MGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions

Neuropharmacology

Volumn 79, Issue , 2014, Pages 679-687

  Lum, Emily N ^a   Campbell, Rianne R ^a   Rostock, Charlotte ^a   Szumlinski, Karen K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Binge drinking; Ethanol; Homer2; mGluR1; Nucleus accumbens; Phospholipase C

Indexed keywords

(3,4-DIHYDRO-2H-PYRANO(2,3)B-QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL) METHANONE; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; ALCOHOL; AMINO ACID RECEPTOR BLOCKING AGENT; CARRIER PROTEIN; CENTRAL DEPRESSANT AGENT; ENZYME INHIBITOR; ESTRANE DERIVATIVE; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR; PHOSPHOLIPASE C; PROTEIN HOMER; QUINOLINE DERIVATIVE; SUCROSE;

ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG EFFECTS; DRUG THERAPY; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MOTIVATION; MOUSE; NUCLEUS ACCUMBENS; PHYSIOLOGY; REINFORCEMENT;

ALCOHOL DRINKING; ANIMALS; CARRIER PROTEINS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING BEHAVIOR; ENZYME INHIBITORS; ESTRENES; ETHANOL; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTIVATION; NUCLEUS ACCUMBENS; PYRROLIDINONES; QUINOLINES; RECEPTORS, METABOTROPIC GLUTAMATE; REINFORCEMENT (PSYCHOLOGY); SUCROSE; TYPE C PHOSPHOLIPASES;

EID: 84893846395     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.024     Document Type: Article

References (42)

