Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial

PLoS Medicine

Volumn 12, Issue 3, 2015, Pages

  Lindesmith, Lisa C ^a   Ferris, Martin T ^b   Mullan, Clancy W ^b   Ferreira, Jennifer ^c   Debbink, Kari ^a   Swanstrom, Jesica ^a   Richardson, Charles ^d   Goodwin, Robert R ^d   Baehner, Frank ^e   Mendelman, Paul M ^d   Bargatze, Robert F ^d   Baric, Ralph S ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c EMMES CORPORATION   (United States)

^d Takeda Vaccines   (United States)

^e Takeda Pharmaceuticals International GmbH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; NOROVIRUS VIRUS LIKE PARTICLE CANDIDATE VACCINE; PLACEBO; UNCLASSIFIED DRUG; VIRUS LIKE PARTICLE VACCINE; ANTIBODY; IMMUNOGLOBULIN G; VIRUS VACCINE;

ADULT; AGED; ANTIBODY RESPONSE; ARTICLE; CROSS REACTION; DRUG DOSE ESCALATION; DRUG RESPONSE; ENZYME IMMUNOASSAY; FOLLOW UP; GENOTYPE; HUMAN; IMMUNIZATION; LIMIT OF DETECTION; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PHASE 1 CLINICAL TRIAL; VERY ELDERLY; ANTIBODY PRODUCTION; BLOOD; CALICIVIRIDAE INFECTIONS; CLASSIFICATION; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GASTROENTERITIS; IMMUNOLOGY; MALE; MIDDLE AGED; NOROVIRUS; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; SPECIES DIFFERENCE; VACCINATION; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; ANTIBODY FORMATION; CALICIVIRIDAE INFECTIONS; EPITOPES; FEMALE; GASTROENTERITIS; HEALTHY VOLUNTEERS; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; NOROVIRUS; REFERENCE VALUES; SPECIES SPECIFICITY; VACCINATION; VIRAL VACCINES; YOUNG ADULT;

EID: 84926483167     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001807     Document Type: Article

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