A novel approach for the intravenous delivery of leuprolide using core-cross-linked polymeric micelles

Journal of Controlled Release

Volumn 205, Issue , 2015, Pages 98-108

  Hu, Qizhi ^a,b   Van Gaal, Ethlinn V B ^b   Brundel, Paul ^b   Ippel, Hans ^c   Hackeng, Tilman ^c   Rijcken, Cristianne J F ^b   Storm, Gert ^a,d   Hennink, Wim E ^d   Prakash, Jai ^a  

^a UNIVERSITY OF TWENTE   (Netherlands)

^b Cristal Therapeutics   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Leuprolide; Pharmacokinetics; Polymeric micelles; Sustained release; Therapeutic peptide

Indexed keywords

CONTROLLED DRUG DELIVERY; ESTERS; FUNCTIONAL POLYMERS; MICELLES; PEPTIDES; PHARMACOKINETICS;

CIRCULATION HALF-LIFES; CROSS-LINKED POLYMERIC MICELLES; INTRAVENOUS ADMINISTRATION; INTRAVENOUS INJECTIONS; LEUPROLIDE; POLYMERIC MICELLE; SUSTAINED RELEASE; THERAPEUTIC PEPTIDES;

TARGETED DRUG DELIVERY;

CORE CROSS LINKED POLYMERIC MICELLE; ESTER; LEUPRORELIN; NANOCARRIER; POLYMER; TESTOSTERONE; UNCLASSIFIED DRUG; CROSS LINKING REAGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; MICELLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD; COVALENT BOND; CROSS LINKING; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG HYDROLYSIS; EVALUATION STUDY; IN VIVO STUDY; MALE; MEAN RESIDENCE TIME; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; POLYMERIZATION; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; SYSTEMIC CIRCULATION; TESTOSTERONE BLOOD LEVEL; VOLUME OF DISTRIBUTION AT STEADY-STATE; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; HALF LIFE TIME; HYDROLYSIS; INTRAVENOUS DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; METABOLIC CLEARANCE RATE; MICELLE; PHARMACEUTICS; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; ESTERS; HALF-LIFE; HYDROLYSIS; INJECTIONS, INTRAVENOUS; LEUPROLIDE; MALE; METABOLIC CLEARANCE RATE; MICELLES; POLYMERS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TESTOSTERONE;

EID: 84926433310     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.12.023     Document Type: Article

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