The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease

Journal of Gastroenterology

Volumn 46, Issue SUPPL. 1, 2011, Pages 70-78

  Eguchi, Yuichiro ^a   Mizuta, Toshihiko ^a   Sumida, Yoshio ^b   Ishibashi, Eriko ^a,c   Kitajima, Yoichiro ^a,c   Isoda, Hiroshi ^a,c   Horie, Hiroko ^c   Tashiro, Takaya ^c   Iwamoto, Eri ^c   Takahashi, Hirokazu ^a   Kuwashiro, Takuya ^a   Soejima, Shu ^a   Kawaguchi, Yasunori ^a   Oda, Yasutomo ^a   Emura, Sei ^a   Iwakiri, Ryuichi ^a   Ozaki, Iwata ^a   Eguchi, Takahisa ^c   Ono, Naofumi ^c   Anzai, Keizo ^a   Fujimoto, Kazuma ^a   Koizumi, Shunzo ^a   more..

^a SAGA UNIVERSITY   (Japan)

^b Nara City Hospital   (Japan)

^c Eguchi Hospital   (Japan)

Author keywords

Abdominal obesity; Adipocytokine; Central obesity; Metabolic syndrome; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; GLUCOSE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ABDOMINAL RADIOGRAPHY; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALYZER; ARTICLE; CHOLESTEROL BLOOD LEVEL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; HEPATITIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRAABDOMINAL FAT; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PATHOGENESIS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; ALANINE TRANSAMINASE; CHOLESTEROL, LDL; DISEASE PROGRESSION; ELECTRIC IMPEDANCE; FATTY LIVER; FEMALE; HUMANS; INFLAMMATION; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; PROGNOSIS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED; TRIGLYCERIDES; YOUNG ADULT;

EID: 78651371839     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0340-3     Document Type: Article

References (34)

