Invariant nkt cells act as an adjuvant to enhance th2 inflammatory response in an ova-induced mouse model of asthma

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Nie, Hanxiang ^a   Yang, Qiaoyu ^a   Zhang, Guqin ^b   Wang, Ailing ^c   He, Qing ^a   Liu, Min ^a   Li, Ping ^b   Yang, Jiong ^b   Huang, Yi ^a   Ding, Xuhong ^a   Yu, Hongying ^a   Hu, Suping ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; ALPHA-GALACTOSYLCERAMIDE; CD1D ANTIGEN; GALACTOSYLCERAMIDE; OVALBUMIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL CULTURE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INFLAMMATORY CELL; INVARIANT NATURAL KILLER T CELL; MOUSE; NATURAL KILLER T CELL; NONHUMAN; T LYMPHOCYTE ACTIVATION; TH2 CELL; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; METABOLISM;

MURINAE; MUS;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD1D; ASTHMA; DISEASE MODELS, ANIMAL; FEMALE; GALACTOSYLCERAMIDES; INFLAMMATION; MICE; MICE, INBRED BALB C; NATURAL KILLER T-CELLS; OVALBUMIN; TH2 CELLS;

EID: 84926433401     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119901     Document Type: Article

References (26)

1. Kim HY, DeKruyff RH, Umetsu DT. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol. 2010; 11:577-584. doi: 10.1038/ni.1892 PMID: 20562844
2. Thomas SY, Chyung YH, Luster AD. Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma. J Allergy Clin Immunol. 2010; 125:980-984. doi: 10.1016/j.jaci. 2010.01.032 PMID: 20304475
3. Balato A, Unutmaz D, Gaspari AA. Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions. J Invest Dermatol. 2009; 129: 1628-1642. doi: 10.1038/jid.2009.30 PMID: 19262602
4. + invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med. 2006; 354:1117-1129. PMID: 16540612
5. Matangkasombut P, Marigowda G, Ervine A, Idris L, Pichavant M, Kim HY, et al. Natural killer T cells in the lungs of patients with asthma. J Allergy Clin Immunol. 2009; 123:1181-1185. doi: 10.1016/j.jaci. 2009.02.013 PMID: 19356791
6. Reynolds C, Barkans J, Clark P, Kariyawasam H, Altmann D, Kay B, et al. Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma. J Allergy Clin Immunol. 2009; 124:860-862. doi: 10.1016/j.jaci.2009.07.022 PMID: 19767076
7. Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, et al. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen- induced airway hyperreactivity. Nat Med. 2003; 9:582-588. PMID: 12669034
8. Lisbonne M, Diem S, de Castro Keller A, Lefort J, Araujo LM, Hachem P, et al. Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Immunol. 2003; 171:1637-1641. PMID: 12902459
9. Hong C, Lee H, Park YK, Shin J, Jung S, Kim H, et al. Regulation of secondary antigen-specific CD8(+) T-cell responses by natural killer T cells. Cancer Res. 2009; 69:4301-4308. doi: 10.1158/0008-5472. CAN-08-1721 PMID: 19401453
10. Fujii S, Shimizu K, Smith C, Bonifaz L, Steinman RM. Activation of natural killer T cells by alphagalactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med. 2003; 198: 267-279. PMID: 12874260
11. + T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol. 2003; 171:5140-5147. PMID: 14607913
12. + T cells upon NK T or T cell activation. J Immunol. 2000; 165: 4305-4311. PMID: 11035065
13. + cytotoxic T cells are critical and sufficient for NKT cell-dependent tumor rejection. J Immunol. 2006; 177:6747-6757. PMID: 17082588
14. Holgate ST. Innate and adaptive immune responses in asthma. Nat Med. 2012; 18:673-683. doi: 10. 1038/nm.2731 PMID: 22561831
15. Zhang G, Nie H, Yang J, Ding X, Huang Y, Yu H, et al. Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma. Am J Physiol Lung Cell Mol Physiol. 2011; 301:L975-984. doi: 10.1152/ajplung.00114.2011 PMID: 21856813
16. Crowe NY, Smyth MJ, Godfrey DI. A critical role for natural killer T cells in immunosurveillance of meth-ylcholanthrene-induced sarcomas. J Exp Med. 2002; 196:119-127. PMID: 12093876
17. Novak J, Lehuen A. Mechanism of regulation of autoimmunity by iNKT cells. Cytokine. 2011; 53: 263-270. doi: 10.1016/j.cyto.2010.11.001 PMID: 21185200
18. Matangkasombut P, Pichavant M, Dekruyff RH, Umetsu DT. Natural killer T cells and the regulation of asthma. Mucosal Immunol. 2009; 2:383-392. doi: 10.1038/mi.2009.96 PMID: 19587638
19. Oki S, Miyake S. Invariant natural Killer T (iNKT) cells in asthma: a novel insight into the pathogenesis of asthma and the therapeutic implication of glycolipid ligands for allergic diseases. Allergol Int. 2007; 56:7-14. PMID: 17259804
20. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol. 2007; 25:297-336. PMID: 17150027
21. Gumperz JE, Roy C, Makowska A, Lum D, Sugita M, Podrebarac T, et al. Murine CD1d-restricted T cell recognition of cellular lipids. Immunity. 2000; 12:211-221. PMID: 10714687
22. Fox LM, Cox DG, Lockridge JL, Wang X, Chen X, Scharf L, et al. Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biol. 2009; 7:e1000228. doi: 10.1371/journal.pbio.1000228 PMID: 19859526
23. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003; 4:1230-1237.NKT cells are not the predominant T cell in asthma and likely modulate, not cause, asthm PMID: 14578883
24. Wingender G, Rogers P, Batzer G, Lee MS, Bai D, Pei B, et al. Invariant NKT cells are required for airway inflammation induced by environmental antigens. J Exp Med. 2011; 208:1151-1162. doi: 10. 1084/jem.20102229 PMID: 21624935
25. + T cell immune responses. J Immunol. 2010; 184:5589-5594. doi: 10. 4049/jimmunol.0903121 PMID: 20375305
26. Wiethe C, Debus A, Mohrs M, Steinkasserer A, Lutz M, Gessner A. Dendritic cell differentiation state and their interaction with NKT cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection. J Immunol. 2008; 180:4371-4381. PMID: 18354157