1. F. Ango, L. Prézeau, T. Muller, J.C. Tu, B. Xiao, P.F. Worley, J.P. Pin, J. Bockaert, and L. Fagni Agonist-independent activation of metabotropic glutamate receptors by the intracellular (Pubitemid 32601494)
2. A.W. Ary, K.D. Lominac, M.G. Wroten, A.R. Williams, R.R. Campbell, O. Ben-Shahar, G. von Jonquieres, M. Klugmann, and K.K. Szumlinski Imbalances in prefrontal cortex CC-Homer1 versus -Homer2 expression promote cocaine-seeking behavior J. Neurosci. 33 2013 8101 8113
3. O. Ben-Shahar, A.D. Sacramento, B.W. Miller, S.M. Webb, M.G. Wroten, and H.E. Silva et al. Deficits in ventral prefrontal cortex Group1 metabotropic glutamate receptor function mediate resistance to extinction during protracted withdrawal from an extensive history of cocaine self-administration J. Neurosci. 33 2013 495 506
4. J. Besheer, S. Faccidomo, J.J. Grondin, and C.W. Hodge Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats Alcohol Clin. Exp. Res. 32 2008 209 221
5. J. Besheer, S. Faccidomo, J.J. Grondin, and C.W. Hodge Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats Alcohol. 42 2008 13 20
6. Y.A. Blednov, R.D. Mayfield, J. Belknap, and R.A. Harris Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data Genes Brain Behav. 11 2012 424 435
7. M.K. Bird, and A.J. Lawrence Group I metabotropic glutamate receptors: involvement in drug-seeking and drug-induced plasticity Curr. Mol. Pharmacol. 2 2009 83 94
8. M.D. Cassell, L.J. Freedman, and C. Shi The intrinsic organization of the central extended amygdala Ann N Y Acad Sci. 877 1999 217 241 (Pubitemid 29351860)
9. R.M. Cleva, J.T. Gass, J.J. Widholm, and M.F. Olive Glutamatergic targets for enhancing extinction learning in drug addiction Curr Neuropharmacol. 8 2010 394 408
10. D.K. Cozzoli, J. Courson, A.L. Caruana, B.W. Miller, A.B. Thompson, M. Wroten, P.W. Zhang, B. Xiao, J.-H. Hu, M. Klugmann, P. Metten, P.W. Worley, J.C. Crabbe, and K.K. Szumlinski Accumbens shell metabotropic glutamate receptor 5-associated signaling regulates binge alcohol drinking: evidence from Drinking-in-the-Dark studies Alcohol Clin. Exp. Res. 36 2012 1623 1633
11. D.K. Cozzoli, J. Courson, M.G. Wroten, D.I. Greentree, E.N. Lum, R.R. Campbell, A.B. Thompson, P.F. Worley, G. Jonquieres, M. Klugmann, D.A. Finn, and K.K. Szumlinski Binge alcohol drinking by mice requires intact Group1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala Neuropsychopharmacology 2013 (in press)
12. D.K. Cozzoli, S.P. Goulding, P.W. Zhang, B. Xiao, J.-H. Hu, A.W. Ary, I. Obara, A. Rahn, H. Abou-Ziab, B. Tyrrel, C. Marini, N. Yoneyama, P. Metten, C. Snelling, M.H. Dehoff, J.C. Crabbe, D.A. Finn, M. Klugmann, P.F. Worley, and K.K. Szumlinski Binge drinking up-regulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism J. Neurosci. 29 2009 8655 8668
13. J.C. Crabbe, P. Metten, J.S. Rhodes, C.H. Yu, L.L. Brown, T.J. Phillips, and D.A. Finn A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication Biol. Psychiatry 65 2009 662 670
14. L. Fagni, P.F. Worley, and F. Ango Homer as both a scaffold and transduction molecule Sci STKE 2002 2002 re8
15. D.A. Finn, J.K. Belknap, K. Cronise, N. Yoneyama, A. Murillo, and J.C. Crabbe A procedure to produce high alcohol intake in mice Psychopharmacology (Berl) 178 2005 471 480 (Pubitemid 40486987)
16. J.T. Gass, and M.F. Olive Role of protein kinase C epsilon (PKCε) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell Psychopharmacology (Berl) 204 2009 587 597
17. S.P. Goulding, I. Obara, K.D. Lominac, A.T. Gould, B.W. Miller, M. Klugmann, and K.K. Szumlinski Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking? Genes Brain Behav. 10 1 2011 Feb 111 126
18. C.W. Hodge, M.F. Miles, A.C. Sharko, R.A. Stevenson, J.R. Hillmann, V. Lepoutre, J. Besheer, and J.P. Schroeder The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice Psychopharmacology (Berl) 183 2006 429 438 (Pubitemid 41721144)
19. P.J. Kammermeier, B. Xiao, J.C. Tu, P.F. Worley, and S.R. Ikeda Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels J. Neurosci. 20 2000 7238 7245
20. M. Kapoor, J.C. Wang, L. Wetherill, N. Le, S. Bertelsen, A.L. Hinrichs, J. Budde, A. Agrawal, K. Bucholz, D. Dick, O. Harari, V. Hesselbrock, J. Kramer, J.I. Nurnberger Jr., J. Rice, N. Saccone, M. Schuckit, J. Tischfield, B. Porjesz, H.J. Edenberg, L. Bierut, T. Foroud, and A. Goate A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks Hum. Genet. 132 2013 1141 1151
