobulinemia. Semin Oncol 2003; 30(2):153-155
    • (2003) Semin Oncol , vol.30 , Issue.2 , pp. 153-155
    • Avet-Loiseau, H.1    Garand, R.2    Lode, L.3
  • 80
    • 58149350437 scopus 로고    scopus 로고
    • Update on treatment recommendations from the Fourth International Workshop on Waldenstrom's Macroglobulinemia
    • Dimopoulos MA, Gertz MA, Kastritis E, et al. Update on treatment recommendations from the Fourth International Workshop on Waldenstrom's Macroglobulinemia. J Clin Oncol 2009; 27(1):120-6
    • (2009) J Clin Oncol , vol.27 , Issue.1 , pp. 120-126
    • Dimopoulos, M.A.1    Gertz, M.A.2    Kastritis, E.3
  • 81
    • 78650068418 scopus 로고    scopus 로고
    • Waldenstrom macroglobulinemia: Is newer really better?
    • Gertz M.A. Waldenstrom macroglobulinemia: is newer really better? Leuk Lymphoma 2010;51(12):2152-3
    • (2010) Leuk Lymphoma , vol.51 , Issue.12 , pp. 2152-2153
    • Ma, G.1
  • 82
    • 67649525702 scopus 로고    scopus 로고
    • Advances in the biology and treatment of Waldenstrom's macroglobulinemia: A report from the 5th International Workshop on Waldenstrom's Macroglobulinemia, Stockholm, Sweden
    • Treon SP, Patterson CJ, Kimby E, et al. Advances in the biology and treatment of Waldenstrom's macroglobulinemia: a report from the 5th International Workshop on Waldenstrom's Macroglobulinemia, Stockholm, Sweden. Clin Lymphoma Myeloma 2009;9(1):10-15
    • (2009) Clin Lymphoma Myeloma , vol.9 , Issue.1 , pp. 10-15
    • Treon, S.P.1    Patterson, C.J.2    Kimby, E.3
  • 83
    • 84870983649 scopus 로고    scopus 로고
    • Waldenstrom's macroglobulinemia/ lymphoplasmacytic lymphoma, version 2
    • Anderson KC, Alsina M, Bensinger W, et al. Waldenstrom's macroglobulinemia/ lymphoplasmacytic lymphoma, version 2. J Natl Compr Canc Netw 2012; 10(10):1211-19
    • (2012) J Natl Compr Canc Netw , vol.10 , Issue.10 , pp. 1211-1219
    • Anderson, K.C.1    Alsina, M.2    Bensinger, W.3
  • 84
    • 84872264088 scopus 로고    scopus 로고
    • Response assessment in Waldenstrom macroglobulinaemia: Update from the VIth International Workshop
    • Owen RG, Kyle RA, Stone MJ, et al. Response assessment in Waldenstrom macroglobulinaemia: update from the VIth International Workshop. Br J Haematol 2013;160(2):171-6
    • (2013) Br J Haematol , vol.160 , Issue.2 , pp. 171-176
    • Owen, R.G.1    Kyle, R.A.2    Stone, M.J.3
  • 85
    • 34249933504 scopus 로고    scopus 로고
    • Therapeutic apheresis in hyperleukocytosis and hyperviscosity syndrome
    • Blum W, Porcu P. Therapeutic apheresis in hyperleukocytosis and hyperviscosity syndrome. Semin Thromb Hemost 2007; 33(4):350-4
    • (2007) Semin Thromb Hemost , vol.33 , Issue.4 , pp. 350-354
    • Blum, W.1    Porcu, P.2
  • 86
    • 84877590466 scopus 로고    scopus 로고
    • Role of plasmapheresis in waldenstrom's macroglobulinemia
    • Stone MJ, Bogen SA. Role of plasmapheresis in Waldenstrom's macroglobulinemia. Clin Lymphoma Myeloma Leuk 2013;13(2):238-40
    • (2013) Clin Lymphoma Myeloma Leuk , vol.13 , Issue.2 , pp. 238-240
    • Stone, M.J.1    Bogen, S.A.2
  • 87
    • 77957727618 scopus 로고    scopus 로고
    • Review of clinical trials conducted in waldenstrom macroglobulinemia and recommendations for reporting clinical trial responses in these patients
    • Rourke M, Anderson KC, Ghobrial IM. Review of clinical trials conducted in Waldenstrom macroglobulinemia and recommendations for reporting clinical trial responses in these patients. Leuk Lymphoma 2010;51(10):1779-92
