shRNA targeting Bmi1 impedes the self-renewal of cisplatin-enriched stem-like cells in human A549 cells

Oncology Reports

Volumn 28, Issue 2, 2012, Pages 629-639

  Xu, Yu ^a   Hu, Yi De ^a   Zhou, Jing ^a   Zhang, Ming Hui ^a   Yuan, Wei Wei ^a   Luo, Yan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bmi1; Cisplatin; Lung cancer; Self renewal; Stem like cells

Indexed keywords

BMI1 PROTEIN; BREAST CANCER RESISTANCE PROTEIN; CD133 ANTIGEN; CELL MARKER; CISPLATIN; CYTOKERATIN 18; CYTOKERATIN 8; SHORT HAIRPIN RNA; TUMOR MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CELL POPULATION; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LENTIVIRINAE; LUNG CANCER; MOLECULAR MODEL; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR VOLUME; WESTERN BLOTTING;

ANIMALS; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CISPLATIN; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; POLYCOMB REPRESSIVE COMPLEX 1; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

EID: 84863441185     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1843     Document Type: Article

References (33)

1. Shackleton M, Quintana E, Fearon ER and Morrison SJ: Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138: 822-829, 2009.
2. Vermeulen L, Todaro M, de Sousa Mello F, et al: Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci USA 105: 13427-13432, 2008.
3. Dick JE: Stem cell concepts renew cancer research. Blood 112: 4793-4807, 2008.
4. Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730-737, 1997. (Pubitemid 27298715)
5. Harrison H, Farnie G, Howell SJ, et al: Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res 70: 709-718, 2010.
6. Visvader JE and Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768, 2008.
7. Kim CF, Jackson EL, Woolfenden AE, et al: Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121: 823-835, 2005. (Pubitemid 40806415)
8. Eramo A, Lotti F, Sette G, et al: Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 15: 504-514, 2008. (Pubitemid 351267301)
9. Seo DC, Sung JM, Cho HJ, et al: Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells. Mol Cancer 6: 75, 2007.
10. Ho MM, Ng AV, Lam S and Hung JY: Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 67: 4827-4833, 2007. (Pubitemid 46910191)
11. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988, 2003. (Pubitemid 36418143)
12. Sullivan JP, Minna JD and Shay JW: Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev 29: 61-72, 2010.
13. Maeda R, Yoshida J, Hishida T, et al: Late recurrence of non-small cell lung cancer more than 5 years after complete resection: incidence and clinical implications in patient followup. Chest 138: 145-150, 2010.
14. Dean M, Fojo T and Bates S: Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-284, 2005. (Pubitemid 40488633)
15. Dylla SJ, Beviglia L, Park IK, et al: Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One 3: e2428, 2008.
16. Eramo A, Ricci-Vitiani L, Zeuner A, et al: Chemotherapy resistance of glioblastoma stem cells. Cell Death Differ 13: 1238-1241,2006. (Pubitemid 43905604)
17. Tamase A, Muraguchi T, Naka K, et al: Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. Proc Natl Acad Sci USA 106: 17163-17168, 2009.
18. Malanchi I, Peinado H, Kassen D, et al: Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 452: 650-653, 2008. (Pubitemid 351483363)
19. Korkaya H, Paulson A, Iovino F and Wicha MS: HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 27: 6120-6130, 2008.
20. Dovey JS, Zacharek SJ, Kim CF and Lees JA: Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc Natl Acad Sci USA 105: 11857-11862, 2008.
21. Levina V, Marrangoni AM, DeMarco R, Gorelik E and Lokshin AE: Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. PLoS One 3: e3077, 2008.
22. Bea S, Tort F, Pinyol M, et al: BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas. Cancer Res 61: 2409-2412, 2001. (Pubitemid 32685815)
23. Tsunoda S, Okumura T, Ito T, et al: ABCG2 expression is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma. Oncology 71: 251-258, 2006.
24. Donnenberg VS and Donnenberg AD: Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis. J Clin Pharmacol 45: 872-877, 2005. (Pubitemid 41060226)
25. Tredan O, Galmarini CM, Patel K and Tannock IF: Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 99: 1441-1454, 2007.
26. Eyler CE and Rich JN: Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 26: 2839-2845, 2008.
27. Kanaji N, Bandoh S, Fujita J, Ishii T, Ishida T and Kubo A: Compensation of type I and type II cytokeratin pools in lung cancer. Lung Cancer 55: 295-302, 2007. (Pubitemid 46329187)
28. Li L and Neaves WB: Normal stem cells and cancer stem cells: the niche matters. Cancer Res 66: 4553-4557, 2006.
29. Beachy PA, Karhadkar SS and Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature 432: 324-331, 2004. (Pubitemid 39551660)
30. Park IK, Morrison SJ and Clarke MF: Bmi1, stem cells, and senescence regulation. J Clin Invest 113: 175-179, 2004. (Pubitemid 38544200)
31. Zhang HW, Ding J, Jin JL, et al: Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice. J Bone Miner Res 25: 640-652, 2010.
32. Shakhova O, Leung C and Marino S: Bmi1 in development and tumorigenesis of the central nervous system. J Mol Med 83: 596-600, 2005. (Pubitemid 41176068)
33. van der Lugt NM, Domen J, Linders K, et al: Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 protooncogene. Genes Dev 8: 757-769, 1994.