메뉴 건너뛰기




Volumn 6, Issue FEB, 2015, Pages

Homer2 deletion alters dendritic spine morphology but not alcohol-associated adaptations in GluN2B-containing N-methyl-D-aspartate receptors in the nucleus accumbens

Author keywords

Cellular morphology; Dendritic spines; Homer2; Nucleus accumbens; Postsynaptic density; Structural plasticity

Indexed keywords

ALCOHOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN HOMER 2;

EID: 84926434643     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00028     Document Type: Article
Times cited : (11)

References (43)
  • 1
    • 46249108210 scopus 로고    scopus 로고
    • The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting
    • Aldridge, G. M., Podrebarac, D. M., and Greenough, W. T. (2008). The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting. J. Neurosci. Methods 172, 250-254. doi: 10.1016/j.jneumeth.2008.05.003
    • (2008) J. Neurosci. Methods , vol.172 , pp. 250-254
    • Aldridge, G.M.1    Podrebarac, D.M.2    Greenough, W.T.3
  • 2
    • 84867125875 scopus 로고    scopus 로고
    • Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses
    • Arnsten, A., Wang, M. J., and Paspalas, C. D. (2012). Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron 76, 223-239. doi: 10.1016/j.neuron.2012.08.038
    • (2012) Neuron , vol.76 , pp. 223-239
    • Arnsten, A.1    Wang, M.J.2    Paspalas, C.D.3
  • 3
    • 34249933982 scopus 로고    scopus 로고
    • Do thin spines learn to be mushroom spines that remember? Curr
    • Bourne, J., and Harris, K. M. (2007). Do thin spines learn to be mushroom spines that remember? Curr. Opin. Neurobiol. 17, 381-386. doi: 10.1016/j.conb.2007.04.009
    • (2007) Opin. Neurobiol. , vol.17 , pp. 381-386
    • Bourne, J.1    Harris, K.M.2
  • 4
    • 0034284106 scopus 로고    scopus 로고
    • Ethanol intake is not elevated in male 5-HT1B receptor knockout mice
    • Bouwknecht, J. A., Hijzen, T. H., and van der Gugten, J. (2000). Ethanol intake is not elevated in male 5-HT1B receptor knockout mice. Eur. J. Pharmacol. 403, 95-98. doi: 10.1016/S0014-2999(00)00527-6
    • (2000) Eur. J. Pharmacol. , vol.403 , pp. 95-98
    • Bouwknecht, J.A.1    Hijzen, T.H.2    van der Gugten, J.3
  • 5
    • 33845622080 scopus 로고    scopus 로고
    • Homeostatic plasticity during alcohol exposure promotes enlargement of dendritic spines
    • Carpenter-Hyland, E., and Chandler, L. (2006). Homeostatic plasticity during alcohol exposure promotes enlargement of dendritic spines. Eur. J. Neurosci. 24, 34963506. doi: 10.1111/j.1460-9568.2006.05247.x
    • (2006) Eur. J. Neurosci. , vol.24
    • Carpenter-Hyland, E.1    Chandler, L.2
  • 6
    • 33847156450 scopus 로고    scopus 로고
    • Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addiction
    • Carpenter-Hyland, E., and Chandler, L. (2007). Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addiction. Pharmacol. Biochem. Behav. 86, 200208. doi: 10.1016/j.pbb.2007.01.016
    • (2007) Pharmacol. Biochem. Behav. , vol.86
    • Carpenter-Hyland, E.1    Chandler, L.2
  • 7
    • 84865965127 scopus 로고    scopus 로고
    • Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures
    • Cozzoli, D. K., Courson, J., Caruana, A. L., Miller, B. W., Greentree, D. I., Thompson, A. B., et al. (2012). Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Alcohol. Clin. Exp. Res. 36, 1623-1633. doi: 10.1111/j.1530-0277.2012.01776.x
    • (2012) Alcohol. Clin. Exp. Res. , vol.36 , pp. 1623-1633
