Kupffer cells interact with hepatitis b surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function

Journal of Infectious Diseases

Volumn 211, Issue 8, 2015, Pages 1268-1278

  Boltjes, Arjan ^a   Van Montfoort, Nadine ^a   Biesta, Paula J ^a   Op Den Brouw, Marjoleine L ^a   Kwekkeboom, Jaap ^a   Van Der Laan, Luc J W ^a   Janssen, Harry L A ^a,b   Boonstra, André ^a   Woltman, Andrea M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

HBsAg; HBV; innate immunity; Kupffer cells; macrophages

Indexed keywords

CD69 ANTIGEN; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; BINDING AFFINITY; CELL FUNCTION; CELL INTERACTION; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; KUPFFER CELL; MACROPHAGE ACTIVATION; MALE; MIDDLE AGED; NATURAL KILLER CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; YOUNG ADULT; DENDRITIC CELL; HEPATITIS B; HEPATITIS B VIRUS; IMMUNOLOGY; INFLAMMATION; LIVER; LYMPHOCYTE ACTIVATION; MACROPHAGE; PROCEDURES;

ADULT; DENDRITIC CELLS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; IN VITRO TECHNIQUES; INFLAMMATION; INTERFERON-GAMMA; KILLER CELLS, NATURAL; KUPFFER CELLS; LIVER; LYMPHOCYTE ACTIVATION; MACROPHAGES; MALE; MIDDLE AGED; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84926668238     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu599     Document Type: Conference Paper

References (41)

1. Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5:215-29.
2. Boonstra A, Woltman AM, Janssen HL. Immunology of hepatitis B and hepatitis C virus infections. Best Pract Res Clin Gastroenterol 2008; 22:1049-61.
3. Yan H, Zhong G, Xu G, et al. Sodium taurocholate cotransporting poly-peptide is a functional receptor for human hepatitis B and D virus. eLife 2012; 1:e00049.
4. Baratta JL, Ngo A, Lopez B, Kasabwalla N, Longmuir KJ, Robertson RT. Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis. Histochem Cell Biol 2009; 131:713-26.
5. Naito M, Hasegawa G, Takahashi K. Development, differentiation, and maturation of Kupffer cells. Microsc Res Tech 1997; 39:350-64.
6. Schulz C, Gomez Perdiguero E, Chorro L, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 2012; 336:86-90.
7. Klein I, Cornejo JC, Polakos NK, et al. Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macro-phages. Blood 2007; 110:4077-85.
8. Yamamoto T, Kaizu C, Kawasaki T, et al. Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion. Cell Tissue Res 2008; 332:245-56.
9. Vollmar B, Menger MD. The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev 2009; 89:1269-339.
10. Tu Z, Bozorgzadeh A, Pierce RH, Kurtis J, Crispe IN, Orloff MS. TLR-dependent cross talk between human Kupffer cells and NK cells. J Exp Med 2008; 205:233-44.
11. Brown KE, Brunt EM, Heinecke JW. Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver. Am J Pathol 2001; 159:2081-8.
12. Baldus SE, Zirbes TK, Weidner IC, et al. Comparative quantitative analysis of macrophage populations defined by CD68 and carbohydrate antigens in normal and pathologically altered human liver tissue. Anal Cell Pathol 1998; 16:141-50.
13. Dominguez-Soto A, Aragoneses-Fenoll L, Gomez-Aguado F, et al. The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1. Hepatology 2009; 49:287-96.
14. Ono K, Nishitani C, Mitsuzawa H, et al. Mannose-binding lectin augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer cells through increased cell surface expression of scavenger receptor A. J Immunol 2006; 177:5517-23.
15. Reid DM, Montoya M, Taylor PR, et al. Expression of the beta-glucan receptor, dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J Leukoc Biol 2004; 76:86-94.
16. Tu Z, Pierce RH, Kurtis J, Kuroki Y, Crispe IN, Orloff MS. Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells. Gastroenterology 2010; 138:305-14.
17. Visvanathan K, Skinner NA, Thompson AJV, et al. Regulation of Tolllike receptor-2 expression in chronic hepatitis B by the precore protein. Hepatology 2007; 45:102-10.
18. Knolle P, Schlaak J, Uhrig A, Kempf P, Meyer zum Buschenfelde KH, Gerken G. Human Kupffer cells secrete IL-10 in response to lipopoly-saccharide (LPS) challenge. J Hepatol 1995; 22:226-9.
19. Li H, Zheng HW, Chen H, et al. Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-beta1 over pro-inflammatory cy-tokines. Dig Liver Dis 2012; 44:328-33.
20. Hösel M, Quasdorff M, Wiegmann K, et al. Not interferon, but interleu-kin-6 controls early gene expression in hepatitis B virus infection. Hep-atology 2009; 50:1773-82.
21. + regulatory T cells detach from the graft and circulate in recipients after liver transplantation. J Immunol 2007; 178:6066-72.
22. Tu Z, Bozorgzadeh A, Crispe IN, Orloff MS. The activation state of human intrahepatic lymphocytes. Clin Exp Immunol 2007; 149:186-93.
23. Tjwa ET, Zoutendijk R, van Oord GW, et al. Intrahepatic natural killer cell activation, but not function, is associated with HBsAg levels in patients with HBeAg-negative chronic hepatitis B. Liver Int 2013; 34:396-404.
24. Riordan SM, Skinner N, Kurtovic J, Locarnini S, Visvanathan K. Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B. Clin Vacc Immunol 2006; 13:972-4.
25. Woltman AM, Op den Brouw ML, Biesta PJ, Shi CC, Janssen HL. Hepatitis B virus lacks immune activating capacity, but actively inhibits plas-macytoid dendritic cell function. PLoS One 2011; 6:e15324.
26. Wu J, Meng Z, Jiang M, et al. Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells. Hepatology 2009; 49:1132-40.
27. Pepe G, Cifarelli A, Paradisi F, De Ritis F. HBsAg uptake by macrophag-es in vitro: an immunofluorescence study. Experientia 1979; 35:382-4.
28. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use mac-ropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: down-regulation by cytokines and bacterial products. J Exp Med 1995; 182:389-400.
29. Kitajima T, Caceres-Dittmar G, Tapia FJ, Jester J, Bergstresser PR, Takashima A. T cell-mediated terminal maturation of dendritic cells: loss of adhesive and phagocytotic capacities. J Immunol 1996; 157:2340-7.
30. Gehring AJ, Haniffa M, Kennedy PT, et al. Mobilizing monocytes to cross-present circulating viral antigen in chronic infection. J Clin Invest 2013; 123:3766-76.
31. Biermer M, Puro R, Schneider RJ. Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid integrity through activation of NF-kappaB. J Virol 2003; 77:4033-42.
32. Diesselhoff-den Dulk MM, Crofton RW, van Furth R. Origin and kinetics of Kupffer cells during an acute inflammatory response. Immunology 1979; 37:7-14.
33. Movita D, Kreefft K, Biesta P, et al. Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages. J Leukoc Biol 2012; 92:723-33.
34. Salazar-Mather TP, Hokeness KL. Cytokine and chemokine networks: pathways to antiviral defense. Curr Top Microbiol Immunol 2006; 303:29-46.
35. Guidotti LG, Rochford R, Chung J, Shapiro M, Purcell R, Chisari FV. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999; 284:825-9.
36. Guy CS, Mulrooney-Cousins PM, Churchill ND, Michalak TI. Intrahe-patic expression of genes affiliated with innate and adaptive immune responses immediately after invasion and during acute infection with woodchuck hepadnavirus. J Virol 2008; 82:8579-91.
37. Webster GJ, Reignat S, Maini MK, et al. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 2000; 32:1117-24.
38. Moretta A, Marcenaro E, Parolini S, Ferlazzo G, Moretta L. NK cells at the interface between innate and adaptive immunity. Cell Death Differ 2008; 15:226-33.
39. Sitia G, Iannacone M, Aiolfi R, et al. Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathog 2011; 7:e1002061.
40. Mandrekar P, Szabo G. Signalling pathways in alcohol-induced liver inflammation. J Hepatol 2009; 50:1258-66.
41. Wallace K, Burt AD, Wright MC. Liver fibrosis. Biochem J 2008; 411:1-18.