Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp)

Journal of Biological Chemistry

Volumn 290, Issue 15, 2015, Pages 9588-9603

  Jansson, Patric J ^a   Yamagishi, Tetsuo ^a   Arvind, Akanksha ^a   Seebacher, Nicole ^a   Gutierrez, Elaine ^a   Stacy, Alexandra ^a   Maleki, Sanaz ^a   Sharp, Danae ^a   Sahni, Sumit ^a   Richardson, Des R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CELLS; CYTOLOGY; CYTOTOXICITY; DISEASES; DRUG THERAPY; GLYCOPROTEINS; MAMMALS; MOBILE SECURITY; TUMORS;

ANTI-TUMOR ACTIVITIES; ANTI-TUMOR AGENTS; ATP-ASE ACTIVITY; DRUG RESISTANCE; LYSOSOMAL MEMBRANES; MULTIDRUG RESISTANCE; THIOSEMICARBAZONES; TRANSPORT ACTIVITY;

DIAGNOSIS;

2 BENZOYLPYRIDINE 4 ETHYL 3 THIOSEMICARBAZONE; ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; DI 2 PYRIDYLKETONE 4,4 DIMETHYL 3 THIOSEMICARBAZONE; DICHLORODIHYDROFLUORESCEIN DIACETATE; DOXORUBICIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; SMALL INTERFERING RNA; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE; DI-2-PYRIDYLKETONE-4,4-DIMETHYL-3-THIOSEMICARBAZONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELL TRANSPORT; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; FEMALE; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; TUMOR VOLUME; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; FLUORESCENCE MICROSCOPY; GENETICS; MCF 7 CELL LINE; METABOLISM; NUDE MOUSE; RNA INTERFERENCE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; WESTERN BLOTTING;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; FEMALE; HUMANS; LYSOSOMES; MCF-7 CELLS; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, FLUORESCENCE; P-GLYCOPROTEIN; RNA INTERFERENCE; THIOSEMICARBAZONES; VINBLASTINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84926617610     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.631283     Document Type: Article

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