1. E Bugianesi N Leone E Vanni G Marchesini F Brunello P Carucci, et al. 2002 Expanding the natural history of non-alcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma Gastroenterology 123 134 140 10.1053/gast.2002.34168 12105842 (Pubitemid 34747534)
2. JM Hui A Hodge GC Farrell JG Kench A Kriketos J George 2004 Beyond insulin resistance in NASH: TNF-alpha (R3-6) or adiponectin? Hepatology 40 46 54 1:CAS:528:DC%2BD2cXmtlSgtLY%3D 10.1002/hep.20280 15239085 (Pubitemid 38868922)
3. Y Eguchi T Eguchi T Mizuta Y Ide T Yasutake R Iwakiri, et al. 2006 Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease J Gastroenterol 41 462 469 1:CAS:528: DC%2BD28XmtFGqu7Y%3D 10.1007/s00535-006-1790-5 16799888 (Pubitemid 43941913)
4. Browning LM, Mugridge O, Chatfield MD, Dixon AK, Aitken SW, Joubert I, et al. Validity of a new abdominal bioelectrical impedance device to measure abdominal and visceral fat: comparison with MRI. Obesity. 2010; Apr 1 [Epub ahead of print].
5. SM Haffner E Kennedy C Gonzalez MP Stern H Miettinen 1996 A prospective analysis of the HOMA model. The Mexico City Diabetes Study Diabetes Care 19 1138 1141 1:STN:280:DyaK2s%2FktFaqsQ%3D%3D 10.2337/diacare.19.10.1138 8886564
6. A Katz SS Nambi K Mather AD Baron DA Follmann G Sullivan, et al. 2000 Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans J Clin Endocrinol Metab 85 2402 2410 1:CAS:528:DC%2BD3cXlt1Wntrg%3D 10.1210/jc.85.7.2402 10902785 (Pubitemid 32269192)
7. DR Matthews JP Hosker AS Rudenski BA Naylor DF Treacher RC Turner 1985 Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 412 419 1:CAS:528:DyaL2MXlslKnu7k%3D 10.1007/BF00280883 3899825 (Pubitemid 15018832)
8. CA Matteoni ZM Younossi T Gramlich N Boparai YC Liu AJ McCullough 1999 Nonalcoholic fatty liver diseases: a spectrum of clinical and pathological severity Gastroenterology 116 1413 1419 1:STN:280:DyaK1M3nvVamtw%3D%3D 10.1016/S0016-5085(99)70506-8 10348825 (Pubitemid 29258890)
9. N Rafiq C Bai Y Fang M Srishord A McCullough T Gramlich, et al. 2009 Long-term follow-up of patients with nonalcoholic fatty liver Clin Gastroenterol Hepatol 7 234 238 10.1016/j.cgh.2008.11.005 19049831
10. EM Brunt CG Janney AM Di Bisceglie BA Neuschwander-Tetri BR Bacon 1999 Non-alcoholic steatohepatitis: a proposal for grading and staging the histological lesions Am J Gastroenterol 94 2467 2474 1:STN:280: DyaK1MvhtFyisw%3D%3D 10.1111/j.1572-0241.1999.01377.x 10484010 (Pubitemid 29420675)
11. DE Kleiner EM Brunt M Van Natta C Behling MJ Contos OW Cummings, et al. 2005 Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 1313 1321 10.1002/hep.20701 15915461 (Pubitemid 40770284)
12. T Yoshizumi T Nakamura M Yamane AH Islam M Menju K Yamasaki, et al. 1999 Abdominal fat: standardized technique for measurement at CT Radiology 211 283 286 1:STN:280:DyaK1M3gsFCrsQ%3D%3D 10189485
13. E Ishibashi Y Eguchi T Eguchi A Matsunobu N Oza S Nakashita, et al. 2008 Waist circumference correlates with hepatic fat accumulation in male Japanese patients with nonalcoholic fatty liver disease, but not in females J Gastroenterol Hepatol 23 908 913 1:CAS:528:DC%2BD1cXptFyls7c%3D 10.1111/j.1440-1746.2008.05366.x 18373563 (Pubitemid 351806579)
14. J Westerbacka A Corner M Tiikkainen M Tamminen S Vehkavaara AM Hakkinen, et al. 2004 Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk Diabetologia 47 1360 1369 1:STN:280: DC%2BD2cvgsVCksw%3D%3D 10.1007/s00125-004-1460-1 15309287 (Pubitemid 39232420)
15. JM Clark AM Diehl 2003 Defining nonalcoholic fatty liver disease: implications for epidemiologic studies Gastroenterology 124 248 250 10.1053/gast.2003.50032 12512048 (Pubitemid 36055357)
16. SS Kunde AJ Lazenby RH Clements GA Abrams 2005 Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women Hepatology 42 650 656 10.1002/hep.20818 16037946 (Pubitemid 41233658)
