Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity

Journal of Hepatology

Volumn 62, Issue 4, 2015, Pages 905-912

  Anjani, Kavya ^a,b,c   Lhomme, Marie ^c   Sokolovska, Nataliya ^a,b,c   Poitou, Christine ^a,b,c   Aron Wisnewsky, Judith ^a,b,c   Bouillot, Jean Luc ^e   Lesnik, Philippe ^a,c,d   Bedossa, Pierre ^f,g   Kontush, Anatol ^a,c,d   Clement, Karine ^a,b,c   Dugail, Isabelle ^a,b,c   Tordjman, Joan ^a,b,c  

^a SORBONNE UNIVERSITÉ   (France)

^b Equipe Nutriomique: Nutrition et Obésité Approches Systémiques   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d Institute OfCardiometabolism and Nutrition   (France)

^e HÔPITAL AMBROISE PARÉ   (France)

^f BEAUJON HOSPITAL   (France)

^g CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

Author keywords

Bariatric surgery.; Glycerophosphatidylethanolamines; Glycerophosphatidylglycerols; Lipidomics; Visceral adipose tissue

Indexed keywords

CERAMIDE; GLYCEROPHOSPHOETHANOLAMINE; GLYCEROPHOSPHORYLCHOLINE; LIVER ENZYME; PHOSPHOLIPID; GLYCEROPHOSPHOLIPID;

ADIPOSE TISSUE; ADULT; ARTICLE; BARIATRIC SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; EFFUSION; EX VIVO STUDY; FEMALE; HUMAN; INTRAABDOMINAL FAT; LIPIDOMICS; MASS SPECTROMETRY; MORBID OBESITY; NONALCOHOLIC FATTY LIVER; PORTAL VEIN BLOOD; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; SYSTEMIC CIRCULATION; WEIGHT REDUCTION; ADVERSE EFFECTS; BLOOD; CLASSIFICATION; COMPLICATION; FOLLOW UP; FRANCE; LIVER; METABOLISM; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, MORBID; PATHOLOGY; PORTAL VEIN; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PROCEDURES;

ADIPOSE TISSUE; ADULT; BARIATRIC SURGERY; CERAMIDES; FEMALE; FOLLOW-UP STUDIES; FRANCE; GLYCEROPHOSPHOLIPIDS; HUMANS; LIVER; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY, MORBID; PORTAL SYSTEM; POSTOPERATIVE COMPLICATIONS; POSTOPERATIVE PERIOD;

EID: 84926421889     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.11.002     Document Type: Article

References (41)