    • Cozzoli, D.K.1    Courson, J.2    Caruana, A.L.3    Miller, B.W.4    Greentree, D.I.5    Thompson, A.B.6
  • 8
    • 34548636072 scopus 로고    scopus 로고
    • PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors
    • Cui, H., Hayashi, A., Sun, H.-S., Belmares, M. P., Cobey, C., Phan, T., et al. (2007). PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J. Neurosci. 27, 9901-9915. doi: 10.1523/JNEUROSCI.1464-07.2007
    • (2007) J. Neurosci. , vol.27 , pp. 9901-9915
    • Cui, H.1    Hayashi, A.2    Sun, H.-S.3    Belmares, M.P.4    Cobey, C.5    Phan, T.6
  • 9
    • 33746738785 scopus 로고    scopus 로고
    • ß-Actin is not a reliable loading control in Western blot analysis
    • Dittmer, A., and Dittmer, J. (2006). ß-Actin is not a reliable loading control in Western blot analysis. Electrophoresis 27, 2844-2845. doi: 10.1002/elps.200500785
    • (2006) Electrophoresis , vol.27 , pp. 2844-2845
    • Dittmer, A.1    Dittmer, J.2
  • 10
    • 84901455026 scopus 로고    scopus 로고
    • Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex
    • Gass, J. T., Trantham-Davidson, H., Kassab, A. S., Glen, W. B., Olive, M. F., and Chandler, L. J. (2014). Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex. J. Neurosci. 34, 7562-7574. doi: 10.1523/JNEUROSCI.5616-12.2014
    • (2014) J. Neurosci. , vol.34 , pp. 7562-7574
    • Gass, J.T.1    Trantham-Davidson, H.2    Kassab, A.S.3    Glen, W.B.4    Olive, M.F.5    Chandler, L.J.6
  • 11
    • 78751695049 scopus 로고    scopus 로고
    • Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking?
    • Goulding, S. P., Obara, I., Lominac, K. D., Gould, A. T., Miller, B. W., Klugmann, M., et al. (2011). Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking? Genes Brain Behav. 10, 111-126. doi: 10.1111/j.1601-183X.2010.00647.x
    • (2011) Genes Brain Behav. , vol.10 , pp. 111-126
    • Goulding, S.P.1    Obara, I.2    Lominac, K.D.3    Gould, A.T.4    Miller, B.W.5    Klugmann, M.6
  • 12
    • 64949181146 scopus 로고    scopus 로고
    • Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice
    • Gremel, C. M., and Cunningham, C. L. (2009). Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice. Neuropsychopharmacology 34, 1443-1453. doi: 10.1038/npp.2008.179
    • (2009) Neuropsychopharmacology , vol.34 , pp. 1443-1453
    • Gremel, C.M.1    Cunningham, C.L.2
  • 13
    • 84892669236 scopus 로고    scopus 로고
    • Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice
    • Griffin, W. C. III, Haun, H. L., Hazelbaker, C. L., Ramachandra, V. S., and Becker, H. C. (2014). Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice. Neuropsychopharmacology 39, 707-717. doi: 10.1038/npp.2013.256
    • (2014) Neuropsychopharmacology , vol.39 , pp. 707-717
    • Griffin, W.C.1    Haun, H.L.2    Hazelbaker, C.L.3    Ramachandra, V.S.4    Becker, H.C.5
  • 14
    • 33745562839 scopus 로고    scopus 로고
    • Experience-dependent and cell-type-specific spine growth in the neocortex
    • Holtmaat, A., Wilbrecht, L., Knott, G. W., and Welker, E. (2006). Experience-dependent and cell-type-specific spine growth in the neocortex. Nature 441, 979-983. doi: 10.1038/nature04783
    • (2006) Nature , vol.441 , pp. 979-983
    • Holtmaat, A.1    Wilbrecht, L.2    Knott, G.W.3    Welker, E.4
  • 15
    • 0014568057 scopus 로고
    • Morphological variations in the dendritic spines of the neocortex.
    • Jones, E. G., and Powell, T. P. (1969). Morphological variations in the dendritic spines of the neocortex. J. Cell Sci. 5, 509-529.
