Detection of Reactive Metabolites Using Isotope-Labeled Glutathione Trapping and Simultaneous Neutral Loss and Precursor Ion Scanning with Ultra-High-Pressure Liquid Chromatography Triple Quadruple Mass Spectrometry

Analytical Chemistry

Volumn 87, Issue 7, 2015, Pages 3646-3654

  Huang, Ke ^a   Huang, Lingyi ^a   Van Breemen, Richard B ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CHEMICAL ACTIVATION; CHROMATOGRAPHY; DIETARY SUPPLEMENTS; DRUG PRODUCTS; FILTRATION; FLAVONOIDS; FOOD ADDITIVES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPES; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; NEGATIVE IONS; NUTRITION; PEPTIDES; PLANTS (BOTANY); SPECTROMETRY; VITAMINS;

BOTANICAL DIETARY SUPPLEMENTS; CYTOCHROME P450 ENZYMES; ELECTROPHILIC SPECIES; ELEMENTAL COMPOSITIONS; HIGH RESOLUTION MASS SPECTROMETRY; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRIES; TRIPLE-QUADRUPOLE MASS SPECTROMETER; ULTRA HIGH PRESSURE LIQUID CHROMATOGRAPHY (UHPLC);

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

DRUG; GLUTATHIONE; PLANT EXTRACT;

GLYCYRRHIZA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE LABELING; LIVER MICROSOME; METABOLISM; METABOLOMICS; PROCEDURES; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUTATHIONE; GLYCYRRHIZA; HUMANS; ISOTOPE LABELING; METABOLOMICS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; PLANT EXTRACTS; TANDEM MASS SPECTROMETRY;

EID: 84926628661     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac504737x     Document Type: Article

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