Effects of cytochrome P450 inducers on 17α-ethinyloestradiol (EE2) conjugation by primary human hepatocytes

British Journal of Clinical Pharmacology

Volumn 48, Issue 5, 1999, Pages 733-742

  Li, A P ^a   Hartman, N R ^b   Lu, C ^a   Collins, J M ^b   Strong, J M ^b  

^a In Vitro Technologies Inc   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Conjugation; Drug drug interactions; Ethinyloestradiol; Glucuronidation; Hepatocytes; Human; Induction; Metabolism; Sulphation

Indexed keywords

2 HYDROXYESTRADIOL; 2 METHOXYESTRADIOL; 3 METHYLCHOLANTHRENE; CYTOCHROME P450; DEXAMETHASONE; DRUG METABOLITE; ENZYME ACTIVATOR; ETHINYLESTRADIOL; ETHINYLESTRADIOL GLUCURONIDE; ETHINYLESTRADIOL SULFATE; OMEPRAZOLE; PHENOBARBITAL; RIFAMPICIN; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG EFFECT; DRUG METABOLISM; DRUG SULFATION; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ETHINYL ESTRADIOL; FEMALE; HUMANS; LIVER; MALE; MIDDLE AGED; PROTEINS; SUBCELLULAR FRACTIONS;

EID: 0032727340     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00081.x     Document Type: Article

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