    • (1969) J. Cell Sci. , vol.5 , pp. 509-529
    • Jones, E.G.1    Powell, T.P.2
  • 16
    • 84872143318 scopus 로고    scopus 로고
    • Constitutive knockout of the membrane cytoskeleton protein beta adducing decreases mushroom spine density in the nucleus accumbens but does not prevent spine remodeling in response to cocaine
    • Jung, Y., Mulholland, P. J., Wiseman, S. L., Chandler, L. J., and Picciotto, M. R. (2013). Constitutive knockout of the membrane cytoskeleton protein beta adducing decreases mushroom spine density in the nucleus accumbens but does not prevent spine remodeling in response to cocaine. Eur. J. Neurosci. 31, 1-9. doi: 10.1111/ejn.12037
    • (2013) Eur. J. Neurosci. , vol.31 , pp. 1-9
    • Jung, Y.1    Mulholland, P.J.2    Wiseman, S.L.3    Chandler, L.J.4    Picciotto, M.R.5
  • 17
    • 67651083577 scopus 로고    scopus 로고
    • The glutamate homeostasis hypothesis of addiction
    • Kalivas, P. W. (2009). The glutamate homeostasis hypothesis of addiction. Nat. Rev. Neurosci. 10, 561-572. doi: 10.1038/nrn2515
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 561-572
    • Kalivas, P.W.1
  • 18
    • 20244389989 scopus 로고    scopus 로고
    • Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations.
    • Kelly, M. A., Rubinstein, M., and Phillips, T. J. (1998). Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J. Neurosci. 18, 3470-3479.
    • (1998) J. Neurosci. , vol.18 , pp. 3470-3479
    • Kelly, M.A.1    Rubinstein, M.2    Phillips, T.J.3
  • 19
    • 33746526525 scopus 로고    scopus 로고
    • Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia
    • Kristiansen, L. V., Beneyto, M., Haroutunian, V., and Meador-Woodruff, J. H. (2006). Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia. Mol. Psychiatry 11, 737-747. doi: 10.1038/sj.mp.4001844
    • (2006) Mol. Psychiatry , vol.11 , pp. 737-747
    • Kristiansen, L.V.1    Beneyto, M.2    Haroutunian, V.3    Meador-Woodruff, J.H.4
  • 20
    • 84893846395 scopus 로고    scopus 로고
    • mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions
    • Lum, E. N., Campbell, R. R., Rostock, C., and Szumlinski, K. K. (2014). mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions. Neuropharmacology 79, 679-687. doi: 10.1016/j.neuropharm.2014.01.024
    • (2014) Neuropharmacology , vol.79 , pp. 679-687
    • Lum, E.N.1    Campbell, R.R.2    Rostock, C.3    Szumlinski, K.K.4
  • 21
    • 84922653048 scopus 로고    scopus 로고
    • Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice
    • McGuier, N. S., Padula, A. E., Lopez, M. F., Woodward, J. J., and Mulholland, P. J. (2014). Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice. Alcohol 49, 21-27. doi: 10.1016/j.alcohol.2014.07.017
    • (2014) Alcohol , vol.49 , pp. 21-27
    • McGuier, N.S.1    Padula, A.E.2    Lopez, M.F.3    Woodward, J.J.4    Mulholland, P.J.5
  • 22
    • 79952543432 scopus 로고    scopus 로고
    • Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses
    • Mulholland, P. J., Becker, H. C., Woodward, J. J., and Chandler, L. J. (2011). Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biol. Psychiatry 69, 625-632. doi: 10.1016/j.biopsych.2010.09.025
    • (2011) Biol. Psychiatry , vol.69 , pp. 625-632
    • Mulholland, P.J.1    Becker, H.C.2    Woodward, J.J.3    Chandler, L.J.4
  • 23
    • 41949108797 scopus 로고    scopus 로고
    • Alcohol related changes in regulation of NMDA receptor functions
    • Nagy, J. (2008). Alcohol related changes in regulation of NMDA receptor functions. Curr. Neuropharmacol. 6, 39-54. doi: 10.2174/157015908783769662
    • (2008) Curr. Neuropharmacol. , vol.6 , pp. 39-54
    • Nagy, J.1
  • 24
    • 0032927824 scopus 로고    scopus 로고
    • Ethanol consumption and place preference conditioning in the alcohol preferring C57BL/6 mouse: relationship with motor activity patterns.
