Structural elucidation of Leuprolide and its analogues in solution: Insight into their bioactive conformation

Amino Acids

Volumn 39, Issue 5, 2010, Pages 1147-1160

  Laimou, Despina K ^a   Katsara, Maria ^a,b   Matsoukas, Minos Timotheos I ^a   Apostolopoulos, Vasso ^b   Troganis, Anastassios N ^c   Tselios, Theodore V ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b BURNET INSTITUTE   (Australia)

^c NONE

Author keywords

Bioactive conformation; Gonadotropin releasing hormone (GnRH); Leuprolide; Molecular dynamics; Nuclear magnetic resonance

Indexed keywords

DIMETHYL SULFOXIDE; G PROTEIN COUPLED RECEPTOR; HYDROGEN PEROXIDE; LEUCINE; LEUPRORELIN; SOLVENT; TYROSINE;

ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SIMULATION;

ANTINEOPLASTIC AGENTS, HORMONAL; CELL PROLIFERATION; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GONADOTROPIN-RELEASING HORMONE; HUMANS; LEUPROLIDE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; WATER;

EID: 78449300608     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-010-0549-8     Document Type: Article

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