    • (2010) Leuk Lymphoma , vol.51 , Issue.10 , pp. 1779-1792
    • Rourke, M.1    Anderson, K.C.2    Ghobrial, I.M.3
  • 88
    • 70350490537 scopus 로고    scopus 로고
    • How i treat Waldenstrom macroglobulinemia
    • Treon SP. How I treat Waldenstrom macroglobulinemia. Blood 2009;114(12): 2375-85
    • (2009) Blood , vol.114 , Issue.12 , pp. 2375-2385
    • Treon, S.P.1
  • 89
    • 0036954114 scopus 로고    scopus 로고
    • Extended rituximab therapy for previously untreated patients with Waldenstrom's macroglobulinemia
    • Dimopoulos MA, Zervas C, Zomas A, et al. Extended rituximab therapy for previously untreated patients with Waldenstrom's macroglobulinemia. Clin Lymphoma 2002; 3(3):163-6
    • (2002) Clin Lymphoma , vol.3 , Issue.3 , pp. 163-166
    • Dimopoulos, M.A.1    Zervas, C.2    Zomas, A.3
  • 90
    • 0036570057 scopus 로고    scopus 로고
    • Treatment of Waldenstrom's macroglobulinemia with rituximab
    • Dimopoulos MA, Zervas C, Zomas A, et al. Treatment of Waldenstrom's macroglobulinemia with rituximab. J Clin Oncol 2002;20(9):2327-33
    • (2002) J Clin Oncol , vol.20 , Issue.9 , pp. 2327-2333
    • Dimopoulos, M.A.1    Zervas, C.2    Zomas, A.3
  • 91
    • 34548229503 scopus 로고    scopus 로고
    • Primary treatment of Waldenstrom macroglobulinemia with dexamethasone, rituximab and cyclophosphamide
    • Dimopoulos MA, Anagnostopoulos A, Kyrtsonis MC, et al. Primary treatment of Waldenstrom macroglobulinemia with dexamethasone, rituximab and cyclophosphamide. J Clin Oncol 2007; 25(22):3344-9
    • (2007) J Clin Oncol , vol.25 , Issue.22 , pp. 3344-3349
    • Dimopoulos, M.A.1    Anagnostopoulos, A.2    Kyrtsonis, M.C.3
  • 92
    • 79953681626 scopus 로고    scopus 로고
    • Bendamustine therapy in patients with relapsed or refractory waldenstrom's macroglobulinemia
    • Treon SP, Hanzis C, Tripsas C, et al. Bendamustine therapy in patients with relapsed or refractory Waldenstrom's macroglobulinemia. Clin Lymphoma Myeloma Leuk 2011;11(1):133-5
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , Issue.1 , pp. 133-135
    • Treon, S.P.1    Hanzis, C.2    Tripsas, C.3
  • 93
    • 84889055745 scopus 로고    scopus 로고
    • Primary treatment of waldenstrom's macroglobulinemia with dexamethasone rituximab and cyclophosphamide (DRC): Final analysis of a phase II study
    • Dimopoulos MA, Roussou M, Kastritis E, et al. Primary treatment of Waldenstrom's macroglobulinemia with Dexamethasone, Rituximab and Cyclophosphamide (DRC): final analysis of a phase II study. Blood (ASH Annual meeting abstracts) 2012;120(21): 438
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120 , Issue.21 , pp. 438
    • Dimopoulos, M.A.1    Roussou, M.2    Kastritis, E.3
  • 94
    • 84880290654 scopus 로고    scopus 로고
    • Bendamustine-Rituximab Induction Followed by Observation or Rituximab Maintenance for Newly Diagnosed Patients with Waldenstro?m's Macroglobulinemia: Results from a Prospective, Randomized, Multicenter Study (StiL NHL 7-2008- MAINTAIN; ClinicalTrials.gov Identifier: NCT00877214)
    • Rummel MJ, Lerchenmuller C, Greil R, et al. Bendamustine-Rituximab Induction Followed by Observation or Rituximab Maintenance for Newly Diagnosed Patients with Waldenstro?m's Macroglobulinemia: Results From a Prospective, Randomized, Multicenter Study (StiL NHL 7-2008- MAINTAIN; ClinicalTrials.gov Identifier: NCT00877214). Blood (ASH Annual meeting abstracts) 2012;(21):2739