17. D Prati E Taioli A Zanella A Zanella TE Della S Butelli, et al. 2002 Updated definitions of healthy ranges for serum alanine aminotransferase levels Ann Intern Med 137 1 10 1:CAS:528:DC%2BD38Xls1entbc%3D 12093239
18. HC Kim CM Nam SH Jee KH Han DK Oh I Suh 2004 Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study BMJ 328 983 988 1:CAS:528:DC%2BD2cXksFOmtbs%3D 10.1136/bmj.38050.593634.63 15028636
19. GN Ioannou EJ Boyko SP Lee 2006 The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002 Am J Gastroenterol 101 76 82 10.1111/j.1572-0241.2005.00341.x 16405537 (Pubitemid 43381712)
20. MC Kew 2000 Serum aminotransferase concentration as evidence of hepatocellular damage Lancet 355 591 592 1:CAS:528:DC%2BD3cXhvVCqu7s%3D 10.1016/S0140-6736(99)00219-6 10696975
21. P Mofrad MJ Contos M Haque C Sargeant RA Fisher VA Luketic, et al. 2003 Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values Hepatology 37 1286 1292 10.1053/jhep.2003.50229 12774006 (Pubitemid 36667307)
22. MH Mendler B Turlin R Moirand AM Jouanolle T Sapey D Guyader, et al. 1999 Insulin resistance-associated hepatic iron overload Gastroenterology 117 1155 1163 1:STN:280:DC%2BD3c%2FgsF2itQ%3D%3D 10.1016/S0016-5085(99)70401-4 10535879 (Pubitemid 29512675)
23. Y Kohgo T Ohtake K Ikuta Y Suzuki Y Torimoto J Kato 2008 Dysregulation of systemic iron metabolism in alcoholic liver disease J Gastroenterol Hepatol 23 S78 S81 1:CAS:528:DC%2BD1cXkslKgtro%3D 10.1111/j.1440-1746.2007.05290.x 18336670 (Pubitemid 351389036)
24. N Fujita H Miyachi H Tanaka M Takeo N Nakagawa Y Kobayashi, et al. 2009 Iron overload is associated with hepatic oxidative damage to DNA in nonalcoholic steatohepatitis Cancer Epidemiol Biomarkers Prev 18 424 432 1:CAS:528:DC%2BD1MXhslShtbk%3D 10.1158/1055-9965.EPI-08-0725 19190144
25. Y Kamada T Takehara N Hayashi 2008 Adipocytokines and liver disease J Gastroenterol 43 811 822 1:CAS:528:DC%2BD1cXhtlyksrrE 10.1007/s00535-008-2213-6 19012034
26. C Pagano G Soardo W Esposito F Fallo L Basan D Donnini, et al. 2005 Plasma adiponectin is decreased in nonalcoholic fatty liver disease Eur J Endocrinol 152 113 118 1:CAS:528:DC%2BD2MXptFartA%3D%3D 10.1530/eje.1.01821 15762194 (Pubitemid 40185459)
27. Y Kamada T Nakamura T Funahashi M Ryo H Nishizawa Y Okauchi, et al. 2009 Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction: an epidemiologic study of 3827 Japanese subjects J Clin Gastroenterol 43 995 1000 1:CAS:528:DC%2BD1MXht1yltrjM 10.1097/MCG. 0b013e3181962de8 19407661
28. M Nishida T Funahashi I Shimomura 2007 Pathophysiological significance of adiponectin Med Mol Morphol 40 55 67 1:CAS:528:DC%2BD2sXmsFKiur8%3D 10.1007/s00795-007-0366-7 17572841 (Pubitemid 47305235)
29. T Okanoue T Saibara M Ono Y Sumida E Hashimoto T Tamura, et al. 2009 JSH Consensus Kobe 2009: diagnosis and treatment of NASH Kanzo 50 741 747 10.2957/kanzo.50.741
30. Y Sumida T Nakashima T Yoh M Furutani A Hirohama Y Kakisaka, et al. 2003 Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease J Hepatol 38 32 38 1:CAS:528: DC%2BD38XptlSqt7k%3D 10.1016/S0168-8278(02)00331-8 12480557 (Pubitemid 36078521)
31. Y Sumida Y Yonei K Kanemasa T Hara Y Inada K Sakai, et al. 2010 Lower circulating levels of dehydroepiandrosterone, independent of insulin resistance, is an important determinant of severity of nonalcoholic steatohepatitis in Japanese patients Hepatol Res 40 901 910 1:CAS:528:DC%2BC3cXhtlSgt7nM 10.1111/j.1872-034X.2010.00704.x 20887595
32. N Oza Y Eguchi T Mizuta E Ishibashi Y Kitajima H Horie, et al. 2009 A pilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staff J Gastroenterol 44 1203 1208 10.1007/s00535-009-0115-x 19728009
33. Y Kitajima Y Eguchi E Ishibashi S Nakashita S Aoki S Toda, et al. 2010 Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver disease J Gastroenterol 45 218 224 10.1007/s00535-009- 0147-2 19882375
34. O Cheung AJ Sanyal 2010 Recent advances in nonalcoholic fatty liver disease Curr Opin Gastroenterol 26 202 208 10.1097/MOG.0b013e328337b0c4 20168226