21. S. Litschig et al. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding Mol. Pharmacol. 55 1999 453 461 (Pubitemid 29128101)
22. K.D. Lominac, Z. Kapasova, R.A. Hannun, C. Patterson, L.D. Middaugh, and K.K. Szumlinski Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties Drug. Alcohol Dep. 85 2006 142 156 (Pubitemid 44441668)
23. K. Minami, R.W. Gereau 4th, M. Minami, S.F. Heinemann, and R.A. Harris Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes Mol. Pharmacol. 53 1998 148 156 (Pubitemid 28068383)
24. E.M. Moore, and S.L. Boehm 2nd Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice Behav. Neurosci. 123 2009 555 563
25. P.M. Newton, and R.O. Messing The substrates and binding partners of protein kinase Cepsilon Biochem. J. 427 2010 189 196
26. C.M. Niswender, and J.P. Pin Metabotropic glutamate receptors: physiology, pharmacology and disease Annu Rev. Pharmacol. Toxicol. 2010 50 2010 295 322
27. I. Obara, R.L. Bell, S.P. Goulding, C.M. Reyes, L.A. Larson, A.W. Ary, W.A. Truitt, and K.K. Szumlinski Subregional selectivity in the effects of alcohol withdrawal upon Homer/glutamate receptor expression in the accumbens and amygdala of P rats Alcohol Clin. Exp. Res. 33 2009 1924 1934
28. M.F. Olive Metabotropic glutamate receptor ligands as potential therapeutics for addiction Curr Drug Abuse Rev. 2 2009 83 98
29. M.F. Olive, R.M. Cleva, P.W. Kalivas, and R.J. Malcolm Glutamatergic medications for the treatment of drug and behavioral addictions Pharmacol. Biochem. Behav. 100 2012 801 810
30. G. Paxinos, and K.B.J. Franklin The mouse brain in stereotaxic coordinates 2004 Academic Press Maryland Heights, MO
31. J.S. Rhodes, K. Best, J.K. Belknap, D.A. Finn, and J.C. Crabbe Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice Physiol. Behav. 84 2005 53 63 (Pubitemid 40092065)
32. R. Rong, J.-Y. Ahn, H. Huang, E. Nagata, D. Kalman, and J.A. Kapp et al. PI3 kinase enhancer-Homer complex couples mGluR1 to PI3 kinase, preventing neuronal apoptosis Nat. Neurosci. 6 2003 1153 1161 (Pubitemid 37346035)
33. J.P. Schroeder, D.H. Overstreet, and C.W. Hodge The mGluR5 antagonist MPEP decreases operant self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats Psychopharmacology (Berl) 179 2005 262 270 (Pubitemid 40576714)
34. M.A. Schuckit, T.L. Smith, and J. Kalmijn Findings across subgroups regarding the level of response to alcohol as a risk factor for alcohol use disorders: a college population of women and Latinos Alcohol Clin. Exp. Res. 28 2004 1499 1508 (Pubitemid 39390471)
35. Y. Shiraishi-Yamaguchi, and T. Furuichi The Homer family proteins Genome Biol. 8 2007 206
36. K.K. Szumlinski, K.E. Abernathy, E.B. Oleson, M. Klugmann, K.D. Lominac, D.-Y. He, D. Ron, M.T. During, and P.W. Kalivas Homer isoforms differentially regulate cocaine-induced neuroplasticity Neuropsychopharmacology 31 2006 768 777
37. K.K. Szumlinski, A.W. Ary, K.D. Lominac, M. Klugmann, and T.E. Kippin Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice Neuropsychopharmacology 33 2008 1365 1378 (Pubitemid 351521705)
38. K.K. Szumlinski, A.W. Ary, K.D. Lominac, M. Klugmann, and T.E. Kippin Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice Neuropsychopharmacology 33 2008 1365 1378 (Pubitemid 351521705)
39. K.K. Szumlinski, M.H. Dehoff, S.H. Kang, K.A. Frys, K.D. Lominac, J. Rohrer, W. Griffin III, M. Klugmann, S. Toda, N.P. Champtiaux, T. Berry, S. Shealy, M. During, L.D. Middaugh, P.F. Worley, and P.W. Kalivas Homer proteins regulate vulnerability to cocaine Neuron 43 2004 401 413 (Pubitemid 39061131)
40. K.K. Szumlinski, K.D. Lominac, E.B. Oleson, J.K. Walker, A. Mason, M.H. Dehoff, M. Klugmann, S. Cagle, K. Welt, M. During, P.F. Worley, L.D. Middaugh, and P.W. Kalivas Homer2 is necessary for EtOH-induced neuroplasticity J. Neurosci. 25 2005 7054 7061 (Pubitemid 41077014)
41. 2+ signaling by excitable and non-excitable cells Cell. Calcium 42 2007 363 371 (Pubitemid 47264010)
42. X. Xie, D.R. Ramirez, H.C. Lasseter, and R.A. Fuchs Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats Psychopharmacology (Berl) 208 2010 1 11