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.21 , pp. 2739
    • Rummel, M.J.1    Lerchenmuller, C.2    Greil, R.3
  • 95
    • 80955178796 scopus 로고    scopus 로고
    • Maintenance Rituximab is associated with improved clinical outcome in rituximab naive patients with Waldenstrom Macroglobulinaemia who respond to a rituximab-containing regimen
    • Treon SP, Hanzis C, Manning RJ, et al. Maintenance Rituximab is associated with improved clinical outcome in rituximab naive patients with Waldenstrom Macroglobulinaemia who respond to a rituximab-containing regimen. Br J Haematol 2011;154(3):357-62
    • (2011) Br J Haematol , vol.154 , Issue.3 , pp. 357-362
    • Treon, S.P.1    Hanzis, C.2    Manning, R.J.3
  • 96
    • 84873340787 scopus 로고    scopus 로고
    • Results of a randomized trial of chlorambucil versus fludarabine for patients with untreated Waldenstrom macroglobulinemia, marginal zone lymphoma, or lymphoplasmacytic lymphoma
    • Leblond V, Johnson S, Chevret S, et al. Results of a randomized trial of chlorambucil versus fludarabine for patients with untreated Waldenstrom macroglobulinemia, marginal zone lymphoma, or lymphoplasmacytic lymphoma. J Clin Oncol 2013;31(3):301-7
    • (2013) J Clin Oncol , vol.31 , Issue.3 , pp. 301-307
    • Leblond, V.1    Johnson, S.2    Chevret, S.3
  • 97
    • 58249093949 scopus 로고    scopus 로고
    • Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenstrom macroglobulinemia treated with nucleoside analogs
    • Leleu X, Soumerai J, Roccaro A, et al. Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenstrom macroglobulinemia treated with nucleoside analogs. J Clin Oncol 2009;27(2):250-5
    • (2009) J Clin Oncol , vol.27 , Issue.2 , pp. 250-255
    • Leleu, X.1    Soumerai, J.2    Roccaro, A.3
  • 98
    • 65549105193 scopus 로고    scopus 로고
    • Long-term outcomes to fludarabine and rituximab in Waldenstrom macroglobulinemia
    • Treon SP, Branagan AR, Ioakimidis L, et al. Long-term outcomes to fludarabine and rituximab in Waldenstrom macroglobulinemia. Blood 2009;113(16): 3673-8
    • (2009) Blood , vol.113 , Issue.16 , pp. 3673-3678
    • Treon, S.P.1    Branagan, A.R.2    Ioakimidis, L.3
  • 99
    • 33646948563 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide and rituximab for the treatment of patients with chronic lymphocytic leukemia or indolent non-Hodgkin lymphoma
    • Tam CS, Wolf M, Prince HM, et al. Fludarabine, cyclophosphamide and rituximab for the treatment of patients with chronic lymphocytic leukemia or indolent non-Hodgkin lymphoma. Cancer 2006; 106(11):2412-20
    • (2006) Cancer , vol.106 , Issue.11 , pp. 2412-2420
    • Tam, C.S.1    Wolf, M.2    Prince, H.M.3
  • 100
    • 84855489471 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide and rituximab in waldenstrom macroglobulinemia: An effective but myelosuppressive regimen to be offered to patients with advanced disease
    • Tedeschi A, Benevolo G, Varettoni M, et al. Fludarabine plus cyclophosphamide and rituximab in Waldenstrom macroglobulinemia: an effective but myelosuppressive regimen to be offered to patients with advanced disease. Cancer 2012;118(2):434-43
    • (2012) Cancer , vol.118 , Issue.2 , pp. 434-443
    • Tedeschi, A.1    Benevolo, G.2    Varettoni, M.3
  • 101
    • 79958845007 scopus 로고    scopus 로고
    • New insights into the pathogenesis and treatment of waldenstrom macroglobulinemia
