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Volumn 12, Issue 1, 2015, Pages 382-388

Icariin recovers the osteogenic differentiation and bone formation of bone marrow stromal cells from a rat model of estrogen deficiency-induced osteoporosis

Author keywords

Differentiation; Icariin; Mesenchymal stem cells; Mineralization; Osteoporosis

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ICARIIN; INTESTINAL TREFOIL FACTOR; MESSENGER RNA; PROGESTERONE RECEPTOR; TRANSCRIPTION FACTOR RUNX2; BONE DENSITY CONSERVATION AGENT; ESTRADIOL; FLAVONOID; FULVESTRANT;

EID: 84926632716     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.3369     Document Type: Article
Times cited : (44)

References (33)
  • 1
    • 0034282474 scopus 로고    scopus 로고
    • Postmenopausal osteoporosis. Strategies for preventing bone loss avoiding fracture
    • 85-88, 91
    • McGarry KA and Kiel DP: Postmenopausal osteoporosis. Strategies for preventing bone loss, avoiding fracture. Postgrad Med 108: 79-82, 85-88, 91, 2000.
    • (2000) Postgrad Med , vol.108 , pp. 79-82
    • McGarry, K.A.1    Kiel, D.P.2
  • 2
    • 34249072897 scopus 로고    scopus 로고
    • The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity
    • Hertrampf T, Gruca MJ, Seibel J et al: The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity. Bone 40: 1529-1535, 2007.
    • (2007) Bone , vol.40 , pp. 1529-1535
    • Hertrampf, T.1    Gruca, M.J.2    Seibel, J.3
  • 3
    • 81255160593 scopus 로고    scopus 로고
    • Suppression of bone formation by osteoclastic expression of semaphorin 4D
    • Negishi-Koga T, Shinohara M, Komatsu N, et al: Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med 17: 1473-1481, 2011.
    • (2011) Nat Med , vol.17 , pp. 1473-1481
    • Negishi-Koga, T.1    Shinohara, M.2    Komatsu, N.3
  • 4
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • Uccelli A, Moretta L and Pistoia V: Mesenchymal stem cells in health and disease. Nat Rev Immunol 8: 726-736, 2008.
    • (2008) Nat Rev Immunol , vol.8 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 5
    • 84855517156 scopus 로고    scopus 로고
    • Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α
    • Liu Y, Wang L, Kikuiri T et al: Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α. Nat Med 17: 1594-1601, 2011.
    • (2011) Nat Med , vol.17 , pp. 1594-1601
    • Liu, Y.1    Wang, L.2    Kikuiri, T.3
  • 6
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan GA and Martin TJ: Therapeutic approaches to bone diseases. Science 289: 1508-1514, 2000.
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 7
    • 33947497852 scopus 로고    scopus 로고
    • Osteoclasts: What do they do and how do they do it?
    • Teitelbaum SL: Osteoclasts: what do they do and how do they do it? Am. J. Pathol 170: 427-435, 2007.
    • (2007) Am. J. Pathol , vol.170 , pp. 427-435
    • Teitelbaum, S.L.1
  • 8
    • 0037434618 scopus 로고    scopus 로고
    • Selective estrogen-receptor modulators - Mechanisms of action and application to clinical practice
    • Riggs BL and Hartmann LC: Selective estrogen-receptor modulators - mechanisms of action and application to clinical practice. N Engl J Med 348: 618-629, 2003.
    • (2003) N Engl J Med , vol.348 , pp. 618-629
    • Riggs, B.L.1    Hartmann, L.C.2
  • 9
    • 0033305438 scopus 로고    scopus 로고
    • Estrogen receptor null mice: What have we learned and where will they lead us?
    • Couse JF and Korach KS: Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20: 358-417, 1999.
    • (1999) Endocr Rev , vol.20 , pp. 358-417
    • Couse, J.F.1    Korach, K.S.2
  • 10
    • 0037192501 scopus 로고    scopus 로고
    • Molecular determinants for the tissue specificity of SERMs
    • Shang Y and Brown M: Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468, 2002.
    • (2002) Science , vol.295 , pp. 2465-2468
    • Shang, Y.1    Brown, M.2
  • 11
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • Mangelsdorf DJ, Thummel C, Beato M, et al: The nuclear receptor superfamily: the second decade. Cell 83: 835-839, 1995.
    • (1995) Cell , vol.83 , pp. 835-839
    • Mangelsdorf, D.J.1    Thummel, C.2    Beato, M.3