1. C.E. Ruhl, and J.E. Everhart Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States Gastroenterology 124 2003 71 79
2. G. Targher, L. Bertolini, R. Padovani, S. Rodella, R. Tessari, and L. Zenari Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients Diabetes Care 30 2007 1212 1218
3. J. Arun, R.H. Clements, A.J. Lazenby, R.R. Leeth, and G.A. Abrams The prevalence of non-alcoholic steatohepatitis is greater in morbidly obese men compared to women Obes Surg 16 2006 1351 1358
4. S.R. Mohanty, T.N. Troy, D. Huo, B.L. O'Brien, D.M. Jensen, and J. Hart Influence of ethnicity on histological differences in non-alcoholic fatty liver disease J Hepatol 50 2009 797 804
5. K. Bambha, P. Belt, M. Abraham, L.A. Wilson, M. Pabst, and L. Ferrell Ethnicity and non-alcoholic fatty liver disease Hepatology 55 2012 769 780
6. S. Romeo, J. Kozlitina, C. Xing, A. Pertsemlidis, D. Cox, and L.A. Pennacchio Genetic variation in PNPLA3 confers susceptibility to non-alcoholic fatty liver disease Nat Genet 40 2008 1461 1465
7. J.M. Clark The epidemiology of non-alcoholic fatty liver disease in adults J Clin Gastroenterol 40 2006 S5 S10
8. L.S. Bhatia, N.P. Curzen, P.C. Calder, and C.D. Byrne Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? Eur Heart J 33 2012 1190 1200
9. G. Targher, A. Mantovani, I. Pichiri, R. Rigolon, M. Dauriz, and G. Zoppini Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with type 2 diabetes Clin Sci (Lond) 125 2013 301 309
10. A. Verrijken, S. Francque, I. Mertens, J. Prawitt, S. Caron, and G. Hubens Prothrombotic factors in histologically proven NAFLD and NASH Hepatology 59 2013 121 129
11. J. Tordjman, A. Divoux, E. Prifti, C. Poitou, V. Pelloux, and D. Hugol Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity J Hepatol 56 2012 1152 1158
12. R. Cancello, J. Tordjman, C. Poitou, G. Guilhem, J.L. Bouillot, and D. Hugol Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity Diabetes 55 2006 1554 1561
13. D. Van der Poorten, K.-L. Milner, J. Hui, A. Hodge, M.I. Trenell, and J.G. Kench Visceral fat: a key mediator of steatohepatitis in metabolic liver disease Hepatology 48 2008 449 457
14. J. Tordjman, C. Poitou, D. Hugol, J.-L. Bouillot, A. Basdevant, and P. Bedossa Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status J Hepatol 51 2009 354 362
15. Y. Eguchi, T. Mizuta, Y. Sumida, E. Ishibashi, Y. Kitajima, and H. Isoda The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of non-alcoholic fatty liver disease J Gastroenterol 46 2011 70 78
16. P. Bjorntorp "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes Arterioscler Thromb Vasc Biol 10 1990 493 496
17. R.N. Bergman, and M. Ader Free fatty acids and pathogenesis of type 2 diabetes mellitus Trends Endocrinol Metab 11 2000 351 356
18. J.M. Rytka, S. Wueest, E.J. Schoenle, and D. Konrad The portal theory supported by venous drainage - selective fat transplantation Diabetes 60 2011 56 63
19. G.S. Hotamisligil Mechanisms of TNF-alpha-induced insulin resistance Exp Clin Endocrinol Diabetes 107 1999 119 125
20. C.M. Steppan, S.T. Bailey, S. Bhat, E.J. Brown, R.R. Banerjee, and C.M. Wright The hormone resistin links obesity to diabetes Nature 409 2001 307 312
21. A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 7 2001 947 953
22. M. Kabir, K.J. Catalano, S. Ananthnarayan, S.P. Kim, G.W. Van Citters, and M.K. Dea Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance Am J Physiol Endocrinol Metab 288 2005 E454 E461
23. M.D. Jensen Role of body fat distribution and the metabolic complications of obesity J Clin Endocrinol Metab 93 2008 S57 S63
24. P. Puri, R.A. Baillie, M.M. Wiest, F. Mirshahi, J. Choudhury, and O. Cheung A lipidomic analysis of non-alcoholic fatty liver disease Hepatology 46 2007 1081 1090
25. D.L. Gorden, P.T. Ivanova, D.S. Myers, J.O. McIntyre, M.N. VanSaun, and J.K. Wright Increased diacylglycerols characterize hepatic lipid changes in progression of human non-alcoholic fatty liver disease; comparison to a murine model PLoS One 6 2011 e22775
26. P. Puri, M.M. Wiest, O. Cheung, F. Mirshahi, C. Sargeant, and H.-K. Min The plasma lipidomic signature of non-alcoholic steatohepatitis Hepatology 50 2009 1827 1838
27. J. Hyysalo, P. Gopalacharyulu, H. Bian, T. Hyötyläinen, M. Leivonen, and N. Jaser Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity Diabetes 63 2014 312 322
28. O. Quehenberger, A.M. Armando, A.H. Brown, S.B. Milne, D.S. Myers, and A.H. Merrill Lipidomics reveals a remarkable diversity of lipids in human plasma J Lipid Res 51 2010 3299 3305
29. P. Bedossa, C. Poitou, N. Veyrie, J.-L. Bouillot, A. Basdevant, and V. Paradis Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients Hepatology 56 2012 1751 1759
30. L. Camont, M. Lhomme, F. Rached, W. Le Goff, A. Nègre-Salvayre, and R. Salvayre Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities Arterioscler Thromb Vasc Biol 33 2013 2715 2723
31. R. Anty, A. Iannelli, S. Patouraux, S. Bonnafous, V.J. Lavallard, and M. Senni-Buratti A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients Aliment Pharmacol Ther 32 2010 1315 1322
32. N. Stefan, and H.-U. Häring Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans Nat Med 19 2013 394 395
33. P. Gupte, D. Amarapurkar, S. Agal, R. Baijal, P. Kulshrestha, and S. Pramanik Non-alcoholic steatohepatitis in type 2 diabetes mellitus J Gastroenterol Hepatol 19 2004 854 858
34. H. Ma, C. Xu, L. Xu, C. Yu, M. Miao, and Y. Li Independent association of HbA1c and non-alcoholic fatty liver disease in an elderly Chinese population BMC Gastroenterol 13 2013 3
35. G. Musso, M. Cassader, F. De Michieli, F. Rosina, F. Orlandi, and R. Gambino Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism Hepatology 56 2012 933 942
36. C. Boza, A. Riquelme, L. Ibañez, I. Duarte, E. Norero, and P. Viviani Predictors of non-alcoholic steatohepatitis (NASH) in obese patients undergoing gastric bypass Obes Surg 15 2005 1148 1153
37. P. Mathurin, A. Hollebecque, L. Arnalsteen, D. Buob, E. Leteurtre, and R. Caiazzo Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease Gastroenterology 137 2009 532 540
38. N. Stefan, and H.-U. Häring The role of hepatokines in metabolism Nat Rev Endocrinol 9 2013 144 152
39. R.E. Ley, F. Bäckhed, P. Turnbaugh, C.A. Lozupone, R.D. Knight, and J.I. Gordon Obesity alters gut microbial ecology Proc Natl Acad Sci U S A 102 2005 11070 11075
40. A. Cotillard, S.P. Kennedy, L.C. Kong, E. Prifti, N. Pons, and E. Le Chatelier Dietary intervention impact on gut microbial gene richness Nature 500 2013 585 588
41. L. Zhu, S.S. Baker, C. Gill, W. Liu, R. Alkhouri, and R.D. Baker Characterization of gut microbiomes in non-alcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH Hepatology 57 2013 601 609