    • Nocjar, C., Middaugh, L. D., and Tavernetti, M. (1999). Ethanol consumption and place preference conditioning in the alcohol preferring C57BL/6 mouse: relationship with motor activity patterns. Alcohol. Clin. Exp. Res. 23, 683-692.
    • (1999) Alcohol. Clin. Exp. Res. , vol.23 , pp. 683-692
    • Nocjar, C.1    Middaugh, L.D.2    Tavernetti, M.3
  • 25
    • 70350507405 scopus 로고    scopus 로고
    • Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats
    • Obara, I., Bell, R. L., Goulding, S. P., Reyes, C. M., Larson, L. A., Ary, A. W., et al. (2009). Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Alcohol. Clin. Exp. Res. 33, 1924-1934. doi: 10.1111/j.1530-0277.2009.01030.x
    • (2009) Alcohol. Clin. Exp. Res. , vol.33 , pp. 1924-1934
    • Obara, I.1    Bell, R.L.2    Goulding, S.P.3    Reyes, C.M.4    Larson, L.A.5    Ary, A.W.6
  • 27
    • 0033989483 scopus 로고    scopus 로고
    • Complications associated with genetic background effects in research using knockout mice
    • Phillips, T. J., Hen, R., and Crabbe, J. C. (1999). Complications associated with genetic background effects in research using knockout mice. Psychopharmacology (Berl.) 147, 5-7. doi: 10.1007/s002130051128
    • (1999) Psychopharmacology (Berl.) , vol.147 , pp. 5-7
    • Phillips, T.J.1    Hen, R.2    Crabbe, J.C.3
  • 28
    • 0023232857 scopus 로고
    • Enzymic ethanol assay: a new colorimetric method based on measurement of hydrogen peroxide.
    • Prencipe, L., Iaccheri, E., and Manzati, C. (1987). Enzymic ethanol assay: a new colorimetric method based on measurement of hydrogen peroxide. Clin. Chem. 33, 486-489.
    • (1987) Clin. Chem. , vol.33 , pp. 486-489
    • Prencipe, L.1    Iaccheri, E.2    Manzati, C.3
  • 29
    • 0034879863 scopus 로고    scopus 로고
    • Regulation of dendritic spine morphology and synaptic function by Shank and Homer
    • Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., and Liu, G. (2002). Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron 31, 115-130. doi: 10.1016/S0896-6273(01)00339-7
    • (2002) Neuron , vol.31 , pp. 115-130
    • Sala, C.1    Piëch, V.2    Wilson, N.R.3    Passafaro, M.4    Liu, G.5
  • 30
    • 18244374184 scopus 로고    scopus 로고
    • Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons
    • Sala, C., Roussignol, G., and Meldolesi, J. (2005). Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons. J. Neurosci. 25, 4587-4592. doi: 10.1523/JNEUROSCI.4822-04.2005
    • (2005) J. Neurosci. , vol.25 , pp. 4587-4592
    • Sala, C.1    Roussignol, G.2    Meldolesi, J.3
  • 31
    • 0034916230 scopus 로고    scopus 로고
    • PDZ domains and the organization of supramolecular complexes
    • Sheng, M., and Sala, C. (2001). PDZ domains and the organization of supramolecular complexes. Annu. Rev. Neurosci. 24, 1-29. doi: 10.1146/annurev.neuro.24.1.1
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 1-29
    • Sheng, M.1    Sala, C.2
  • 32
    • 0042672922 scopus 로고    scopus 로고
    • Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCß GAP activities
    • Shin, D. M., Dehoff, M., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., et al. (2003). Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCß GAP activities. J. Cell Biol. 162, 293-303. doi: 10.1083/jcb.200210109
    • (2003) J. Cell Biol. , vol.162 , pp. 293-303
    • Shin, D.M.1    Dehoff, M.2    Luo, X.3    Kang, S.H.4    Tu, J.5    Nayak, S.K.6
  • 33
  • 34
    • 64549087145 scopus 로고    scopus 로고
    • Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines
    • Shiraishi-Yamaguchi, Y., Sato, Y., and Sakai, R. (2009). Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines. BMC Neurosci. 10:25. doi: 10.1186/1471-2202-10-25
    • (2009) BMC Neurosci. , vol.10 , pp. 25
    • Shiraishi-Yamaguchi, Y.1    Sato, Y.2    Sakai, R.3
  • 36
    • 84907228219 scopus 로고    scopus 로고
    • Hampered long-term depression and thin spine loss in the nucleus accumbens of ethanol-dependent rats
    • Spiga, S., Talani, G., Mulas, G., and Licheri, V. (2014). Hampered long-term depression and thin spine loss in the nucleus accumbens of ethanol-dependent rats. Proc. Natl. Acad. Sci. U.S.A. 111, 3745-3754. doi: 10.1073/pnas.1406768111
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 3745-3754
    • Spiga, S.1    Talani, G.2    Mulas, G.3    Licheri, V.4
  • 37
    • 4043082754 scopus 로고    scopus 로고
    • Homer proteins regulate sensitivity to cocaine
    • Szumlinski, K. K., Dehoff, M. H., Kang, S. H., and Frys, K. A. (2004). Homer proteins regulate sensitivity to cocaine. Neuron 43, 401-413. doi: 10.1016/j.neuron.2004.07.019
    • (2004) Neuron , vol.43 , pp. 401-413
    • Szumlinski, K.K.1    Dehoff, M.H.2    Kang, S.H.3    Frys, K.A.4
  • 39
    • 0345932930 scopus 로고    scopus 로고
    • Repeated cocaine administration changes the function and subcellular distribution of adenosine A1 receptor in the rat nucleus accumbens
    • Toda, S., Alguacil, L. F., and Kalivas, P. W. (2003). Repeated cocaine administration changes the function and subcellular distribution of adenosine A1 receptor in the rat nucleus accumbens. J. Neurochem. 87, 1478-1484. doi: 10.1046/j.1471-4159.2003.02121.x
    • (2003) J. Neurochem. , vol.87 , pp. 1478-1484
    • Toda, S.1    Alguacil, L.F.2    Kalivas, P.W.3
  • 40
    • 37149006927 scopus 로고    scopus 로고
    • Regulation of spine morphology and spine density by NMDA receptor signaling in vivo
    • Ultanir, S. K., Kim, J. E., and Hall, B. J. (2007). Regulation of spine morphology and spine density by NMDA receptor signaling in vivo. Proc. Natl. Acad. Sci. U.S.A. 104, 19553-19558. doi: 10.1073/pnas.0704031104
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 19553-19558
    • Ultanir, S.K.1    Kim, J.E.2    Hall, B.J.3
  • 41
    • 84926498213 scopus 로고    scopus 로고
    • Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines.
    • In press
    • Uys, J. D., McGuier, N. S., Gass, J. T., Griffin, W. C. III., Ball, L. E., and Mulholland, P. J. (in press). Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict. Bio.
    • Addict. Bio.
    • Uys, J.D.1    McGuier, N.S.2    Gass, J.T.3    Griffin, W.C.4    Ball, L.E.5    Mulholland, P.J.6
  • 42
    • 18544393408 scopus 로고    scopus 로고
    • Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins
    • Xiao, B., Tu, J. C., Petralia, R. S., Yuan, J. P., and Doan, A. (1998). Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21, 707-716. doi: 10.1016/S0896-6273(00)80588-7
    • (1998) Neuron , vol.21 , pp. 707-716
    • Xiao, B.1    Tu, J.C.2    Petralia, R.S.3    Yuan, J.P.4    Doan, A.5
  • 43
    • 33846345905 scopus 로고    scopus 로고
    • Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens
    • Zhou, F. C., Anthony, B., Dunn, K. W., Lindquist, W. B., and Xu, Z. C. (2007). Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens. Brain Res. 1134, 148-161. doi: 10.1016/j.brainres.2006.11.046
    • (2007) Brain Res. , vol.1134 , pp. 148-161
    • Zhou, F.C.1    Anthony, B.2    Dunn, K.W.3    Lindquist, W.B.4    Xu, Z.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.