    • Issa GC, Leblebjian H, Roccaro AM, Ghobrial IM. New insights into the pathogenesis and treatment of Waldenstrom macroglobulinemia. Curr Opin Hematol 2011;18(4):260-5
    • (2011) Curr Opin Hematol , vol.18 , Issue.4 , pp. 260-265
    • Issa, G.C.1    Leblebjian, H.2    Roccaro, A.M.3    Ghobrial, I.M.4
  • 103
    • 79953300497 scopus 로고    scopus 로고
    • Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to antitumor activity in waldenstrom's macroglobulinemia
    • Sacco A, Aujay M, Morgan B, et al. Carfilzomib-dependent selective inhibition of the chymotrypsin-like activity of the proteasome leads to antitumor activity in Waldenstrom's Macroglobulinemia. Clin Cancer Res 2011;17(7):1753-64
    • (2011) Clin Cancer Res , vol.17 , Issue.7 , pp. 1753-1764
    • Sacco, A.1    Aujay, M.2    Morgan, B.3
  • 104
    • 84893252168 scopus 로고    scopus 로고
    • Prospective phase II clinical trial of carfilzomib rituximab and dexamethasone (CARD) in patients with symptomatic waldenstrom's macroglobulinemia (WM) [Abstract]
    • Treon SP, Tripsas CK, Sheehy P, et al. Prospective Phase II Clinical Trial of Carfilzomib, rituximab and Dexamethasone (CARD) in Patients with Symptomatic Waldenstrom's Macroglobulinemia (WM) [Abstract]. IWWM-7; 2012
    • (2012) IWWM-7
    • Treon, S.P.1    Tripsas, C.K.2    Sheehy, P.3
  • 105
    • 77950464935 scopus 로고    scopus 로고
    • Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia
    • Ghobrial IM, Gertz M, Laplant B, et al. Phase II trial of the oral mammalian target of rapamycin inhibitor everolimus in relapsed or refractory Waldenstrom macroglobulinemia. J Clin Oncol 2010; 28(8):1408-14
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1408-1414
    • Ghobrial, I.M.1    Gertz, M.2    Laplant, B.3
  • 106
    • 84888987504 scopus 로고    scopus 로고
    • Phase i trial of everolimus and rituximab or everolimus, bortezomib and rituximab in relapsed or relapsed/refractory waldenstrom's macroglobulinemia
    • Ghobrial IM, Boswell E, Banwait R, et al. Phase I trial of everolimus and rituximab or everolimus, bortezomib and rituximab in relapsed or relapsed/refractory waldenstrom's macroglobulinemia. Blood (ASH Annual meeting abstracts) 2011;118(21):2705
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 2705
    • Ghobrial, I.M.1    Boswell, E.2    Banwait, R.3
  • 107
    • 84866392045 scopus 로고    scopus 로고
    • A multicenter phase II study of single-agent enzastaurin in previously treated waldenstrom macroglobulinemia
    • Ghobrial IM, Moreau P, Harris B, et al. A multicenter Phase II study of single-agent enzastaurin in previously treated Waldenstrom macroglobulinemia. Clin Cancer Res 2012;18(18):5043-50
    • (2012) Clin Cancer Res , vol.18 , Issue.18 , pp. 5043-5050
    • Ghobrial, I.M.1    Moreau, P.2    Harris, B.3
  • 108
    • 76049121742 scopus 로고    scopus 로고
    • Clinical and translational studies of a phase ii trial of the novel oral akt inhibitor perifosine in relapsed or relapsedrefractory waldenstrom's Macroglobulinemia
    • Ghobrial IM, Roccaro A, Hong F, et al. Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia. Clin Cancer Res 2010;16(3):1033-41
    • (2010) Clin Cancer Res , vol.16 , Issue.3 , pp. 1033-1041
    • Ghobrial, I.M.1    Roccaro, A.2    Hong, F.3
  • 109
    • 57649198069 scopus 로고    scopus 로고
    • Thalidomide and rituximab in Waldenstrom macroglobulinemia