  • 12
    • 0041589541 scopus 로고    scopus 로고
    • Nuclear receptors: A rendezvous for chromatin remodeling factors
    • Belandia B and Parker MG: Nuclear receptors: a rendezvous for chromatin remodeling factors. Cell 114: 277-280, 2003.
    • (2003) Cell , vol.114 , pp. 277-280
    • Belandia, B.1    Parker, M.G.2
  • 13
    • 84870447931 scopus 로고    scopus 로고
    • Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodelling
    • Ming LG, Chen KM and Xian CJ: Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodelling. J Cell Physiol 228: 513-521, 2013.
    • (2013) J Cell Physiol , vol.228 , pp. 513-521
    • Ming, L.G.1    Chen, K.M.2    Xian, C.J.3
  • 14
    • 29244441174 scopus 로고    scopus 로고
    • Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells
    • Chen KM, Ge BF, Ma HP, et al: Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells. Pharmazie 60: 939-942, 2005.
    • (2005) Pharmazie , vol.60 , pp. 939-942
    • Chen, K.M.1    Ge, B.F.2    Ma, H.P.3
  • 15
    • 34249810332 scopus 로고    scopus 로고
    • Icariin inhibits the osteoclast formation induced by RANKL and macrophage-colony stimulating factor in mouse bone marrow culture
    • Chen KM, Ma HP, Ge BF, et al: Icariin inhibits the osteoclast formation induced by RANKL and macrophage-colony stimulating factor in mouse bone marrow culture. Pharmazie 62: 388-391, 2007.
    • (2007) Pharmazie , vol.62 , pp. 388-391
    • Chen, K.M.1    Ma, H.P.2    Ge, B.F.3
  • 16
    • 49949119153 scopus 로고    scopus 로고
    • Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents
    • Yamaza T, Miura Y, Bi Y, et al: Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. PLoS One 3: e2615, 2008.
    • (2008) PLoS One , vol.3 , pp. e2615
    • Yamaza, T.1    Miura, Y.2    Bi, Y.3
  • 17
    • 78651263812 scopus 로고    scopus 로고
    • Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE(2) synthesis
    • Hsieh TP, Sheu SY, Sun JS and Chen MH: Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE(2) synthesis. Phytomedicine 18: 176-185, 2011.
    • (2011) Phytomedicine , vol.18 , pp. 176-185
    • Hsieh, T.P.1    Sheu, S.Y.2    Sun, J.S.3    Chen, M.H.4
  • 18
    • 34548317241 scopus 로고    scopus 로고
    • Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro
    • Huang J, Yuan L, Wang X, et al: Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro. Life Sci 81: 832-840, 2007.
    • (2007) Life Sci , vol.81 , pp. 832-840
    • Huang, J.1    Yuan, L.2    Wang, X.3
  • 19
    • 80052279293 scopus 로고    scopus 로고
    • Comparative study on the osteogenic differentiation of rat bone marrow stromal cells effected by icariin and icariside II
    • In Chinese
    • Zhai YK, Ge BF and Ma HP: Comparative study on the osteogenic differentiation of rat bone marrow stromal cells effected by icariin and icariside II. Zhong Yao Cai 33: 1896-1900, 2010 (In Chinese).
    • (2010) Zhong Yao Cai , vol.33 , pp. 1896-1900
    • Zhai, Y.K.1    Ge, B.F.2    Ma, H.P.3
  • 20
    • 79251492979 scopus 로고    scopus 로고
    • Icariin promotes osteogenic differentiation of rat bone marrow stromal cells in vitro
    • In Chinese
    • Zhai YK, Ge BF and Ma HP: Icariin promotes osteogenic differentiation of rat bone marrow stromal cells in vitro. Zhongguo Zhong Yao Za Zhi 35: 3219-3222, 2010 (In Chinese).
    • (2010) Zhongguo Zhong Yao Za Zhi , vol.35 , pp. 3219-3222
    • Zhai, Y.K.1    Ge, B.F.2    Ma, H.P.3
  • 21
    • 79951804968 scopus 로고    scopus 로고
    • Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro
    • Ma HP, Ming LG and Ge BF: Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro. J Cell Biochem 112: 916-923, 2011.
    • (2011) J Cell Biochem , vol.112 , pp. 916-923
    • Ma, H.P.1    Ming, L.G.2    Ge, B.F.3
  • 22
    • 79959835117 scopus 로고    scopus 로고
    • Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro
    • Ming LG, Zhou J, Cheng GZ, et al: Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro. Pharmacology 88: 33-43, 2011.
    • (2011) Pharmacology , vol.88 , pp. 33-43
    • Ming, L.G.1    Zhou, J.2    Cheng, G.Z.3
  • 23
    • 77249175670 scopus 로고    scopus 로고
    • Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells
    • Mok SK, Chen WF and Lai WP: Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells, Br J Pharmacol 159: 939-949, 2010.
    • (2010) Br J Pharmacol , vol.159 , pp. 939-949
    • Mok, S.K.1    Chen, W.F.2    Lai, W.P.3
  • 24
    • 0346432628 scopus 로고
    • The determination of serum acid and alkaline phosphatase activity with 4-aminoantipyrine (A.A.P.)
    • Powell ME and Smith MJ: The determination of serum acid and alkaline phosphatase activity with 4-aminoantipyrine (A.A.P.). J Clin Pathol 7: 245-248, 1954.
    • (1954) J Clin Pathol , vol.7 , pp. 245-248
    • Powell, M.E.1    Smith, M.J.2
  • 25
    • 62549091847 scopus 로고    scopus 로고
    • Antiosteoporotic activity of icariin in ovariectomized rats
    • Nian H, Ma MH, Nian SS and Xu LL: Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 16: 320-326, 2009.
    • (2009) Phytomedicine , vol.16 , pp. 320-326
    • Nian, H.1    Ma, M.H.2    Nian, S.S.3    Xu, L.L.4
  • 26
    • 33747619425 scopus 로고    scopus 로고
    • The testosterone mimetic properties of icariin
    • Zhang ZB and Yang QT: The testosterone mimetic properties of icariin. Asian J Androl 8: 601-605, 2006.
    • (2006) Asian J Androl , vol.8 , pp. 601-605
    • Zhang, Z.B.1    Yang, Q.T.2
  • 27
    • 33845296134 scopus 로고    scopus 로고
    • Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells
    • Ning H, Xin ZC, Lin G, et al: Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology 68: 1350-1354, 2006.
    • (2006) Urology , vol.68 , pp. 1350-1354
    • Ning, H.1    Xin, Z.C.2    Lin, G.3
  • 28
    • 54149089653 scopus 로고    scopus 로고
    • Potent inhibition of human phosphodiesterase-5 by icariin derivatives
    • Dell'Agli M, Galli GV, Dal Cero E, et al: Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod 71: 1513-1517, 2008.
    • (2008) J Nat Prod , vol.71 , pp. 1513-1517
    • Dell'Agli, M.1    Galli, G.V.2    Dal Cero, E.3
  • 29
    • 34249280557 scopus 로고    scopus 로고
    • Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro
    • Xu HB and Huang ZQ: Icariin enhances endothelial nitric-oxide synthase expression on human endothelial cells in vitro. Vascul Pharmacol 47: 18-24, 2007.
    • (2007) Vascul Pharmacol , vol.47 , pp. 18-24
    • Xu, H.B.1    Huang, Z.Q.2
  • 30
    • 84860851569 scopus 로고    scopus 로고
    • Different molecular targets of icariin on bMSCs in CORT and OVX-rats
    • Bian Q, Huang JH, Liu SF, et al: Different molecular targets of icariin on bMSCs in CORT and OVX-rats. Front Biosci (Elite Ed) 4: 1224-1236, 2012.
    • (2012) Front Biosci (Elite Ed) , vol.4 , pp. 1224-1236
    • Bian, Q.1    Huang, J.H.2    Liu, S.F.3
  • 31
    • 0036842982 scopus 로고    scopus 로고
    • Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor-alpha depends on the coactivator subtype, the type of estrogen response element, and the promoter context
    • Barkhem T, Haldosén LA, Gustafsson JA and Nilsson S: Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor-alpha depends on the coactivator subtype, the type of estrogen response element, and the promoter context. Mol Endocrinol 16: 2571-2581, 2002.
    • (2002) Mol Endocrinol , vol.16 , pp. 2571-2581
    • Barkhem, T.1    Haldosén, L.A.2    Gustafsson, J.A.3    Nilsson, S.4
  • 32
    • 84859156397 scopus 로고    scopus 로고
    • Presenilin-2 modulation of ER-mitochondria interactions: FAD mutations, mechanisms and pathological consequences
    • Zampese E, Fasolato C, Pozzan T and Pizzo P: Presenilin-2 modulation of ER-mitochondria interactions: FAD mutations, mechanisms and pathological consequences. Commun Integr Biol 4: 357-360, 2011.
    • (2011) Commun Integr Biol , vol.4 , pp. 357-360
    • Zampese, E.1    Fasolato, C.2    Pozzan, T.3    Pizzo, P.4
  • 33
    • 77950021664 scopus 로고    scopus 로고
    • Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression
    • Hsieh TP, Sheu SY, Sun JS, et al: Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression. Phytomedicine 17: 414-423, 2011.
    • (2011) Phytomedicine , vol.17 , pp. 414-423
    • Hsieh, T.P.1    Sheu, S.Y.2    Sun, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.