    • Treon SP, Soumerai JD, Branagan AR, et al. Thalidomide and rituximab in Waldenstrom macroglobulinemia. Blood 2008;112(12):4452-7
    • (2008) Blood , vol.112 , Issue.12 , pp. 4452-4457
    • Treon, S.P.1    Soumerai, J.D.2    Branagan, A.R.3
  • 110
    • 58849160495 scopus 로고    scopus 로고
    • Lenalidomide and rituximab in Waldenstrom's macroglobulinemia
    • Treon SP, Soumerai JD, Branagan AR, et al. Lenalidomide and rituximab in Waldenstrom's macroglobulinemia. Clin Cancer Res 2009;15(1):355-60
    • (2009) Clin Cancer Res , vol.15 , Issue.1 , pp. 355-360
    • Treon, S.P.1    Soumerai, J.D.2    Branagan, A.R.3
  • 111
    • 84893309325 scopus 로고    scopus 로고
    • A phase i trial of pomalidomide in patients with relapsed and/or refractory waldenstrom's macroglobulinemia (WM)
    • Sheeba KT, Donna MW, Michael W, et al. A Phase I Trial of Pomalidomide in Patients with Relapsed and/or Refractory Waldenstro?m's Macroglobulinemia (WM). IWWM-7 Session-9; 2012
    • (2012) IWWM-7 Session-9
    • Sheeba, K.T.1    Donna, M.W.2    Michael, W.3
  • 112
    • 84893340153 scopus 로고    scopus 로고
    • Phase i study of pomalidomide dexamethasone and rituximab (PDR) in patients with relapsed or refractory waldenstrom's macroglobulenima
    • Treon SP, Tripsas C, Warren D, et al. Phase I Study of Pomalidomide, Dexamethasone and Rituximab (PDR) in Patients with Relapsed or Refractory Waldenstrom's Macroglobulenima. Hematol Oncol (Abstract) 2013;31(S1):536
    • (2013) Hematol Oncol (Abstract) , vol.31 , Issue.S1 , pp. 536
    • Treon, S.P.1    Tripsas, C.2    Warren, D.3
  • 113
    • 80052062789 scopus 로고    scopus 로고
    • Targeting waldenstrom macroglobulinemia with histone deacetylase inhibitors
    • Grant S. Targeting Waldenstrom macroglobulinemia with histone deacetylase inhibitors. Leuk Lymphoma 2011;52(9): 1623-5
    • (2011) Leuk Lymphoma , vol.52 , Issue.9 , pp. 1623-1625
    • Grant, S.1
  • 114
    • 84874401753 scopus 로고    scopus 로고
    • Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed refractory waldenstrom macroglobulinemia
    • Ghobrial IM, Campigotto F, Murphy TJ, et al. Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/ refractory Waldenstrom macroglobulinemia. Blood 2013;121(8):1296-303
    • (2013) Blood , vol.121 , Issue.8 , pp. 1296-1303
    • Ghobrial, I.M.1    Campigotto, F.2    Murphy, T.J.3
  • 115
    • 84927048196 scopus 로고    scopus 로고
    • Participation of BTK in MYD88 signaling in malignant cells expressing the L265P mutation in Waldenstrom's macroglobulinemia and effect on tumor cell with BTK-inhibitor PCI-32765 in combination with MYD88 pathway inhibitors [abstract]
    • Abstract 8106
    • Yang G, Xu L, Zhou Y, et al. Participation of BTK in MYD88 signaling in malignant cells expressing the L265P mutation in Waldenstrom's macroglobulinemia and effect on tumor cell with BTK-inhibitor PCI-32765 in combination with MYD88 pathway inhibitors [abstract]. J Clin Oncol 2012;30(Suppl):Abstract 8106
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Yang, G.1    Xu, L.2    Zhou, Y.3
  • 116
    • 84871806385 scopus 로고    scopus 로고
    • Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
    • Advani RH, Buggy JJ, Sharman JP, et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J Clin Oncol 2013;31(1): 88-94
    • (2013) J Clin Oncol , vol.31 , Issue.1 , pp. 88-94
    • Advani, R.H.1    Buggy, J.J.2    Sharman, J.P.3


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